Abstract：
BACKGROUND:Because of the potential role of orexin neuronal circuitry in the regulation of sleep and wakefulness and arousal and breathing, it seems reasonable to speculate that abnormalities in the prepro-orexin gene could be relevant to studies of obstructive sleep apnea/hypopnea syndrome (OSAHS); and it might be a candidate gene in the pathogenesis of OSAHS. OBJECTIVE:The present study investigated whether single nucleotide polymorphisms (SNPs) in the human prepro-orexin gene are associated with OSAHS in Han Chinese people. METHODS:A total of 394 subjects (217 cases and 177 control subjects) were recruited from China. Diagnostic polysomnography was performed in all patients and control subjects. SNPs in potentially functional regions of the gene were identified; and genotypes, determined by direct sequencing. RESULTS:By sequencing the promoter, 2 exons, and the exon-intron junctions of the prepro-orexin gene, the g11182C>T SNP was identified. Statistical analysis showed that there were significant differences in the genotype distribution between patients with OSAHS and the control group (χ(2)(2) = 6.437, P = .04). Variant allele T of the g1182C>T polymorphism was more commonly found in patients with OSAHS as compared with control subjects (χ(2)(1) = 5.648, P = .017; odds ratio, 1.449; 95% confidence interval, 1.0466-1.968). CONCLUSIONS:Our results suggest that the prepro-orexin gene polymorphism g1182C>T is associated with susceptibility to OSAHS in Han Chinese. This study provides insights into the genetic information for future studies regarding this gene in OSAHS.
journal_name
Am J Otolaryngoljournal_title
American journal of otolaryngologyauthors
Chen W,Ye J,Han D,Yin G,Wang B,Zhang Ydoi
10.1016/j.amjoto.2010.12.005subject
Has Abstractpub_date
2012-01-01 00:00:00pages
31-6issue
1eissn
0196-0709issn
1532-818Xpii
S0196-0709(10)00256-5journal_volume
33pub_type
杂志文章abstract：PURPOSE:The aim of our study was to determine whether the combination of intratympanic (IT) corticosteroid with melatonin could be associated with decreased tinnitus in patients with unilateral acute idiopathic tinnitus developed within 3months. MATERIALS AND METHODS:We evaluated this hypothesis through a prospective,...
journal_title：American journal of otolaryngology
pub_type： 杂志文章,随机对照试验
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更新日期：2014-09-01 00:00:00
abstract：PURPOSE:To assess malpractice claims related to the management of dizziness in otolaryngology in order to improve care and minimize the risk of litigation. MATERIALS AND METHODS:This is a retrospective review of the LexisNexis "Jury Verdicts and Settlements" database. All lawsuits and out of court adjudications relate...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
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更新日期：2017-01-01 00:00:00
abstract：:The isotypic pattern of antipneumococcal polysaccharide antibodies with respect to IgG subclasses differs in adults and children. Adults show almost exclusively IgG2 activity, whereas children exhibit both IgG1 and IgG2 activity. The IgG subclass pattern of the antibody response after pneumococcal vaccination was eval...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
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更新日期：1985-07-01 00:00:00
abstract：:A 61-year-old woman presented with painful ophthalmoplegia, Tolosa-Hunt syndrome. The patient had undergone a placement of dental implant 5 months before the presentation and had a local maxillary sinusitis 1 month later. She had not been aware of any preceding head trauma or infection. On examination, the patient sho...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
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更新日期：2012-05-01 00:00:00
abstract：:There have been recent reports of sarcoid-like granulomatosis development following the administration of tumor necrosis factor (TNF) inhibitors. To date, only four cases of neurosarcoidosis have been reported in association with TNF inhibitors, two of which were attributed to etanercept. We present the first case of ...
