Utility of therapeutic drug monitoring in the management of HIV-infected pregnant women in receipt of lopinavir.


:The pharmacokinetics of antiretroviral drugs in pregnancy is poorly understood. We reviewed the use of therapeutic drug monitoring (TDM) in clinical settings to document plasma concentrations of lopinavir during pregnancy and investigated how clinicians acted upon TDM results. A retrospective review was carried out of all HIV-infected pregnant women taking boosted lopinavir-based highly active antiretroviral therapy (HAART) at five National Health Service (NHS) centres in the UK between May 2004 and March 2007. Seventy-three women in receipt of lopinavir were identified, of whom 89% had plasma lopinavir concentrations above the suggested minimum recommended for wild-type HIV. Initial TDM results prompted dosage change in 10% and assessment of adherence and/or pharmacist review in 11%. TDM was repeated in 29%. TDM can play an important role in the clinical management of HIV-positive pregnant women, allowing informed dose modification and an alternative measure of adherence.




Caswell RJ,Phillips D,Chaponda M,Khoo SH,Taylor GP,Ghanem M,Poulton M,Welch J,Gibbons S,Jackson V,Lambert JS




Has Abstract


2011-01-01 00:00:00














  • Are there any differences between patients attending a genitourinary medicine clinic with appointments and those without?

    abstract::The aim of this study is to identify the demographic and diagnostic characteristics of patients attending a genitourinary medicine clinic with booked appointments and compare them with those of walk-in attendees. During a period of three months, 749 patients were seen with new episodes; 61% of them had booked appointm...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Elawad BB

    更新日期:2009-03-01 00:00:00

  • Azithromycin as the first-line treatment of non-gonococcal urethritis (NGU): a study of follow-up rates, contact attendance and patients' treatment preference.

    abstract:AIMS:To identify any differences in follow-up rates or sexual contact attendance rates in men presenting with non-gonococcal urethritis (NGU) after treatment by single dose azithromycin rather than longer standard duration therapies and to identify patients' treatment preferences. METHODS:A prospective study was perfo...

    journal_title:International journal of STD & AIDS

    pub_type: 临床试验,杂志文章


    authors: Carlin EM,Barton SE

    更新日期:1996-05-01 00:00:00

  • Anogenital non-gonococcal neisseriae: prevalence and clinical significance.

    abstract::Over a 13-year period non-gonococcal neisseriae (NGN) were isolated from 114 of 88,670 patients (0.13%) screened for anogenital gonorrhoea at a Genitourinary Medicine Unit. During the same period there were approximately 9000 anogenital gonococcal infections (10%). The prevalence of NGN was 0.09% (27/31,500) in women,...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: McKenna JG,Fallon RJ,Moyes A,Young H

    更新日期:1993-01-01 00:00:00

  • The reassurance of experience.

    abstract::Stavudine is a potent nucleoside analogue and a well-recognized component of highly active antiretroviral therapy. Clinical trials have shown stavudine to have a superior or at least comparable virological efficacy and immune reconstitution when compared with other nucleoside analogues. Studies have shown that the pre...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章,评审


    authors: Martínez E

    更新日期:2003-10-01 00:00:00

  • European guideline for the organization of a consultation for sexually transmitted infections, 2012.

    abstract::This guideline is intended to serve as a framework for those working in any location where sexually transmitted infections (STIs) are managed. It offers recommendations which will need to be adapted depending on local facilities and policies, and is not intended to be all encompassing. This guideline should be read in...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章,实务指引


    authors: Radcliffe KW,Flew S,Poder A,Cusini M

    更新日期:2012-09-01 00:00:00

  • Factors associated with accurate self-reported adherence to HIV antiretrovirals.

    abstract::The purpose of this study was to determine the conditions in which self-reports provide an accurate assessment of adherence to HIV antiretrovirals. In a sample of 58 participants, self-reported and electronically monitored adherence to antiretroviral therapy were compared over a three-day period. Of the 16 who reporte...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Kimmerling M,Wagner G,Ghosh-Dastidar B

