Higher cord C-peptide concentrations are associated with slower growth rate in the 1st year of life in girls but not in boys.

Abstract:

OBJECTIVE:To understand the relationships between maternal glycemia during pregnancy and prenatal and early postnatal growth by evaluating cord C-peptide and IGF-I as mediating biomarkers in boys and girls separately. RESEARCH DESIGN AND METHODS:We evaluated 342 neonates within the EDEN mother-child cohort study born to mothers without diabetes diagnosis before pregnancy. We measured maternal glycemia at 24-28 weeks of gestation and neonates' cord blood C-peptide (used as a proxy for fetal insulin) and IGF-I at birth. Reported maternal prepregnancy BMI and all measured infant weights and lengths in the 1st year were recorded. Growth modeling was used to obtain an individual growth curve for each infant in the 1st year. Path models, a type of structural equation modeling, were used for statistical analysis. Path analysis is a multivariate method associated with a graphical display that allows evaluation of mediating factors and distinguishes direct, indirect, and total effects. RESULTS:Cord C-peptide at birth was positively correlated with maternal prepregnancy BMI and maternal glycemia and was higher in girls. In a path model that represented prenatal growth, there was no significant direct effect of maternal glycemia on birth weight, but the effect of maternal glycemia on birth weight was mediated by fetal insulin and IGF-I in both girls and boys. However, in girls only, higher concentrations of cord C-peptide (but not cord IGF-I or maternal glucose) were associated with slower weight growth in the first 3 months of life. CONCLUSIONS:Our study underlines the role of the fetal insulin-IGF-I axis in the relationship between maternal glycemia during pregnancy and birth weight. We also show for the first time that high insulin concentration in female fetuses is associated with slower early postnatal growth. This slow, early growth pattern may be programmed by fetal hyperinsulinemia, and girls may be more susceptible than boys to its consequences.

journal_name

Diabetes

journal_title

Diabetes

authors

Regnault N,Botton J,Heude B,Forhan A,Hankard R,Foliguet B,Hillier TA,Souberbielle JC,Dargent-Molina P,Charles MA,EDEN Mother-Child Cohort Study Group.

doi

10.2337/db10-1189

subject

Has Abstract

pub_date

2011-08-01 00:00:00

pages

2152-9

issue

8

eissn

0012-1797

issn

1939-327X

pii

db10-1189

journal_volume

60

pub_type

杂志文章

相关文献

DIABETES文献大全
  • Glucosylated collagen is antigenic.

    abstract::Sera from rats inoculated with in vitro glucosylated rat skin acid-soluble collagen were evaluated for specific antibody response using the enzyme-linked immunosorbent assay. The data indicate that the altered protein is capable of eliciting the production of antibodies, but unmodified collagen is not. The specificity...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.32.12.1182

    authors: Bassiouny AR,Rosenberg H,McDonald TL

    更新日期:1983-12-01 00:00:00

  • Adipocyte-specific glucocorticoid inactivation protects against diet-induced obesity.

    abstract::Local glucocorticoid (GC) action depends on intracellular GC metabolism by 11beta-hydroxysteroid dehydrogenases (11betaHSDs). 11betaHSD1 activates GCs, while 11betaHSD2 inactivates GCs. Adipocyte-specific amplification of GCs through transgenic overexpression of 11betaHSD1 produces visceral obesity and the metabolic s...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diabetes.54.4.1023

    authors: Kershaw EE,Morton NM,Dhillon H,Ramage L,Seckl JR,Flier JS

    更新日期:2005-04-01 00:00:00

  • Increased hemoglobin AIc in diabetic mice.

    abstract::The minor hemoglobins AIa, AIb, and AIc were studied in mice with either genetic or chemically induced diabetes. Hemoglobin AIc was elevated approximately twofold in all the phenotypically diabetic mice studied (C57BL/KsJ-db/db, C57BL/KsJ-ob/ob, C57BL/6J-db/db, and alloxan- and streptozotocin-treated mice). Elevation ...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.25.1.1

    authors: Koenig RJ,Araujo DC,Cerami A

    更新日期:1976-01-01 00:00:00

  • Deficiency of phosphoinositide 3-kinase enhancer protects mice from diet-induced obesity and insulin resistance.

