Abstract：
:A series of novel 2,4-disubstituted quinazoline derivatives were prepared and their inhibitory activities on hPin1 were evaluated. Of all the synthesized compounds, eight compounds displayed inhibitory activities with IC(50) value at the level of 10(-6)mol/L. Preliminary structure-activity relationships were analyzed in details and the binding mode of the titled compounds was predicted using FlexX algorithm. The design and optimization of novel small molecule Pin1 inhibitors will be guided by the results of this report.
journal_name
Bioorg Med Chemjournal_title
Bioorganic & medicinal chemistryauthors
Zhu L,Jin J,Liu C,Zhang C,Sun Y,Guo Y,Fu D,Chen X,Xu Bdoi
10.1016/j.bmc.2011.03.058subject
Has Abstractpub_date
2011-05-01 00:00:00pages
2797-807issue
9eissn
0968-0896issn
1464-3391pii
S0968-0896(11)00247-1journal_volume
19pub_type
杂志文章abstract：:Breast cancer resistance protein (BCRP/ABCG2) belongs to the ATP binding cassette family of transport proteins. BCRP has been found to confer multidrug resistance in cancer cells. A strategy to overcome resistance due to BCRP overexpression is the investigation of potent and specific BCRP inhibitors. The aim of the cu...
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journal_title：Bioorganic & medicinal chemistry
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更新日期：2005-04-01 00:00:00
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journal_title：Bioorganic & medicinal chemistry
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