Association of prepro-orexin polymorphism with obstructive sleep apnea/hypopnea syndrome.


BACKGROUND:Because of the potential role of orexin neuronal circuitry in the regulation of sleep and wakefulness and arousal and breathing, it seems reasonable to speculate that abnormalities in the prepro-orexin gene could be relevant to studies of obstructive sleep apnea/hypopnea syndrome (OSAHS); and it might be a candidate gene in the pathogenesis of OSAHS. OBJECTIVE:The present study investigated whether single nucleotide polymorphisms (SNPs) in the human prepro-orexin gene are associated with OSAHS in Han Chinese people. METHODS:A total of 394 subjects (217 cases and 177 control subjects) were recruited from China. Diagnostic polysomnography was performed in all patients and control subjects. SNPs in potentially functional regions of the gene were identified; and genotypes, determined by direct sequencing. RESULTS:By sequencing the promoter, 2 exons, and the exon-intron junctions of the prepro-orexin gene, the g11182C>T SNP was identified. Statistical analysis showed that there were significant differences in the genotype distribution between patients with OSAHS and the control group (χ(2)(2) = 6.437, P = .04). Variant allele T of the g1182C>T polymorphism was more commonly found in patients with OSAHS as compared with control subjects (χ(2)(1) = 5.648, P = .017; odds ratio, 1.449; 95% confidence interval, 1.0466-1.968). CONCLUSIONS:Our results suggest that the prepro-orexin gene polymorphism g1182C>T is associated with susceptibility to OSAHS in Han Chinese. This study provides insights into the genetic information for future studies regarding this gene in OSAHS.


Am J Otolaryngol


Chen W,Ye J,Han D,Yin G,Wang B,Zhang Y




Has Abstract


2012-01-01 00:00:00














  • Intratympanic dexamethasone plus melatonin versus melatonin only in the treatment of unilateral acute idiopathic tinnitus.

    abstract:PURPOSE:The aim of our study was to determine whether the combination of intratympanic (IT) corticosteroid with melatonin could be associated with decreased tinnitus in patients with unilateral acute idiopathic tinnitus developed within 3months. MATERIALS AND METHODS:We evaluated this hypothesis through a prospective,...

    journal_title:American journal of otolaryngology

    pub_type: 杂志文章,随机对照试验


    authors: Albu S,Chirtes F

    更新日期:2014-09-01 00:00:00

  • Dizziness, malpractice, and the otolaryngologist.

    abstract:PURPOSE:To assess malpractice claims related to the management of dizziness in otolaryngology in order to improve care and minimize the risk of litigation. MATERIALS AND METHODS:This is a retrospective review of the LexisNexis "Jury Verdicts and Settlements" database. All lawsuits and out of court adjudications relate...

    journal_title:American journal of otolaryngology

    pub_type: 杂志文章


    authors: Tolisano AM,Song SA,Ruhl DS,Littlefield PD

    更新日期:2017-01-01 00:00:00

  • Antibody activity of IgG subclasses against pneumococcal polysaccharides after vaccination.

    abstract::The isotypic pattern of antipneumococcal polysaccharide antibodies with respect to IgG subclasses differs in adults and children. Adults show almost exclusively IgG2 activity, whereas children exhibit both IgG1 and IgG2 activity. The IgG subclass pattern of the antibody response after pneumococcal vaccination was eval...

    journal_title:American journal of otolaryngology

    pub_type: 杂志文章


    authors: Rynnel-Dagöö B,Freijd A,Prellner K

    更新日期:1985-07-01 00:00:00

  • Carotid cavernous sinus fistula caused by dental implant-associated infection.

    abstract::A 61-year-old woman presented with painful ophthalmoplegia, Tolosa-Hunt syndrome. The patient had undergone a placement of dental implant 5 months before the presentation and had a local maxillary sinusitis 1 month later. She had not been aware of any preceding head trauma or infection. On examination, the patient sho...

