Abstract:
:The pharmacokinetics of antiretroviral drugs in pregnancy is poorly understood. We reviewed the use of therapeutic drug monitoring (TDM) in clinical settings to document plasma concentrations of lopinavir during pregnancy and investigated how clinicians acted upon TDM results. A retrospective review was carried out of all HIV-infected pregnant women taking boosted lopinavir-based highly active antiretroviral therapy (HAART) at five National Health Service (NHS) centres in the UK between May 2004 and March 2007. Seventy-three women in receipt of lopinavir were identified, of whom 89% had plasma lopinavir concentrations above the suggested minimum recommended for wild-type HIV. Initial TDM results prompted dosage change in 10% and assessment of adherence and/or pharmacist review in 11%. TDM was repeated in 29%. TDM can play an important role in the clinical management of HIV-positive pregnant women, allowing informed dose modification and an alternative measure of adherence.
journal_name
Int J STD AIDSjournal_title
International journal of STD & AIDSauthors
Caswell RJ,Phillips D,Chaponda M,Khoo SH,Taylor GP,Ghanem M,Poulton M,Welch J,Gibbons S,Jackson V,Lambert JSdoi
10.1258/ijsa.2009.009184subject
Has Abstractpub_date
2011-01-01 00:00:00pages
11-4issue
1eissn
0956-4624issn
1758-1052pii
22/1/11journal_volume
22pub_type
杂志文章abstract::Rates of sexually transmitted infections (STI) in the UK continue to increase. A discrepancy between knowledge and awareness of STIs, and sexual behaviour appears to be ubiquitous throughout the world. We hypothesize that human beings are biologically programmed to fall in love and bond in powerful relationships, whic...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章,评审
doi:10.1258/0956462054944435
更新日期:2005-09-01 00:00:00
abstract::We examined treatment-seeking behaviours amongst a consecutive sample of 188 first-time attenders at a busy genitourinary (GU) clinic in a general hospital. Participants were interviewed and completed a battery of questionnaires prior to receiving diagnosis or treatment. Delay in treatment seeking was measured in 3 wa...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462001916083
更新日期:2000-06-01 00:00:00
abstract::This document addresses medical workforce needs for the speciality of Genitourinary Medicine (GUM) for the next 10 years. Data on current consultant numbers, working patterns and retirement are based on information from the Royal College of Physicians (RCP) Workforce Unit annual census undertaken on 30 September 2000....
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/09564620260079662
更新日期:2002-07-01 00:00:00
abstract::Accelerating antiretroviral therapy (ART) administration, improving retention, and achieving viral suppression in low- and middle-income countries must be prioritized. We evaluated trends and disparities in these milestones in a large Latin American cohort. Adults starting ART (ARTstart) from 2003 to 2014 at Caribbean...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462417714094
更新日期:2018-01-01 00:00:00
abstract::Background In Kenya, HIV incidence and prevalence have declined. HIV rates are lower in rural areas than in urban areas. However, HIV infection is reported higher in men in rural areas (4.5%) compared to those in urban areas (3.7%). Objectives This study examined HIV knowledge, feelings, and interactions towards HIV-i...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462416680764
更新日期:2017-08-01 00:00:00
abstract::A recent survey reported that 36% of UK genitourinary medicine clinics offer testing for pharyngeal Chlamydia trachomatis (CT). Screening at this site is targeted at high-risk groups attending our centre, including female sex workers (FSWs) and male sex workers (MSWs). A total of 2406 patients were screened between No...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2010.009494
更新日期:2010-11-01 00:00:00
abstract::With the increasing incidence of chronic kidney disease in patients with human immunodeficiency virus (HIV), the number of HIV-infected patients requiring hemodialysis has also increased. Dolutegravir is an integrase inhibitor that is a common component of HIV treatment regimens. Currently, there is no guidance regard...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462418816785
更新日期:2019-05-01 00:00:00
