Milk and sugar: regulation of cell wall synthesis in the milk yeast Kluyveromyces lactis.

Abstract:

:The milk yeast Kluyveromyces lactis is an alternative model yeast to the well established Saccharomyces cerevisiae. The cell wall of these fungi consists of polysaccharides (i.e. long chains of β-1,3- and β-1,6-linked sugar chains and some chitin) and mannoproteins, both of which are continually adapted to environmental conditions in terms of their abundance and organization. This implies the need to perceive signals at the cell surface and to transform them into a proper cellular response. The signal transduction cascade involved in this process is generally referred to as the cell wall integrity (CWI) pathway. CWI signaling and cell wall composition have been extensively studied in the Baker's yeast S. cerevisiae and are also of interest in other yeast species with commercial potential, such as K. lactis. We here summarize the results obtained in the past years on CWI signaling in K. lactis and use a comparative approach to the findings obtained in S. cerevisiae to highlight special adaptations to their natural environments.

journal_name

Eur J Cell Biol

authors

Backhaus K,Buchwald U,Heppeler N,Schmitz HP,Rodicio R,Heinisch JJ

doi

10.1016/j.ejcb.2011.04.005

subject

Has Abstract

pub_date

2011-09-01 00:00:00

pages

745-50

issue

9

eissn

0171-9335

issn

1618-1298

pii

S0171-9335(11)00078-1

journal_volume

90

pub_type

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