Abstract:
:Historically, the diagnosis of Hirschsprung disease was made by evaluating multiple hematoxylin and eosin-stained slides and performing acetylcholinesterase histochemical staining. Recently, calretinin immunohistochemical staining has been reported and found to be superior to acetylcholinesterase staining in the confirmation of aganglionosis. We retrieved tissue blocks from 23 patients with proven Hirschsprung disease from the archives of the Medical College of Georgia. In addition, we selected 23 control patients with ganglion cells. All cases were stained with calretinin, and the presence or absence of both intrinsic nerve fibers (INFs) and ganglion cells was scored by 4 pathologists with fairly strong agreement (κ = 0.858). All cases of proven Hirschsprung disease were negative for INFs. Eighty-three percent of non-Hirschsprung patients were positive for INFs. Based on statistical analysis, the association between disease status and pathologist rating was statistically significant (P < .0001). We also found calretinin immunostaining to be a useful adjunctive modality in the diagnosis of Hirschsprung disease.
journal_name
Ann Diagn Patholjournal_title
Annals of diagnostic pathologyauthors
Holland SK,Ramalingam P,Podolsky RH,Reid-Nicholson MD,Lee JRdoi
10.1016/j.anndiagpath.2011.02.010subject
Has Abstractpub_date
2011-10-01 00:00:00pages
323-8issue
5eissn
1092-9134issn
1532-8198pii
S1092-9134(11)00043-8journal_volume
15pub_type
杂志文章abstract:BACKGROUND:Rigid diagnostic criteria for NIFTP have been recently proposed. The frequency of NIFTP using the new criteria is unknown, and whether abortive papillae are associated with BRAFV600E mutation has not been studied. The aim of this study is to identify NIFTP by a retrospective review of Follicular Variant of P...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/j.anndiagpath.2019.151439
更新日期:2020-02-01 00:00:00
abstract::Only 1% of gynecological neoplasms are vaginal, and mesenchymal tumors constitute only 2% of vaginal neoplasms. The most common form is leiomyomas. Schwannomas arise from the peripheral nerve sheath. We report a case of vaginal schwannoma associated with uterine myoma. A 52-year-old woman presented with lower abdomina...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/j.anndiagpath.2009.06.012
更新日期:2010-04-01 00:00:00
abstract::Myoid angioendothelioma of the spleen is an uncommon, benign vascular tumor that is morphologically characterized by a composite of vascular spaces and stromal cells with myoid feature. Herein, we report a case of the myoid angioendothelioma of the spleen, concurrent with rectal adenocarcinoma. A 41-year-old woman pre...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/j.anndiagpath.2012.03.001
更新日期:2013-02-01 00:00:00
abstract::A clear cell variant of solid-pseudopapillary tumor (SPT) of the pancreas was initially reported in 2006 as a tumor that arose in the pancreatic body and tail in young adults; to date, only 4 cases of this entity have been reported. Here, we present the case of a 58-year-old man with clear cell variant of SPT with dis...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/j.anndiagpath.2010.11.011
更新日期:2012-04-01 00:00:00
abstract::Helicobacter pylori infection is associated with gastritis, gastric ulcer, gastric adenocarcinoma, and mucosal associated lymphoid tissue lymphoma. Documenting the presence of H pylori in a gastric biopsy is essential for appropriate patient care. Several special stains and immunohistochemistry (IHC) stain for H pylor...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/j.anndiagpath.2010.05.002
更新日期:2010-08-01 00:00:00
abstract::Systemic anaplastic large-cell lymphoma is an uncommon type of non-Hodgkin lymphoma characterized by strong expression of the Ki-1 (CD30) antigen. Gastrointestinal involvement typically is less common than in other types of non-Hodgkin's lymphoma. We report a case of CD30-positive anaplastic large-cell lymphoma occurr...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1053/adpa.2001.25408
更新日期:2001-06-01 00:00:00
abstract:OBJECTIVE:Comparison of analytical and immunohistochemical performance of progesterone receptor (PR) antibodies with correlation to recurrence of invasive breast cancer treated with endocrine therapy. METHODS:The binding-affinity kinetics of PR clones 1E2, 1A6, 16 and 636 were compared using synthetic peptides derived...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/j.anndiagpath.2018.02.007
更新日期:2018-08-01 00:00:00
abstract::Cases of cerebral neuroblastoma or supratentorial primitive neuroectodermal tumor with malignant gliomatous components are relatively uncommon. Less frequent is the combination of these 2 elements with a mesenchymal component. This is a case report of a lipomatous supratentorial primitive neuroectodermal tumor with gl...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/j.anndiagpath.2007.04.009