abstract::The aim of this revision is to evaluate ethnicity and gender rate of enrolment in registrative clinical trials of the protease inhibitors (Pls) from 1996 to 2009. Company-sponsored, phase II or III registrative clinical trials of PIs were evaluated. Forty-nine clinical trials were included. Clinical trials were conduc...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章,评审
doi:10.1258/ijsa.2012.012047
更新日期:2012-12-01 00:00:00
abstract::Global data on cervical lesion incidence and progression in HIV-positive women are essential for understanding the natural history of cervical neoplasia and informing screening policy. A systematic review was performed summarizing the incidence and progression of cervical lesions in HIV-positive women. Of 5882 HIV-pos...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章,评审
doi:10.1177/0956462413491735
更新日期:2014-03-01 00:00:00
abstract::The objective was to investigate the financial situation of people living with HIV in Europe. Two surveys using an anonymous questionnaire were organized in Europe among people living with HIV, the first in 1996-97 and the second in 1998-99. One thousand one hundred and sixty-one people from the 1996-97 survey and 899...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/095646202760326453
更新日期:2002-10-01 00:00:00
abstract::This paper assesses the associations between intimate partner violence (IPV) and sexually transmitted infections (STIs) and sexual risks among HIV-positive female drinkers in St Petersburg, Russia. Survey and STI data were analysed from 285 women in HERMITAGE, a secondary prevention study of HIV-positive heavy drinker...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462412472809
更新日期:2013-04-01 00:00:00
abstract::The aim of this study was to investigate the factors relating to CD4 level at HIV diagnosis and HIV testing behaviour. Participants were newly diagnosed patients (n = 654) in Japan from 2000 to 2005. Around 75% of participants were diagnosed at hospital and clinics. Mean CD4 counts at diagnosis through voluntary HIV t...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2009.009493
更新日期:2012-04-01 00:00:00
abstract::Despite the success of combination antiretroviral therapies, people living with HIV (PLWH) are at an increased risk of developing diverse malignancies, including oral cancer. We here present two cases of PLWH where the early diagnosis of potentially malignant disorders in the oral cavity impacted their treatment and s...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462419838102
更新日期:2019-06-01 00:00:00
abstract::Local genital tract inflammation stimulates leukocyte activity and causes HIV shedding, potentially increasing HIV sexual infectiousness. Although there are available clinical markers for genital tract inflammation, such as urinary leukocyte esterase, none have yet been examined in relation to HIV sexual risk behaviou...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462414536147
更新日期:2015-04-01 00:00:00
abstract::Cutaneous Candida infections may occur in patients with HIV/AIDS, cancer, receiving chemotherapy and solid organ transplantation. A 32-year-old woman was admitted to the department suffering from pruritic and erythematous plaque on left side of her face for the past two months. The patient was HIV positive, diagnosed ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462413479897
更新日期:2013-09-01 00:00:00
abstract::We assessed the validity of a syndromic case management approach for reproductive tract infections (RTIs) among 371 pregnant women attending antenatal care facilities in Kingston, Jamaica, using an algorithm previously validated in high-risk Jamaican women. For our antenatal attenders, the algorithm had low sensitivit...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/095646204774195209
更新日期:2004-06-01 00:00:00
abstract::The protozoon Blastocystis hominis may cause episodes of diarrhoea with abdominal pain, tenesmus, fever and eosinophilia. We have observed 5 cases of blastocystosis in male subjects with symptomatic HIV infection. All patients had a complete response to metronidazole. This report confirms that Blastocystis hominis may...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/095646249000100214
更新日期:1990-03-01 00:00:00
abstract::We aim to assess the usefulness of the cytomegalovirus (CMV) pp65 antigenaemia test, also called the CMV direct antigen test (DAT), in the management of patients with advanced human immunodeficiency virus (HIV) infection; we studied all patients who had pp65 assays between 8 September 1995 and 30 August 1996. Twenty-t...