journal_title：American journal of otolaryngology
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更新日期：2016-05-01 00:00:00
abstract：INTRODUCTION:In this study, we evaluate the effect of acyclovir in the treatment of recurrent respiratory papillomatosis (RRP), in addition to CO2 surgery. MATERIALS AND METHODS:We include 12 patients who had aggressive RRP and required at least three prior endoscopic surgeries in this study. Acyclovir treatment start...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/0196-0709(94)90007-8
更新日期：1994-05-01 00:00:00
abstract：PURPOSE:Sleep disturbances are common in patients with allergic rhinitis (AR). Perennial allergens like house dust mites (HDM) are difficult to avoid and have nocturnal impacts on the respiratory system and Quality of Life (QOL). The Rapid Eye Movement (REM) sleep stage is associated with memory, cognition, dreams, and...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
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更新日期：2020-01-01 00:00:00
abstract：OBJECTIVE:The clinical use of aminoglycoside antibiotics is limited in most countries because of auditory toxicity side effects. However, their use is common in developing countries because they are inexpensive and convenient. Salvia miltiorrhiza extracts are used clinically in China for their antioxidant properties. W...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2013.08.022
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journal_title：American journal of otolaryngology
pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 杂志文章
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更新日期：2010-05-01 00:00:00
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journal_title：American journal of otolaryngology
pub_type： 杂志文章
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更新日期：2020-12-29 00:00:00
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journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/s0196-0709(99)90075-3
更新日期：1999-11-01 00:00:00
abstract：:The exact architecture of the normal nasopharyngeal tonsil remains obscure because most histopathologic investigations have been based on surgically removed adenoids. We compared enlarged adenoids and normal nasopharyngeal tonsils under both light and electron microscopes. The marked features of clinically enlarged ad...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/0196-0709(89)90135-x
更新日期：1989-03-01 00:00:00
abstract：INTRODUCTION:The jugular foramen (Vernet) syndrome with neuropathy of cranial nerves IX-XI is more commonly due to metastatic lesions than primary neoplasms. Hypoglossal nerve involvement is referred to as the Collet Sicard variant of the jugular foramen syndrome. MATERIALS AND METHODS:We report an elderly man who pre...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/0196-0709(93)90025-3
更新日期：1993-05-01 00:00:00
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journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2005.07.017
更新日期：2006-03-01 00:00:00
abstract：OBJECTIVES:To explore surgical timing of facial paralysis after temporal bone trauma. METHODS:The clinical data of the patients with facial paralysis after temporal bone trauma who underwent subtotal facial nerve decompression were retrospectively collected, and 80 cases followed-up for one year were enrolled in the s...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2017.01.002
更新日期：2017-01-01 00:00:00
abstract：OBJECTIVES:A case of pediatric otogenic lateral sinus thrombosis is reported, followed by a substantive literature review. DESIGN:104 patients were reviewed, culled from published case reports from 1993 to 2011 on the PubMed database. METHODS:All full text case reports on the PubMed database from 1993 to 2011 with pa...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2012.09.011
更新日期：2013-03-01 00:00:00
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journal_title：American journal of otolaryngology
pub_type： 杂志文章
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journal_title：American journal of otolaryngology
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更新日期：2014-01-01 00:00:00
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journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2013.03.014
更新日期：2013-11-01 00:00:00
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doi：10.1053/ajot.2001.24822
更新日期：2001-07-01 00:00:00
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journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2009.11.003
更新日期：2011-03-01 00:00:00
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journal_title：American journal of otolaryngology
pub_type： 杂志文章,评审
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更新日期：2015-03-01 00:00:00
abstract：PURPOSE:Obstructive sleep apnea is characterized by repetitive cessation of breathing during sleep. It affects different aspects of sexuality. We aimed to assess male sexual function & risk factors in obstructive sleep apnea patients. METHODS:This case control study included 2 groups, 45 healthy volunteers as control ...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2020.102899
更新日期：2021-01-05 00:00:00
abstract：:It is imperative that surgeons should have some knowledge and understanding of the beliefs of Jehovah's Witnesses to respect the patient's wishes and effectively minimize and manage blood loss. The objective of this review was to provide a management strategy for Jehovah's Witness patients undergoing otolaryngology, h...
journal_title：American journal of otolaryngology
pub_type： 杂志文章,评审
doi：10.1016/j.amjoto.2007.08.006
更新日期：2008-07-01 00:00:00
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journal_title：American journal of otolaryngology
pub_type： 杂志文章
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更新日期：2017-01-01 00:00:00
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journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/0196-0709(95)90006-3
更新日期：1995-01-01 00:00:00
abstract：PURPOSE:The purpose of this work is to explore audiometry following cochlear implantation (CI) in patients with enlarged vestibular aqueduct (EVA) and to investigate the effects of inner ear morphological variation on post CI audiometry. METHODS:This was a retrospective review of both natural and cochlear-implant-aide...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2018.06.006
更新日期：2018-01-01 00:00:00
abstract：PURPOSE:Suspension laryngoscopy is a commonly performed procedure in otolaryngology. During the procedure, the laryngoscope applies direct force to the tongue. Postoperative tongue symptoms include pain, swelling, numbness, taste disturbance, and rarely motor deficits. Duration and magnitude of force applied have previ...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2020.102402
更新日期：2020-01-01 00:00:00
abstract：PURPOSE:To evaluate the efficacy of the neoadjuvant chemotherapy and radiation therapy in treatment of patients with advanced hypopharyngeal cancer, which is notorious for its poor prognosis and severe surgical morbidity with functional deficits. MATERIALS AND METHODS:Medical records of 62 patients with squamous cell ...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/s0196-0709(98)90064-3
更新日期：1998-01-01 00:00:00
