Abstract:
:Pregnancy is a unique immunological situation in which 2 allogeneic organisms live in intimate symbiosis without developing rejection reactions. At different locations, interfaces exist between mother and foetus with direct contact between both individuals: 1) maternal blood surrounds foetal villi, which are covered with syncitiotrophoblast cells; 2) cytotrophoblast cells invade the decidua, in which they touch tissue lymphocytes; 3) trophoblast cells, which substitute endothelium of maternal arterioles filled with maternal blood; and 4) trophoblast particles, which are expressed from syncytiotrophoblast and circulate within the maternal blood until they settle in the lung capillaries, where they become degraded by alveolar macrophages. Several factors are known which support the specific immunotolerance of the mother to her foetus and are focussed by current research in reproductive immunology. One of these factors is progesterone-induced blocking factor (PIBF). Originally, it was discovered as a 34 kDa protein, which is released from lymphocytes of healthy pregnant women under the influence of progesterone. PIBF has immunomodulatory functions in vivo and in vitro, which are important for the establishment of immunotolerance between mother and foetus and, thereby, for the regular course of pregnancy. Finally, during the last years, several tumours have been identified to produce PIBF, which supports their immune escape and which may have the potential to become a novel tumour biomarker and which may lead to the development of new therapeutic strategies.
journal_name
Z Geburtshilfe Neonatoljournal_title
Zeitschrift fur Geburtshilfe und Neonatologieauthors
Ermisch C,Markert URdoi
10.1055/s-0031-1271742subject
Has Abstractpub_date
2011-06-01 00:00:00pages
93-7issue
3eissn
0948-2393issn
1439-1651journal_volume
215pub_type
杂志文章,评审abstract::Progressive systemic sclerosis is a connective tissue disease with inflammation and fibrosis. Pregnant women with progressive systemic sclerosis have an increased risk for preterm births and probably for small-for-date babies. We report the case of a 28-year-old II G O P suffering from progressive systemic sclerosis w...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:10.1055/s-2005-916247
更新日期:2005-12-01 00:00:00
abstract::Disorders of laterality and heterotaxy syndromes are rare diseases with an incidence of 1-1.5/10,000 live births. They are associated with numerous viscerocardiac anomalies and malformations. In particular, heterotaxy syndromes are associated with complex cardiac and extracardiac malformations that have an important i...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章,评审
doi:10.1055/s-0032-1314808
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Growing competition among maternity hospitals and declining birth rates make pregnant women a target group that is much in demand. This article examines how satisfied women are with the maternity care they received in their hospital and which are the most important factors for women's satisfaction and their ...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:10.1055/s-0028-1119387
更新日期:2009-02-01 00:00:00
abstract:BACKGROUND:After the establishment of the FertiPROTEKT network in 2006, an impetus for possibilities of pregnancy during and after breast cancer was introduced. Nowadays, breast cancer survivors are confronted with the question how often women become pregnant after breast cancer and whether there have been significant ...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:10.1055/s-0034-1395539
更新日期:2015-08-01 00:00:00
abstract::Frühgeburtenrate in 6 Perinatalzentren in Baden-Württemberg – Potential zur Reduktion der Frühgeborenenzahl Sehr geehrte Damen und Herren,mit großem Interesse haben wir die Arbeit von Trotter et al. 1 gelesen und teilen die Auffassung, dass eine Vermeidung von Frühgeburten und eine Reduzierung der Frühgeburtenrate unb...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:10.1055/a-0950-6770
更新日期:2019-08-01 00:00:00
abstract::We report on prenatal diagnosis of gastroschisis at 20th gestational week. In addition to gastroschisis intraabdominal intestinal stenosis was detected. As a consequence cesarean section was planned close to term. Control examinations in the last trimester didn't confirm initial diagnosis so that the recommended mode ...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:
更新日期:1998-03-01 00:00:00
abstract::A fetal heart-rate pattern that has a reduced oscillation amplitude may indicate a physiological fetal dormant period but could also be an indication of fetal hypoxemia. In some rare cases such a fetal heart rate-pattern can be an indicator of cerebral or cardial fetal malformation or of an intoxication caused by seda...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:10.1055/s-2003-40974
更新日期:2003-05-01 00:00:00