    journal_title:American journal of otolaryngology

    pub_type: 杂志文章


    authors: Shimizu Y,Tsutsumi S,Yasumoto Y,Ito M

    更新日期:2012-05-01 00:00:00

  • Multiple cranial neuropathies following etanercept administration.

    abstract::There have been recent reports of sarcoid-like granulomatosis development following the administration of tumor necrosis factor (TNF) inhibitors. To date, only four cases of neurosarcoidosis have been reported in association with TNF inhibitors, two of which were attributed to etanercept. We present the first case of ...

    journal_title:American journal of otolaryngology

    pub_type: 杂志文章


    authors: Hunter JB,Rivas A

    更新日期:2016-05-01 00:00:00

  • Acyclovir in the treatment of recurrent respiratory papillomatosis: a preliminary report.

    abstract:INTRODUCTION:In this study, we evaluate the effect of acyclovir in the treatment of recurrent respiratory papillomatosis (RRP), in addition to CO2 surgery. MATERIALS AND METHODS:We include 12 patients who had aggressive RRP and required at least three prior endoscopic surgeries in this study. Acyclovir treatment start...

    journal_title:American journal of otolaryngology

    pub_type: 杂志文章


    authors: Kiroğlu M,Cetik F,Soylu L,Abedi A,Aydoğan B,Akçali C,Kiroğlu F,Ozsahinoğlu C

    更新日期:1994-05-01 00:00:00

  • House Dust Mite Related Allergic Rhinitis and REM Sleep Disturbances.

    abstract:PURPOSE:Sleep disturbances are common in patients with allergic rhinitis (AR). Perennial allergens like house dust mites (HDM) are difficult to avoid and have nocturnal impacts on the respiratory system and Quality of Life (QOL). The Rapid Eye Movement (REM) sleep stage is associated with memory, cognition, dreams, and...

    journal_title:American journal of otolaryngology

    pub_type: 杂志文章


    authors: Berson SR,Klimczak JA,Prezio EA,Abraham MT

    更新日期:2020-01-01 00:00:00

  • The protective effect of Salvia miltiorrhiza on gentamicin-induced ototoxicity.

    abstract:OBJECTIVE:The clinical use of aminoglycoside antibiotics is limited in most countries because of auditory toxicity side effects. However, their use is common in developing countries because they are inexpensive and convenient. Salvia miltiorrhiza extracts are used clinically in China for their antioxidant properties. W...

    journal_title:American journal of otolaryngology

    pub_type: 杂志文章


    authors: Shi L,An Y,Wang A,Gao Q,Yang Y

    更新日期:2014-03-01 00:00:00

  • Low-dose dexamethasone reduces nausea and vomiting after tympanomastoid surgery: a comparison of tropisetron with saline.

    abstract:PURPOSE:The aim of the study was to evaluate the efficacy of low-dose dexamethasone sodium phosphate (5 mg) on the prophylaxis of nausea and vomiting after tympanomastoid surgery. Tropisetron hydrochloride (2 mg) and saline were used as controls. MATERIALS AND METHODS:One hundred twenty patients (n = 40 in each of 3 g...

    journal_title:American journal of otolaryngology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Wang JJ,Wang PC,Liu YH,Chien CC

    更新日期:2002-09-01 00:00:00

  • Bacteriology and antimicrobial susceptibility of pediatric chronic rhinosinusitis: a 6-year result of maxillary sinus punctures.

    abstract:PURPOSE:Few studies in the past decade have focused on antimicrobial resistance of bacteria in pediatric rhinosinusitis. This study aimed to characterize organisms cultured from pediatric chronic rhinosinusitis, as well as current resistance patterns of pathogens. MATERIALS AND METHODS:The study was conducted from Jan...

    journal_title:American journal of otolaryngology

    pub_type: 杂志文章


    authors: Hsin CH,Su MC,Tsao CH,Chuang CY,Liu CM

    更新日期:2010-05-01 00:00:00

  • Characterization of patient head motion in otologic surgery: Implications for TEES.

