Progress in therapy for Duchenne muscular dystrophy.

abstract：NEW FINDINGS:What is the topic of this review? Excitation-contraction coupling in fish hearts is maintained over a range of temperatures that would be cardioplegic to most mammals. Here, we review what is known about the fish cardiac ryanodine receptor, and consider how it may be regulated in a different manner from th...

journal_title：Experimental physiology

authors： Shiels HA,Sitsapesan R

更新日期：2015-12-01 00:00:00

abstract：:This study investigated whether sensitivity to nociceptive stimuli is altered in obese rats using established models of inflammatory pain, and using real-time PCR, profiled alterations in expression of key adipokine and inflammatory mediator mRNA (adiponectin, tumor necrosis factor-α, interleukin-1β, cyclooxygenase-2,...

journal_title：Experimental physiology

authors： Iannitti T,Graham A,Dolan S

更新日期：2012-11-01 00:00:00

abstract：:The properties of two types of calcium current (ICa(T) and ICa(L)) and their relationship with contraction were studied in isolated frog atrial trabeculae using the double mannitol gap technique. In Ringer solution containing TTX the calcium currents observed are similar to the ICa(T) and ICa(L) found in single frog a...

journal_title：Experimental physiology

authors： Badaoui A,Léoty C

更新日期：1994-09-01 00:00:00

abstract：:Branched fibres are a well-documented phenomenon of regenerating skeletal muscle. They are found in the muscles of boys with Duchenne muscular dystrophy (DMD), a severe condition of progressive muscle wasting caused by an absence of the sarcolemmal protein dystrophin, and in the muscles of the mdx mouse, an animal mod...

journal_title：Experimental physiology

authors： Chan S,Head SI

更新日期：2011-06-01 00:00:00

abstract：:The aim of this study was to evaluate whether long-term administration of L-arginine, a physiological substrate for the production of nitric oxide, improved blood pressure, heart rate, cardiac hypertrophy and particularly structural changes in the coronary and carotid artery of spontaneously hypertensive rats (SHR). T...

journal_title：Experimental physiology

authors： Kristek F

更新日期：1998-09-01 00:00:00

abstract：:Intestinal secretion is enhanced by starvation in rats. The rectum from fed and 3-day-starved rats generates a basal electrogenic ion transfer (short-circuit current) in vitro which is mainly electrogenic Na+ absorption (amiloride-sensitive, 66-71%) with a small component of electrogenic chloride secretion (furosemide...

journal_title：Experimental physiology

authors： Levin RJ,Parker AJ

更新日期：1990-07-01 00:00:00

abstract：:This review explores the current concepts relating the structural and functional modifications of skeletal muscle mitochondria to the molecular mechanisms activated when organisms are exposed to a hypoxic environment. In contrast to earlier assumptions it is now established that permanent or long-term exposure to seve...

journal_title：Experimental physiology

authors： Hoppeler H,Vogt M,Weibel ER,Flück M

更新日期：2003-01-01 00:00:00

abstract：:This investigation was designed to determine the participation of the vagus nerve and muscarinic receptors in the remote ischaemic preconditioning (rIPC) mechanism. New Zealand rabbits were anaesthetized, and the femoral artery was dissected. After 30 min of monitoring, the hearts were isolated and subjected to 30 min...

journal_title：Experimental physiology

authors： Donato M,Buchholz B,Rodríguez M,Pérez V,Inserte J,García-Dorado D,Gelpi RJ

更新日期：2013-02-01 00:00:00

abstract：:We measured plasma levels of L-arginine, its analogue NG-monomethyl-L-arginine (L-NMMA), and related amino acids in normal subjects and uraemic patients (n = 31), before and after haemodialysis. Plasma levels of L-arginine were reduced to less than half of normal values in uraemic subjects compared with controls, and ...

journal_title：Experimental physiology

authors： Mendes Ribeiro AC,Roberts NB,Lane C,Yaqoob M,Ellory JC

更新日期：1996-05-01 00:00:00

abstract：:This study was undertaken to determine the reflex cardiovascular and respiratory responses to discrete stimulation of pulmonary arterial baroreceptors using a preparation in which secondary modulation of responses from other reflexes was prevented. Dogs were anaesthetised with -chloralose, artificially ventilated, the...