abstract::Maternal emergencies can significantly affect the outcome of pregnancy and childbirth. Since obstetrical emergencies may happen at any time during pregnancy an emergency transport to a hospital nearby may not always be possible. So, obstetrical emergency-management may already become mandatory in a prehospital setting...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:10.1055/a-0762-1024
更新日期:2019-04-01 00:00:00
abstract:INTRODUCTION:Associations between the size of the placenta and birth weight have been described before. This connection has also been found in (sonographically estimated) second trimester placental size. The aim of this study was to find out if there are any differences in first trimester placental volume between vario...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:10.1055/s-2002-33671
更新日期:2002-07-01 00:00:00
abstract::Several prospective clinical trials have indicated an association between maternal periodontal status and adverse pregnancy outcome, e.g., low birth weight, pre-term birth and pre-eclampsia. However, the translation of these findings into clinical care and decision making is still a matter of debate. Gynecologists and...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章,评审
doi:10.1055/s-0034-1385859
更新日期:2014-12-01 00:00:00
abstract::Cardiac etiologies of hydrops fetalis have been a topic of concern due to challenging perinatal management. The common cardiac etiologies leading to hydrops fetalis include structural cardiac anomalies, cardiac dysrhythmias, cardiac tumors, cardiomyopathy and myocarditis. The mechanisms of cardiogenic hydrops fetalis ...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章,评审
doi:10.1055/s-0042-123825
更新日期:2017-04-01 00:00:00
abstract::The cesarean section rate and the associated complications are still rising in Germany. An important indication is term breech in singletons. Not significant data concerning a higher morbidity or mortality in vaginal breech birth indicate the cesarean but a deficit in education and experience. ...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:10.1055/s-0032-1309052
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:Meconium aspiration syndrome is a disease in near term infants which requires invasive techniques to decrease mortality. Lavage of the tracheobronchial tree with exogenous surfactant has been shown to be effective in animal studies. We studied the effectiveness of this technique in newborn infants and compar...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:10.1055/s-2002-20945
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:The extent to which faulty medical treatment and defective apparatus are concomitant causes for the development of subpartal acidosis was investigated in a retrospective study. At the same time, the incidence of acidosis in the Lippe-Detmold Hospital, Department of Gynaecology and Obstetrics, its morbidity an...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:10.1055/s-2002-34962
更新日期:2002-09-01 00:00:00
abstract::Careful analysis of current adjudication reveals increasing demand of adequate record-keeping as well as meticulously documented informed consent forms regarding all aspects of medicine. Although standardized informed consent forms or explicit guidelines for obtaining procedural consent already exist in surgical disci...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章,评审
doi:10.1055/s-0034-1398520
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:A sufficient quality of data transfer from written patient records to electronic data processing is a precondition for a reasonable usage of perinatal data. However the quality of data transfer of the almost 200 characteristics routinely recorded at each delivery is largely unknown. MATERIALS AND METHODS:Th...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:10.1055/s-2006-931583
更新日期:2006-04-01 00:00:00
abstract::Neonatal mysthenia gravis (NMG) is a rare cause of arthrogryposis multiplex congenita (AMC) due to diaplacental transfer of maternal acetylcholine receptors (AChR) antibodies. 2 cases of severe NMG complicated by chronic lung disease and pulmonary arterial hypertension are reported. With respect to the severe course o...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:10.1055/s-0033-1349888
更新日期:2013-08-01 00:00:00
abstract:INTRODUCTION:Computer analysing software is required for the assessment of CTGs because of the low sensitivity and high intra- and interobserver variability. The German Society of Gynaecology and Obstetrics advises the use of computer analysing CTG software. This study is aimed at evaluating the use of a new foetal ECG...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:10.1055/s-0028-1098718
更新日期:2008-12-01 00:00:00