    abstract:OBJECTIVE:Phosphoinositide 3-kinase enhancer A (PIKE-A) is a proto-oncogene that promotes tumor growth and transformation by enhancing Akt activity. However, the physiological functions of PIKE-A in peripheral tissues are unknown. Here, we describe the effect of PIKE deletion in mice and explore the role of PIKE-A in o...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db09-1404

    authors: Chan CB,Liu X,Jung DY,Jun JY,Luo HR,Kim JK,Ye K

    更新日期:2010-04-01 00:00:00

  • Lung and Kidney ACE2 and TMPRSS2 in Renin Angiotensin System Blocker Treated Comorbid Diabetic Mice Mimicking Host Factors That Have Been Linked to Severe COVID-19.

    abstract::The causes of the increased risk of severe COVID-19 in persons with diabetes are unclear. It has been speculated that renin angiotensin system (RAS) blockers may promote COVID-19 by increasing ACE2, which SARS-CoV-2 uses to enter host cells, along with the host protease TMPRSS2. Taking a reverse translational approach...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db20-0765

    authors: Batchu SN,Kaur H,Yerra VG,Advani SL,Kabir MG,Liu Y,Klein T,Advani A

    更新日期:2020-12-11 00:00:00

  • Synthesis rate of muscle proteins, muscle functions, and amino acid kinetics in type 2 diabetes.

    abstract::Improvement of glycemic status by insulin is associated with profound changes in amino acid metabolism in type 1 diabetes. In contrast, a dissociation of insulin effect on glucose and amino acid metabolism has been reported in type 2 diabetes. Type 2 diabetic patients are reported to have reduced muscle oxidative enzy...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diabetes.51.8.2395

    authors: Halvatsiotis P,Short KR,Bigelow M,Nair KS

    更新日期:2002-08-01 00:00:00

  • The human GLP-1 analogs liraglutide and semaglutide: absence of histopathological effects on the pancreas in nonhuman primates.

    abstract::Increased pancreas mass and glucagon-positive adenomas have been suggested to be a risk associated with sitagliptin or exenatide therapy in humans. Novo Nordisk has conducted extensive toxicology studies, including data on pancreas weight and histology, in Cynomolgus monkeys dosed with two different human glucagon-lik...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db13-1087

    authors: Gotfredsen CF,Mølck AM,Thorup I,Nyborg NC,Salanti Z,Knudsen LB,Larsen MO

    更新日期:2014-07-01 00:00:00

  • Impact of acute hyperglycemia on myocardial infarct size, area at risk, and salvage in patients with STEMI and the association with exenatide treatment: results from a randomized study.

    abstract::Hyperglycemia upon hospital admission in patients with ST-segment elevation myocardial infarction (STEMI) occurs frequently and is associated with adverse outcomes. It is, however, unsettled as to whether an elevated blood glucose level is the cause or consequence of increased myocardial damage. In addition, whether t...

    journal_title:Diabetes

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/db13-1849

    authors: Lønborg J,Vejlstrup N,Kelbæk H,Nepper-Christensen L,Jørgensen E,Helqvist S,Holmvang L,Saunamäki K,Bøtker HE,Kim WY,Clemmensen P,Treiman M,Engstrøm T

    更新日期:2014-07-01 00:00:00

  • Glucose transporters of rat peripheral nerve. Differential expression of GLUT1 gene by Schwann cells and perineural cells in vivo and in vitro.

    abstract::Expression of GLUTs in rat peripheral nerve was first studied at the mRNA level with Northern transfer analysis with cDNAs specific for GLUT1, GLUT2, GLUT3, and GLUT4. GLUT1 mRNA was the only GLUT mRNA detectable in rat sciatic nerve. In situ hybridization localized this mRNA to the perineurium and to some endo- and e...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.41.12.1587

    authors: Muona P,Sollberg S,Peltonen J,Uitto J

    更新日期:1992-12-01 00:00:00

  • A genome-wide linkage scan for genes controlling variation in renal function estimated by serum cystatin C levels in extended families with type 2 diabetes.

    abstract::We performed a variance components linkage analysis of renal function, measured as glomerular filtration rate (GFR), in 63 extended families with multiple members with type 2 diabetes. GFR was estimated from serum concentrations of cystatin C and creatinine in 406 diabetic and 428 nondiabetic relatives. Results for cy...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db06-0781

    authors: Placha G,Poznik GD,Dunn J,Smiles A,Krolewski B,Glew T,Puppala S,Schneider J,Rogus JJ,Rich SS,Duggirala R,Warram JH,Krolewski AS

