Immunological regulation of trophoblast invasion.

abstract：:The expression of the nonclassical MHC class Ib molecule HLA-G is nearly exclusively restricted to the feto-maternal interface during pregnancy. There it probably serves the same physiological functions already known for classical MHC class I molecules; these include peptide presentation, natural killer cell (NK) inhi...

journal_title：Journal of reproductive immunology

authors： Münz C,Stevanović S,Rammensee HG

更新日期：1999-07-01 00:00:00

abstract：:Members of the galectin family are expressed within the female reproductive tract and have been shown to be involved in multiple biological functions that support the progression of pregnancy. Specific expression patterns of different members of this family have been identified at the maternal decidua and on the place...

journal_title：Journal of reproductive immunology

authors： Blois SM,Barrientos G

更新日期：2014-03-01 00:00:00

abstract：:We have previously shown that progesterone-treated lymphocytes of healthy pregnant women can produce a 34 kDa protein, progesterone-induced blocking factor (PIBF) capable of blocking lymphocyte function in vitro. Lymphocytes of women with idiopathic threatened pre-term delivery failed to produce this factor. On the as...

journal_title：Journal of reproductive immunology

authors： Szekeres-Bartho J,Varga P,Pejtsik B

更新日期：1989-09-01 00:00:00

abstract：:The tissue distribution, molecular weight, and biochemical nature of an antigen detected by a mouse monoclonal antibody designated 283D3 and raised against rabbit visceral yolk sac endodermal cells, has been investigated. The antigen is located on the luminal side of apical tubules and large sub-apical vesicles in rab...

journal_title：Journal of reproductive immunology

authors： Meads TJ,Wild AE

更新日期：1993-04-01 00:00:00

abstract：:This study aimed to evaluate changes in natural killer (NK) cell activity and the percentage of monocytes in women with recurrent miscarriage who received medium-dose intravenous immunoglobulin (IVIg) therapy. Fourteen women with a history of six or more recurrent miscarriages of unexplained etiology received 60-g IVI...

journal_title：Journal of reproductive immunology

authors： Yamada H,Deguchi M,Maesawa Y,Nakajima Y,Nishino Y,Tanimura K,Ebina Y

更新日期：2015-06-01 00:00:00

abstract：:The syndrome of preeclampsia has previously been ascribed to generalized maternal endothelial dysfunction, poor placentation and excessive maternal inflammatory response. Recent reports suggest that preeclampsia is associated with a Th1 predominant profile and may be considered as a failure of the tolerance system all...

journal_title：Journal of reproductive immunology

authors： Saito S,Sakai M

更新日期：2003-08-01 00:00:00

abstract：:Currently, different approaches are used to select oocytes for in vitro fertilization (IVF) procedures, but they do not assure a significant association with the pregnancy outcome. Since several studies have proposed the expression of HLA-G antigens in early embryos to be a possible marker of elevated implantation rat...

journal_title：Journal of reproductive immunology

authors： Rizzo R,Fuzzi B,Stignani M,Criscuoli L,Melchiorri L,Dabizzi S,Campioni D,Lanza F,Marzola A,Branconi F,Noci I,Baricordi OR

更新日期：2007-06-01 00:00:00

abstract：:Controversy exists as to whether active immunotherapy with allogeneic lymphocyte transfusions (ALT) or passive immunotherapy with intravenous immunoglobulin (IvIg) improve the chance of live birth in women with unexplained recurrent miscarriages (RM). Meta-analyses of the placebo-controlled trials carried out as Cochr...

journal_title：Journal of reproductive immunology

authors： Christiansen OB,Nielsen HS,Pedersen B

更新日期：2004-06-01 00:00:00

abstract：:Autophagy is an evolutionarily conserved process in eukaryotes to maintain cellular homeostasis against stress. This process has two main functions: producing energy and quality control of intracellular proteins. During early pregnancy, extravillous trophoblasts (EVTs) invade the uterine myometrium and migrate along t...

journal_title：Journal of reproductive immunology

authors： Nakashima A,Aoki A,Kusabiraki T,Cheng SB,Sharma S,Saito S

更新日期：2017-09-01 00:00:00

abstract：:Viviparity has many evolutionary advantages but brings with it the problem of the semi-allogeneic foetus having to coexist with the mother for the duration of pregnancy. In species with haemochorial placentation this problem is particularly evident as foetal trophoblast cells are extensively intermingled with maternal...

journal_title：Journal of reproductive immunology

authors： Hemberger M

更新日期：2013-03-01 00:00:00

abstract：:Sperm antigens are being sought for the development of prototype contraceptive vaccines. For vaccine-induced antisperm antibodies to inhibit the function of viable sperm, target antigens must be expressed on the sperm surface before, during or after the acrosome reaction. The purpose of this study was to develop an ap...