更新日期:2009-02-01 00:00:00
abstract::The pathologist's approach to pulmonary hemorrhage is outlined. Most cases fall into those examples of pulmonary hemorrhage caused by localized sites of bleeding, and those examples that fall within the spectrum of diffuse alveolar hemorrhage. The histologic evaluation of pulmonary hemorrhage is outlined including ass...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1053/adpa.2001.27923
更新日期:2001-10-01 00:00:00
abstract::The appropriate follow-up and treatment for patients with a core biopsy diagnosis of lobular neoplasia (atypical lobular hyperplasia or lobular carcinoma in situ) remains controversial. Several studies have attempted to address this issue, with recommendations ranging from close clinical follow-up or surveillance to m...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/j.anndiagpath.2016.07.009
更新日期:2016-12-01 00:00:00
abstract::Twenty-four years after apparently successful treatment for nodular lymphocyte predominant Hodgkin's disease (nLPHD), a 41-year old male developed "B" symptoms and extensive adenopathy. A right axillary lymph node biopsy showed two distinct regions including (1) histiocyte-rich B-cell lymphoma and (2) diffuse small T-...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1016/s1092-9134(99)80006-9
更新日期:1999-02-01 00:00:00
abstract:BACKGROUND:Estrogen receptors (ER), progesterone receptors (PR) and the human epidermal growth factor receptor-2 (HER2) are basic breast cancer molecular markers that are also best recognized prognostic factors and predictors of type of targeted therapy to be given. The objectives are to study the correlation of expres...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/j.anndiagpath.2020.151659
更新日期:2020-11-05 00:00:00
abstract::We report the case of a rare cardiac lesion, mesothelial/monocytic incidental cardiac excrescences, and also provide a review of the literature. Diagnosis of this entity was based on both its unique morphologic features and imunohistochemical stains. Cytokeratin positivity confirmed the epithelial component, mesotheli...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1016/s1092-9134(00)90009-1
更新日期:2000-02-01 00:00:00
abstract::Acral lentiginous melanoma is a rare variant of melanoma that is associated with a relatively low survival rate. The latter is partly due to the advanced stage in which the tumor is usually diagnosed. The diagnostic delay is mainly due to difficulties in identifying the very early histopathological signs of acral mela...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1016/j.anndiagpath.2016.08.005
更新日期:2017-02-01 00:00:00
abstract::The mucosal surfaces represent the third most common site of origin for melanoma, after the skin and ocular uveal tract. However, anorectal mucosal melanoma is a rare neoplasm, usually occurring in the sixth and seventh decades of life. It may often be confused clinically with other pathologic entities, such as prolap...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/j.anndiagpath.2009.07.003
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:Anal cytology (AC) is accepted as a practical screening modality for anal cancer. However, studies suggest that AC and anal biopsy dysplasia correlation is less robust than in cervicovaginal specimens. The current study goals were to look at our institutional experience in a subset of ACs and correlate with ...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/j.anndiagpath.2020.151670
更新日期:2020-11-20 00:00:00
abstract::Chondroblastoma-like chondroma (CLC) of soft tissue is a rare benign neoplasm that usually involves the soft tissues of the hand. This report describes the first case of CLC of soft tissue arising in the base of the skull. A 33-year-old man was seen with a slow growing mass in the right parotid region of his face. The...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/j.anndiagpath.2012.05.005
更新日期:2013-06-01 00:00:00
abstract::The appearance of a sarcoma of bone is a well-recognized complication of Paget's disease. The most common type of such a sarcoma is osteosarcoma. Much less common are soft tissue lesions adjoining the pagetic bone that clinically and radiologically simulate sarcoma but histologically represent exaggerated periosteal b...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/s1092-9134(99)80037-9
更新日期:1999-04-01 00:00:00
abstract::We present the case of a patient who has a life-threatening hemoptysis caused by occlusion of the right pulmonary vein owing to external compression by excessive fibrous tissue. Because the patient's lung was essentially nonfunctional and hemoptysis persisted, we performed a pneumonectomy on her. Pathological analysis...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/j.anndiagpath.2005.07.006