    更新日期:2006-12-01 00:00:00

  • Altered natural killer cells in type 1 diabetic patients.

    abstract::Evidence from animal models suggests that natural killer (NK) cells can be important players in the development of type 1 diabetes, although data in humans are still sparse. We studied the frequency and activation state of blood NK cells at different stages of human type 1 diabetes, and whether genetic or phenotypic N...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db06-0493

    authors: Rodacki M,Svoren B,Butty V,Besse W,Laffel L,Benoist C,Mathis D

    更新日期:2007-01-01 00:00:00

  • Association of the T-G polymorphism in adiponectin (exon 2) with obesity and insulin sensitivity: interaction with family history of type 2 diabetes.

    abstract::The adipocyte-derived hormone adiponectin seems to protect from insulin resistance, a key factor in the pathogenesis of type 2 diabetes. Genome-wide scans have mapped a susceptibility locus for type 2 diabetes and the metabolic syndrome to chromosome 3q27, where the adiponectin gene is located. A common silent T-G exc...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diabetes.51.1.37

    authors: Stumvoll M,Tschritter O,Fritsche A,Staiger H,Renn W,Weisser M,Machicao F,Häring H

    更新日期:2002-01-01 00:00:00

  • Intrahepatic glucose flux as a mechanism for defective intrahepatic islet alpha-cell response to hypoglycemia.

    abstract:OBJECTIVE:Glucagon responses to hypoglycemia from islets transplanted in the liver are defective. To determine whether this defect is related to intrahepatic glycogen, islets from inbred Lewis rats were transplanted into the hepatic sinus (H group), peritoneal cavity (P group), omentum (O group), and kidney capsule (K ...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db08-0137

    authors: Zhou H,Zhang T,Bogdani M,Oseid E,Parazzoli S,Vantyghem MC,Harmon J,Slucca M,Robertson RP

    更新日期:2008-06-01 00:00:00

  • Macrophage adiponectin expression improves insulin sensitivity and protects against inflammation and atherosclerosis.

    abstract:OBJECTIVE:Adiponectin is one of several important metabolically active cytokines secreted from adipose tissue. Epidemiologic studies have associated low-circulating levels of this adipokine with multiple metabolic disorders including obesity, insulin resistance, type 2 diabetes, and cardiovascular disease. To investiga...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db09-1338

    authors: Luo N,Liu J,Chung BH,Yang Q,Klein RL,Garvey WT,Fu Y

    更新日期:2010-04-01 00:00:00

  • Functional variants in MBL2 are associated with type 2 diabetes and pre-diabetes traits in Pima Indians and the old order Amish.

    abstract:OBJECTIVE:MBL2 encodes the mannose-binding lectin, which is a key player in the innate immune system and has recently been found to play a role in insulin resistance and development of type 1 diabetes and gestational diabetes mellitus. To assess the role of MBL2 in diabetes susceptibility, this gene was analyzed in the...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db09-1593

    authors: Muller YL,Hanson RL,Bian L,Mack J,Shi X,Pakyz R,Shuldiner AR,Knowler WC,Bogardus C,Baier LJ

    更新日期:2010-08-01 00:00:00

  • Potential role of tumor necrosis factor-α in downregulating sex hormone-binding globulin.

    abstract::Low plasma sex hormone-binding globulin (SHBG) levels are associated with obesity and predict the development of type 2 diabetes. The reason why obese individuals have low circulating SHBG has been attributed to hyperinsulinemia, but no mechanistic evidence has been described. The aim of the current study is to explor...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db11-0727

    authors: Simó R,Barbosa-Desongles A,Lecube A,Hernandez C,Selva DM

    更新日期:2012-02-01 00:00:00

  • Functional redundancy of CXCR3/CXCL10 signaling in the recruitment of diabetogenic cytotoxic T lymphocytes to pancreatic islets in a virally induced autoimmune diabetes model.

    abstract::Cytotoxic T lymphocytes (CTLs) constitute a major effector population in pancreatic islets from patients suffering from type 1 diabetes (T1D) and thus represent attractive targets for intervention. Some studies have suggested that blocking the interaction between the chemokine CXCL10 and its receptor CXCR3 on activate...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db12-1370

    authors: Coppieters KT,Amirian N,Pagni PP,Baca Jones C,Wiberg A,Lasch S,Hintermann E,Christen U,von Herrath MG