journal_title:International journal of STD & AIDS
pub_type: 临床试验,杂志文章
doi:10.1258/0956462981922809
更新日期:1998-09-01 00:00:00
abstract::In Latin America, men who have sex with men (MSM) remain disproportionately impacted by HIV. Pre-exposure prophylaxis (PrEP) is an effective HIV prevention tool and has been FDA approved in the United States since 2012, but no Latin American state, with the recent exception of Brazil, has implemented PrEP guidelines. ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462419825944
更新日期:2019-05-01 00:00:00
abstract::Women who have a prevention mindset may opt for concurrent use of oral pre-exposure prophylaxis (PrEP) and all forms of contraception; we therefore assessed how contraception may influence PrEP use or vice versa. We analyzed data from Kenyan and Ugandan HIV-uninfected non-pregnant women in sero-discordant partnerships...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462420951501
更新日期:2020-11-01 00:00:00
abstract::This case is about an HIV seropositive young woman referred for the treatment of severe menorrhagia causing anaemia due to adenomyosis where the levonorgestrel-releasing intrauterine system (Mirena) proved useful in treating her heavy periods and also provided effective contraception without interference from the live...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2008.008107
更新日期:2008-10-01 00:00:00
abstract::Condom promotion in sub-Saharan Africa has been accused by some conservative groups of encouraging promiscuity. This study explored the relationship between condom availability and sexually transmitted infection (STI) incidence in a closed Malawian community. An audit of clinic records charted the changing availabilit...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/095646207781439801
更新日期:2007-08-01 00:00:00
abstract::Perigenital molluscum contagiosum in adults is recognized as being a sexually transmitted infection. A retrospective casenote review was performed on patients attending a department of genitourinary medicine (GUM) who had been diagnosed as having molluscum. One or more co-existent sexually transmitted diseases (STD) w...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/095646249100200604
更新日期:1991-11-01 00:00:00
abstract::In recognition of the increasing number of HIV-infected young people attending the HIV department at a district general hospital, a case note review was conducted. There was a high prevalence of psychosocial problems and medical complexity among this cohort. As a result, tailored young persons' services were developed...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462413486453
更新日期:2013-11-01 00:00:00
abstract::We aim to assess the prevalence of HIV sexual risk behaviours and substance use among runaway and homeless adolescents in San Francisco, Denver and New York City. Survey data were examined from 775 runaway and homeless adolescents recruited from street settings and youth agencies during 1992/1993. Nearly all (98%) rep...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462971919651
更新日期:1997-02-01 00:00:00
abstract::External genital warts, caused by human papillomavirus, have a significant clinical, epidemiological, and financial impact, including the risk for malignant transformation. Treatment modalities include: (a) destructive (ablative); (b) cytotoxic (proapoptotic) and (c) immunomodulatory, with success and recurrence rates...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1177/0956462415607375
更新日期:2016-10-01 00:00:00
abstract::The purpose of this study was to investigate internal medicine residents' HIV-related knowledge and their attitudes towards caring for HIV-infected patients, and determine the extent to which these variables influence their care-providing intention. A cross-sectional survey was conducted in 56 internal medicine reside...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462011923787
更新日期:2001-09-01 00:00:00
abstract::The management of cases of Chlamydia trachomatis genital infection diagnosed in clinics in Wessex in the last quarter of 1996 was surveyed, and the results compared with those obtained in the national gonorrhoea audit. Treatment regimens were extremely varied both between and within clinics. Overall, 71% of patients s...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/0956462981921675
更新日期:1998-02-01 00:00:00
abstract::The objective of this study was to audit the management of syphilis in our integrated sexual health clinic according to the British Association for Sexual Health and HIV (BASHH) guideline using the 'Treponemal Infection Care' (TIC) audit tool devised by our clinic. The case notes of patients diagnosed with all stages ...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/ijsa.2011.010392
更新日期:2011-05-01 00:00:00
abstract::The management and outcome of all cases of gonorrhoea which presented to a south London genitourinary medicine clinic during 1999 were assessed and compared with published national guidelines. The incidence of penicillin resistance was calculated, as was the rate of co-infection with chlamydia and trichomonas. Informa...
journal_title:International journal of STD & AIDS
pub_type: 杂志文章
doi:10.1258/095646203322301095
更新日期:2003-09-01 00:00:00