The sensitivity of artesunate against Schistosoma japonicum decreased after 10 years of use in China?

Abstract:

:Artesuante (AS) is a good chemoprophylactic drug for preventing against schistosome infection, but Hua et al. recently reported that the sensitivity of AS against Schistosoma japonicum decreased after 10 years of use in China. There are at least three problems, to our knowledge, making the finding suspicious or inconclusive in that report. In consideration of it as the first report about the emergence of potential artemisinin derivative-resistant S. japonicum to date and the possible severe influences of the emergence of AS-resistant S. japonicum on the future choice of chemoprophylactic drugs for preventing against S. japonicum infections in China, we write this comment and call for some more rigorous and convincing trials to confirm this finding further.

journal_name

Parasitol Res

journal_title

Parasitology research

authors

Liu R,Dong HF,Jiang MS

doi

10.1007/s00436-011-2641-8

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

1563-4

issue

4

eissn

0932-0113

issn

1432-1955

journal_volume

110

pub_type

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