A morphogenetic regulatory role for ethyl alcohol in Candida albicans.

Abstract:

:Regulation of morphogenesis through the production of chemical signalling molecules such as isoamyl alcohol, 2-phenylethyl alcohol, 1-dodecanol, E-nerolidol and farnesol is reported in Candida albicans. The present study focuses on the effect of ethyl alcohol on C. albicans dimorphism and biofilm development. Ethyl alcohol inhibited germ tube formation induced by the four standard inducers in a concentration-dependent manner. The germ tube inhibitory concentration (4%) did not have any effect on the growth and viability of C. albicans cells. Ethyl alcohol also inhibited the elongation of germ tubes. Four percentage of ethyl alcohol significantly inhibited biofilm development on polystyrene and silicone surfaces. We suggest a potential morphogenetic regulatory role for ethyl alcohol, which may influence dissemination, virulence and establishment of infection.

journal_name

Mycoses

journal_title

Mycoses

authors

Chauhan NM,Raut JS,Karuppayil SM

doi

10.1111/j.1439-0507.2010.02002.x

subject

Has Abstract

pub_date

2011-11-01 00:00:00

pages

e697-703

issue

6

eissn

0933-7407

issn

1439-0507

journal_volume

54

pub_type

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