journal_title：Experimental physiology

authors： McMahon NC,Drinkhill MJ,Myers DS,Hainsworth R

更新日期：2000-07-01 00:00:00

abstract：:This study presents a perfused preparation for evaluation of metabolism in pig intercostal muscle in vitro. Preserved vessels and nerves to an intercostal segment including two adjacent ribs allowed for tissue perfusion and electrical stimulation with measurement of contraction force, oxygen consumption and 31P-magnet...

journal_title：Experimental physiology

authors： Pedersen BL,Arendrup H,Secher NH,Quistorff B

更新日期：2006-07-01 00:00:00

abstract：:It is unclear whether measurement of limb or conduit artery blood flow during recovery from exercise provides an accurate representation of flow to the muscle capillaries where gas exchange occurs. To investigate this, we: (a) examined the kinetic responses of femoral artery blood flow (QFA), estimated muscle capillar...

journal_title：Experimental physiology

authors： Harper AJ,Ferreira LF,Lutjemeier BJ,Townsend DK,Barstow TJ

更新日期：2008-10-01 00:00:00

abstract：:To better understand the mechanisms underlying the pulmonary O(2) uptake (V(O(2P))) slow component during high-intensity exercise, we used (31)P magnetic resonance spectroscopy, gas exchange, surface electromyography and near-infrared spectroscopy measurements to examine the potential relationship between the slow com...

journal_title：Experimental physiology

authors： Layec G,Bringard A,Yashiro K,Le Fur Y,Vilmen C,Micallef JP,Perrey S,Cozzone PJ,Bendahan D

更新日期：2012-08-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? The central question of this study was to investigate the interaction of mild exposures to O2 and CO2 on chemoreflex control of SNA and the modulation of lung volume and respiratory phase on this interaction. What is the main finding and its importance? We demons...

journal_title：Experimental physiology

authors： Jouett NP,Watenpaugh DE,Dunlap ME,Smith ML

更新日期：2015-09-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Clinical reports have described and suggested central and peripheral respiratory abnormalities in Parkinson's disease (PD) patients; however, these reports have never addressed the occurrence of these abnormalities in an animal model. What is the main finding and...

journal_title：Experimental physiology

authors： Oliveira LM,Oliveira MA,Moriya HT,Moreira TS,Takakura AC

更新日期：2019-05-01 00:00:00

abstract：:The contractile regulation of neonatal smooth muscle was studied in rat neonatal portal vein. Strips of beta-escin-permeabilized portal vein from 3- to 5-day-old rats and 5- to 6-week-old rats were mounted on a 'bubble chamber' in calcium solutions buffered with 10 mM EGTA. Although the overall tension development was...

journal_title：Experimental physiology

authors： Bruce L,Nixon GF

更新日期：1997-11-01 00:00:00

abstract：:The uptake and distribution of CO throughout the circulatory system during two different methods of CO rebreathing (2 min 'Schmidt' and 40 min 'Burge' methods) were determined in nine healthy volunteers. Specifically, the impact of (i) differences in circulatory mixing time (t(mix)), (ii) CO diffusion to myoglobin (Mb...

journal_title：Experimental physiology

authors： Garvican LA,Burge CM,Cox AJ,Clark SA,Martin DT,Gore CJ

更新日期：2010-12-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Is an anti-oedematous effect of ghrelin associated with increased expression of tight junction proteins in the hypoxic brain? What is the main finding and its importance? We showed that injection of ghrelin during acute and chronic systemic hypoxia is associated ...

journal_title：Experimental physiology

authors： Mohaddes G,Abdolalizadeh J,Babri S,Hossienzadeh F

更新日期：2017-03-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Does treatment of obstructive sleep apnoea (OSA) with nocturnal oxygen or continuous positive airway pressure (CPAP) improve hypoxic vascular responses, which are reportedly impaired in OSA? What is the main finding and its importance? Cerebrovascular and cardiov...

journal_title：Experimental physiology

authors： Beaudin AE,Hanly PJ,Raneri JK,Sajobi TT,Anderson TJ,Poulin MJ

更新日期：2019-04-01 00:00:00

abstract：:Animal studies show that arginine vasopressin facilitates aggression, while serotonin (5-HT) inhibits aggression by blocking the activity of the vasopressin system. Clinical studies report that subjects with a history of 'fighting and assault' show a significant positive correlation between cerebrospinal fluid concent...