    更新日期:2003-04-01 00:00:00

  • HSV-2 antibodies in female sex workers in Vietnam.

    abstract::Little information is available on the prevalence of herpes simplex type-2 (HSV-2) antibodies among groups at potential high risk of HIV in Asia. This study was carried out to determine the prevalence of HSV-2 antibodies and correlates of HSV-2 infection in female sex workers (FSWs) in border provinces of Vietnam. Nin...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: O'Farrell N,Thuong NV,Nghia KV,Tram LT,Long NT

    更新日期:2006-11-01 00:00:00

  • Medical workforce speciality review for genitourinary medicine 2001/2002-England, wales, northern ireland and Scotland.

    abstract::This document addresses medical workforce needs for the speciality of Genitourinary Medicine (GUM) for the next 10 years. Data on current consultant numbers, working patterns and retirement are based on information from the Royal College of Physicians (RCP) Workforce Unit annual census undertaken on 30 September 2000....

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Rogstad KE

    更新日期:2002-07-01 00:00:00

  • Targeted screening for Trichomonas vaginalis in women, a pH-based approach.

    abstract::In the genitourinary medicine clinic setting, the most practical and widely used method of diagnosing Trichomonas vaginalis (TV) is direct microscopy of a wet mount preparation (WMP) of a sample taken from the posterior vaginal fornix. We retrospectively reviewed the potential impact of further limiting WMP to women w...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Bell C,Hough E,Smith A,Greene L

    更新日期:2007-06-01 00:00:00

  • Patient-led partner referral enhances sexually transmitted disease service delivery in two towns in the Central African Republic.

    abstract::In Bambari and Bria, 2 towns in the Central African Republic (CAR), we analysed a patient-led partner referral programme within enhanced sexually transmitted disease (STD) services. New (index) patients received syndromic management, counselling about notifying and treating contacts, and vouchers for distribution. Fro...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Koumans EH,Barker K,Massanga M,Hawkins RV,Somse P,Parker KA,Moran J

    更新日期:1999-06-01 00:00:00

  • Seroprevalence of HSV-1 and HSV-2 antibodies in Canadian women screened for enrolment in a herpes simplex virus vaccine trial.

    abstract::Herpes simplex virus 1 and 2 (HSV-1 and HSV-2) infections continue to be among the most common and unrecognized sexually transmitted infections in the world. Although treatable, HSV-1 and HSV-2 infections remain incurable. Hence, there is interest in the development of a vaccine to prevent genital herpes. As part of a...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章,随机对照试验


    authors: Gorfinkel IS,Aoki F,McNeil S,Dionne M,Shafran SD,Zickler P,Halperin S,Langley J,Bellamy A,Schulte J,Heineman T,Belshe R

    更新日期:2013-05-01 00:00:00

  • Increase in visceral adipose tissue in a woman living with HIV after introduction of integrase strand transfer inhibitor.

    abstract::Integrase strand transfer inhibitors (INSTIs) are a class of antiretroviral drugs with high virologic efficacy and excellent tolerability. Recent evidence showed a possible link of dolutegravir-based regimens with weight gain, and a relationship between raltegravir use and changes in adipose tissue density and metabol...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Piacentini D,Lanzafame M,Rizzardo S,Chiesi S,Lattuada E,Mehrabi S,Zamboni G,Mazzi R,Tacconelli E,Vento S

    更新日期:2020-12-01 00:00:00

  • Factors that can influence feelings towards and interactions with people living with HIV/AIDS in rural Central Kenya.

    abstract::Background In Kenya, HIV incidence and prevalence have declined. HIV rates are lower in rural areas than in urban areas. However, HIV infection is reported higher in men in rural areas (4.5%) compared to those in urban areas (3.7%). Objectives This study examined HIV knowledge, feelings, and interactions towards HIV-i...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Kingori C,Haile ZT,Ngatia P,Nderitu R

    更新日期:2017-08-01 00:00:00

  • A review of cervical cytology in genitourinary medicine clinics in England between 1997 and 2008.

