The augmenter of liver regeneration protects the kidneys after orthotopic liver transplantation possibly by upregulating HIF-1α and O2-sensitive K+ channels.


PURPOSE:The augmenter of liver regeneration (ALR) might promote better renal function after orthotopic liver transplantation (OLT). Using a rat allogeneic OLT model, we investigated if ALR can mediate renal protection and its potential mechanisms. METHODS:Orthotopic liver transplant recipients were assigned to a cyclosporine A (CsA)-treated group (CsA group) and an ALR+CsA group (ALR group). Transplanted liver, kidneys, and serum were harvested on post-transplantation days 1, 3, and 7 for histological examination, and hepatic function and renal function analysis. We also measured the expression of hypoxiainducible factor-1 (HIF-1α) and O(2)-sensitive K(+) cannels (KV1.5 and KV2.1), and free Ca(2+) in the smooth muscle cells (SMCs) of intrarenal arterioles in the kidneys. RESULTS:All transplanted livers suffered mild acute rejection after OLT. Recipient kidney damage was more severe in the CsA group, characterized by increased serum creatinine, tubular epithelial apoptosis and necrosis, and the formation of casts. In the ALR group, HIF-1α, KV1.5, and KV2.1 were upregulated, accompanied by lower Ca(2+) concentration, in the SMCs shortly after OLT. CONCLUSION:Augmenter of liver regeneration might increase the expression of HIF-1α and K(+) channels and decrease intracellular free Ca(2+), thereby inhibiting arterial contraction and promoting kidney perfusion immediately after OLT.


Surg Today


Surgery today


Chen Y,Luo F,Luo S,Wu Z,Zhou J




Has Abstract


2011-03-01 00:00:00












  • No inflammatory benefit obtained by single-incision laparoscopic surgery for right hemicolectomy compared with conventional laparoscopy.

    abstract:PURPOSE:We evaluated the perioperative inflammatory mediators in a right hemicolectomy performed with single-incision laparoscopic surgery (SILS) and traditional multi-port laparoscopic surgery (MLS) to compare the postoperative inflammatory response and feasibility of SILS with that of MLS. METHODS:In this retrospect...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Hara M,Shiga K,Yanagita T,Nakai N,Ando N,Takasu K,Maeda Y,Nagasaki T,Hirokawa T,Matsuo Y,Ishiguro H,Takahashi H,Takiguchi S

    更新日期:2019-07-01 00:00:00

  • Efficacy of prostaglandin I2 analog on liver grafts subjected to 30 minutes of warm ischemia.

    abstract::Due to the fact that no effective conditioning agent for hemodynamically unstable donors exists, the number of suitable donors is limited. The efficacy of OP-41483, a stable analog of prostaglandin I2, as a conditioning agent of the liver was investigated in this study using pigs. OP-41483 was administered via the por...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Kishida A,Kurumi Y,Kodama M

    更新日期:1997-01-01 00:00:00

  • A new method of anterior mediastinal tracheostomy following resection of cervical esophagus and the larynx: report of a case.

    abstract::We report herein the case of a 52-year-old man for whom a split pectoralis major myocutaneous flap was applied at the time of extended radical surgery for esophageal carcinoma with tracheal involvement, to avoid the postoperative complications of anterior tracheostomy such as tracheal necrosis and rupture of the major...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Kimura A,Nimura Y,Hayakawa N,Yasui A,Torii S

    更新日期:1994-01-01 00:00:00

  • Decreased expression of DCC mRNA in gastric and colorectal cancer.

    abstract::The deleted-in-colorectal-cancer (DCC) gene, located on chromosome 18q 21.3, is considered to be a tumor suppressor gene related to cellular adhesion receptors. A loss of heterozygosity (LOH) on chromosome 18q is frequently observed in adenomatous polyposis coli, as well as in sporadic colon carcinoma and its liver me...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Kataoka M,Okabayashi T,Orita K

    更新日期:1995-01-01 00:00:00

  • Mixed medullary-papillary carcinoma of the thyroid with lymph node metastases: report of a case.

    abstract::We report herein the case of a 77-year-old woman found to have mixed medullary-papillary carcinoma in the right thyroid with lymph node metastases 30 years after a left thyroidectomy. The preoperative values of serum calcitonin and carcinoembryonic antigen (CEA) were high, and fine-needle aspiration biopsy revealed cl...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Shiroko T,Yokoo N,Okamoto K,Kitakado Y,Azuma H,Fukui T,Tanaka C

    更新日期:2001-01-01 00:00:00

  • Parathyroid adenoma manifested by mediastinal hemorrhage: report of a case.

