Abstract:
:Epilepsy is a neurological disorder that affects 1-2% of the population. Despite the available treatments (drug therapy, resective surgery, vagus nerve stimulation), there is a significant subgroup of patients that continues to have disabling seizures. The indications of deep brain stimulation are exponentially growing, and there is a wide experience with deep brain stimulation (DBS) for the treatment of abnormal movements. DBS for epilepsy may be a new therapy for the subgroup of patients that remain disabled despite other treatments. Experiments with animal models, and the new advances in our knowledge about the neurophysiological processes that govern the genesis of epilepsy, have led to the selection of various brain targets for stimulation. The thalamus is a fundamental relay centre in the corticothalamic and corticostriatal thalamocortical circuits, and it has been studied with this purpose. Studies on epileptic patients have shown various degrees of effectiveness; however, controlled studies do not permit definitive conclusions about the role of DBS in the treatment of epilepsy. Probably a better patient selection would lead to more decisive conclusions. Further randomised studies are needed to draw reliable conclusions and scientific evidence on the effectiveness of DBS for refractory epilepsy.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
Torres CV,Pastor J,Navarrete EG,Sola RGsubject
Has Abstractpub_date
2011-07-16 00:00:00pages
99-106issue
2eissn
0210-0010issn
1576-6578pii
rn2011091journal_volume
53pub_type
杂志文章,评审abstract::Neuroinflammation is a key process in the neuropathogenesis of AIDS virus since as a result of the aberrant activation of the chemokine receptors (CXCR4, CX3CR1 and CR5) produces proinflammatory cytokine release by infected cells, increases microglial neurotoxicity and generates lipoperoxides and reactive oxygen speci...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2011-01-16 00:00:00
abstract:INTRODUCTION:Charcot-Marie-Tooth disease (CMT) is a neuropathy that affects sensory and motor nerves. The most common CMT subtype is CMT1A due to a PMP22 duplication of a 1.5 Mb fragment on the 17p11.2-p12. The development of a specific molecular technique that detects the PMP22 duplication is necessary for the diagnos...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2014-08-01 00:00:00
abstract::Disorders of gait are a common problem in elderly people. It is estimated that over 15% of people aged over 65 years have disorders of gait. Disorders of balance are also common in old age, with increased risk of falling and lesions due to falls. Every year 20-30% of the elderly people living alone have falls. The cau...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2000-07-01 00:00:00
abstract:TITLE:Polimiositis secundaria a un linfoma no Hodgkin. : ...
journal_title:Revista de neurologia
pub_type: 信件
doi:
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVE:To present a new formulation of human death based on neurological considerations. DEVELOPMENT:One of the reasons there is still controversy over a new formulation of human death which is acceptable to society, is that many authors do not suitably integrate three fundamental aspects which should be included i...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:1998-06-01 00:00:00
abstract:INTRODUCTION:The SOX5 gene encodes a transcription factor involved in the regulation of chondrogenesis and the development of the nervous system. CASE REPORT:We report a 10 years-old girl with developmental delay, behavior problems and dysmorphic features of this new syndrome with developmental delay. She had a 12p12 ...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2015-05-16 00:00:00
abstract:INTRODUCTION:Language widely varies in children with autism spectrum disorders (ASD). Evidence, however, suggests that these children understand language worse than their peers with typical development, showing a delay in acquisition of receptive vocabulary. Research relating quality of life (QOL) and language is limit...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2015-03-01 00:00:00
abstract:INTRODUCTION:Although there is agreement that working memory in older adults diminished with age, there is still controversy whether this reduction occurs equally for all kind of information or it is more pronounced for a particular type of information. AIM:To compare verbal working memory with visual and spatial work...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2011-02-01 00:00:00
abstract:INTRODUCTION:Attention deficit disorder with or without hyperactivity (ADHD) is characterised by the patients' inability to pay attention in non selective activities, hyperactivity that is difficult to inhibit, impulsiveness with failure to control their reactions and an unstable personality, which gives rise to diffic...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2004-03-16 00:00:00
abstract:INTRODUCTION:The term «gossypiboma» comes from the Latin gossypium, which refers to a genus of cotton plants, and from the Swahili word boma, which translates as «place of concealment». It may be mistaken for tumorous lesions or abscesses due to the way it is encapsulated, as evidenced in imaging examinations, and its ...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:10.33588/rn.6909.2019282
更新日期:2019-11-01 00:00:00
abstract:INTRODUCTION:Although the overall incidence of inborn errors of metabolism is low, their early diagnosis is essential, since some of them have a specific treatment. DEVELOPMENT:We review the main treatable inborn errors of metabolism that can present as early-onset epileptic encephalopathies, together with their bioch...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2017-05-17 00:00:00
abstract:INTRODUCTION:Despite progress in understanding its pathogenesis, there has not yet been found any independent predictive marker of aggressive behavior of pituitary adenomas, to facilitate the treatment and monitoring of patients. AIM:To analyze the expression of folliculo-stellate cells by immunostaining with S-100 pr...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2016-10-01 00:00:00
abstract:INTRODUCTION:Tourette syndrome is a neurologic disorder characterized by involuntary vocal and motor tics. It affects around 1 to 2% of school-age children and is the most common movement disorder in paediatric age. Tics are involuntary or semivoluntary, sudden, brief, intermittent, repetitive movements (motor tics) or...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2009-01-23 00:00:00
abstract:INTRODUCTION AND AIMS:Trepanation is one of the earliest examples of a surgical procedure being carried out by human beings and was performed from the Neolithic period onwards in a large number of primitive cultures throughout the five continents. Trepanation and cranial deformation were both common in the pre-Columbin...