    abstract:PURPOSE:Middle ear disease is increasingly being managed via transcanal endoscopic ear surgery (TEES). A limitation of TEES is that it restricts the surgeon to single-handed dissection. One solution to this would be an endoscope holder to facilitate two-handed dissection. Current endoscope holders are stationary, and c...

    journal_title:American journal of otolaryngology

    pub_type: 杂志文章


    authors: Berges AJ,Razavi C,Shahbazi M,Taylor R,Carey JP,Creighton FX

    更新日期:2020-12-29 00:00:00

  • Residual mesenchyme persisting into adulthood.

    abstract:PURPOSE:(1) To detect the presence of residual mesenchyme in temporal bones of adults and children above 5 years of age; (2) to evaluate its regression with increasing age, and; (3) to detect pathologic conditions associated with the presence of unresolved mesenchyme. MATERIALS AND METHODS:We examined 1,404 human temp...

    journal_title:American journal of otolaryngology

    pub_type: 杂志文章


    authors: Jaisinghani VJ,Paparella MM,Schachern PA,Schneider DS,Le CT

    更新日期:1999-11-01 00:00:00

  • Functional architecture of the nasopharyngeal tonsil.

    abstract::The exact architecture of the normal nasopharyngeal tonsil remains obscure because most histopathologic investigations have been based on surgically removed adenoids. We compared enlarged adenoids and normal nasopharyngeal tonsils under both light and electron microscopes. The marked features of clinically enlarged ad...

    journal_title:American journal of otolaryngology

    pub_type: 杂志文章


    authors: Fujiyoshi T,Watanabe T,Ichimiya I,Mogi G

    更新日期:1989-03-01 00:00:00

  • Jugular foramen syndrome as a complication of metastatic melanoma.

    abstract:INTRODUCTION:The jugular foramen (Vernet) syndrome with neuropathy of cranial nerves IX-XI is more commonly due to metastatic lesions than primary neoplasms. Hypoglossal nerve involvement is referred to as the Collet Sicard variant of the jugular foramen syndrome. MATERIALS AND METHODS:We report an elderly man who pre...

    journal_title:American journal of otolaryngology

    pub_type: 杂志文章


    authors: Schweinfurth JM,Johnson JT,Weissman J

    更新日期:1993-05-01 00:00:00

  • New-onset facial paralysis and undiagnosed recurrence of cutaneous malignancy: evaluation and management.

    abstract::Perineural invasion of cranial nerves, including the facial nerve by squamous cell carcinoma of the skin, is a poor prognostic factor for recurrent disease and disease-specific mortality. We discuss 2 patients who presented to the Otolaryngology/Head and Neck Surgery service with complete facial nerve paralysis and a ...

    journal_title:American journal of otolaryngology

    pub_type: 杂志文章


    authors: Scurry WC Jr,Isaacson JE,Fedok FG

    更新日期:2006-03-01 00:00:00

  • Surgical timing for facial paralysis after temporal bone trauma.

    abstract:OBJECTIVES:To explore surgical timing of facial paralysis after temporal bone trauma. METHODS:The clinical data of the patients with facial paralysis after temporal bone trauma who underwent subtotal facial nerve decompression were retrospectively collected, and 80 cases followed-up for one year were enrolled in the s...

    journal_title:American journal of otolaryngology

    pub_type: 杂志文章


    authors: Xu P,Jin A,Dai B,Li R,Li Y

    更新日期:2017-01-01 00:00:00

  • Contemporary management of pediatric lateral sinus thrombosis: a twenty year review.

    abstract:OBJECTIVES:A case of pediatric otogenic lateral sinus thrombosis is reported, followed by a substantive literature review. DESIGN:104 patients were reviewed, culled from published case reports from 1993 to 2011 on the PubMed database. METHODS:All full text case reports on the PubMed database from 1993 to 2011 with pa...