    更新日期:2013-07-01 00:00:00

  • Diet-induced muscle insulin resistance in rats is ameliorated by acute dietary lipid withdrawal or a single bout of exercise: parallel relationship between insulin stimulation of glucose uptake and suppression of long-chain fatty acyl-CoA.

    abstract::Chronic high-fat feeding in rats induces profound whole-body insulin resistance, mainly due to effects in oxidative skeletal muscle. The mechanisms of this reaction remain unclear, but local lipid availability has been implicated. The aim of this study was to examine the influence of three short-term physiological man...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.46.12.2022

    authors: Oakes ND,Bell KS,Furler SM,Camilleri S,Saha AK,Ruderman NB,Chisholm DJ,Kraegen EW

    更新日期:1997-12-01 00:00:00

  • Diurnal pattern to insulin secretion and insulin action in healthy individuals.

    abstract::Evaluation of the existence of a diurnal pattern of glucose tolerance after mixed meals is important to inform a closed-loop system of treatment for insulin requiring diabetes. We studied 20 healthy volunteers with normal fasting glucose (4.8 ± 0.1 mmol/L) and HbA(1c) (5.2 ± 0.0%) to determine such a pattern in nondia...

    journal_title:Diabetes

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/db11-1478

    authors: Saad A,Dalla Man C,Nandy DK,Levine JA,Bharucha AE,Rizza RA,Basu R,Carter RE,Cobelli C,Kudva YC,Basu A

    更新日期:2012-11-01 00:00:00

  • Insulin sensitivity, binding, and kinetics in pancreatogenic and type I diabetes.

    abstract::Pancreatogenic diabetes (PD), secondary either to chronic calcific pancreatitis or to pancreatectomy, is characterized by higher frequency of hypoglycemic events during insulin therapy in comparison with type I insulin-dependent diabetes (IDD). Not only glucagon deficiency, but an enhanced peripheral tissue sensitivit...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.31.4.346

    authors: Nosadini R,del Prato S,Tiengo A,Duner E,Toffolo G,Cobelli C,Faronato PP,Moghetti P,Muggeo M

    更新日期:1982-04-01 00:00:00

  • Insulin reverses the high-fat diet-induced increase in brain Aβ and improves memory in an animal model of Alzheimer disease.

    abstract::Defects in insulin production and signaling are suspected to share a key role in diabetes and Alzheimer disease (AD), two age-related pathologies. In this study, we investigated the interrelation between AD and diabetes using a high-fat diet (HFD) in a mouse model of genetically induced AD-like neuropathology (3xTg-AD...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db14-0375

    authors: Vandal M,White PJ,Tremblay C,St-Amour I,Chevrier G,Emond V,Lefrançois D,Virgili J,Planel E,Giguere Y,Marette A,Calon F

    更新日期:2014-12-01 00:00:00

  • Gene expression profiles of nondiabetic and diabetic obese mice suggest a role of hepatic lipogenic capacity in diabetes susceptibility.

    abstract::Obesity is a strong risk factor for the development of type 2 diabetes. We have previously reported that in adipose tissue of obese (ob/ob) mice, the expression of adipogenic genes is decreased. When made genetically obese, the BTBR mouse strain is diabetes susceptible and the C57BL/6J (B6) strain is diabetes resistan...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diabetes.52.3.688

    authors: Lan H,Rabaglia ME,Stoehr JP,Nadler ST,Schueler KL,Zou F,Yandell BS,Attie AD

    更新日期:2003-03-01 00:00:00

  • The AGE-breaker ALT-711 restores high blood flow-dependent remodeling in mesenteric resistance arteries in a rat model of type 2 diabetes.

    abstract::Flow-mediated remodeling of resistance arteries is essential for revascularization in ischemic diseases, but this is impaired in diabetes. We hypothesized that breaking advanced glycation end product (AGE) cross-links could improve remodeling in mesenteric resistance arteries in Zucker diabetic fatty (ZDF) rats compar...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db11-0750

    authors: Freidja ML,Tarhouni K,Toutain B,Fassot C,Loufrani L,Henrion D

    更新日期:2012-06-01 00:00:00

  • Environmental triggers and determinants of type 1 diabetes.

