Abstract:
:Regulation of morphogenesis through the production of chemical signalling molecules such as isoamyl alcohol, 2-phenylethyl alcohol, 1-dodecanol, E-nerolidol and farnesol is reported in Candida albicans. The present study focuses on the effect of ethyl alcohol on C. albicans dimorphism and biofilm development. Ethyl alcohol inhibited germ tube formation induced by the four standard inducers in a concentration-dependent manner. The germ tube inhibitory concentration (4%) did not have any effect on the growth and viability of C. albicans cells. Ethyl alcohol also inhibited the elongation of germ tubes. Four percentage of ethyl alcohol significantly inhibited biofilm development on polystyrene and silicone surfaces. We suggest a potential morphogenetic regulatory role for ethyl alcohol, which may influence dissemination, virulence and establishment of infection.
journal_name
Mycosesjournal_title
Mycosesauthors
Chauhan NM,Raut JS,Karuppayil SMdoi
10.1111/j.1439-0507.2010.02002.xsubject
Has Abstractpub_date
2011-11-01 00:00:00pages
e697-703issue
6eissn
0933-7407issn
1439-0507journal_volume
54pub_type
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