更新日期:2005-12-01 00:00:00
abstract::The hematoxylin and eosin slides of 100 consecutive cases diagnosed as CIN 1-2 were combined with 25 CIN 1 and 25 negative for CIN as documented by in situ HPV testing. The 150 cases were then reviewed blinded and scored as "CIN" or "negative for CIN". Each of the 50 controls was correctly scored. Of the 100 cases, 62...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/j.anndiagpath.2020.151515
更新日期:2020-06-01 00:00:00
abstract::Papillary renal cell carcinoma (PRCC) is currently a well-studied type of RCC. In addition to PRCC type 1, there are a number of other subtypes and variants of PRCCs which have been reported. We describe a series of 6 PRCCs with papillary, micropapillary and/or tubulopapillary architecture and prominent spindle cell s...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/j.anndiagpath.2019.151441
更新日期:2020-02-01 00:00:00
abstract::Cribriform areas are common features of both adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. Both are malignant salivary gland tumors that share similar histologic patterns, but with marked distinct clinical behavior. This study was undertaken to improve the accuracy of the histopathology diagnosti...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1053/adpa.2001.29339
更新日期:2001-12-01 00:00:00
abstract::An uncommon manifestation of plasma cell neoplasia occurs outside the bone marrow and is designated "extramedullary plasmacytoma." These are usually encountered in mucosal sites of the head and neck region. The gastrointestinal tract may be secondarily involved in multiple myeloma or be the site of primary extramedull...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/s1092-9134(03)00017-0
更新日期:2003-06-01 00:00:00
abstract::A case of an unusual, primary alveolar soft part sarcoma of the tongue in a 3-year-old boy is presented. Alveolar soft part sarcoma is a rare malignant tumor that presents more frequently in the head and neck region of infants and children. To date, only six cases of lingual alveolar soft part sarcoma presenting in th...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/s1092-9134(99)80029-x
更新日期:1999-10-01 00:00:00
abstract::Inflammatory pseudotumor (IPT) (also known as inflammatory myofibroblastic tumor) is an uncommon spindle cell lesion that was initially recognized in the lung and is now known to occur in virtually every major organ of the body. Its precise biological nature and clinical characteristics are still relatively uncertain....
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1053/adpa.2002.32380
更新日期:2002-04-01 00:00:00
abstract:INTRODUCTION:Biphenotypic sinonasal sarcoma (BSNS) is a recently described mesenchymal tumor exclusive to the sinonasal region. It is a low grade sarcoma, displaying evidence of myogenic and neural differentiation. Role of β-catenin immunohistochemistry in distinguishing it from its morphological mimics is not well-est...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/j.anndiagpath.2017.11.005
更新日期:2018-04-01 00:00:00
abstract::Littoral cell angioma (LCA) is a rare vascular tumor of the spleen. It has an immunohistochemical staining pattern that is somewhat distinctive but can still be occasionally confused with other vascular and stromal proliferations in the spleen. In this study, LCA was evaluated using Ets-related gene (ERG) and Wilms tu...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/j.anndiagpath.2015.02.007
更新日期:2015-06-01 00:00:00
abstract::Cutaneous angiosarcoma is an aggressive malignant mesenchymal vasoformative neoplasm that accounts for 1% of all soft tissue sarcomas. Using data from the National Cancer Institute's Surveillance, Epidemiology, and End Results program, we analyzed the demographics and survival of cutaneous angiosarcoma. The Surveillan...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/j.anndiagpath.2010.07.012
更新日期:2011-04-01 00:00:00
abstract::Eosinophilic pancreatitis is a rare disorder that is frequently diagnosed only after pancreatic resection for suspected pancreatic tumor. It typically occurs in the setting of either eosinophilic gastroenteritis or the hypereosinophilic syndrome. Isolated eosinophilic infiltration of the pancreas is less common. We de...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1053/adpa.2000.19371
更新日期:2000-12-01 00:00:00
abstract::Frozen section (FS) for intraoperative evaluation of central nervous system (CNS) lesions provides the neurosurgeon with a rapid preliminary pathologic diagnosis. Diagnosis of nonneoplastic lesions is particularly challenging in this venue. To highlight common diagnostic pitfalls, we sought to identify discrepancies b...
journal_title:Annals of diagnostic pathology
pub_type: 杂志文章
doi:10.1016/j.anndiagpath.2009.05.006
更新日期:2009-12-01 00:00:00