    journal_title:American journal of otolaryngology

    pub_type: 杂志文章


    authors: Au JK,Adam SI,Michaelides EM

    更新日期:2013-03-01 00:00:00

  • Ipsilateral single stage conversion from BAHA to cochlear implant.

    abstract::Profound unilateral sensorineural hearing loss is an indication for the placement of a bone anchored hearing aid. In a few unfortunate patients who later develop contralateral hearing loss, a cochlear implant becomes a good option. We present our experience in these cases and discuss our technique for single stage con...

    journal_title:American journal of otolaryngology

    pub_type: 杂志文章


    authors: Li S,Hrisomalos EN,Semaan MT,Megerian CA

    更新日期:2015-09-01 00:00:00

  • Complication of a columellar strut in an edentulous patient.

    abstract::The cartilaginous columellar strut is a well established, commonly used graft in rhinoplasty which provides support and stability to the nasal base. The risk of such a graft is related to grafts designs, whereby the posterior aspect can cause clicking with movement across the anterior nasal spine. We present an additi...

    journal_title:American journal of otolaryngology

    pub_type: 杂志文章


    authors: Harirchian S,Murray KP,Eloy JA

    更新日期:2014-01-01 00:00:00

  • Safety of cranial fixation in endoscopic brow lifts.

    abstract:INTRODUCTION:The endoscopic brow lift technique relies on brow mobilization and often soft fixation to the underlying calvarium. While the endoscopic brow lift has been used safely, there are anecdotal reports of cerebrospinal fluid leak. We sought to measure calvarial thickness to improve the safety of cranial fixatio...

    journal_title:American journal of otolaryngology

    pub_type: 杂志文章


    authors: Harirchian S,Kuperan AB,Shah AR

    更新日期:2013-11-01 00:00:00

  • Menière's disease as a manifestation of vestibular ganglionitis.

    abstract:OBJECTIVE:To present morphologic evidence of viral-induced vestibular nerve pathology in Menière's Disease (MD). MATERIAL STUDIED: Twelve temporal bones (TB) from 8 patients with the clinical symptoms of MD. RESULTS:There was endolymphatic hydrops (EH) and perilymphatic fibrosis in 10 of the 12 TB from MD patients. Of...

    journal_title:American journal of otolaryngology

    pub_type: 杂志文章


    authors: Gacek RR,Gacek MR

    更新日期:2001-07-01 00:00:00

  • Diagnostic efficacy of different methods in the assessment of adenoid hypertrophy.

    abstract:OBJECTIVE:This study was designed for better understanding of the role of different methods of nasal endoscopy in the assessment of adenoid hypertrophy and comparing them with lateral neck radiography and patients' symptoms. SUBJECTS AND METHOD:From August 2007 until January 2009, in the otolaryngology ward of a terti...

    journal_title:American journal of otolaryngology

    pub_type: 杂志文章


    authors: Saedi B,Sadeghi M,Mojtahed M,Mahboubi H

    更新日期:2011-03-01 00:00:00

  • Intramuscular myxoma of the cervical paraspinal musculature: case report and review of the literature.

    abstract:CASE:A 57year old female patient presented with a painful right-sided neck mass that on MRI was shown to be adherent to the posterior aspect of the sternocleidomastoid muscle. The mass was surgically resected en bloc without complications. Histopathologic analysis revealed the mass to be a myxoma. REVIEW:To date, ther...

    journal_title:American journal of otolaryngology

    pub_type: 杂志文章,评审


    authors: Tataryn Z,Tracy J,Tsang C,Wu J,Heilman CB,Wein RO

    更新日期:2015-03-01 00:00:00

  • Assessment of sexual functions in male patients with obstructive sleep apnea.

    abstract:PURPOSE:Obstructive sleep apnea is characterized by repetitive cessation of breathing during sleep. It affects different aspects of sexuality. We aimed to assess male sexual function & risk factors in obstructive sleep apnea patients. METHODS:This case control study included 2 groups, 45 healthy volunteers as control ...