journal_title：Journal of reproductive immunology

authors： Fichorova R,Anderson DJ

更新日期：1991-05-01 00:00:00

abstract：:Natural killer (NK) cells comprise of ∼70% of the immune cell population in the maternal decidua and ∼15% of the mononuclear cells in the peripheral blood. The decidual NK cells capable of producing high levels of cytokines are functionally distinct from the peripheral NK cells that exhibit high cytotoxicity. The numb...

journal_title：Journal of reproductive immunology

authors： Dixit A,Karande AA

更新日期：2020-02-01 00:00:00

abstract：:The present review article compares NK cell subsets and cytokine patterns determined in the peripheral blood as well as results of functional in-vitro assays using peripheral NK cells of idiopathic recurrent miscarriage (iRM) patients with corresponding results obtained in female healthy controls and female renal tran...

journal_title：Journal of reproductive immunology

authors： Toth B,Zhu L,Karakizlis H,Weimer R,Morath C,Opelz G,Kuon RJ,Daniel V

更新日期：2020-04-01 00:00:00

abstract：:Prolactin (PRL) influences immune reactivity in animals and in humans and both T-cell abnormalities and reduced natural killer (NK) cell activity have been reported in women with pathological hyperprolactinemia. To investigate further the possible interactions between PRL and the immune system in humans, we analysed T...

journal_title：Journal of reproductive immunology

authors： Nicoletti I,Gerli R,Orlandi S,Migliorati G,Rambotti P,Riccardi C

更新日期：1989-05-01 00:00:00

abstract：:Pregnancy is thought to be a state of immunological tolerance. The mechanisms underlying this phenomenon are still poorly understood. In our previous study, adenovirus mediated CTLA4Ig transgene (Ad-CTLA4Ig) therapy was demonstrated to improve pregnancy outcome in an abortion-prone mouse model by skewing the Th2/Th1 c...

journal_title：Journal of reproductive immunology

authors： Li W,Li B,Li S

更新日期：2013-04-01 00:00:00

abstract：:In vitro fertilization (IVF) pregnancies potentially have a higher rate of preterm delivery (PTD) than do spontaneously conceived gestations, and differences persist following adjustment for multiple gestation, maternal age, and parity. The reasons for this increased susceptibility to PTD remain incompletely elucidate...

journal_title：Journal of reproductive immunology

authors： Kanninen TT,Sisti G,Ramer I,Goldschlag D,Witkin SS,Spandorfer SD

更新日期：2015-11-01 00:00:00

abstract：:The immunosuppressive activity of a JEG-3 choriocarcinoma-derived factor in human IL-2-dependent T cell responses has been studied, together with its effect on IL-2-independent T cell responses induced by 10 nM TPA. The factor completely suppressed the IL-2-independent proliferative responses of T cells but failed to ...

journal_title：Journal of reproductive immunology

authors： Matsuzaki N,Saji F,Okada T,Sawai K,Kameda T,Tanizawa O

更新日期：1991-02-01 00:00:00

abstract：:Interferon-gamma (IFN-gamma) is a lymphokine, produced by activated T lymphocytes, which plays a key regulatory role in the host immunological responses. In addition, IFN-gamma is expressed by human and porcine trophoblast. As IFN-gamma exerts its biological functions through specific cell surface receptors and a grea...

journal_title：Journal of reproductive immunology

authors： Paulesu L,Romagnoli R,Cintorino M,Ricci MG,Garotta G

更新日期：1994-08-01 00:00:00

abstract：:Despite immense effort, the development of vaccines effective at mucosal sites has proceeded at a faltering pace. Efforts concentrating on humoral immunity but neglecting cellular immunity may be misdirected by ignoring many viral mucosal pathogens. Improved understanding of the development and maintenance of lymphocy...

journal_title：Journal of reproductive immunology

authors： Gould DS,Ploegh HL,Schust DJ

更新日期：2001-10-01 00:00:00

abstract：:Autologous anti-horseradish peroxidase antibody has been localized in pregnant rats at various levels through placental membranes en passage to fetal circulation. The antibody was complexed in situ with the antigen and the resulting complex was made visible electron microscopically by immunohistochemical techniques. V...

journal_title：Journal of reproductive immunology

authors： Jollie WP

更新日期：1985-05-01 00:00:00

abstract：:We conducted a large case-control study to assess the risk of preeclampsia with elevated sTNFp55 concentrations (markers of excessive TNF-alpha release) in Peruvian women. A total of 125 women with preeclampsia and 179 normotensive women were included in a study conducted during the period, June 1997 through January 1...

