NAP (davunetide) provides functional and structural neuroprotection.

Abstract:

:NAP (davunetide) is an eight amino acid peptide (NAPVSIPQ) that has been shown to provide potent neuroprotection, in vitro and in vivo. In human clinical trials, NAP has been shown to increase memory scores in patients suffering from amnestic mild cognitive impairment, a precursor to Alzheimer's disease and to enhance functional daily behaviors in schizophrenia patients. NAP is derived from activity-dependent neuroprotective protein (ADNP) a molecule that is essential for brain formation, interacting with chromatin associated protein alpha and the chromatin remodeling complex SWI/SNF and regulating >400 genes during embryonic development. Partial loss in ADNP results in cognitive deficits and pathology of the microtubule associated protein tau (tauopathy) that is ameliorated in part by NAP replacement therapy. Recent studies increased the scope of NAP neuroprotection and provided further insights into the NAP mechanisms of action. Thus, it has been hypothesized that the presence of tau on axonal microtubules renders them notably less sensitive to the microtubule-severing protein katanin, and NAP was shown to protect microtubules from katanin disruption in the face of reduced tau expression. Parallel studies showed that NAP reduced the number of apoptotic neurons through activation of PI-3K/Akt pathway in the cortical plate or both PI-3K/Akt and MAPK/MEK1 kinases in the white matter. The interaction of these disparate yet complementary pathways is the subject of future studies toward human brain neuroprotection in the clinical scenario.

journal_name

Curr Pharm Des

authors

Gozes I

doi

10.2174/138161211795589373

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

1040-4

issue

10

eissn

1381-6128

issn

1873-4286

pii

BSP/CPD/E-Pub/000374

journal_volume

17

pub_type

杂志文章,评审
  • Advanced glycation end products and insulin resistance.

    abstract::Non-enzymatic modification of proteins by reducing sugars, a process that is also known as Maillard reaction, leads to the formation of advanced glycation end products (AGEs) in vivo. There is a growing body of evidence that formation and accumulation of AGEs progress during normal aging, and at an extremely accelerat...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161208784139747

    authors: Unoki H,Yamagishi S

    更新日期:2008-01-01 00:00:00

  • Mouse models of autoimmune uveitis.

    abstract::Uveitis is a sight threatening intraocular inflammation accounting for approximately 10% of blindness worldwide. On the basis of aetiology, disease can be classified as infectious or non-infectious; and by anatomical localization of inflammation as anterior, posterior and panuveitis. Non-infectious uveitis is believed...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612821666150316122928

    authors: Klaska IP,Forrester JV

    更新日期:2015-01-01 00:00:00

  • Antiepileptic Treatment Strategy in Vascular Malformations.

    abstract:BACKGROUND:Antiepileptic treatment strategy plays an important role in the management of intracranial vascular malformations. The intracranial vascular malformations can be divided into cavernous hemangiomas, arteriovenous malformations, developmental venous anomalies and capillary telangiectasias. Seizures and hemorrh...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612823666171027142718

    authors: Giakoumettis D,Margetis K,Stranjalis G,Haliasos N,Papaioannou TG,Themistocleous MS

    更新日期:2017-01-01 00:00:00

  • Cancer/testis antigens trigger epithelial-mesenchymal transition and genesis of cancer stem-like cells.

    abstract::Malignant tumors aberrantly overexpress various embryonic genes and proto-oncogenes, including a variety of cancer-testis antigens (CTAs). CTAs belong to a class of testis-derived proteins which are only expressed in germ cells in the male testis, and the expression of CTA genes is entirely silenced in the adult somat...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612821666141211154707

    authors: Yang P,Huo Z,Liao H,Zhou Q

    更新日期:2015-01-01 00:00:00

  • Oncogenic microRNAs in the genesis of leukemia and lymphoma.

    abstract::Emerging evidence has shown that microRNAs (miRNAs) can act as oncogenes in the initiation and progression of leukemia and lymphoma. Aberrant expression of oncogenic miRNAs, including miR-155, miR-17-92, miR-21, miR-125b, miR-93, miR-143-p3, miR-196b, and miR-223 promotes leukemogenesis through increasing the leukemic...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612820666140128211724

    authors: Pan Y,Meng M,Zhang G,Han H,Zhou Q

    更新日期:2014-01-01 00:00:00

  • Novel therapeutic approaches to autoimmune demyelinating disorders.

