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Effect of in vivo therapy with a CD8 monoclonal antibody on delayed engraftment after autologous bone marrow transplantation.

Abstract：

:Very long delay to engraftment (or non-engraftment) was observed in eight patients presenting common immunological features, i.e. excess of blood and bone marrow lymphocytes coexpressing CD8 and CD57 (HNK1) antigens. They were therefore treated by CD8 immunotherapy. Such treatment induced a complete clearance of CD8+, CD57+ cells from the blood and bone marrow in five cases, a partial clearance in one, the absence of clearance in one and a modulation in the last case. No toxic side effects were observed. Platelet recovery was observed in only two patients, but long-lasting granulocyte recovery was seen in six of the cases from day 6 to day 30 after the beginning of CD8 infusion (median = 17 days).

journal_name

Bone Marrow Transplant

journal_title

Bone marrow transplantation

authors

Favrot M,Philip T,Combaret V,Lemerle J,Marie JP,Bernard A

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

33-8

issue

1

eissn

0268-3369

issn

1476-5365

journal_volume

5

pub_type

杂志文章

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