Design, Synthesis and antiHIV activity of Novel Isatine-Sulphonamides.

Abstract:

:A series of novel isatine-sulphonamide derivatives have been synthesized by combining isatin derivatives with sulphonamides. The structure of the synthesized compounds were elucidated by spectral analysis (IR, NMR and Mass). Investigation of anti-HIV activity was done against HIV-1(IIIB) in MT-4 cells and HIV integrase inhibitory activity. 4-(1-acetyl-5-methyl-2-oxoindolin-3-ylideneamino)-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide (SPIII-5ME-AC) inhibits the HIV Integrase enzymatic activity as both over all and strand transfer reaction and 4-(1-benzoyl-5-chloro-2-oxoindolin-3-ylideneamino)-N-(4,6-dimethylpyrimidin-2-yl)benzene sulfonamide (SPIII-5Cl-BZ) exhibits 36 percent maximum protection against HIV-1 at sub toxic concentration.

journal_name

Indian J Pharm Sci

authors

Selvam P,Murugesh N,Chandramohan M,Debyser Z,Witvrouw M

doi

10.4103/0250-474X.49121

subject

Has Abstract

pub_date

2008-11-01 00:00:00

pages

779-82

issue

6

eissn

0250-474X

issn

1998-3743

journal_volume

70

pub_type

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