Bioactive tetrapeptide GEKG boosts extracellular matrix formation: in vitro and in vivo molecular and clinical proof.

abstract：:Chronic pruritus (CP) is defined by itching lasting 6 weeks or more and is known to be both a highly prevalent and burdensome symptom of many pruritogenic diseases. Its status as a symptom has many implications mainly that the symptom should evolve and subside with the disease. However, according to the clinical exper...

journal_title：Experimental dermatology

authors： Ständer S

更新日期：2019-12-01 00:00:00

abstract：:Thymic stromal lymphopoietin (TSLP) induces naïve CD4+ T cells to produce Th2 cytokines. In addition, to low production of Th2 cytokines, strong Th1 response, which plays an important role in vitiligo development, has been induced by blockade of TSLP or TSLP receptor. This study examined whether a functional TSLP poly...

journal_title：Experimental dermatology

authors： Cheong KA,Chae SC,Kim YS,Kwon HB,Chung HT,Lee AY

更新日期：2009-12-01 00:00:00

abstract：:A number of single gene mutations in laboratory mice produce hair follicle defects resulting in deformed hair shafts. The radiation-induced (SB/LeJ-Foxq1(sa)) satin mutant mice have a satin-like sheen to their hair and dilute colouration. This sheen is due to failure of the hair shafts to develop normal medullas, whil...

journal_title：Experimental dermatology

authors： Wu B,Herbert Pratt C,Potter CS,Silva KA,Kennedy V,Sundberg JP

更新日期：2013-03-01 00:00:00

abstract：:Lipoid proteinosis (OMIM 247100), also known as Urbach-Wiethe disease or hyalinosis cutis et mucosae, is a rare autosomal recessive disorder characterized by generalized thickening and scarring of the skin and mucosae. In 2002, the disorder was mapped to a locus on chromosome 1q21 and pathogenic mutations were identif...

journal_title：Experimental dermatology

authors： Chan I,Liu L,Hamada T,Sethuraman G,McGrath JA

更新日期：2007-11-01 00:00:00

abstract：:C1 inhibitor (C1INH) plays an important role in the classical pathway of the complement system. Mutations in C1INH gene cause quantitative or qualitative deficiencies in C1INH, which can lead to hereditary angioedema (HAE) type I or II. Here, we identified a novel frame-shift mutation c.1391-1445del55 (p.v464fsx556) i...

journal_title：Experimental dermatology

authors： Qu L,Wei B,Liu M,Zhang L,Xiao T,Chen HD,Zhou L,Mi QS,He C

更新日期：2012-10-01 00:00:00

abstract：:Recent studies have demonstrated that keratinocytes closely participate in sensory transduction, and therefore, intra-epidermal free nerve endings are not exclusive transducers of pain. This discovery implies the existence of close afferent communication from keratinocytes to sensory neurons. Although reciprocal inter...

journal_title：Experimental dermatology

authors： Talagas M,Lebonvallet N,Leschiera R,Marcorelles P,Misery L

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:The circadian rhythm is an endogenous clock that governs a wide range of physiological functions. In the skin, rhythmic changes in skin barrier function have been investigated at the physiological level; however, few studies at the molecular level have been reported. Additionally, there is no study on lipido...

journal_title：Experimental dermatology

authors： Jia Y,Zhou M,Huang H,Gan Y,Yang M,Ding R

更新日期：2019-07-01 00:00:00

abstract：:All species have evolved mechanisms of repair to restore tissue function following injury. Skin scarring is an inevitable and permanent endpoint for many postnatal organisms except for non-amniote vertebrates such as amphibians, which are capable of tissue regeneration. Furthermore, mammalian foetuses through mid-gest...

journal_title：Experimental dermatology

authors： Ud-Din S,Volk SW,Bayat A

更新日期：2014-09-01 00:00:00

abstract：:In the inherited blistering skin disease, recessive dystrophic epidermolysis bullosa (RDEB), there is clinical heterogeneity with variable scarring and susceptibility to malignancy. Currently, however, there are few biochemical markers of tissue inflammation or disease progression. We assessed whether the non-histone ...

journal_title：Experimental dermatology

authors： Petrof G,Abdul-Wahab A,Proudfoot L,Pramanik R,Mellerio JE,McGrath JA

更新日期：2013-06-01 00:00:00

abstract：:Dermal white adipose tissue (DWAT) is a main component of human skin, composed of individual lipid-laden mesenchymal cells known as dermal adipocytes (DAs). Besides their well-known role in lipid storage and release, DAs also promote skin immunity, wound healing and hair follicle cycling and are important players in c...

journal_title：Experimental dermatology

authors： Nicu C,Pople J,Bonsell L,Bhogal R,Ansell DM,Paus R

更新日期：2018-06-01 00:00:00

abstract：:It has been suggested that the increased rate of bacterial infection in atopic dermatitis (AD) may be caused by reduced antimicrobial protein (AMP) expression. We were interested whether common treatments in AD affect antimicrobial defense. We investigated the effects of topically applied corticosteroids betamethasone...

