Matrix metalloproteinases and their inhibitors: promising novel biomarkers in severe sepsis?

abstract：:Disagreements between the perceptions of nurses and physicians regarding end-of-life (EOL) decisions are frequent. In a survey carried out in 13 Brazilian ICUs, Fumis and Deheinzelin reported that the majority of nurses, physicians and family members are in favor of limiting life-sustaining therapies in terminally ill...

journal_title：Critical care (London, England)

authors： Soares M

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Many patients experience 'relocation stress' when they are transferred from an intensive care unit (ICU) to step-down (high dependency) or general ward care, and much has been written about the psychological causes. This qualitative analysis of in-depth, narrative interviews with former ICU patients explor...

journal_title：Critical care (London, England)

authors： Field K,Prinjha S,Rowan K

更新日期：2008-01-01 00:00:00

abstract：:Using biomarkers as a guide to tailor the duration of antibiotic treatment in respiratory infections is an attractive hypothesis assessed in several studies. Recent work aiming to summarize the evidence assessed the effect of a procalcitonin (PCT)-guided antibiotic treatment on outcomes in acute lower respiratory trac...

journal_title：Critical care (London, England)

authors： Lisboa T,Salluh J,Povoa P

更新日期：2018-01-27 00:00:00

abstract：BACKGROUND:We sought to determine the effects of alternative resuscitation strategies on microcirculatory perfusion and examine any association between microcirculatory perfusion and mortality in sepsis. METHODS:This was a prospective, formally designed substudy of participants in the Protocolized Care in Early Septic...

journal_title：Critical care (London, England)

authors： Massey MJ,Hou PC,Filbin M,Wang H,Ngo L,Huang DT,Aird WC,Novack V,Trzeciak S,Yealy DM,Kellum JA,Angus DC,Shapiro NI,ProCESS investigators.

更新日期：2018-11-20 00:00:00

abstract：INTRODUCTION:The aim of this study was to assess the volume of gas being poorly ventilated or non-ventilated within the lungs of patients treated with mechanical ventilation and suffering from acute respiratory distress syndrome (ARDS). METHODS:A prospective, descriptive study was performed of 25 sedated and paralysed...

journal_title：Critical care (London, England)

authors： Rylander C,Tylén U,Rossi-Norrlund R,Herrmann P,Quintel M,Bake B

更新日期：2005-04-01 00:00:00

abstract：INTRODUCTION:Recombinant human activated protein C (rhAPC) is the first drug for which a reduction of mortality in severe sepsis has been demonstrated. However, the mechanism by which this reduction in mortality is achieved is still not clearly defined. The aim of the present study was to evaluate the dynamics of the a...

journal_title：Critical care (London, England)

authors： de Pont AC,Bakhtiari K,Hutten BA,de Jonge E,Vroom MB,Meijers JC,Büller HR,Levi M

更新日期：2005-10-05 00:00:00

abstract：OBJECTIVE:Exposure to hyperoxemia and hypoxemia is common in out-of-hospital cardiac arrest (OHCA) patients following return of spontaneous circulation (ROSC), but its effects on neurological outcome are uncertain, and study results are inconsistent. METHODS:Exploratory post hoc substudy of the Target Temperature Mana...

journal_title：Critical care (London, England)

authors： Ebner F,Ullén S,Åneman A,Cronberg T,Mattsson N,Friberg H,Hassager C,Kjærgaard J,Kuiper M,Pelosi P,Undén J,Wise MP,Wetterslev J,Nielsen N

更新日期：2019-01-28 00:00:00

abstract：INTRODUCTION:The objective was to study the effects of a novel lung volume optimization procedure (LVOP) using high-frequency oscillatory ventilation (HFOV) upon gas exchange, the transpulmonary pressure (TPP), and hemodynamics in a porcine model of surfactant depletion. METHODS:With institutional review board approva...

journal_title：Critical care (London, England)

authors： Karmrodt J,David M,Yuan S,Markstaller K

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:The administration of dopexamine may constitute a therapeutical option to improve hepatosplanchnic perfusion in sepsis. In order to verify this hypothesis, we administered dopexamine in an experimental sepsis model in rats. METHODS:This prospective, randomized, controlled laboratory study was conducted in...

journal_title：Critical care (London, England)

authors： Birnbaum J,Klotz E,Spies CD,Lorenz B,Stuebs P,Hein OV,Grundling M,Pavlovic D,Usichenko T,Wendt M,Kox WJ,Lehmann C

更新日期：2006-01-01 00:00:00

abstract：:The use of corticosteroids in septic shock remains controversial. It has been demonstrated that high doses of steroids (30 mg/kg methylprednisolone) for short periods of time are not beneficial. More recent studies using smaller doses (200-300 mg/day hydrocortisone) for longer periods of time have shown beneficial eff...

journal_title：Critical care (London, England)

authors： Goodman S,Sprung CL,International Sepsis Forum.

