Inhibitory effects of IL-12 on experimental tooth movement and root resorption in mice.

Abstract:

OBJECTIVE:Interleukin (IL)-12 is an important cytokine for innate and adaptive immunity. We previously reported that IL-12 inhibits tumour necrosis factor (TNF)-α-mediated osteoclast formation by inducing apoptosis. We also reported that TNF-α plays an important role in mechanical loading-induced osteoclast formation and bone resorption during orthodontic tooth movement. In this study, we investigated the effects of IL-12 on mechanical tooth movement in mice. DESIGN:A Ni-Ti closed coil spring was inserted between the upper incisors and the upper left first molar in mice. IL-12 was injected locally adjacent to the first molar every other day during the experimental period, at doses varying from 0 to 1.5μg/day. After 12 days, the animals were killed and their jaws were processed for histological evaluation using tartrate-resistant acid phosphatase (TRAP) and TdT-mediated dUTP-biotin nick end-labelling (TUNEL) staining, and measurements of the root resorption area. RESULTS:In the IL-12-treated mice, tooth movement and root resorption appeared to be reduced. In TUNEL-stained sections, many apoptotic cells were recognized on the pressure side in the IL-12-treated mice. CONCLUSIONS:Our findings suggest that IL-12 inhibits not only mechanical tooth movement, but also root resorption during orthodontic tooth movement. These findings may arise through apoptosis induced by IL-12.

journal_name

Arch Oral Biol

journal_title

Archives of oral biology

authors

Yoshimatsu M,Kitaura H,Fujimura Y,Kohara H,Morita Y,Eguchi T,Yoshida N

doi

10.1016/j.archoralbio.2011.07.006

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

36-43

issue

1

eissn

0003-9969

issn

1879-1506

pii

S0003-9969(11)00228-7

journal_volume

57

pub_type

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