    abstract::The current cervical screening guidelines lay the duty of care of women under 25 years of age on genitourinary (GU) medicine clinics. To date there has not been an extensive review of cervical cytology results sourced from GU medicine departments. We reviewed the annual reports of the cervical screening programme, wit...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章,评审


    authors: Markos AR

    更新日期:2009-10-01 00:00:00

  • Blastocystosis: a new disease in the acquired immunodeficiency syndrome?

    abstract::The protozoon Blastocystis hominis may cause episodes of diarrhoea with abdominal pain, tenesmus, fever and eosinophilia. We have observed 5 cases of blastocystosis in male subjects with symptomatic HIV infection. All patients had a complete response to metronidazole. This report confirms that Blastocystis hominis may...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Garavelli PL,Scaglione L,Bicocchi R,Libanore M

    更新日期:1990-03-01 00:00:00

  • Cutaneous tuberculosis of the penis in an HIV-infected adult.

    abstract::We report a case of cutaneous penile tuberculosis (TB) in an HIV-positive man masquerading as a sexually transmitted infection. This case details a patient who was diagnosed with HIV and achieved virological suppression on antiretroviral therapy. He subsequently stopped his therapy and travelled to a TB-endemic area. ...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Stockamp NW,Paul S,Sharma S,Libke RD,Boswell JS,Nassar NN

    更新日期:2013-01-01 00:00:00

  • An investigation of concurrent sex partnering in two samples of drug users having large numbers of sex partners.

    abstract::The objective of this study was to quantitatively measure the nature of concurrent sex partnering in two samples of drug users having large numbers of sex partners. The purpose of this study was to measure concurrent sex partnering and overlap in concurrent sex partners in two samples of drug users in which some or al...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Williams ML,Ross MW,Atkinson J,Bowen A,Klovdahl A,Timpson SC

    更新日期:2006-05-01 00:00:00

  • Vulvodynia--new and more effective approaches to therapy.

    abstract::Two cases are described of treatment-resistant vulvodynia that responded well to gabapentin. Gabapentin, an anti-epileptic drug, has been used in the treatment of neuropathic pain such as diabetic neuropathy and post-herpetic neuralgia. However, there has been little experience of its use in the relief of symptoms in ...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Bates CM,Timmins DJ

    更新日期:2002-03-01 00:00:00

  • Spontaneous comparisons with others in gay men's judgements of HIV risk.

    abstract::In studies on 'unrealistic optimism' (UO), when people are asked questions designed to make them compare their risk of experiencing an undesirable event with that of the average person, they tend to respond that their risk is lower. This study investigated whether comparisons of own and others' risk also occur spontan...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Gold RS

    更新日期:2007-03-01 00:00:00

  • Distribution of HIV and acute hepatitis B infection among drug injectors in Glasgow.

    abstract::This study compared the distributions of known human immunodeficiency virus (HIV) and acute hepatitis B virus (HBV) infection among drug injectors in Glasgow over a 3.5 year period. Data were obtained from all relevant laboratory request forms submitted to Glasgow's 3 virology laboratories during the period 1 January ...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Gruer LD,Peedle M,Carrington D,Clements GB,Follett EA

    更新日期:1991-09-01 00:00:00

  • An unusual vulval lesion in an HIV-infected woman.

    abstract::This is the case of a black African woman who presented with three distinct episodes of herpes simplex virus (HSV) infection unresponsive to first-line therapy. Clinical and virological resistance to aciclovir therapy was demonstrated, and although the first two episodes manifested as the deep ulceration often associa...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Boothby M,Radcliffe K

    更新日期:2007-03-01 00:00:00

  • Sweet's syndrome in a patient with haemophilia, HIV and hepatitis C infection.

    abstract::Sweet's syndrome is a rare skin condition associated with both drug treatment and a number of different disease processes including haematological malignancies, inflammatory conditions and HIV infection. In this case report, we present a patient with HIV, haemophilia and hepatitis C who presented to our team with sign...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Deasy AM,Walker B,Layton AM,Lacey CJ

    更新日期:2012-06-01 00:00:00

  • Surveillance of an infectious syphilis outbreak in south London, UK: a comparison of reporting systems.

