Nuclear protein in testis midline carcinomas: a lethal and underrecognized entity.

Abstract:

:A 54-year-old woman presented with a nasal mass. Biopsy demonstrated undifferentiated tumor cells with extensive apoptosis and necrosis. Chromosome analysis identified a 46,XX,t(15;19)(q13;p13.1) pattern. Nuclear protein in testis (NUT) immunohistochemistry and fluorescence in situ hybridization confirmed NUT rearrangement. A Ewing sarcoma-based chemotherapy regimen and concurrent irradiation obtained a dramatic response; however, the patient died of her disease less than 7 months after initial diagnosis. NUT midline carcinomas are rare, aggressive tumors defined by rearrangement of the NUT gene on 15q14. A solitary translocation involving 15q14 is usually the sole chromosomal abnormality in these carcinomas. Immunohistochemical expression of NUT in the nuclei of non-germ cell tumors is theoretically diagnostic. More widespread use of a newly available NUT immunohistochemical stain will facilitate the diagnosis of NUT rearranged carcinomas. From the growing numbers of identified cases, effective targeted therapies can be developed.

journal_name

Arch Pathol Lab Med

authors

Davis BN,Karabakhtsian RG,Pettigrew AL,Arnold SM,French CA,Brill YM

doi

10.5858/arpa.2010-0389-CR

subject

Has Abstract

pub_date

2011-11-01 00:00:00

pages

1494-8

issue

11

eissn

0003-9985

issn

1543-2165

journal_volume

135

pub_type

杂志文章
  • Number of levels needed for diagnosis of cervical biopsies.

    abstract:CONTEXT:Three levels of histologic sections are routinely prepared for small biopsies in many surgical pathology laboratories. The first level is superficial and may not be representative of the entire biopsy, and may therefore represent wasted resources and time for technologists and pathologists alike. OBJECTIVE:To ...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.1043/0003-9985(2002)126<1205:NOLNFD>2.0.CO;2

    authors: Luo YV,Prihoda TJ,Sharkey FE

    更新日期:2002-10-01 00:00:00

  • Mammary sarcoidosis. Two cases and literature review.

    abstract::A patient with sarcoidosis had a biopsy of a firm nontender breast nodule that at analysis disclosed multiple noncaseating granulomas. In another patient with sarcoidosis, noncaseating granulomas were an incidental finding in a mastectomy specimen containing medullary carcinoma and in two subsequent biopsy specimens o...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Gansler TS,Wheeler JE

    更新日期:1984-08-01 00:00:00

  • In vitro susceptibility of Cryptococcus neoformans isolates from patients with acquired immunodeficiency syndrome.

    abstract::Cryptococcus neoformans strains from 26 individual patients with acquired immunodeficiency syndrome (AIDS) and three isolates from patients without AIDS were tested for their susceptibility to amphotericin B, flucytosine, ketoconazole, and miconazole nitrate. Ninety percent of the C neoformans isolates from patients w...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Poon M,Cronin DC 2nd,Wormser GP,Bottone EJ

    更新日期:1988-02-01 00:00:00

  • Primary Malignant Deciduoid Mesothelioma: A Challenging Diagnosis.

    abstract::Primary malignant deciduoid mesothelioma is a rare subtype of epithelioid mesothelioma that was first described in the peritoneum in young women without a history of asbestos exposure. It was thought to be a distinct clinicopathologic entity with ominous prognosis; recent studies have better characterized this entity....

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.5858/arpa.2017-0461-RS

    authors: Regragui M,Guebessi NB

    更新日期:2019-04-01 00:00:00

  • Changes of biochemical and biomechanical properties in Dupuytren disease.

    abstract:BACKGROUND:The major biochemical characteristic of Dupuytren disease is the progressive and irreversible deposition of excess fibrous collagen characterized by an enhanced type III collagen proportion. OBJECTIVE:To investigate the influence of changes of the collagen spectrum on the biophysical properties of the palma...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.1043/0003-9985(2000)124<1275:COBABP>2.0.CO;2

    authors: Melling M,Karimian-Teherani D,Mostler S,Behnam M,Sobal G,Menzel EJ

    更新日期:2000-09-01 00:00:00

  • Policies and procedures related to testing for weak D phenotypes and administration of Rh immune globulin: results and recommendations related to supplemental questions in the Comprehensive Transfusion Medicine survey of the College of American Pathologis

    abstract:CONTEXT:Advances in RHD genotyping offer an opportunity to update policies and practices for testing weak D phenotypes and administration of Rh immune globulin to postpartum women. OBJECTIVES:To repeat questions from a 1999 College of American Pathologists proficiency test survey, to evaluate current practices for tes...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.5858/arpa.2013-0141-CP

    authors: Sandler SG,Roseff SD,Domen RE,Shaz B,Gottschall JL

    更新日期:2014-05-01 00:00:00

  • Interpretation of diagnostic cytology with likelihood ratios.