journal_title：Experimental physiology

authors： Ferris CF

更新日期：2000-03-01 00:00:00

abstract：:Chronic heart failure (CHF) impairs muscle O2 delivery (QO2) and, at a given O2 uptake (VO2), lowers microvascular O2 pressures (PmvO2: determined by the QO2-to-VO2 ratio), which may impair recovery of high-energy phosphates following exercise. Because CHF preferentially decreases QO2 to slow-twitch muscles, we hypoth...

journal_title：Experimental physiology

authors： McDonough P,Behnke BJ,Musch TI,Poole DC

更新日期：2004-07-01 00:00:00

abstract：:Exercise performance in hypoxia may be limited by a critical reduction in cerebral and skeletal tissue oxygenation, although the underlying mechanisms remain unclear. We examined whether increased systemic free radical accumulation during hypoxia would be associated with elevated microvascular deoxygenation and reduce...

journal_title：Experimental physiology

authors： Woodside JD,Gutowski M,Fall L,James PE,McEneny J,Young IS,Ogoh S,Bailey DM

更新日期：2014-12-01 00:00:00

abstract：:Phosphoethanolamine and taurine have been identified in uterine extracts from rat and, for the first time, human tissue. The concentration of phosphoethanolamine [PEtn] determined by HPLC and 31P NMR spectroscopy, increased markedly (40%) within the first 6-12 h following parturition in rats, suggesting a role in invo...

journal_title：Experimental physiology

authors： Phoenix J,Wray S

更新日期：1994-07-01 00:00:00

abstract：:The effect of mechanical loading on the negative inotropic effect of acidosis in isolated rat ventricular myocytes was investigated. The mechanical loading of the myocytes was changed by attaching carbon fibres to the ends of the cell. To monitor intracellular Ca2+ and Na+ concentrations, cells were loaded with fluore...

journal_title：Experimental physiology

authors： Hongo K,White E,Orchard CH

更新日期：1995-09-01 00:00:00

abstract：:A sustained postexercise vasodilatation, which is histamine receptor mediated, has been observed following single bouts of whole-body exercise, but the mechanisms that regulate activation of histamine receptors following exercise are undefined. Exploration of vasodilatation after small muscle-mass dynamic or resistanc...

journal_title：Experimental physiology

authors： Barrett-O'Keefe Z,Kaplon RE,Halliwill JR

更新日期：2013-01-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Carotid artery longitudinal wall motion (CALM) is a bidirectional forward and backward motion of the arterial wall; however, there is no evidence in humans for what controls CALM despite proposals for pulse pressure, left ventricular motion and shear rate. What i...

journal_title：Experimental physiology

authors： Au JS,Bochnak PA,Valentino SE,Cheng JL,Stöhr EJ,MacDonald MJ

更新日期：2018-01-01 00:00:00

abstract：:This study compared the concentration of ethanol, both absolute and relative to water content, in sweat and blood. Ten male volunteers consumed approximately 13 mmol (kg body weight)-1 of ethanol. Blood and sweat samples were collected approximately 1, 2 and 3 h following ingestion. Sweat was collected following piloc...

journal_title：Experimental physiology

authors： Buono MJ

更新日期：1999-03-01 00:00:00

abstract：:Ionic mechanisms and signal transduction underlying noradrenaline (NA)-induced depolarization in single smooth muscle cells of guinea-pig vas deferens were studied. NA caused depolarization followed by action potentials through activation of 1-adrenoceptors. In the presence of nifedipine, no action potential was gener...

journal_title：Experimental physiology

authors： Kamimura N,Suga S,Nakano K,Kanno T,Takeo T,Wakui M

更新日期：2000-01-01 00:00:00

abstract：:In the present study, we tested the hypothesis that chronic intermittent hypoxia (CIH) produces changes in the autonomic and respiratory responses to acute peripheral chemoreflex activation. To attain this goal, 3-week-old rats were exposed to 10 days of CIH (6% O(2) for 40 s at 9 min intervals; 8 h day(-1)). They wer...

journal_title：Experimental physiology

authors： Braga VA,Soriano RN,Machado BH

更新日期：2006-11-01 00:00:00

abstract：:All eukaryotic cells utilize oxidative phosphorylation to maintain their high-energy phosphate stores. Mitochondrial oxygen consumption is required for ATP generation, and cell survival is threatened when cells are deprived of O(2). Consequently, all cells have the ability to sense O(2), and to activate adaptive proce...

journal_title：Experimental physiology

authors： Guzy RD,Schumacker PT

更新日期：2006-09-01 00:00:00