Recent advances in single molecule studies of nucleosomes.

Abstract:

:As the fundamental packing units of DNA in eukaryotes, nucleosomes play a central role in governing DNA accessibility in a variety of cellular processes. Our understanding of the mechanisms underlying this complex regulation has been aided by unique structural and dynamic perspectives offered by single molecule techniques. Recent years have witnessed remarkable advances achieved using these techniques, including the generation of a detailed histone-DNA energy landscape, elucidation of nucleosome disassembly processes, and real-time monitoring of molecular motors interacting with nucleosomes. These and other highlights of single molecule nucleosome studies will be discussed in this review.

journal_name

Curr Opin Struct Biol

authors

Killian JL,Li M,Sheinin MY,Wang MD

doi

10.1016/j.sbi.2011.11.003

subject

Has Abstract

pub_date

2012-02-01 00:00:00

pages

80-7

issue

1

eissn

0959-440X

issn

1879-033X

pii

S0959-440X(11)00183-7

journal_volume

22

pub_type

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