    abstract::Rising heterosexual syphilis in south London in 2002 prompted Local Enhanced Syphilis Surveillance (LESS) in five of the 10 genitourinary medicine clinics. LESS reported a fall in heterosexual infectious syphilis in 2004 that was corroborated by the National Enhanced Syphilis Surveillance (NESS). However, mandatory cl...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Menon-Johansson AS,Young Y,Maguire H,Trail P,Ward H

    更新日期:2009-03-01 00:00:00

  • Soft tissue augmentation with PMMA-microspheres for the treatment of HIV-associated buttock lipodystrophy.

    abstract::Progression of lipodystrophy syndrome is a big challenge in HIV treatment. Nowadays, fat loss at the lower part of buttocks has become another problem as patients have started to complain that it is painful to be seated for a long time and/or on hard surfaces. We developed a method for buttock lipoatrophy treatment wi...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Serra MS,Gonçalves LZ,Ramos-e-Silva M

    更新日期:2015-03-01 00:00:00

  • HIV risk behaviour patterns, predictors, and sexually transmitted disease prevalence in the social networks of young men who have sex with men in St Petersburg, Russia.

    abstract::HIV seroconversions and sexually transmitted diseases (STDs) are often clustered in social networks within community populations. The present study was carried out among men who have sex with men in Russia, where a major HIV epidemic is unfolding, and where social networks have played a historically important role. In...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Amirkhanian YA,Kelly JA,Kirsanova AV,DiFranceisco W,Khoursine RA,Semenov AV,Rozmanova VN

    更新日期:2006-01-01 00:00:00

  • OptionE: innovative model of HIV care increases satisfaction and reduces clinic visits.

    abstract::OptionE incorporates nurse-led HIV clinics, review of blood results by doctors, patient contact by email and the option of home delivery of medication. Patient questionnaires showed increased satisfaction associated with fewer, shorter clinic visits. A retrospective case note review suggested clinical outcomes are as ...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Coyne KM,Kerley A,Mandalia S,McOwan AG

    更新日期:2008-05-01 00:00:00

  • Impact of rectal gonorrhoea and chlamydia on HIV viral load in the rectum: potential significance for onward transmission.

    abstract::The aim of this study was to investigate the effect of asymptomatic rectal bacterial sexually transmitted infections (STIs) on rectal HIV viral load (VL). A prospective cohort study of HIV-positive men who have sex with men attending a tertiary centre in London, UK, for their routine HIV care was performed. Forty-two ...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Davies O,Costelloe S,Cross G,Dew T,O'Shea S,White J,Fox J

    更新日期:2017-09-01 00:00:00

  • Vulval herpetic adhesion: a steroid success story.

    abstract::Vulval adhesion is a rare but recognized local complication following genital herpes infection. We believe this is only the second reported case of successful resolution of vulval herpetic adhesion using topical potent corticosteroid as the primary early treatment. ...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Challenor R,Alexander I

    更新日期:2008-01-01 00:00:00

  • Secondary syphilis masquerading as lupus vulgaris in an HIV-infected patient: A diagnosis suggested by histology.

    abstract::We report a case of secondary syphilis mimicking lupus vulgaris in an HIV-infected patient. A 21-year-old Brazilian man presented with a two-month history of asymptomatic cutaneous lesions accompanied by fever and fatigue. Dermatological evaluation revealed an erythematous, crusted, large plaque on the neck with the '...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Genovese G,Nazzaro G,Coggi A,Gianotti R,Ramoni S,Cusini M

    更新日期:2018-12-01 00:00:00

  • Young adults HIV-1 infected by vertical transmission in southern Brazil - Clinical, demographic, and virological features.

    abstract::Combination antiretroviral therapy promotes longer life expectancy, making it possible for perinatally HIV-infected patients to achieve adulthood. Past therapy was not always optimized, suggesting that virological and host features may also play a role in survival. The aim of this study is to describe characteristics ...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章


    authors: Martin BM,Santos JS,Scapinello FV,Ribeiro CE,Gomes-da-Silva MM,Raboni SM

    更新日期:2017-12-01 00:00:00