Utility of therapeutic drug monitoring in the management of HIV-infected pregnant women in receipt of lopinavir.

Abstract:

:The pharmacokinetics of antiretroviral drugs in pregnancy is poorly understood. We reviewed the use of therapeutic drug monitoring (TDM) in clinical settings to document plasma concentrations of lopinavir during pregnancy and investigated how clinicians acted upon TDM results. A retrospective review was carried out of all HIV-infected pregnant women taking boosted lopinavir-based highly active antiretroviral therapy (HAART) at five National Health Service (NHS) centres in the UK between May 2004 and March 2007. Seventy-three women in receipt of lopinavir were identified, of whom 89% had plasma lopinavir concentrations above the suggested minimum recommended for wild-type HIV. Initial TDM results prompted dosage change in 10% and assessment of adherence and/or pharmacist review in 11%. TDM was repeated in 29%. TDM can play an important role in the clinical management of HIV-positive pregnant women, allowing informed dose modification and an alternative measure of adherence.

journal_name

Int J STD AIDS

authors

Caswell RJ,Phillips D,Chaponda M,Khoo SH,Taylor GP,Ghanem M,Poulton M,Welch J,Gibbons S,Jackson V,Lambert JS

doi

10.1258/ijsa.2009.009184

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

11-4

issue

1

eissn

0956-4624

issn

1758-1052

pii

22/1/11

journal_volume

22

pub_type

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