Endometrial adenocarcinoma with osteoclastic giant cells in stroma: a case report and review of literature.

Abstract:

:It is rare to find osteoclastic giant cells (OGCs) as a stromal reaction in uterine adenocarcinoma of endometrium. Here, we report a case of a 60-year-old female diagnosed with adenocarcinoma of endometrium. Total hysterectomy with bilateral salpingo-oopherectomy and removal of pelvic lymphnodes was performed. Histologically, the tumour showed adenocarcinoma of the endometrium with mucin secretion. The stroma showed some plump reactive pleomorphic cells, resembling stromal cells, infiltrated uniformly with OGCs and mononuclear cells (MNCs). The epithelial cells of adenocarcinoma stained positive for cytokeratin (CK 7) (CAM 5.2). The osteoclastic giant cells and mononuclear cells stained positive with CD68 and negative with cytokeratin and vimentin. We conclude that the osteoclastic giant cells originated from reactive histiocytes/monocytes as a stromal reaction to malignancy.

journal_name

Arch Gynecol Obstet

authors

Vasenwala SM,Beg S,Ansari HA,Haider N,Sharma R

doi

10.1007/s00404-011-2089-1

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

1157-60

issue

4

eissn

0932-0067

issn

1432-0711

journal_volume

285

pub_type

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