    abstract::Multiple Sclerosis (MS) is the most common autoimmune demyelinating disorder in Western countries and can lead to permanent disability. Over the past decades remarkable progress has been made in providing new therapeutic strategies to tackle the burden of the disease. Oral drugs and monoclonal antibodies are the main ...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161211798157630

    authors: Sanvito L,Constantinescu CS,Gran B

    更新日期:2011-01-01 00:00:00

  • Trends in Nanotechnology for in vivo Cancer Diagnosis: Products and Patents.

    abstract:BACKGROUND:Cancer is a set of diseases formed by abnormal growth of cells leading to the formation of the tumor. The diagnosis can be made through symptoms' evaluation or imaging tests, however, the techniques are limited and the tumor detection may be late. Thus, pharmaceutical nanotechnology has emerged to optimize t...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612826666200219094853

    authors: do Nascimento T,Tavares M,Monteiro MSSB,Santos-Oliveira R,Todeschini AR,de Souza VT,Ricci-Júnior E

    更新日期:2020-01-01 00:00:00

  • Clinical applications and biosafety of human adult mesenchymal stem cells.

    abstract::Mesenchymal Stem Cells (MSCs) are a population of adherent cells that can differentiate into mesenchymal lineage populations (cartilage, bone and fat tissue). In addition, they seem to be able to differentiate also into a broader type of lineages other than the original mesodermal germ layer. Bone marrow MSCs are a st...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161212799859666

    authors: Mariani E,Facchini A

    更新日期:2012-01-01 00:00:00

  • Pharmacophore identification and quantitative bioactivity prediction using the electron-conformational method.

    abstract::A review of the Electron-Conformational (EC) method of pharmacophore (Pha) identification and quantitative bioactivity prediction in drug design and toxicology is presented, which includes the latest advances and improvements of the method as a whole and details of its realization with illustration of results. In the ...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612033454586

    authors: Bersuker IB

    更新日期:2003-01-01 00:00:00

  • Mechanisms and risk of chemically induced aneuploidy in mammalian germ cells.

    abstract::Aneuploidy is a pathological condition that affects 35% of human spontaneous abortions and 0.3% of livebirths. In spite of the increasing knowledge about molecular mechanisms of meiosis and chromosome segregation, maternal age remains the only ascertained aetiological factor. Genetically modified mouse models have bee...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161206776389859

    authors: Pacchierotti F,Ranaldi R

    更新日期:2006-01-01 00:00:00

  • Left ventricular non-compaction: from recognition to treatment.

    abstract::We have gained considerable insight and understanding about the etiology, embryogenesis of the myocardium, genetic background, diagnosis and outcome of left ventricular non-compaction (LVNC) over the last 2 decades. LVNC has a distinct morphological appearance with a thickened, two-layered myocardium consisting of an ...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161282104141204143212

    authors: Ganame J

    更新日期:2015-01-01 00:00:00

  • Nicotine-Derived Compounds as Therapeutic Tools Against Post-Traumatic Stress Disorder.

    abstract::Post-traumatic stress disorder (PTSD) is an anxiety disorder that develops after experiencing trauma. Actual therapies do not help majority of patients with PTSD. Moreover, extinguished fear memories usually reappear in the individuals when exposed to trauma cues. New drugs to reduce the impact of conditioned cues in ...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612821666150710145250

    authors: Barreto GE,Yarkov A,Avila-Rodriguez M,Aliev G,Echeverria V

    更新日期:2015-01-01 00:00:00

  • Customizing G Protein-coupled receptor models for structure-based virtual screening.

    abstract::This review will focus on the construction, refinement, and validation of G Protein-coupled receptor models for the purpose of structure-based virtual screening. Practical tips and tricks derived from concrete modeling and virtual screening exercises to overcome the problems and pitfalls associated with the different ...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161209789824786

    authors: de Graaf C,Rognan D

    更新日期:2009-01-01 00:00:00

  • Immunology of Chronic Obstructive Pulmonary Disease and Sulfur Mustard Induced Airway Injuries: Implications for Immunotherapeutic Interventions.

    abstract:BACKGROUND:Sulfur mustard (SM)-induced airway injuries and chronic obstructive pulmonary disease (COPD) are characterized by chronic inflammation of the respiratory tract and share some similarities regarding the cellular and molecular mechanisms orchestrating airway destruction. Since available data regarding the immu...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612822666160307150818

    authors: Panahi Y,Jadidi-Niaragh F,Jamalkandi SA,Ghanei M,Pedone C,Nikravanfard N,Nikravesh F,Sahebkar A