    abstract::Sensitivity, specificity, and predictive values are commonly used to report the performance characteristics of a diagnostic test. With tests that by their nature have more than two classes of results, calculation of sensitivity and specificity demands the combination of categories into two classes, leading to a loss o...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Giard RW,Hermans J

    更新日期:1990-08-01 00:00:00

  • Nonneoplastic lesions that simulate primary tumors of bone.

    abstract:CONTEXT:The skeletal system may be affected by a variety of nonneoplastic lesions, which may potentially be confused with primary bone tumors on clinical, radiologic, and pathologic grounds. These conditions include fractures, infections, and reactive and degenerative processes, as well as an array of quasineoplastic e...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.5858/arpa.2011-0557-RA

    authors: Remotti F,Feldman F

    更新日期:2012-07-01 00:00:00

  • Clinical consequences of specimen rejection: a College of American Pathologists Q-Probes analysis of 78 clinical laboratories.

    abstract:CONTEXT:Clinical laboratory specimens may be rejected as unsuitable for analysis for a variety of reasons and specimen rejection may have significant clinical consequences. OBJECTIVE:To quantify the clinical consequences of specimen rejection and determine the impact of laboratories' policies and practices on these co...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.5858/arpa.2013-0331-CP

    authors: Karcher DS,Lehman CM

    更新日期:2014-08-01 00:00:00

  • Application of immunohistochemistry to cytology.

    abstract:CONTEXT:The uses of monoclonal antibodies via immunochemistry have been reported frequently within the literature using various methodologies with applications to cytology specimens. The direct application of immunochemistry to cytology may have a variety of pitfalls that the general pathologist familiar with its appli...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1043/1543-2165(2008)132[373:AOITC]2.0.CO;2

    authors: Fowler LJ,Lachar WA

    更新日期:2008-03-01 00:00:00

  • Frozen section of thyroid and parathyroid specimens.

    abstract:CONTEXT:Preoperative fine-needle aspiration of thyroid lesions has greatly diminished the need for surgical evaluation. However, because thyroid nodules are common lesions, many still require surgical intervention and represent a substantial number of cases that the pathologist encounters in the frozen section laborato...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1043/1543-2165(2005)129[1575:FSOTAP]2.0.CO;2

    authors: Anton RC,Wheeler TM

    更新日期:2005-12-01 00:00:00

  • Localized cytomegalovirus encephalitis contiguous to metastatic nasopharyngeal carcinoma.

    abstract::We report a case of focal infection of the brain with cytomegalovirus (CMV) in a 14-year-old boy with metastatic lymphoepithelioma (nasopharyngeal carcinoma). Cytomegalovirus-bearing subependymal glia were only seen in the fourth ventricle, in close proximity to tumor cells, these were associated with an intense infla...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Soffer D,Horoupian DS

    更新日期:1979-07-01 00:00:00

  • Pulse granulomas detected in gallbladder, fallopian tube, and skin.

    abstract:CONTEXT:Foreign material typically elicits reactions dominated by multinucleated giant cells. Pulse granulomas are peculiar reactions to particles of food that are characterized by clusters of small to medium-sized hyaline rings. Pulse granulomas are rare and have occupied only the lungs, in association with aspiration...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.1043/1543-2165(2006)130[1839:PGDIGF]2.0.CO;2

    authors: Rhee DD,Wu ML

    更新日期:2006-12-01 00:00:00

  • The multiple faces of carcinoid tumor: performance characteristics of low-grade neuroendocrine carcinoma metastatic to the liver in an educational interlaboratory slide comparison program.

    abstract:CONTEXT:Cytologic features of low-grade neuroendocrine carcinoma are well described in primary sites. There are fewer reports of the cytologic features specific to metastatic liver lesions or the frequency of misdiagnosis. OBJECTIVE:To identify discriminating cytologic features and characterize the rate of misdiagnosi...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.1043/2009-0616-CP.1

    authors: Clayton AC,Wasserman PG,Souers RJ,Chmara BA,Renshaw A,Wilbur DC,Moriarty AT,College of American Pathologists Cytopathology Resource Committee.

