Diffuse metanephric adenoma after in utero aspirin intoxication. A unique case of progressive renal failure.

Abstract:

:Diffuse persistent glomerular immaturity and focal proximal tubular ectasia were seen in bilateral open renal biopsy specimens for an infant with fluid and salt depletion and slowly progressive renal failure. Subsequently, diffuse tubulopapillary renal adenoma subtotally replaced each kidney, thereby, necessitating renal transplantation. Origin of diffuse metanephric adenoma from persistent primitive epithelium of the proximal nephron is postulated and partly substantiated. We propose that this case of persistent proximal nephronic epithelial immaturity and diffuse metanephric adenoma is a variant of nephroblastomatosis and that in this case, a first trimester suicide attempt with aspirin may have initiated the maturation defect that preceded neoplastic transformation.

journal_name

Arch Pathol Lab Med

authors

Bove KE,Bhathena D,Wyatt RJ,Lucas BA,Holland NH

subject

Has Abstract

pub_date

1979-04-01 00:00:00

pages

187-90

issue

4

eissn

0003-9985

issn

1543-2165

journal_volume

103

pub_type

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