journal_title：Journal of reproductive immunology

authors： Sanchez SE,Zhang C,Williams MA,Ware-Jauregui S,Larrabure G,Bazul V,Farrand A

更新日期：2000-05-01 00:00:00

abstract：:Secretory leukocyte protease inhibitor (SLPI) and progranulin (PGRN) are secretory proteins with an anti-inflammatory property. Their involvement in cervical remodeling in pregnant uterus is not yet elucidated. Thus, this study aimed to explore the significance of SLPI and PGRN in the maintenance of pregnancy by inves...

journal_title：Journal of reproductive immunology

authors： Samejima T,Nagamatsu T,Akiba N,Fujii T,Sayama S,Kawana K,Taguchi A,Kumasawa K,Iriyama T,Osuga Y,Fujii T

更新日期：2021-02-01 00:00:00

abstract：:The inhibitory effect of antilymphocyte globulin on spontaneous rosette formation by peripheral blood T cells between 10 and 21 weeks gestation was examined. No evidence was obtained from either a cross-sectional or a longitudinal study that increased rosette inhibition levels occur during early human pregnancy. Compa...

journal_title：Journal of reproductive immunology

authors： Thomson AW,Milton JI,Campbell DM,Horne CH

更新日期：1980-12-01 00:00:00

abstract：:The feasibility of using the rhesus monkey as a non-human primate model for testing the efficacy of a contraceptive vaccine based on FA-1 antigen was evaluated. Affinity-purified anti-FA-1 polyclonal antibodies (Fab' fragments) and anti-FA-1 monoclonal antibody were used as probes in these studies. Anti-FA-1 antibodie...

journal_title：Journal of reproductive immunology

authors： Naz RK,Wolf DP

更新日期：1994-10-01 00:00:00

abstract：:A quantitative immunohistochemical study of IgA-containing plasma cells in the human uterine cervix has shown that the number of such cells increases during the late secretory phase of the menstrual cycle but decreases in the early secretory phase of the cycle, in pregnancy, in cystic glandular hyperplasia of the endo...

journal_title：Journal of reproductive immunology

authors： Murdoch AJ,Buckley CH,Fox H

更新日期：1982-02-01 00:00:00

abstract：:Herpes simplex virus type 2 (HSV-2) is becoming increasingly prevalent worldwide, despite the widespread use of antiviral drugs. Its ability to evade the immune system and establish a latent infection has made it difficult to develop an effective vaccine. Our understanding of the immune response against HSV-2 remains ...

journal_title：Journal of reproductive immunology

authors： Chan T,Barra NG,Lee AJ,Ashkar AA

更新日期：2011-03-01 00:00:00

abstract：:Several members of the immunoglobulin-like transcript (ILT), also called leukocyte immunoglobulin-like receptor (LIR), family of transmembrane proteins have been identified as receptors for class I HLA molecules and transduce inhibitory signals to leukocytes upon binding of these ligands. The ligands for ILT2 (LIR1/CD...

journal_title：Journal of reproductive immunology

authors： Petroff MG,Sedlmayr P,Azzola D,Hunt JS

更新日期：2002-07-01 00:00:00

abstract：:Lymphocytes in human colostrum were examined for evidence of alloreactivity specifically directed against the paternal HLA haplotype. Such reactivity was detected using umbilical cord blood leukocytes as stimulator cells in the mixed lymphocyte reaction, but the responses were reduced when compared to those of the sam...

journal_title：Journal of reproductive immunology

authors： Parmely MJ,Williams SB

更新日期：1981-06-01 00:00:00

abstract：:Secondary recurrent miscarriage (RM) is defined as three or more consecutive pregnancy losses after delivery of a viable infant. Previous reports suggest that a firstborn male child is associated with less favourable subsequent reproductive potential, possibly due to maternal immunisation against male-specific minor h...

journal_title：Journal of reproductive immunology

authors： Ooi PV,Russell N,O'Donoghue K

更新日期：2011-01-01 00:00:00

abstract：:Hypertensive disorders of pregnancy (HDP) represent 10% of human births globally and the major complication preeclampsia has a 3-5% prevalence. The etiology of HDP remains uncertain; however, major advances have been made over the last 25 years. The Seventh International Workshop on Reproductive Immunology, Immunologi...

journal_title：Journal of reproductive immunology

authors： Robillard PY,Dekker G,Chaouat G,Hulsey TC,Saftlas A

更新日期：2011-05-01 00:00:00