    更新日期:2011-03-01 00:00:00

  • Ruptured myocardial abscess causing left ventricle to pulmonary artery communication in an infant with community-associated methicillin-resistant Staphylococcus aureus endocarditis.

    abstract::Myocardial abscess perforation is an extremely rare complication of infective endocarditis. We present a case of a 12-month-old infant who developed community-associated methicillin-resistant Staphylococcus aureus bacteremia after an incision and drainage of a skin abscess. He subsequently developed septic emboli to t...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.5858/2010-0144-CRR1

    authors: Hershenson JA,Baker PB,Rowland DG

    更新日期:2011-08-01 00:00:00

  • Molecular Testing of Thyroid Nodules: A Review of Current Available Tests for Fine-Needle Aspiration Specimens.

    abstract:CONTEXT:- Fine-needle aspiration of thyroid nodules is a reliable diagnostic method to determine the nature of thyroid nodules. Nonetheless, indeterminate cytology diagnoses remain a diagnostic challenge. The development of multiplex molecular techniques and the identification of genetic alterations associated with dif...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.5858/arpa.2016-0100-RA

    authors: Zhang M,Lin O

    更新日期:2016-12-01 00:00:00

  • Degeneration of aortic smooth muscle cells in swine fed excess vitamin D3.

    abstract::Twenty-eight weanling swine were divided into two groups and fed a basal ration of corn and soybean meal or one containing a high fat and cholesterol supplement. One subgroup of each received 220,000 IU of vitamin D3 per kilogram. Grossly normal areas of the distal abdominal aorta were used for quantitative comparison...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Kamio A,Kummerow FA,Imai H

    更新日期:1977-07-01 00:00:00

  • Glomus tumor.

    abstract::Glomus tumor is a benign mesenchymal neoplasm comprising less than 2% of soft tissue tumors. It is composed of cells resembling modified smooth muscle cells of the normal glomus body. The glomus body, a thermoregulator, is a specialized form of arteriovenous anastomosis localized in dermal and precoccygeal soft tissue...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1043/1543-2165(2008)132[1448:GT]2.0.CO;2

    authors: Gombos Z,Zhang PJ

    更新日期:2008-09-01 00:00:00

  • Multiple factors contribute to positive results for hepatitis A virus immunoglobulin M antibody.

    abstract:CONTEXT:In the United States, a successful vaccination program for hepatitis A virus (HAV) infection has decreased both its incidence and the true positive rate for diagnostic immunoglobulin M (IgM) antibody to HAV in acute hepatitis. OBJECTIVE:To survey positive results of HAV IgM tests and determine the effect of ch...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.5858/arpa.2011-0693-OA

    authors: Alatoom A,Ansari MQ,Cuthbert J

    更新日期:2013-01-01 00:00:00

  • Approach to intraoperative consultation for donor liver biopsies.

    abstract:CONTEXT:As demand for organs to treat end-stage liver disease increases, donor livers once deemed only marginally suitable for donation are being considered for transplantation. Pathologists are increasingly being asked to evaluate these livers for acceptability. This article provides guidelines for frozen section eval...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.5858/arpa.2011-0689-RA

    authors: Melin C,Miick R,Young NA,Ortiz J,Balasubramanian M

    更新日期:2013-02-01 00:00:00

  • Continuous monitoring of stat and routine outlier turnaround times: two College of American Pathologists Q-Tracks monitors in 291 hospitals.

    abstract:CONTEXT:The laboratory test turnaround times (TATs) that exceed the expectations of clinicians who order those tests, the so-called outlier test reporting rates, may be responsible for perceptions of inadequate laboratory service. OBJECTIVE:To monitor outlier test reporting rates for emergency department stat potassiu...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.1043/1543-2165(2004)128<621:CMOSAR>2.0.CO;2

    authors: Novis DA,Walsh MK,Dale JC,Howanitz PJ,College of American Pathologists Q-Tracks.

