Magnifying chromoendoscopic findings of early gastric cancer and gastric adenoma.


PURPOSE:In the field of colorectal cancer and adenoma, Kudo's classification of pit pattern with magnifying chromocolonoscopy using crystal violet (CV) staining is now accepted. Magnifying endoscopy using narrow band imaging has been used for the diagnosis of gastric carcinoma; the characteristic findings of microvascular patterns have been demonstrated. However, there was limited information on magnified endoscopic findings with CV staining for gastric neoplasms in terms of their pit patterns. METHODS:Magnifying chromoendoscopy with CV was performed in 175 patients with early gastric cancer and 18 with gastric adenoma, prior to treatment. Surface patterns of gastric tumors were classified into five types: (1) long tubular pit pattern, (2) irregular size pit pattern, (3) small round pit pattern, (4) destroyed pit pattern, and (5) non-structural pattern. RESULTS:Long tubular pit pattern was most common in gastric adenoma. Well differentiated adenocarcinoma and papillary adenocarcinoma tended to show different size of pit pattern or destroyed pit pattern. Small round pit pattern was most commonly seen in moderately differentiated adenocarcinoma. Non-structural pattern was most frequently observed in poorly differentiated adenocarcinoma and signet ring cell carcinoma (P < 0.0001). CONCLUSION:For gastric neoplasms, magnifying endoscopy may help predict histopathological type.


Dig Dis Sci


Ohnita K,Isomoto H,Shikuwa S,Yamaguchi N,Nakayama T,Nishiyama H,Okamoto K,Fukuda E,Takeshima F,Hayashi T,Kohno S,Nakao K




Has Abstract


2011-09-01 00:00:00












  • Yoghurts containing probiotics reduce disruption of the small intestinal barrier in methotrexate-treated rats.

    abstract::Small intestinal permeability was employed to assess the efficacy of commercially available yoghurts containing probiotics in a rat model of methotrexate (MTX)-induced mucositis. Male Sprague-Dawley rats were allocated to four groups (n = 8): MTX + water, MTX + cow's milk yoghurt (CY; fermented with Lactobacillus john...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Southcott E,Tooley KL,Howarth GS,Davidson GP,Butler RN

    更新日期:2008-07-01 00:00:00

  • The role of phospholipase A2 in calcium-ionophore-mediated injury to rat gastric mucosal cells.

    abstract::Although transient increases in intracellular Ca2+ ([Ca2+]i) underlie a number of important physiological processes, sustained elevations in [Ca2+]i mediate damage to a number of tissues and cell types including gastric mucosal cells. Increases in [Ca2+]i can activate phospholipid hydrolysis via increases in phospholi...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Tepperman BL,Soper BD

    更新日期:1999-03-01 00:00:00

  • Hepatopulmonary syndrome in noncirrhotic portal hypertensive patients.

    abstract::Hepatopulmonary syndrome has yet not been sufficiently assessed in noncirrhotic portal hypertension. The prevalence of hepatopulmonary syndrome was determined in 31 consecutive patients with noncirrhotic portal hypertension (19 idiopathic portal hypertension, 7 portal vein thrombosis, 5 congenital hepatic fibrosis) an...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Kaymakoglu S,Kahraman T,Kudat H,Demir K,Cakaloglu Y,Adalet I,Dincer D,Besisik F,Boztas G,Sözen AB,Mungan Z,Okten A

    更新日期:2003-03-01 00:00:00

  • Pre-stimulated Mice with Carbon Tetrachloride Accelerate Early Liver Regeneration After Partial Hepatectomy.

    abstract:BACKGROUND AND AIM:The liver has a high capacity of its regeneration. Most hepatic cells are quiescent unless otherwise stimulated such as their injury or ablation. A previous study suggest that pre-activated hepatic cells have a positive effect on their regeneration. In this study, we examined whether the pre-activate...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Arioka Y,Ito H,Ando T,Ogiso H,Hirata A,Hara A,Seishima M

    更新日期:2015-06-01 00:00:00

  • Predictors of mortality in patients with hepatocellular carcinoma undergoing transarterial chemoembolization.

    abstract:BACKGROUND/AIM:Transarterial chemoembolization (TACE) is the recommended treatment for patients with Barcelona stage B hepatocellular carcinoma; however, community practice varies from these American Association for the Study of Liver Diseases guidelines. In this study, we sought to assess factors determining outcome a...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Barman PM,Sharma P,Krishnamurthy V,Willatt J,McCurdy H,Moseley RH,Su GL

    更新日期:2014-11-01 00:00:00

  • Endoscopy, gastric ulcer, and gastric cancer. Follow-up endoscopy for all gastric ulcers?