    abstract::Acute mediastinal hemorrhage is rarely caused by a rupture of mediastinal neoplasms. We herein report a 70-year-old man who presented with mediastinal parathyroid adenoma manifested by the sudden onset of mediastinal bleeding. Preoperatively, he showed no symptoms or complications associated with hypercalcemia. No par...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Nakajima J,Takamoto S,Tanaka M,Takeuchi E,Murakawa T,Kitagawa H,Fukayama M

    更新日期:2002-01-01 00:00:00

  • Use of a vacuum-assisted closure system for the management of enteroatmospheric fistulae.

    abstract:PURPOSE:The aim of this study was to analyze the management of enteroatmospheric fistulae (EAF) in an open abdomen using vacuum-assisted closure (VAC) therapy. METHODS:Eighteen patients (ten male/eight female) were treated in our surgical department for the management of EAF. VAC therapy was used to manage both comple...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Tavusbay C,Genc H,Cin N,Kar H,Kamer E,Atahan K,Haciyanli M

    更新日期:2015-09-01 00:00:00

  • Risk factors for postoperative complications after gastrectomy in gastric cancer patients with comorbidities.

    abstract:PURPOSE:We conducted this retrospective cohort study to evaluate which preoperative comorbidities and their combinations are most strongly associated with postoperative complications after gastrectomy. METHODS:We collected data on 214 consecutive patients who underwent gastrectomy for gastric cancer. Preoperative como...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Hamakawa T,Kurokawa Y,Mikami J,Miyazaki Y,Takahashi T,Yamasaki M,Miyata H,Nakajima K,Takiguchi S,Mori M,Doki Y

    更新日期:2016-02-01 00:00:00

  • The role of tumor necrosis factor receptors in cell signaling and the significance of soluble form levels in the serum.

    abstract::Two types of tumor necrosis factor membrane receptors (TNF-R) have been identified, namely 55 and 75 kDa TNF-R. Soluble forms of these receptors are present in the human serum. Recent findings on the role of these two TNF-R in biological cell signaling and the clinical significance of the serum levels of soluble TNF-R...

    journal_title:Surgery today

    pub_type: 杂志文章,评审


    authors: Abe Y,Watanabe Y,Kimura S

    更新日期:1994-01-01 00:00:00

  • Modified Limberg transposition flap for sacrococcygeal pilonidal sinus.

    abstract:PURPOSE:To investigate the results of wide rhomboid excision with Limberg transposition flap reconstruction to treat pilonidal sinus. METHODS:We analyzed the well-documented records of 238 patients with sacrococcygeal pilonidal sinus who underwent wide excision with a Limberg transposition flap and were followed up fo...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Mentes BB,Leventoglu S,Cihan A,Tatlicioglu E,Akin M,Oguz M

    更新日期:2004-01-01 00:00:00

  • Successful coil embolization for spontaneous arterial rupture in association with Ehlers-Danlos syndrome type IV: report of a case.

    abstract::When a patient with Ehlers-Danlos syndrome (EDS) presents with a vascular emergency, performing life-saving surgery can be difficult because of the profound fragility of the arterial tissue. We report the case of a 27-year-old woman with EDS in whom a spontaneous arterial rupture was successfully treated with transcat...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Sugawara Y,Ban K,Imai K,Okada K,Watari M,Orihashi K,Sueda T,Naitoh A

    更新日期:2004-01-01 00:00:00

  • Implantation of human adipose-derived stromal cells for the functional recovery of a murine heat-damaged muscle model.

    abstract::In cases of lower rectum-located tumor or severe disease, surgical resection is currently the effective management; however, it also carries increased risks of function loss. The interdisciplinary field of regenerative medicine offers strategies that can potentially restore severely diseased and injured tissues and or...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Miyoshi N,Fujino S,Takahashi Y,Yasui M,Ohue M,Mizushima T

    更新日期:2020-12-01 00:00:00

  • Evaluation of the health-related quality of life for patients following laparoscopic cholecystectomy.

    abstract:PURPOSE:Laparoscopic cholecystectomy (LC) has become the standard procedure, and contributes to a shorter hospital stay. However, there have been no reports regarding when the patients can be discharged in terms of their health-related quality of life (HRQOL). METHODS:The HRQOL was evaluated by using the SF-8 health s...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Tani M,Kawai M,Okada K,Hirono S,Hotta T,Takifuji K,Yamaue H

    更新日期:2015-05-01 00:00:00

  • The use of bioelectrical impedance analysis for monitoring body composition changes during nutritional support.

    abstract::Body composition was measured with bioelectric impedance analysis (BIA) in 30 patients with protein malnutrition following biliopancreatic diversion. Determinations were carried out prior to, during, and at the completion of intravenous nutritional support when the nutritional parameters had completely reverted to nor...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Adami GF,Marinari G,Gandolfo P,Cocchi F,Friedman D,Scopinaro N