更新日期：2002-10-01 00:00:00

abstract：INTRODUCTION:Despite recent modifications, the clinical definition of the acute respiratory distress syndrome (ARDS) remains non-specific, leading to under-diagnosis and under-treatment. This study was designed to test the hypothesis that a biomarker panel would be useful for biologic confirmation of the clinical diagn...

journal_title：Critical care (London, England)

authors： Ware LB,Koyama T,Zhao Z,Janz DR,Wickersham N,Bernard GR,May AK,Calfee CS,Matthay MA

更新日期：2013-10-24 00:00:00

abstract：:This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2020. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2020. Further information about the Annual Update in Intensive Care and Emergency Medicine is available ...

journal_title：Critical care (London, England)

authors： Bassetti M,Bandera A,Gori A

更新日期：2020-03-24 00:00:00

abstract：INTRODUCTION:In the past two decades, healthcare adopted industrial strategies for process measurement and control. In the industry model, care is taken to avoid minimal deviations from a standard. In healthcare there is scarce data to support that a similar strategy can lead to better outcomes. Briefly, when complianc...

journal_title：Critical care (London, England)

authors： Amaral AC,Kure L,Jeffs A

更新日期：2012-05-08 00:00:00

abstract：INTRODUCTION:Recent evidence suggests a link between excess lipid peroxidation and specific organ failures in sepsis. No study has been performed in sepsis by multidrug-resistant (MDR) Gram-negative bacteria. METHODS:Lethal sepsis was induced in rats by the intraperitoneal injection of one MDR isolate of Pseudomonas a...

journal_title：Critical care (London, England)

authors： Toufekoula C,Papadakis V,Tsaganos T,Routsi C,Orfanos SE,Kotanidou A,Carrer DP,Raftogiannis M,Baziaka F,Giamarellos-Bourboulis EJ

更新日期：2013-01-16 00:00:00

abstract：BACKGROUND:Augmented renal clearance (ARC) is recognized as a leading cause of β-lactam subexposure when conventional dosing regimens are used. The main objective was to compare the clinical outcome of ARC patients treated by conventional or increased β-lactam dosing regimens for a first episode of hospital or ventilat...

journal_title：Critical care (London, England)

authors： Carrié C,Chadefaux G,Sauvage N,de Courson H,Petit L,Nouette-Gaulain K,Pereira B,Biais M

更新日期：2019-11-27 00:00:00

abstract：INTRODUCTION:This small observational study was motivated by our belief that scaling the tidal volume in mechanically ventilated patients to the size of the injured lung is safer and more 'physiologic' than scaling it to predicted body weight, i.e. its size before it was injured. We defined Total Lung Capacity (TLC) as...

journal_title：Critical care (London, England)

authors： Mattingley JS,Holets SR,Oeckler RA,Stroetz RW,Buck CF,Hubmayr RD

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Little is known about mortality rates following general surgical procedures in the United Kingdom. Deaths are most common in the 'high-risk' surgical population consisting mainly of older patients, with coexisting medical disease, who undergo major surgery. Only limited data are presently available to desc...

journal_title：Critical care (London, England)

authors： Pearse RM,Harrison DA,James P,Watson D,Hinds C,Rhodes A,Grounds RM,Bennett ED

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Hemophagocytic lymphohistiocytosis (HLH) is a rare though often fatal hyperinflammatory syndrome mimicking sepsis in the critically ill. Diagnosis relies on the HLH-2004 criteria and HScore, both of which have been developed in pediatric or adult non-critically ill patients, respectively. Therefore, we aimed...

journal_title：Critical care (London, England)

authors： Knaak C,Nyvlt P,Schuster FS,Spies C,Heeren P,Schenk T,Balzer F,La Rosée P,Janka G,Brunkhorst FM,Keh D,Lachmann G

更新日期：2020-05-24 00:00:00

abstract：BACKGROUND:Acute-on-chronic liver failure (ACLF) is characterized by the presence of acute decompensation (AD) of cirrhosis, organ failure, and high short-term mortality rates. Hemodynamic dysfunction and activation of endogenous vasoconstrictor systems are thought to contribute to the pathogenesis of ACLF. We explored...

journal_title：Critical care (London, England)

authors： Kerbert AJC,Verspaget HW,Navarro ÀA,Jalan R,Solà E,Benten D,Durand F,Ginès P,van der Reijden JJ,van Hoek B,Coenraad MJ,CANONIC Study Investigators of the EASL-CLIF Consortium.