    abstract::The practice of following benign-appearing gastric ulcers until healing was critically evaluated in a retrospective manner by reviewing all gastric ulcers that were followed with serial endoscopy and all gastric cancers diagnosed at the University of Alabama at Birmingham. The stated purpose of following ulcers to hea...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Pruitt RE,Truss CD

    更新日期:1993-02-01 00:00:00

  • Coagulation protein function: enhancement of the anticoagulant effect of acetaldehyde by sulfated glycosaminoglycans.

    abstract::In view of the increased anticoagulant effect of acetaldehyde-treated heparin, other glycosaminoglycans (GAGs) such as chondroitin sulfates A and C, dermatan sulfate (chondroitin sulfate B), heparan sulfate, and hyaluronic acid were tested for anticoagulant activity before and after exposure to acetaldehyde. Clotting ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Brecher AS,Adamu MT

    更新日期:2001-09-01 00:00:00

  • Control of nocturnal gastric acidity: a role for low dose bedtime ranitidine to supplement daily omeprazole.

    abstract::In some patients, proton pump inhibitors do not abolish nocturnal gastric acidity and additional evening antisecretory medication may be required. In 16 subjects with chronic heartburn, 24-hr gastric and esophageal pH were measured at baseline and again after six days of 20 mg omeprazole alone at 08:00 hr followed by ...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章


    authors: Robinson M,Rodriguez-Stanley S,Ciociola AA,Filinto J,Zubaidi S,Miner PB Jr,Gardner JD

    更新日期:2002-02-01 00:00:00

  • Probability-based interpretation of liver stiffness measurement in untreated chronic hepatitis B patients.

    abstract:BACKGROUND:Liver stiffness measurement (LSM) by transient elastography is a popular noninvasive test of fibrosis. Traditional LSM cutoffs dichotomize patients and do not clearly indicate the confidence of diagnosis. AIM:We derived and validated probability functions of fibrosis and cirrhosis based on LSM and determine...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,多中心研究


    authors: Wong VW,Lampertico P,de Lédinghen V,Chang PE,Kim SU,Chen Y,Chan HL,Mangia G,Foucher J,Chow WC,Ahn SH,Hou J

    更新日期:2015-05-01 00:00:00

  • Breath ammonia measurement in Helicobacter pylori infection.

    abstract::Our aim was to define the utility of breath ammonia measurement in assessing Helicobacter pylori infection. Volunteers breathed into a device containing three fiberoptic NH3 sensors at baseline and after ingesting 300 mg of urea. Breath ammonia levels were compared to the [14C]urea breath test. Thirteen subjects were ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Kearney DJ,Hubbard T,Putnam D

    更新日期:2002-11-01 00:00:00

  • A Treat-to-Target Concept to Guide the Medical Management of Hepatorenal Syndrome.

    abstract:BACKGROUND:The principle of treating-to-target has been successfully applied to many diseases with significant improvement in patient care and as a useful guidance for healthcare providers. Appreciation of the central role for arterial vasodilatation in the pathogenesis of hepatorenal syndrome (HRS) has led to routine ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Cai CX,Maddukuri G,Jaipaul N,Zhang Z

    更新日期:2015-05-01 00:00:00

  • Immunopathology on hepatocyte expression of HBV surface, core, and x antigens in chronic hepatitis B: clinical and virological correlation.

    abstract:PURPOSE:Hepatocyte expression of HBV surface, core, and x antigens (HBsAg, HBcAg and HBxAg), semi-quantitated by immunopathology, were correlated with clinical and virological data in 80 patients with chronic hepatitis B. RESULTS:Seventy patients were HBsAg positive in cytoplasm, 61 were HBcAg positive, including 45 i...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Chu CM,Shyu WC,Liaw YF

    更新日期:2010-02-01 00:00:00

  • Influence of spasmolytic analgesics on motility of sphincter of Oddi.

    abstract::The effects on the sphincter of Oddi of intravenous administration of dipyrone, 2.5 g; tramadol, 50 mg; indomethacin, 75 mg; N-butylscopolamine, 20 mg; and nitroglycerin, 1 mg, in comparison to physiological saline were assessed in a single-blind study in 36 patients hospitalized with upper abdominal pain. Basal sphin...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章


    authors: Brandstätter G,Schinzel S,Wurzer H

    更新日期:1996-09-01 00:00:00

  • Different mechanism of magnesium and calcium transport across rat duodenum.

    abstract::Concentration and voltage dependence of Mg transport across the rat duodenum was measured in an Ussing chamber. Mucosa (m) to serosa (s) Mg flux exhibits a cellular fraction comparable to that found for Ca. Mg sm flux is purely diffusive and probably restricted to the paracellular pathway. At all concentrations betwee...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Karbach U,Schmitt A,Saner FH