abstract::Introduction and Hypothesis This study investigated how well pregnant patients were informed about the causes and effects of gingivitis during pregnancy. Factors such as age, level of education and nationality were taken into account. Data was collected for the overall oral hygiene of the patients and differences betw...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:10.1055/s-0043-108762
更新日期:2017-08-01 00:00:00
abstract::1. Many benefits claimed for episiotomy are not sufficiently proven. In recent literature, some of them are questioned and some have been disproven. 2. Episiotomy, especially median episiotomy, has a higher risk of third-degree lacerations. Mediolateral episiotomy is more often followed by postpartum pain and impaired...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章,评审
doi:
更新日期:1997-01-01 00:00:00
abstract:PATIENT REPORTS:We report on a male preterm infant (gestational age 31 weeks, birth weight 1420 g) and a male term infant (gestational age 38 weeks, birth weight 3680 g) with ornithine transcarbamylase (OTC) deficiency. After inconspicuous cardiopulmonary adjustment, both entered a state of metabolic crisis with respir...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:10.1055/s-2001-19056
更新日期:2001-11-01 00:00:00
abstract::Fetal heart rate pathology is seen in up to 40% of complications of the umbilical cord. We report a case in which long lasting bradycardia was associated with fetal grasping of the umbilical cord. Using colour doppler, the reason for the bradycardia could be detected. After vibro-acoustic stimulation the fetus release...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract::Among the very rare intracerebral lipomas, those of the corpus callosum are the most frequent. Due to the advanced technology and the frequent use of ultrasonography these lesions are diagnosed more and more often. A female neonate was admitted to our hospital because of a progressive thrombocytopenia. Pregnancy was c...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:
更新日期:1998-09-01 00:00:00
abstract::Newly diagnosed cancer in pregnancy is an issue with increasing importance, because fulfilling the wish to have a child is shifted later in life. Tumour disease is diagnosed in around 0.1% of all pregnancies in Germany. Most common tumour entities involve the breast, the cervix and the hematopoietic system. As tumour ...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章,评审
doi:10.1055/s-0044-100259
更新日期:2018-04-01 00:00:00
abstract::The present study discusses problems of maternal infection with hepatitis C virus in pregnancy with respect to the recent publications on this subject. In particular, questions of vertical transmission during pregnancy and fetal infection sub partu are discussed using three cases as an example. It was shown that recen...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章,评审
doi:
更新日期:1996-11-01 00:00:00
abstract:BACKGROUND:Specific DNA probes allow rapid prenatal diagnosis of numerical chromosome disorders (chromosomes 13, 18, 21, X, Y) by FISH on interphase nuclei. The diagnostic reliability is presently under evaluation. STUDY GROUP:In a period of 1.5 years a total 1126 amniotic fluid samples was investigated by FISH compar...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章,评审
doi:10.1055/s-2000-10189
更新日期:2000-01-01 00:00:00
abstract::We report two cases of premature rupture of membranes and oligohydramnios (gestational age: 23rd/24th week). In both pregnancies artificial instillation of amniotic fluid (AIF) was performed once a week. We hypothesize that fetal head compression with impaired cerebral perfusion due to oligohydramnios causes periventr...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:
更新日期:1999-07-01 00:00:00
abstract::Supine sleeping is recommended to prevent the sudden infant death syndrome (SIDS). Low birth weight infants are at increased risk for SIDS, which is increased further if they are placed prone. Prone sleeping, however, also has advantages for preterm infants, such as a reduced apnoea rate, an increased lung volume and ...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章,评审
doi:10.1055/s-2008-1004610
更新日期:2008-02-01 00:00:00
abstract:OBJECTIVES:The intrauterine growth retardation (IUGR) contributes specially to perinatal mortality and morbidity. An effective treatment is not yet available. The purpose of this study is to analyse the perinatal data of a cohort with IUGR-infants including mortality and morbidity and to describe prematurity and IUGR a...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:10.1055/s-2000-9581
更新日期:2000-11-01 00:00:00
abstract:BACKGROUND:In 2001 the Austrian government provided the legal means that formally enabled "anonymous birth": a woman can now give birth in any hospital in Austria without giving her name or insurance number, the baby is taken into care by social services and placed with adoptive parents. The cost of the hospital stay i...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:10.1055/s-2005-916172
更新日期:2005-10-01 00:00:00