更新日期：2017-12-21 00:00:00

abstract：:Recent interest in transfusion management of trauma patients has heightened expectation in the role of blood component therapy in improving patient outcome. Optimal transfusion support in supplementation with fibrinogen has not been defined by high-quality evidence. Current evidence comes mainly from case series and u...

journal_title：Critical care (London, England)

authors： Stanworth SJ,Hunt BJ

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Ventilation according to the open lung concept (OLC) consists of recruitment maneuvers, followed by low tidal volume and high positive end-expiratory pressure, aiming at minimizing atelectasis. The minimization of atelectasis reduces the right ventricular (RV) afterload, but the increased intrathoracic pre...

journal_title：Critical care (London, England)

authors： Miranda DR,Klompe L,Cademartiri F,Haitsma JJ,Palumbo A,Takkenberg JJ,Lachmann B,Bogers AJ,Gommers D

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Simvastatin therapy for patients with acute respiratory distress syndrome (ARDS) has been shown to be safe and associated with minimal adverse effects, but it does not improve clinical outcomes. The aim of this research was to report on mortality and cost-effectiveness of simvastatin in patients with ARDS at...

journal_title：Critical care (London, England)

authors： Agus A,Hulme C,Verghis RM,McDowell C,Jackson C,O'Kane CM,Laffey JG,McAuley DF

更新日期：2017-05-17 00:00:00

abstract：:Refractory cardiac shock in the cardiac surgical intensive care unit confers significant morbidity and mortality. Extracorporeal membrane oxygenation (ECMO) has become a common intervention for refractory cardiogenic shock when other therapies have failed. However, it is difficult to predict who will benefit from this...

journal_title：Critical care (London, England)

authors： Stephens R,Fan E

更新日期：2014-02-20 00:00:00

abstract：:Care of the critically ill patient is becoming increasingly complex. Protocols, which standardize care of patients with similar diseases, represent a potential solution to managing multiple simultaneous problems in critically ill patients. In this article, we examine the advantages and disadvantages to care protocoliz...

journal_title：Critical care (London, England)

authors： Chang SY,Sevransky J,Martin GS

更新日期：2012-01-01 00:00:00

abstract：INTRODUCTION:We report a case of twin toddlers who both suffered near drowning but with different post-trauma treatment and course, and different neurological outcomes. METHODS AND RESULTS:Two twin toddlers (a boy and girl, aged 2 years and 3 months) suffered hypothermic near drowning with protracted cardiac arrest an...

journal_title：Critical care (London, England)

authors： Hein OV,Triltsch A,von Buch C,Kox WJ,Spies C

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:Sepsis is an important cause of neonatal morbidity and mortality; therefore, the early diagnosis of neonatal sepsis is essential. METHOD:Our aim was to compare the diagnostic accuracy of procalcitonin (PCT), C-reactive protein (CRP), procalcitonin combined with C-reactive protein (PCT + CRP) and presepsin i...

journal_title：Critical care (London, England)

authors： Ruan L,Chen GY,Liu Z,Zhao Y,Xu GY,Li SF,Li CN,Chen LS,Tao Z

更新日期：2018-11-21 00:00:00

abstract：BACKGROUND:In hospitalised patients, anaemia increases the risk of developing acute kidney injury (AKI). Our aim was to determine whether anaemia also has an impact on the risk of progression from early AKI to more severe AKI in critically ill patients. METHODS:We retrospectively analysed the data of patients admitted...

journal_title：Critical care (London, England)

authors： Powell-Tuck J,Crichton S,Raimundo M,Camporota L,Wyncoll D,Ostermann M

更新日期：2016-03-08 00:00:00

abstract：BACKGROUND:(1,3)-β-D-Glucan has been widely used in clinical practice for the diagnosis of invasive Candida infections. However, such serum biomarker showed potential to guide antimicrobial therapy in order to reduce the duration of empirical antifungal treatment in critically ill septic patients with suspected invasiv...

journal_title：Critical care (London, England)

authors： De Pascale G,Posteraro B,D'Arrigo S,Spinazzola G,Gaspari R,Bello G,Montini LM,Cutuli SL,Grieco DL,Di Gravio V,De Angelis G,Torelli R,De Carolis E,Tumbarello M,Sanguinetti M,Antonelli M

更新日期：2020-09-05 00:00:00

abstract：INTRODUCTION:Our understanding of septic acute kidney injury (AKI) remains incomplete. A fundamental step is the use of animal models designed to meet the criteria of human sepsis. Therefore, we dynamically assessed renal haemodynamic, microvascular and metabolic responses to, and ultrastructural sequelae of, sepsis in...

journal_title：Critical care (London, England)

authors： Chvojka J,Sykora R,Krouzecky A,Radej J,Varnerova V,Karvunidis T,Hes O,Novak I,Radermacher P,Matejovic M

更新日期：2008-01-01 00:00:00

abstract：:Sepsis and septic shock are the leading causes of acute renal failure, multiple organ system dysfunction, and death in the intensive care unit. The pathogenesis of sepsis is complex and comprises a mosaic of interconnected pathways. Several attempts to improve patient outcomes by targeting specific components of this ...

journal_title：Critical care (London, England)

authors： Venkataraman R,Subramanian S,Kellum JA

更新日期：2003-04-01 00:00:00