journal_title：Experimental dermatology

authors： Jensen JM,Ahrens K,Meingassner J,Scherer A,Bräutigam M,Stütz A,Schwarz T,Fölster-Holst R,Harder J,Gläser R,Proksch E

更新日期：2011-10-01 00:00:00

abstract：:This review focuses on the photoprotection conferred by lycopene, one of the most potent anti-oxidants. Lycopene has been recently proposed to play a critical role on anticarcinogenic action at different levels. The photoprotective properties of lycopene remain contradictory. Some studies point out a positive and othe...

journal_title：Experimental dermatology

authors： Ascenso A,Ribeiro H,Marques HC,Oliveira H,Santos C,Simões S

更新日期：2014-12-01 00:00:00

abstract：:Acquisition of potent human dermal papilla (DP) cells that can induce hair follicle neogenesis is an overarching concern, and various approaches have been tried. In an attempt to solve the problem, we previously introduced the three-dimensional (3D) culture of human DP cells and observed de novo formation of hair foll...

journal_title：Experimental dermatology

authors： Seo CH,Kwack MH,Kim MK,Kim JC,Sung YK

更新日期：2017-02-01 00:00:00

abstract：:The ethanolic extract of Resina Draconis (RDEE) has been reported beneficial to normal wound healing yielding more regularly arranged collagen fibres. Loureirin B, a major component in RDEE, has been supposed to be effective on the prevention and treatment of pathological scars. To investigate the therapeutic effects ...

journal_title：Experimental dermatology

authors： Bai X,He T,Liu J,Wang Y,Fan L,Tao K,Shi J,Tang C,Su L,Hu D

更新日期：2015-05-01 00:00:00

abstract：:Chronic exposure to ultraviolet (UV) radiation alters components of the skin. We previously reported that chronic low-dose UV irradiation induced wrinkle formation but did not significantly alter dermal components of hairless mice. In the present study, we examined whether the epidermal changes by UV irradiation could...

journal_title：Experimental dermatology

authors： Kambayashi H,Odake Y,Takada K,Funasaka Y,Ichihashi M

更新日期：2003-01-01 00:00:00

abstract：:Nitric oxide (NO) is a potent intercellular mediator of melanogenesis, whereas metallothionein (MT) is an inducible intracellular antioxidant that has been reported to scavenge NO. We investigated the existence and induction of MT in melanocytes, and its inhibitory effect on NO-induced melanogenesis. The expression of...

journal_title：Experimental dermatology

authors： Sasaki M,Kizawa K,Igarashi S,Horikoshi T,Uchiwa H,Miyachi Y

更新日期：2004-08-01 00:00:00

abstract：:The correlation between the degrees of integrity and cohesion in healthy human Stratum corneum (SC) and the properties of the SC lipid matrix could be examined non-invasively in vivo using ATR-FTIR spectroscopy and measurements of pH, conductance, and transepidermal water loss (TEWL) taken in the course of tape-stripp...

journal_title：Experimental dermatology

authors： Berthaud F,Boncheva M

更新日期：2011-03-01 00:00:00

abstract：:The proportion of acral melanoma (AM) is much higher in Asian populations than in Caucasian populations. Although mutational profiles associated with AM have been discovered in Caucasian populations, knowledge of its genetic alterations in Asian populations is limited. To describe the molecular nature of AM in Korean ...

journal_title：Experimental dermatology

authors： Shim JH,Shin HT,Park J,Park JH,Lee JH,Yang JM,Kim DH,Jang KT,Lee DY

更新日期：2017-10-01 00:00:00

abstract：:There is likely general consensus within the skin research community that cell cycle control is critical to epidermal homeostasis and disease. The current predominant model proposes that keratinocytes switch off DNA replication and undergo cell cycle and cell growth arrest as they initiate terminal differentiation. Ho...

journal_title：Experimental dermatology

authors： Gandarillas A,Freije A

更新日期：2014-02-01 00:00:00

abstract：:Diminished suppressive capacity of regulatory T cells (Treg) has been demonstrated in blood and in lesional skin of psoriatic patients. Treatment with anti-TNFα restored the number and function of circulating Treg in psoriasis. We aimed to study Treg in the skin of psoriatic patients undergoing topical treatment with ...

journal_title：Experimental dermatology

authors： Keijsers RR,Joosten I,Hendriks AG,Koenen HJ,van Erp PE,van de Kerkhof PC

更新日期：2015-01-01 00:00:00

abstract：:Chemokines are small chemotactic proteins that have a crucial role in leukocyte recruitment into tissue. Targeting these mediators has been suggested as a potential therapeutic option in inflammatory skin diseases such as psoriasis. Using quantitative RT-PCR, we found CCL7, a chemokine ligand known to interact with mu...