    更新日期:2016-01-01 00:00:00

  • Development of a Physiologically-Based Pharmacokinetic Model for Preterm Neonates: Evaluation with In Vivo Data.

    abstract::Among pediatric patients, preterm neonates and newborns are the most vulnerable subpopulation. Rapid developmental changes of physiological factors affecting the pharmacokinetics of drug substances in newborns require extreme care in dose and dose regimen decisions. These decisions could be supported by in silico meth...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612821666150901110533

    authors: Claassen K,Thelen K,Coboeken K,Gaub T,Lippert J,Allegaert K,Willmann S

    更新日期:2015-01-01 00:00:00

  • Vitamin D: A Micronutrient Regulating Genes.

    abstract:BACKGROUND:At sufficient sun exposure, humans can synthesize vitamin D3 endogenously in their skin, but today's lifestyle makes the secosteroid a true vitamin that needs to be taken up by diet or supplementation with pills. The vitamin D3 metabolite 1α,25-dihydroxyvitamin D3 acts as a nuclear hormone activating the tra...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612825666190705193227

    authors: Carlberg C

    更新日期:2019-01-01 00:00:00

  • Insulin-Like Growth Factor-1, a Potential Predicative Biomarker for Postoperative Delirium Among Elderly Patients with Open Abdominal Surgery.

    abstract:BACKGROUND:Delirium is commonly observed among elderly surgical subjects during the postoperative period, and the incidence of postoperative delirium (POD) in elderly patients (≥65 years) ranges widely from 10% to 70%. This study aimed at investigating potential serum predicative factors for POD in elderly patients aft...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章

    doi:10.2174/1381612822666160813234311

    authors: Shen H,Shao Y,Chen J,Guo J

    更新日期:2016-01-01 00:00:00

  • Gold Nanoparticles- Boon in Cancer Theranostics.

    abstract:BACKGROUND:Cancer is the world's second-largest cause of death, with an estimated 9.6 million fatalities in 2018. Malignant tumour (cancer) is caused by a mixture of genetic modifications due to the environmental variables that tend to activate or inactivate different genes, ultimately resulting in neoplastic transform...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章

    doi:10.2174/1381612826666200701151403

    authors: Jindal M,Nagpal M,Singh M,Aggarwal G,Dhingra GA

    更新日期:2020-01-01 00:00:00

  • Molecular mechanisms explaining the preventive effects of catechins on the development of proliferative diseases.

    abstract::Various growth factors such as the platelet derived growth factor (PDGF), insulin-like growth factor (IGF), epidermal growth factor (EGF), fibroblast growth factor (FGF), and vascular endothelial growth factor (VEGF) transduce their mitogenic signals through the activation of tyrosine kinase receptors (RTKs). Since en...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612043452578

    authors: Gouni-Berthold I,Sachinidis A

    更新日期:2004-01-01 00:00:00

  • Detecting Personalized Determinants During Drug Treatment from Omics Big Data.

    abstract:BACKGROUNDS:Targeted therapy is the foundation of personalized medicine in cancer, which is often understood as the right patient using the right drug. Thinking from the viewpoint of determinants during personalized drug treatment, the genetics, epigenetics and metagenomics would provide individual-specific biological ...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612824666181106102111

    authors: Wang L,Yu X,Zhang C,Zeng T

    更新日期:2018-01-01 00:00:00

  • Correlation of Salusin Beta with hs-CRP and ADMA in Hypertensive Children and Adolescents.

    abstract:PURPOSE:The emerging evidence has recently shown an evident dependence between recently identified salusin peptides and atherosclerosis, and their important roles as endogenous modulators of atherogenesis. It was reported that the development of atherosclerosis could also be affected by endogenous salusin- β overproduc...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章

    doi:10.2174/1381612824666180607124531

    authors: Kołakowska U,Kuroczycka-Saniutycz E,Olański W,Wasilewska A

    更新日期:2018-01-01 00:00:00

  • Peripheral Corticotropin Releasing Factor Signaling Inhibits Gastric Emptying: Mechanisms of Action and Role in Stress-related Gastric Alterations of Motor Function.

