Assessing response in bone metastases in prostate cancer with diffusion weighted MRI.

Abstract:

OBJECTIVES:To determine whether changes in ADC of bone metastases secondary to prostate carcinoma are significantly different in responders compared with progressors on chemotherapy. METHODS:Twenty-six patients with known bone metastases secondary to prostate carcinoma underwent diffusion-weighted MRI of the lumbar spine and pelvis at baseline and 12 weeks following chemotherapy. RECIST assessment of staging CT and PSA taken at the same time points were used to classify patients as responders, progressors or stable. ADC (from b = 0,50,100,250,500,750 smm⁻²) and ADC(slow) (from b = 100,250,500,750 smm⁻²) were calculated for up to 5 lesions per patient. RESULTS:Mean ADC/ADC(slow) in lesions from responders and progressors showed a significant increase. Although the majority of lesions demonstrated an ADC/ADC(slow) rise, some lesions in both responders and progressors demonstrated a fall in ADC beyond the limits of reproducibility. CONCLUSIONS:Mean ADC is not an appropriate measure of response in bone metastases. The heterogeneity of changes in ADC is likely to be related to the composition of bone marrow with changes that have opposing effects on ADC.

journal_name

Eur Radiol

journal_title

European radiology

authors

Messiou C,Collins DJ,Giles S,de Bono JS,Bianchini D,de Souza NM

doi

10.1007/s00330-011-2173-8

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

2169-77

issue

10

eissn

0938-7994

issn

1432-1084

journal_volume

21

pub_type

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