    更新日期:2004-06-01 00:00:00

  • Heterogeneity of epithelial marker expression in routinely processed, poorly differentiated carcinomas.

    abstract::The application of immunohistochemical markers against epithelial antigens has proved useful for studying tumor differentiation and in aiding tumor diagnosis. However, the reactivity of various epithelial markers with poorly differentiated carcinomas (the situation in which they are most often used) has not been well ...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Kamel OW,Rouse RV,Warnke RA

    更新日期:1991-06-01 00:00:00

  • Determination of genotypes using a fully automated molecular detection system.

    abstract:CONTEXT:Although the value of pharmacogenomics to improve patient outcomes has become increasingly clear, adoption in medical practice has been slow, which can be attributed to several factors, including complicated and expensive testing procedures and required equipment, lack of training by private practice physicians...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.5858/arpa.2014-0059-OA

    authors: Spizz G,Chen Z,Li P,McGuire IC,Klimkiewicz P,Zysling D,Yasmin R,Hungerford W,Thomas B,Wilding G,Mouchka G,Young L,Zhou P,Montagna RA

    更新日期:2015-06-01 00:00:00

  • Abstract/Case Study Review Committee for the College of American Pathologists 2016 Annual Meeting (CAP16).

    abstract::The Archives of Pathology & Laboratory Medicine acknowledges the following individuals for volunteering to review abstract and case study submissions for the CAP16 meeting. ...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.5858/arpa.2016-0240-AB

    authors:

    更新日期:2016-09-01 00:00:00

  • Longitudinal case-based evaluation of diagnostic competency among pathology residents: a statistical approach.

    abstract:CONTEXT:Accreditation Council for Graduate Medical Education guidelines require the evaluation of residents in 6 competencies. Pathology residents demonstrate medical knowledge, patient care, communication, and practice-based learning competencies in their attainment of competency in surgical pathology diagnosis. OBJE...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.1043/1543-2165(2006)130[188:LCEODC]2.0.CO;2

    authors: Ducatman BS,Ducatman AM

    更新日期:2006-02-01 00:00:00

  • Multimodality Technologies in the Assessment of Hematolymphoid Neoplasms.

    abstract::Accurate assessment of tissues for hematolymphoid neoplasms requires an integrated multiparameter approach. Although morphologic examination by light microscopy remains the mainstay of initial assessment for hematolymphoid neoplasms, immunophenotypic analysis by immunohistochemistry and/or flow cytometry is essential ...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.5858/arpa.2016-0260-SA

    authors: Li S,Jaye DL,Bradley KT,Zhang L,Saxe D,Deeb G,Hill CE,Mann KP

    更新日期:2017-03-01 00:00:00

  • Cardiac denervation and adrenalectomy. Its effects on myocardial lesions of hemorrhagic shock in dogs.

    abstract::Myocardial lesions were seen in dogs subjected to experimental hemorrhagic shock. In contrast, dogs that had been previously surgically treated by cardiac denervation and adrenalectomy, showed less myocardial damage. The latter group also had a substantially decreased myocardial I-norepinephrine content and a much low...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Hackel DB,Graham TC,Mikat EM

    更新日期:1980-02-01 00:00:00

  • Radiology estimates of viable tumor percentage in hepatocellular carcinoma ablation cavities correlate poorly with pathology assessment.

    abstract:CONTEXT:No study has evaluated radiology/pathology correlation of percentage viable tumor (PVT) estimates in ablated hepatocellular carcinoma (HCC) to examine the reliability of radiologic estimates. OBJECTIVE:To determine how well interdisciplinary PVT estimates correlate and identify pathologic factors that influenc...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.5858/arpa.2012-0126-OA

    authors: Hanson JA,Ason R,Weinreb J,Van Dyke A,Mitchell KA

    更新日期:2013-03-01 00:00:00

  • Postoperative spindle-cell nodule of the endometrium.

    abstract::The clinical and pathologic features of a case of postoperative spindle-cell nodule within the endometrium are reported, a lesion hitherto undescribed in this site. The nodule was found in the hysterectomy specimen from a 75-year-old woman, 2 1/2 weeks after a dilatation and curettage had revealed a well-differentiate...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Clement PB

    更新日期:1988-05-01 00:00:00

  • Disparate urinary catecholamine patterns in secondary hypertension due to unique sequential development of pheochromocytoma and neuroblastoma.

    abstract::A 43-year-old white woman had a pheochromocytoma removed from her left adrenal gland, and one year later she developed a new left upper abdominal mass that was found to be a neuroblastoma. On both occasions, urinary vanillylmandelic acid level was elevated. However, urinary norepinephrine and epinephrine levels were i...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Amodeo C,Perez J,Sturgill BC,Turner SM,Atuk NO

    更新日期:1989-07-01 00:00:00