journal_title：Experimental dermatology

authors： Brunner PM,Glitzner E,Reininger B,Klein I,Stary G,Mildner M,Uhrin P,Sibilia M,Stingl G

更新日期：2015-07-01 00:00:00

abstract：:The molecular nature of the hair cycle clock (HCC), the intrinsic oscillator system that drives hair follicle (HF) cycling, remains incompletely understood; therefore, all relevant key players need to be identified. Here, we present evidence that implicates myelin protein zero-like 3 (MPZL3), a multifunctional nuclear...

journal_title：Experimental dermatology

authors： Nicu C,Wikramanayake TC,Paus R

更新日期：2020-12-01 00:00:00

abstract：:TNF is critically involved in the pathogenesis of psoriasis. TL1A is a TNF-like cytokine, which, after binding to death domain receptor DR3, provides costimulatory signals to lymphocytes, amplifies Th1- and Th17-mediated immune responses and induces apoptotic cell death. These functions are inhibited when TL1A associa...

journal_title：Experimental dermatology

authors： Bamias G,Evangelou K,Vergou T,Tsimaratou K,Kaltsa G,Antoniou C,Kotsinas A,Kim S,Gorgoulis V,Stratigos AJ,Sfikakis PP

更新日期：2011-09-01 00:00:00

abstract：:Decorin is a natural transforming growth factor-β1 (TGF-β1) antagonist. Reduced decorin synthesis is associated with dermal scarring, and increased decorin expression appears to reduce scar tissue formation. To investigate the therapeutic potential of decorin for keloids, human dermal fibroblasts (HDFs) and keloid-der...

journal_title：Experimental dermatology

authors： Lee WJ,Ahn HM,Roh H,Na Y,Choi IK,Lee JH,Kim YO,Lew DH,Yun CO

更新日期：2015-08-01 00:00:00

abstract：:The best characterized signalling pathway employed by transforming growth factor-beta (TGF-β) is the Smad pathway. We focused on Smad4, because it is essential for the activation of Smad-dependent target genes. We aimed to explore the possibility of inhibiting scar formation after wounding by blocking TGF-β signalling...

journal_title：Experimental dermatology

authors： Tan WQ,Gao ZJ,Xu JH,Yao HP

更新日期：2011-02-01 00:00:00

abstract：:Pachyonychia congenita type 1 (PC-1) is an autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy, focal non-epidermolytic palmoplantar keratoderma and variable features of oral leukokeratosis and follicular keratosis. Previously, we have shown that this disease can be caused by mutations...

journal_title：Experimental dermatology

authors： Smith FJ,McKenna KE,Irvine AD,Bingham EA,Coleman CM,Uitto J,McLean WH

更新日期：1999-04-01 00:00:00

abstract：:Inter-α-trypsin inhibitors are protease inhibitors that are thought to be important regulators in various acute-phase processes. They are composed of one light chain (bikunin) and different heavy chains (ITIHs). The only function known so far of ITIHs is the covalent linkage to hyaluronan (HA). As there is virtually n...

journal_title：Experimental dermatology

authors： Huth S,Heise R,Vetter-Kauczok CS,Skazik C,Marquardt Y,Czaja K,Knüchel R,Merk HF,Dahl E,Baron JM

更新日期：2015-09-01 00:00:00

abstract：:Type-1 cytokine-producing T cells are important in the pathogenesis of psoriasis vulgaris, for which efficient therapy is provided by means of narrow-band ultraviolet-B (NB-UVB). The expression of the type-1 cytokine interferon-gamma (IFN-gamma) is regulated by interleukin-12 (IL-12), IL-15, IL-18 and IL-23; however, ...

journal_title：Experimental dermatology

authors： Piskin G,Tursen U,Sylva-Steenland RM,Bos JD,Teunissen MB

更新日期：2004-12-01 00:00:00

abstract：:Tyrosine kinase inhibitors of the tyrphostin family which block EGF receptor kinase are reported to arrest the growth of psoriatic keratinocytes in vitro. Three tyrphostins with the potency ratio AG555 > AG18 > AG814 were found to arrest growth with no adverse cytotoxic effects. The potency ratio to inhibit keratinocy...

journal_title：Experimental dermatology

authors： Ben-Bassat H,Vardi DV,Gazit A,Klaus SN,Chaouat M,Hartzstark Z,Levitzki A

更新日期：1995-04-01 00:00:00

abstract：:Pemphigus foliaceus (PF) is a severe autoimmune bullous disorder, characterized by autoantibodies (autoAb) against desmoglein 1 (Dsg1). As T cells may be critical in the pathology of PF, the aim of the present study was to identify and characterize autoaggressive T-helper cells reactive to Dsg1 in PF patients and heal...

journal_title：Experimental dermatology

authors： Gebhard KL,Veldman CM,Wassmuth R,Schultz E,Schuler G,Hertl M

更新日期：2005-08-01 00:00:00