[Study of albumin conformational changes in human serum using an immunoenzymatic technic using monoclonal antibodies].

Abstract:

:The specificity of six peroxidase-labelled anti-albumin monoclonal antibodies was studied by allowing them to react with albumin-derived fragments of known structure comprising the whole albumin molecule. The epitopes corresponding to these antibodies were located on defined regions of the albumin molecule extending from the N to the C-terminal ends. These antibodies have been used for investigating by ELISA the conformational alterations of albumin molecule brought about by the N-B transition in twelve individual sera. The results do not show any significant differences between the sera. The N-B transition involves essentially the N-terminal portion of the albumin molecule. There also exists as modification of the C-terminal region which is however much less pronounced than the one in the N-terminal region. In addition, it is not observed when using isolated albumin.

journal_name

Ann Biol Clin (Paris)

authors

Lapresle C

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

105-10

issue

2

eissn

0003-3898

issn

1950-6112

journal_volume

48

pub_type

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