Abstract:
:To identify a candidate etiologic agent for turkey viral hepatitis, we analyzed samples from diseased turkey poults from 8 commercial flocks in California, USA, that were collected during 2008-2010. High-throughput pyrosequencing of RNA from livers of poults with turkey viral hepatitis (TVH) revealed picornavirus sequences. Subsequent cloning of the ≈9-kb genome showed an organization similar to that of picornaviruses with conservation of motifs within the P1, P2, and P3 genome regions, but also unique features, including a 1.2-kb sequence of unknown function at the junction of P1 and P2 regions. Real-time PCR confirmed viral RNA in liver, bile, intestine, serum, and cloacal swab specimens from diseased poults. Analysis of liver by in situ hybridization with viral probes and immunohistochemical testing of serum demonstrated viral nucleic acid and protein in livers of diseased poults. Molecular, anatomic, and immunologic evidence suggests that TVH is caused by a novel picornavirus, tentatively named turkey hepatitis virus.
journal_name
Emerg Infect Disjournal_title
Emerging infectious diseasesauthors
Honkavuori KS,Shivaprasad HL,Briese T,Street C,Hirschberg DL,Hutchison SK,Lipkin WIdoi
10.3201/eid1703.101410subject
Has Abstractpub_date
2011-03-01 00:00:00pages
480-7issue
3eissn
1080-6040issn
1080-6059journal_volume
17pub_type
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