    journal_title:American journal of otolaryngology

    pub_type: 杂志文章


    authors: Mostafa RM,Kamel NM,Elsayed EM,Saad HM

    更新日期:2021-01-05 00:00:00

  • Management of Jehovah's Witnesses in otolaryngology, head and neck surgery.

    abstract::It is imperative that surgeons should have some knowledge and understanding of the beliefs of Jehovah's Witnesses to respect the patient's wishes and effectively minimize and manage blood loss. The objective of this review was to provide a management strategy for Jehovah's Witness patients undergoing otolaryngology, h...

    journal_title:American journal of otolaryngology

    pub_type: 杂志文章,评审


    authors: Adelola OA,Ahmed I,Fenton JE

    更新日期:2008-07-01 00:00:00

  • Treatment of laryngopharyngeal reflux using a sleep positioning device: A prospective cohort study.

    abstract:OBJECTIVE:Laryngopharyngeal reflux (LPR) symptoms are often resistant to management and cause significant quality of life impairment to patients with this disease. This study assesses the utility of a sleep-positioning device (SPD) in treating LPR. DESIGN:Single center prospective cohort study. SETTING:Tertiary medic...

    journal_title:American journal of otolaryngology

    pub_type: 杂志文章


    authors: Tierney WS,Gabbard SL,Milstein CF,Benninger MS,Bryson PC

    更新日期:2017-01-01 00:00:00

  • Management of tonsillectomy hemorrhage: results of a survey of pediatric otolaryngology fellowship programs.

    abstract:PURPOSE:To reach a consensus on the preoperative evaluation and management of intraoperative and postoperative tonsillectomy hemorrhage. METHOD:A survey on the preoperative evaluation and the management of intraoperative and postoperative tonsillectomy hemorrhage was given to one of the faculty members at each of the ...

    journal_title:American journal of otolaryngology

    pub_type: 杂志文章


    authors: Cressman WR,Myer CM 3rd

    更新日期:1995-01-01 00:00:00

  • Morphology and cochlear implantation in enlarged vestibular aqueduct.

    abstract:PURPOSE:The purpose of this work is to explore audiometry following cochlear implantation (CI) in patients with enlarged vestibular aqueduct (EVA) and to investigate the effects of inner ear morphological variation on post CI audiometry. METHODS:This was a retrospective review of both natural and cochlear-implant-aide...

    journal_title:American journal of otolaryngology

    pub_type: 杂志文章


    authors: Patel ND,Ascha MS,Manzoor NF,Gupta A,Semaan M,Megerian C,Otteson TD

    更新日期:2018-01-01 00:00:00

  • Tongue symptoms, suspension force and duration during operative laryngoscopy.

    abstract:PURPOSE:Suspension laryngoscopy is a commonly performed procedure in otolaryngology. During the procedure, the laryngoscope applies direct force to the tongue. Postoperative tongue symptoms include pain, swelling, numbness, taste disturbance, and rarely motor deficits. Duration and magnitude of force applied have previ...

    journal_title:American journal of otolaryngology

    pub_type: 杂志文章


    authors: Lindemann TL,Kamrava B,Sarcu D,Soliman AMS

    更新日期:2020-01-01 00:00:00

  • Neoadjuvant chemotherapy and radiotherapy for the treatment of advanced hypopharyngeal carcinoma.

    abstract:PURPOSE:To evaluate the efficacy of the neoadjuvant chemotherapy and radiation therapy in treatment of patients with advanced hypopharyngeal cancer, which is notorious for its poor prognosis and severe surgical morbidity with functional deficits. MATERIALS AND METHODS:Medical records of 62 patients with squamous cell ...

    journal_title:American journal of otolaryngology

    pub_type: 杂志文章


    authors: Kim KH,Sung MW,Rhee CS,Koo JW,Koh TY,Lee DW,Heo DS,Park CI

    更新日期:1998-01-01 00:00:00