Abstract:
:In a previous investigation we reported that exposure to a moderate (300 mT) static magnetic field (SMF) causes transient DNA damage and promotes mitochondrial biogenesis in human umbilical vein endothelial cells (HUVECs). To better understand the response of HUVECs to the 300 mT SMF, a high-quality subtracted cDNA library representative of genes induced in cells after 4 h of static magnetic exposure was constructed. The global gene expression profile showed that several genes were induced after the SMF exposure. The characterized clones are involved in cell metabolism, energy, cell growth/division, transcription, protein synthesis, destination and storage, membrane injury, DNA damage/repair, and oxidative stress response. Quantitative real-time polymerase chain reaction (qRT-PCR) experiments were performed at 4 and 24 h on four selected genes. Their expression profiles suggest that HUVEC's response to SMF exposure is transient. Furthermore, compared to control cells, an up-regulation of several genes involved in cell growth and division was observed. This up-regulation is likely to be the cause of the slight, but significant, increase in cell proliferation at 12 h post-treatment. These results provide additional support to the notion that SMFs may be harmless to human health, and could support the rationale for their possible use in medical treatments.
journal_name
Bioelectromagneticsjournal_title
Bioelectromagneticsauthors
Polidori E,Zeppa S,Potenza L,Martinelli C,Colombo E,Casadei L,Agostini D,Sestili P,Stocchi Vdoi
10.1002/bem.20686subject
Has Abstractpub_date
2012-01-01 00:00:00pages
65-74issue
1eissn
0197-8462issn
1521-186Xjournal_volume
33pub_type
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journal_title:Bioelectromagnetics
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journal_title:Bioelectromagnetics
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journal_title:Bioelectromagnetics
pub_type: 评论,杂志文章
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Bioelectromagnetics
pub_type: 评论,杂志文章
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更新日期:1996-01-01 00:00:00
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journal_title:Bioelectromagnetics
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pub_type: 杂志文章,随机对照试验
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