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Effect of H-ras proteins on the activity of polyphosphoinositide phospholipase C in HL60 membranes.

Abstract：

:The present study was undertaken to investigate whether purified ras proteins can affect the activity of polyphosphoinositide specific phospholipase C in a cell-free membrane system. For this purpose we used homogenous preparations of the proto-oncogenic (H-ras(gly 12)) and the oncogenic (H-ras(val 12)) forms of the human H-ras proteins and membranes prepared from the human leukemic HL60 cells. We demonstrate that both the proto-oncogenic and the oncogenic form of H-ras proteins stimulate phospholipase C activity only when coupled to non-hydrolysable analogues of GTP.

journal_name

Cell Signal

journal_title

Cellular signalling

authors

Cockcroft S,Bar-Sagi D

doi

10.1016/0898-6568(90)90050-k

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

227-34

issue

3

eissn

0898-6568

issn

1873-3913

pii

0898-6568(90)90050-K

journal_volume

2

pub_type

杂志文章

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