    更新日期:1991-11-01 00:00:00

  • Direct transmission of H. pylori from challenged to nonchallenged mice in a single cage.

    abstract::To understand whether direct transmission of H. pylori occurs from infected mouse to noninfected mouse, the system using a mouse model we developed previously was tested. Six nude mice were challenged with H. pylori inocula; one group consisted of one challenged nude mouse 1 week after inoculation raised with four non...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Karita M,Matsumoto S,Kamei T,Shinohara K,Sugiyama T

    更新日期:2005-06-01 00:00:00

  • Menarche in pediatric patients with Crohn's disease.

    abstract:BACKGROUND AND AIMS:The timing of menarche in Crohn's disease (CD) is poorly described. Our objectives were to study age at menarche onset in CD, and factors associated with this. METHODS:We compared the age at menarche of 34 CD patients with that for 545 controls, using data in the National Health and Nutrition Exami...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Gupta N,Lustig RH,Kohn MA,Vittinghoff E

    更新日期:2012-11-01 00:00:00

  • Self-expanding metal stents for biliary drainage in patients with resectable pancreatic cancer: single-center experience with 79 cases.

    abstract:BACKGROUND AND AIMS:To study pre-operative and peri-operative course and outcome on follow up after pancreaticoduodenenctomy (PD) for resectable pancreatic cancer amongst patients receiving self-expanding metal stents (SEMS). METHODS:Medical charts of consecutively reviewed patients (2005-2009) with resectable pancrea...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Singal AK,Ross WA,Guturu P,Varadhachary GR,Javle M,Jaganmohan SR,Raju RP,Fleming JB,Raju GS,Kuo YF,Lee JH

    更新日期:2011-12-01 00:00:00

  • Unusual Sites of Necrotic Collections in Acute Necrotizing Pancreatitis: Association with Parenchymal Necrosis and Clinical Outcomes.

    abstract:BACKGROUND:The presence of necrotic collection in acute necrotizing pancreatitis (ANP) at intra-abdominal sites other than the retroperitoneum has not been systematically studied. AIM:To investigate unusual sites of necrotic collections at computed tomography (CT) and to evaluate association with pancreatic necrosis a...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Gupta P,Virk M,Gulati A,Muktesh G,Shah J,Samanta J,Mandavdhare H,Sharma V,Dutta U,Kochhar R

    更新日期:2020-08-10 00:00:00

  • Effect of ribavirin and amantadine on early hepatitis C virus RNA rebound and clearance in serum during daily high-dose interferon.

    abstract::The early rebound in serum HCV RNA during HCV dynamic studies with high-dose interferon may be due to de novo infection with interferon escape quasispecies. We simultaneously measured serum alanine aminotransferase (ALT) and HCV RNA at rapid intervals in chronic HCV liver disease patients during interferon therapy alo...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Lake-Bakaar G,Ruffini L,Kuzmic P

    更新日期:2003-01-01 00:00:00

  • Long-term results of Nissen fundoplication in reflux esophagitis without strictures. Clinical, endoscopic, and pH-metric evaluation.

    abstract::The present paper evaluates the efficiency of Nissen fundoplication as an antireflux technique in a series of 51 patients with different grades of esophagitis. Follow-up time averaged 6.6 years. The evaluation includes a clinical assessment, endoscopic study, and 24-hr pH monitoring. The results reveal an acceptable r...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Martinez de Haro LF,Ortiz A,Parrilla P,Garcia Marcilla JA,Aguayo JL,Morales G

    更新日期:1992-04-01 00:00:00

  • Efficacy of T2 in active Crohn's disease: a prospective study report.

    abstract::To date few therapies have been shown to reliably prevent the evolution of Crohn's disease (CD). The traditional Chinese medicine, Tripterygium wilfordii Hook F (TWHF), has both immunomodulatory and anti-inflammatory activities. Our aim was to investigate the potential efficacy of T2, the major constituent of extracts...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Ren J,Tao Q,Wang X,Wang Z,Li J

    更新日期:2007-08-01 00:00:00

  • One stomach--one strain: does Helicobacter pylori strain variation influence disease outcome?

    abstract::The aim of the study was to determine inter- and intrapatient variation of Helicobacter pylori strains based on genomic fingerprinting and cagA (cytotoxin-associated gene A) status. Ten bacterial colonies from each of 10 patients with gastric cancer (GC), 10 with duodenal ulcer (DU), and 10 with gastritis (GI) were us...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Enroth H,Nyrén O,Engstrand L