    更新日期:1993-01-01 00:00:00

  • An effective device to keep the sternum open.

    abstract::Delayed sternal closure following cardiothoracic surgery facilitates the treatment of heart failure and arrhythmias caused by sternal closure, and also allows access to treat uncontrollable bleeding. The present study examines the use of stents made from disposable syringes for keeping the sternum open. The syringes d...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Kaneda T,Aoshima M,Ishigami N,Iemura J,Matsumoto T

    更新日期:1999-01-01 00:00:00

  • Spontaneous hemorrhage of a thymic cyst in an adult: report of a case.

    abstract::Mediastinal cysts account for about 19% of all mediastinal masses, and thymic cysts represent only about 1.5% of anterior mediastinal masses. Thymic cysts do not usually cause symptoms and are often found incidentally on routine chest radiography. We report the case of a thymic cyst that hemorrhaged into the mediastin...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Saito Y,Murai K,Kawai Y,Takahashi N,Ikeya T,Hoshi E,Kawabata Y

    更新日期:2010-10-01 00:00:00

  • Clinical characteristics of 12 cases of appendiceal diverticulitis: a comparison with 378 cases of acute appendicitis.

    abstract:PURPOSE:Previous authors have suggested that a diverticulum of the vermiform appendix has a higher risk of perforation than acute appendicitis. Therefore, this study compared appendiceal diverticulitis with acute appendicitis to explain the characteristics of appendiceal diverticulitis. METHODS:Data for this study cam...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Yamana I,Kawamoto S,Inada K,Nagao S,Yoshida T,Yamashita Y

    更新日期:2012-04-01 00:00:00

  • Neoadjuvant therapy for rectal cancer down-stages the tumor but reduces lymph node harvest significantly.

    abstract:PURPOSE:The impact of neoadjuvant therapy (NAT) for rectal cancer on lymph node yield is not well known. This study evaluates the impact of NAT on tumor regression and lymph node harvest. METHODS:The subjects were 40 patients with rectal cancer; 20 receiving high-dose, long-course neoadjuvant therapy, and 20 age- and ...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Wijesuriya RE,Deen KI,Hewavisenthi J,Balawardana J,Perera M

    更新日期:2005-01-01 00:00:00

  • Perioperative management for pancreatoduodenectomy following severe acute pancreatitis in patients with periampullary cancer: our experience with six consecutive cases.

    abstract:PURPOSE:We rarely have an opportunity to perform pancreatoduodenectomy (PD) following the onset of severe acute pancreatitis (SAP) for patients with periampullary cancer. The perioperative risks and optimal timing of subsequent PD have, therefore, remained unclear. METHODS:Between January 2006 and December 2012, we pe...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Asari S,Matsumoto I,Ajiki T,Shinzeki M,Goto T,Fukumoto T,Ku Y

    更新日期:2015-02-01 00:00:00

  • The significance of proliferating cell nuclear antigen (PCNA) expression in cancer of the ampulla of vater in terms of prognosis.

    abstract::Seventeen patients with cancer of the ampulla of Vater were studied retrospectively using immunohistochemical staining with a monoclonal antibody to the proliferating cell nuclear antigen (PCNA). The relationships between the PCNA-positive rate, being the number of PCNA-positive cancer cells to total cancer cells, the...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Isozaki H,Okajima K,Ichinona T,Tanimura M,Morita S,Takada Y,Ishibashi T,Hara H

    更新日期:1994-01-01 00:00:00

  • Successful repair of a huge right coronary artery to a right ventricular fistula: report of a case.

    abstract::Congenital coronary artery fistulas account for only 0.27%-0.4% of all congenital cardiac defects. We report a case of a right coronary artery (RCA) to a right ventricular(RV) fistula found in 14-year-old girl with clinical signs of heart failure. Echocardiography and cardiac catheterization showed the fistula and a d...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Charokopos N,Rouska E,Antonitsis P,Spanos P

    更新日期:2007-01-01 00:00:00

  • Use of the double-stapling technique in esophageal surgery.

    abstract::This study was conducted to examine the effectiveness of the double-stapling technique (DST) for performing esophageal anastomoses. A total of 17 patients, 10 with esophageal cancer and 7 with gastric cancer, underwent esophageal anastomosis employing this technique. Of the ten patients who underwent esophageal operat...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Akiyama S,Kodera Y,Sekiguchi H,Fujiwara M,Hibi T,Kondo K,Ito K,Takagi H