journal_title:Revista de neurologia
pub_type: 历史文章,杂志文章
doi:
更新日期:2004-05-01 00:00:00
abstract:TITLE:Síndrome de depleción de ADN mitocondrial tipo 13: un caso con un inicio poco común. : ...
journal_title:Revista de neurologia
pub_type: 信件
doi:10.33588/rn.6910.2019221
更新日期:2019-11-16 00:00:00
abstract:INTRODUCTION:Ocrelizumab is a humanised monoclonal antibody that targets the CD20 antigen on B cells. It has recently been approved by the US (Food and Drug Administration) and European health agencies (European Medicines Agency) for the treatment of multiple sclerosis (MS) and is the first drug marketed for both relap...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2018-06-16 00:00:00
abstract:OBJECTIVE:The object of this study to analyse and compare the efficacy of the classic language tasks (repetition, phonological fluency and lexical decision), for the purpose of identifying the dominant hemisphere for language by means of functional magnetic resonance. SUBJECTS AND METHODS:The three tasks were performa...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2002-07-16 00:00:00
abstract:INTRODUCTION:Significant progress in the understanding of the molecular genetics and pathophysiology of inherited neuropathies has been achieved during the last years. DEVELOPMENT:The causative genetic defects of most of the demyelinating forms are known and different chromosomal loci have been identified for the rare...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2001-01-16 00:00:00
abstract:AIMS:To evaluate the presence of epileptiform discharges and the organisation of nocturnal sleep of autistic children without nocturnal polysomnographic epileptic seizures. SUBJECTS AND METHODS:Cross section analysis. SUBJECTS:21 boys and girls with autistic spectrum using DSM IV criteria between the ages of 4 and 12...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2002-06-16 00:00:00
abstract:INTRODUCTION:The new 2015 criteria for neuromyelitis optica spectrum disorders (NMOSD) have been recently incorporated in the study of different international cohorts. AIM:To describe clinical-radiological characteristics and prognostic factors in patients with NMOSD according to the 2015 criteria. PATIENTS AND METHO...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2017-09-01 00:00:00
abstract:INTRODUCTION:Purely bulbar hematomas are not common (0.25%-0.50% of all intraparenchymatous hematomas), probably because of the particular characteristics of the anatomy and hemodynamics of the bulbar circulation. CLINICAL CASES:We selected 18 cases. Three of these were our own and the purely bulbar localization was c...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:1998-10-01 00:00:00
abstract:INTRODUCTION:Transient ischemic attacks (TIA) often precede a stroke. AIMS:The purpose of this study is to examine the modifiable cardiovascular risk factors for non-cardioembolic TIA. PATIENTS AND METHODS:A population based case control study was conducted in a district within the city of Barcelona. The cases were 1...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2003-08-01 00:00:00
abstract::We have carried out an overall analysis of the diagnostic approach to generalized epileptic crises in children. It is emphasized that the clinical history is an essential factor in reaching the correct diagnosis. This is inevitably followed by a general and then a specifically neurological physical examination. Four p...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:1998-02-01 00:00:00
abstract::Neuromodulation for treating pain goes back to the times of the ancient Egyptians, who applied natural electric currents to modulate the painful sensation. Since then, this concept has been developed in parallel with the scientific and technological development, and various forms of neuromodulation with different indi...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2011-12-01 00:00:00
abstract::The neuropathology of haemorrhagic and hypoxic-ischaemic perinatal encephalopathies and their effect on the post-natal development of the brain, has been studied in children who survived with these lesions (for days, weeks, months and even years). Eventually some children developed neurological sequelae, including epi...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:1997-05-01 00:00:00
abstract:INTRODUCTION:In partial seizures, from a clinical point of view or even from electroencephalography characterization of post-ictal period can be difficult. The spectral and complex network analysis could lead to a more accurate definition of its limits, as well as to a great understanding of the seizures. PATIENTS AND...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2017-04-16 00:00:00
abstract::INTRODUCTION. Scientific collaboration is vital for to the advance of knowledge and is especially important in health sciences. The aim of this study is to identify scientific collaboration indicators and co-authorship networks of researchers and Spanish institutions that publish on multiple sclerosis (MS) during the ...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2013-08-16 00:00:00
abstract:INTRODUCTION:The advance in the achievement of effective therapies for multiple sclerosis (MS), the definition of appropriate therapeutic windows and to establish better diagnostic and prognostic biomarkers have become a challenging task for both researchers and clinicians. Some pitfalls in clinical trials might be rel...
journal_title:Revista de neurologia
pub_type: 指南,杂志文章
doi:
更新日期:2012-01-16 00:00:00
abstract:OBJECTIVE:The atherosclerosis is the most common cause of death and disability in developed countries by causing ischemic cardiopathic and stroke. The ischemic atherotrombotic stroke is the most frequent form of the last one. In this sense we review herein the mechanisms underlying the artherosclerotic process. DEVELO...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2002-09-01 00:00:00
abstract:INTRODUCTION:Unilateral isolated paralysis of the soft palate is a rare clinical entity. CASE REPORT:We describe the case of a 12 year old girl who presented acute dysphagia, a nasal voice and regurgitation of liquids into the nose. Exploration revealed right velopalatine insufficiency with normal gag reflex and phary...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2003-02-15 00:00:00