Oxidation and amidation of salicylate by Streptomyces species.

Abstract:

:Seven streptomycete strains were tested for biotransformation of salicylate. The products were identified by nuclear magnetic resonance spectroscopy and three types of conversion were found. Streptomyces cinnamonensis and Streptomyces spectabilis formed gentisate and salicylamide concurrently. Streptomyces rimosus transformed salicylate to salicylamide. Streptomyces lividans, Streptomyces coelicolor, Streptomyces griseus and Streptomyces avermitilis produced only gentisate. Time course studies of salicylate conversion by thin-layer chromatography and high pressure liquid chromatography showed that salicylamide was accumulated in the culture broth, whereas gentisate was further metabolized.Key words: salicylate, gentisate, salicylamide, biotransformation, Streptomyces spp.

journal_name

Can J Microbiol

authors

Pospíšil S,Přikrylová V,Němeček J,Spížek J

doi

10.1139/m96-111

subject

Has Abstract

pub_date

1996-08-01 00:00:00

pages

867-9

issue

8

eissn

0008-4166

issn

1480-3275

journal_volume

42

pub_type

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