    更新日期:1995-01-01 00:00:00

  • Emergent laparoscopic cholecystectomy for acute acalculous cholecystitis revisited.

    abstract:PURPOSE:To compare the safety of emergent laparoscopic cholecystectomy for acute acalculous cholecystitis (AAC) with surgery for acute calculous cholecystitis (ACC). METHODS:We retrospectively reviewed the perioperative records of 111 patients who underwent emergent laparoscopic cholecystectomy for acute cholecystitis...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Ueno D,Nakashima H,Higashida M,Yoshida K,Hino K,Irei I,Moriya T,Matsumoto H,Hirai T,Nakamura M

    更新日期:2016-03-01 00:00:00

  • The safety and prognostic factors for mortality in extremely elderly patients undergoing an emergency operation.

    abstract:PURPOSE:As the number of elderly people has increased, the number of elderly patients who need emergency operations has also increased. Although there are many models to evaluate the risk of surgery in elderly patients, they all are associated with limitations. We herein evaluated the prognostic factors for surgical mo...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Park SY,Chung JS,Kim SH,Kim YW,Ryu H,Kim DH

    更新日期:2016-02-01 00:00:00

  • Serum calcitonin reference values for calcium stimulation tests by electrochemiluminescence immunoassay in Japanese men with non-medullary thyroid carcinoma.

    abstract:PURPOSE:Calcitonin is the most sensitive tumor marker of medullary thyroid carcinoma (MTC) and a calcium stimulation test is used to improve this sensitivity. In Japan, the electrochemiluminescence immunoassay (ECLIA) is currently the only test performed to measure serum calcitonin. There is a gender difference in the ...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Kihara M,Miyauchi A,Kudo T,Hirokawa M,Miya A

    更新日期:2018-02-01 00:00:00

  • Translation and validation of the Japanese version of the fecal incontinence quality of life scale.

    abstract:PURPOSE:The aim of the study was to conduct a psychometric evaluation of the fecal incontinence quality of life scale (FIQL) in the Japanese language using rigorous methodologies. METHODS:The FIQL was translated into Japanese. After being linguistically validated, the Japanese version of the FIQL was administered to a...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Tsunoda A,Yamada K,Kano N,Takano M

    更新日期:2013-10-01 00:00:00

  • The importance of neural invasion (NI) as a prognostic factor in diffuse invasive gastric cancer.

    abstract::The relationship between histological factors, including neural invasion (NI), and survival rates in patients with Borrmann type IV diffuse invasive gastric cancer was examined to determine the significance of NI as a prognostic factor. NI was studied histochemically in 75 patients who underwent resection after 1982, ...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Tanaka A,Yoshikawa H,Okuno K,Koh K,Watatani M,Matsumura E,Yasutomi M

    更新日期:1997-01-01 00:00:00

  • Changes in lung lobar volume and bronchial deformity after right upper lobectomy.

    abstract::To explore the anatomical repositioning of the middle lobe following right upper (RU) lobectomy, we measured the lobar volumes of the lung and the branching angles of the airway, and defined their changes after RU lobectomy in a rabbit model. Groups A1 (n = 10) and A2 (n = 10) were control groups and groups B1 (n = 10...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Nonaka M,Kadokura M,Tanio N,Yamamoto S,Kataoka D,Inoue K,Takaba T

    更新日期:1998-01-01 00:00:00

  • A prognostic index for colorectal cancer based on preoperative absolute lymphocyte, monocyte, and neutrophil counts.

    abstract:PURPOSE:Associations between the preoperative absolute neutrophil count (NC), lymphocyte count (LC), and monocyte count (MC) in the peripheral blood and the prognosis of colorectal cancer (CRC) patients have not been widely studied. METHODS:We enrolled 361 patients who underwent surgery for CRC between January 2007 an...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Tanio A,Saito H,Uejima C,Takaya S,Yamamoto M,Tokuyasu N,Sakamoto T,Honjo S,Ashida K,Fujiwara Y

    更新日期:2019-03-01 00:00:00

  • Prognostic impact of home oxygen therapy on patients with resected non-small-cell lung cancer with interstitial lung disease.

    abstract:PURPOSE:Non-small-cell lung cancer (NSCLC) patients with interstitial lung disease (ILD) have a poor prognosis. The present study evaluated the prognostic impact of home oxygen therapy (HOT) in NSCLC patients with ILD. METHODS:Overall, 3099 consecutive patients underwent complete resection of stage IA to IIIA NSCLC at...

    journal_title:Surgery today

    pub_type: 杂志文章


    authors: Sekihara K,Aokage K,Hiyama T,Oiwa H,Miyoshi T,Tane K,Ishii G,Tsuboi M

    更新日期:2021-01-03 00:00:00