    更新日期:1999-01-01 00:00:00

  • Activation of beta-catenin in the stem cell region of crypts during growth of the small intestine in infant rats.

    abstract::The Wnt/beta-catenin pathway has been proposed as promoting intestinal stem cell division. Wnt ligands activate cytoplasmic beta-catenin and increase nuclear translocation of beta-catenin that binds to the Tcf-4 transcription factor. The aim of this study was to investigate beta-catenin expression in the stem cell reg...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Camac KS,Thompson FM,Cummins AG

    更新日期:2007-05-01 00:00:00

  • Diagnostic Ability of Endoscopic Bile Cytology Using a Newly Designed Biliary Scraper for Biliary Strictures.

    abstract:BACKGROUND:A new device with metallic wires for scrape cytology was developed. AIMS:To compare the diagnostic performance of scrape cytology and conventional cytology during endoscopic retrograde cholangiopancreatography for biliary strictures. METHODS:A total of 420 cases with biliary stricture underwent transpapill...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Nakahara K,Michikawa Y,Morita R,Suetani K,Morita N,Sato J,Tsuji K,Ikeda H,Matsunaga K,Watanabe T,Matsumoto N,Kobayashi S,Otsubo T,Itoh F

    更新日期:2019-01-01 00:00:00

  • Modulation of mediator release from human intestinal mast cells by sulfasalazine and 5-aminosalicylic acid.

    abstract::Intestinal mast cells are thought to contribute to the mucosal inflammation in ulcerative colitis and Crohn's disease through release of inflammatory mediators. Since sulfasalazine and its metabolite 5-aminosalicylic acid are effective therapeutic agents in inflammatory bowel disease and have been shown to inhibit gen...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Fox CC,Moore WC,Lichtenstein LM

    更新日期:1991-02-01 00:00:00

  • MicroRNA-30a Inhibits Colorectal Cancer Metastasis Through Down-Regulation of Type I Insulin-Like Growth Factor Receptor.

    abstract:BACKGROUND:miR-30a expression is down-regulated and regulates tumor suppressors in various cancers. AIM:We investigated the mechanisms underlying the biological role of miR-30a in CRC. METHODS:MicroRNA, mRNA, and protein expression were analyzed by quantitative real-time PCR and Western blot. The migration and invasi...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Liu YC,Park YR,Kim SL,Lee ST,Kim SW

    更新日期:2017-11-01 00:00:00

  • Transjugular Intrahepatic Porto-Systemic Shunt in Patients with Liver Cirrhosis and Model for End-Stage Liver Disease ≥15.

    abstract:BACKGROUND:It is not known whether transjugular intrahepatic porto-systemic shunt (TIPS) is safe in patients with advanced liver cirrhosis. The aim of our study was to evaluate the impact of TIPS on transplant-free survival in patients with liver cirrhosis and MELD score ≥15. METHODS:All adult patients who underwent T...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Ascha M,Hanouneh M,S Ascha M,Zein NN,Sands M,Lopez R,Hanouneh IA

    更新日期:2017-02-01 00:00:00

  • Effectiveness of leukocyte interferon-alpha treatment in patients with chronic hepatitis C not responsive to recombinant interferon.

    abstract::Twenty-four patients with chronic active HCV infection, nonresponders to a previous treatment cycle with recombinant interferon-alpha (r-IFNA), underwent retreatment with leukocyte (LE-) IFN-alpha. This was administered at the dose of 3 MU three times a week, for either six months (group A) or 12 months (group B). All...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Scotto G,Grimaldi M

    更新日期:1998-10-01 00:00:00

  • Prevalence and Impact of Post-traumatic Stress Disorder in Gastrointestinal Conditions: A Systematic Review.

    abstract::Psychological distress is often observed in patients with gastrointestinal illness. To date, there has been limited research conducted to assess the prevalence and impact of post-traumatic stress disorder (PTSD) in gastrointestinal cohorts. The aim of this systematic review is to review the evidence for the prevalence...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审


    authors: Glynn H,Möller SP,Wilding H,Apputhurai P,Moore G,Knowles SR

    更新日期:2021-01-12 00:00:00

  • Cisapride stimulates propulsive motility patterns in human jejunum.

    abstract::The effects of cisapride on upper gut motility were studied in seven healthy volunteers by means of a novel intraluminal electromyographic technique in a placebo-controlled study. In the interdigestive state, cisapride (10 mg intravenous bolus injection) markedly increased the number of spike bursts. The most obvious ...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章


    authors: Coremans G,Janssens J,Vantrappen G,Chaussade S,Ceccatelli P

    更新日期:1988-12-01 00:00:00