    abstract::The activation of Corticotrophin Releasing-Factor (CRF) receptors in the brain is well established to coordinate the endocrine, behavioral, autonomic and visceral responses to stress. In addition, CRF receptors are also expressed within the gut where they exert biological actions and play a role in modulating stress-r...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612823666170228142428

    authors: Czimmer J,Tache Y

    更新日期:2017-01-01 00:00:00

  • Computer-based strategy for modeling the interaction of AGRP and related peptide ligands with the AGRP-binding site of murine melanocortin receptors.

    abstract::The hypothesis that the interaction of agouti-related protein (AGRP) and the melanocortin-4 receptor (MC4R) modulates feeding behavior in humans has stimulated the synthesis of conformationally constrained peptides, peptoids and small molecules in efforts to identify novel compounds that can potentially be used in the...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612053382188

    authors: Wang X,Richards NG

    更新日期:2005-01-01 00:00:00

  • Gene vectors for cytokine expression in vivo.

    abstract::The understanding of cytokine networks and the exploitation of these networks for the treatment of immune and inflammatory diseases as well as cancer depend on in vivo delivery of cytokines. Due to instability of recombinant cytokine proteins, investigators have employed cytokine-encoding gene therapy vectors to induc...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612003400551

    authors: Hitt MM,Gauldie J

    更新日期:2000-04-01 00:00:00

  • Phosphodiesterase type 5 inhibitors: molecular pharmacology and interactions with other phosphodiesterases.

    abstract::Erectile function is determined by tight regulation of relaxation or contraction of corpus cavernosal smooth muscle, which is the result of a long and complex chain of molecular events. Control of erectile function resides in signaling pathways of the central and peripheral nervous system, as well as intracellular eve...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161205774913426

    authors: Seftel AD

    更新日期:2005-01-01 00:00:00

  • A novel class of HIV-1 inhibitors that targets the viral envelope and inhibits CD4 receptor binding.

    abstract::BMS-378806 is a prototype of a new class of small molecule HIV-1 inhibitors that blocks viral attachment to cells. This compound exhibits potent inhibitory activity against a panel of HIV-1 laboratory and clinical isolates (M- and T-tropic), selective for HIV-1 and inactive against HIV-2, SIV and a panel of other viru...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612043384565

    authors: Wang HG,Williams RE,Lin PF

    更新日期:2004-01-01 00:00:00

  • Clinical aspects of tumor necrosis factor-α signaling in hepatocellular carcinoma.

    abstract::Tumor necrosis factor alpha (TNF-α) is a multi-functional cytokine that regulates a variety of signaling pathways implicated in inflammation, immunity, cell death (apoptosis), cell survival (anti-apoptosis), and even tumorigenesis. TNF-α is predominantly produced by macrophages (or Kupffer cells within the liver), but...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/13816128113199990587

    authors: Jang MK,Kim HS,Chung YH

    更新日期:2014-01-01 00:00:00

  • Ocular involvement in fetal alcohol spectrum disorder: a review.

    abstract::Fetal Alcohol Syndrome (FAS), the most severe manifestation of Fetal Alcohol Spectrum Disorder (FASD) is considered the leading non-hereditary cause of mental retardation and neurological deficit in the Western world. There lie a huge associated human cost to both FASD victims and their families and a considerable fin...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612820666140205144114

    authors: Brennan D,Giles S

    更新日期:2014-01-01 00:00:00

  • Immunological properties of donkey's milk: its potential use in the prevention of atherosclerosis.

    abstract::Donkey's milk is the best substitute of human milk for its content in lactose, proteins, minerals, and omega-3 fatty acids. Here, we have evaluated the effects of colostrum and milk from donkeys (Martina Franca breed) on the function of human peripheral blood mononuclear cells (PBMCs) at different intervals from lacta...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章

    doi:10.2174/138161207783018590

    authors: Tafaro A,Magrone T,Jirillo F,Martemucci G,D'Alessandro AG,Amati L,Jirillo E

    更新日期:2007-01-01 00:00:00

  • Serotonin 5-HT1A Receptors and Antipsychotics - An Update in Light of New Concepts and Drugs.

    abstract::Schizophrenia is characterised by positive, negative, cognitive, depressive and anxiety symptoms. Over the last decades a number of novel treatment strategies with better clinical efficacy and scope, but with lower side-effect profiles have been developed. These have significantly improved the management and prognosis...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612821666150605105215

    authors: McCreary AC,Newman-Tancredi A

    更新日期:2015-01-01 00:00:00