Current progress in the development of RNAi-based therapeutics for HIV-1.

Abstract:

:Highly active antiretroviral therapy (HAART) treatment for HIV has changed the course of AIDS in societies in which the drugs are readily available. Despite the great success of HAART, drug resistance and toxicity issues still remain a concern for some individuals. Thus, a number of investigators have been exploring other approaches for inhibiting HIV-1 replication. One of the most potent of these is the use of RNA interference (RNAi). This review will focus solely on the use of RNAi for the treatment of HIV-1 infection, including the problems, progress and future prospects.

journal_name

Gene Ther

journal_title

Gene therapy

authors

Zhou J,Rossi JJ

doi

10.1038/gt.2011.149

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

1134-8

issue

12

eissn

0969-7128

issn

1476-5462

pii

gt2011149

journal_volume

18

pub_type

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