    abstract::Type 1 diabetes is perceived as a chronic immune-mediated disease with a subclinical prodromal period characterized by selective loss of insulin-producing beta-cells in the pancreatic islets in genetically susceptible subjects. A series of evidence supports a critical role of exogenous factors in the development of ty...

    journal_title:Diabetes

    pub_type: 杂志文章,评审

    doi:10.2337/diabetes.54.suppl_2.s125

    authors: Knip M,Veijola R,Virtanen SM,Hyöty H,Vaarala O,Akerblom HK

    更新日期:2005-12-01 00:00:00

  • A novel role for CD36 in VLDL-enhanced platelet activation.

    abstract::Type 2 diabetes is characterized by increased plasma triglyceride levels and a fourfold increase in ischemic heart disease, but the mechanism is unclear. CD36 is a receptor/transporter that binds fatty acids of lipoproteins. CD36 deficiency has been linked with insulin resistance. There is strong evidence of in vivo i...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diabetes.52.5.1248

    authors: Englyst NA,Taube JM,Aitman TJ,Baglin TP,Byrne CD

    更新日期:2003-05-01 00:00:00

  • MafB: an activator of the glucagon gene expressed in developing islet alpha- and beta-cells.

    abstract::The large Maf family of basic leucine-zipper-containing transcription factors are known regulators of key developmental and functional processes in various cell types, including pancreatic islets. Here, we demonstrate that within the adult pancreas, MafB is only expressed in islet alpha-cells and contributes to cell t...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diabetes.55.02.06.db05-0946

    authors: Artner I,Le Lay J,Hang Y,Elghazi L,Schisler JC,Henderson E,Sosa-Pineda B,Stein R

    更新日期:2006-02-01 00:00:00

  • Differences in insulin resistance in nondiabetic subjects with isolated impaired glucose tolerance or isolated impaired fasting glucose.

    abstract::Both impaired glucose tolerance (IGT) (as defined by the 1985 World Health Organization criteria) and impaired fasting glucose (IFG) (as defined by the 1997 American Diabetes Association criteria) represent intermediate metabolic states between normal and diabetic glucose homeostasis. Cardiovascular disease may be rel...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diabetes.53.6.1549

    authors: Festa A,D'Agostino R Jr,Hanley AJ,Karter AJ,Saad MF,Haffner SM

    更新日期:2004-06-01 00:00:00

  • Hypolipidemic, antiobesity, and hypoglycemic-hypoinsulinemic effects of beta,beta'-methyl-substituted hexadecanedioic acid in sand rats.

    abstract::Treatment of male sand rats kept on a balanced laboratory chow diet ad libitum with beta,beta'-tetramethyl-substituted hexadecanedioic acid (MEDICA 16) resulted in a hypolipidemic effect accompanied by an extensive reduction in adiposity, with a concomitant hypoglycemic-hypoinsulinemic effect. The overall effect was s...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.37.12.1618

    authors: Tzur R,Rose-Kahn G,Adler JH,Bar-Tana J

    更新日期:1988-12-01 00:00:00

  • A selective aldose reductase inhibitor of a new structural class prevents or reverses early retinal abnormalities in experimental diabetic retinopathy.

    abstract::Previously studied inhibitors of aldose reductase were largely from two chemical classes, spirosuccinamide/hydantoins and carboxylic acids. Each class has its own drawbacks regarding selectivity, in vivo potency, and human safety; as a result, the pathogenic role of aldose reductase in diabetic retinopathy remains con...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/db06-0138

    authors: Sun W,Oates PJ,Coutcher JB,Gerhardinger C,Lorenzi M

    更新日期:2006-10-01 00:00:00

  • Lipid and carbohydrate metabolism in IDDM during moderate and intense exercise.

    abstract::Insulin-dependent diabetes mellitus (IDDM) is characterized by a metabolic and hormonal disarray that may be more evident during exercise. However, the metabolic response to exercise of different intensities has not been evaluated in IDDM. We therefore used stable isotope techniques and indirect calorimetry to quantif...

    journal_title:Diabetes

    pub_type: 杂志文章

    doi:10.2337/diab.44.9.1066

    authors: Raguso CA,Coggan AR,Gastaldelli A,Sidossis LS,Bastyr EJ 3rd,Wolfe RR

    更新日期:1995-09-01 00:00:00