Magnifying chromoendoscopic findings of early gastric cancer and gastric adenoma.


PURPOSE:In the field of colorectal cancer and adenoma, Kudo's classification of pit pattern with magnifying chromocolonoscopy using crystal violet (CV) staining is now accepted. Magnifying endoscopy using narrow band imaging has been used for the diagnosis of gastric carcinoma; the characteristic findings of microvascular patterns have been demonstrated. However, there was limited information on magnified endoscopic findings with CV staining for gastric neoplasms in terms of their pit patterns. METHODS:Magnifying chromoendoscopy with CV was performed in 175 patients with early gastric cancer and 18 with gastric adenoma, prior to treatment. Surface patterns of gastric tumors were classified into five types: (1) long tubular pit pattern, (2) irregular size pit pattern, (3) small round pit pattern, (4) destroyed pit pattern, and (5) non-structural pattern. RESULTS:Long tubular pit pattern was most common in gastric adenoma. Well differentiated adenocarcinoma and papillary adenocarcinoma tended to show different size of pit pattern or destroyed pit pattern. Small round pit pattern was most commonly seen in moderately differentiated adenocarcinoma. Non-structural pattern was most frequently observed in poorly differentiated adenocarcinoma and signet ring cell carcinoma (P < 0.0001). CONCLUSION:For gastric neoplasms, magnifying endoscopy may help predict histopathological type.


Dig Dis Sci


Ohnita K,Isomoto H,Shikuwa S,Yamaguchi N,Nakayama T,Nishiyama H,Okamoto K,Fukuda E,Takeshima F,Hayashi T,Kohno S,Nakao K




Has Abstract


2011-09-01 00:00:00












  • Combinatory RNA-Sequencing Analyses Reveal a Dual Mode of Gene Regulation by ADAR1 in Gastric Cancer.

    abstract:BACKGROUND:Adenosine deaminase acting on RNA 1 (ADAR1) is known to mediate deamination of adenosine-to-inosine through binding to double-stranded RNA, the phenomenon known as RNA editing. Currently, the function of ADAR1 in gastric cancer is unclear. AIMS:This study was aimed at investigating RNA editing-dependent and...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Cho CJ,Jung J,Jiang L,Lee EJ,Kim DS,Kim BS,Kim HS,Jung HY,Song HJ,Hwang SW,Park Y,Jung MK,Pack CG,Myung SJ,Chang S

    更新日期:2018-07-01 00:00:00

  • Rehospitalization, Treatment, and Resource Use After Inpatient Admission for Achalasia in the USA.

    abstract:INTRODUCTION:Readmission for achalasia treatment is associated with significant morbidity and cost. Factors predictive of readmission would be useful in identifying patients at risk. METHODS:We performed a retrospective study using the Nationwide Readmission Database for the year 2016 and 2017. We collected data on ho...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Gupta K,Khan A,Chalhoub J,Groudan K,Desilets D

    更新日期:2021-01-01 00:00:00

  • Liver Transplantation for Nonalcoholic Steatohepatitis: Pathophysiology of Recurrence and Clinical Challenges.

    abstract::Nonalcoholic steatohepatitis is the fastest-growing indication for the liver transplant and a leading cause of hepatocellular carcinoma among patients listed for liver transplantation in the USA. Post-transplant nonalcoholic hepatic steatosis and steatohepatitis are frequent complications of liver transplantation. Non...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审


    authors: Samji NS,Verma R,Keri KC,Singal AK,Ahmed A,Rinella M,Bernstein D,Abdelmalek MF,Satapathy SK

    更新日期:2019-12-01 00:00:00

  • Exogenous interleukin-6 facilitated the contraction of the colon in a depression rat model.

    abstract:BACKGROUND:Gut dysmotility is closely associated with proinflammatory cytokines both in irritable bowel syndrome and inflammatory bowel disease. There is a dose-response relationship between depression and these inflammatory cytokines. AIMS:In the present study, we aimed to investigate the effect of Interleukin-6 (IL-...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Zhang L,Hu L,Chen M,Yu B

    更新日期:2013-08-01 00:00:00

  • Effect of 5-hydroxytryptamine and its antagonists on colonic smooth muscle of the rabbit.

    abstract::The effect of 5-hydroxytryptamine (5HT) was studied in circular and longitudinal muscle from the proximal and distal colon of New Zealand white rabbits. 5HT stimulated a dose-dependent isometric contraction of distal and proximal circular muscle that was greater than in distal longitudinal muscle (P less than 0.01). 5...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Ng WW,Jing J,Hyman PE,Snape WJ Jr

    更新日期:1991-02-01 00:00:00

  • Heterogeneity of HPLC profiles of human class II MHC-bound peptides isolated from intestine with inflammatory bowel disease.

    abstract::Studies of the T-cell-receptor repertoire and oligoclonal expansion of lamina propria T cells in patients with Crohn's disease suggest restricted antigen processing in this disease. We examined HPLC elution profiles of HLA-DR-bound peptides isolated from human intestine. Surgical samples of colon and ileum were obtain...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Oshitani N,Hato F,Jinno Y,Sawa Y,Hara J,Nakamura S,Matsumoto T,Arakawa T,Kitano A,Kitagawa S,Kuroki T

    更新日期:2002-09-01 00:00:00

  • Methionine deficiency and hepatic injury in a dietary steatohepatitis model.

    abstract::Methionine (Meth) is an essential amino acid involved in DNA methylation and glutathione biosynthesis. We examined the effect of Meth on the development of steatohepatitis. Rats were fed (five weeks) amino acid-based Meth-choline-sufficient (A-MCS) or total deficient (MCD) diets and gavaged daily (two weeks) with vehi...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Oz HS,Chen TS,Neuman M

    更新日期:2008-03-01 00:00:00

  • Interferon in the management of chronic hepatitis B.

    abstract::Many drugs have been used in the treatment of chronic hepatitis B, but with the exception of interferon, none have proved to be effective. Several studies have found that a sustained loss of viral replication occurs in approximately 40% of patients who started with a 16-week course of recombinant interferon alfa-2b gi...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审


    authors: Perrillo RP

    更新日期:1993-04-01 00:00:00

  • Algorithmic approach to patients presenting with heartburn and epigastric pain refractory to empiric proton pump inhibitor therapy.

    abstract:BACKGROUND:Reflux-like dyspepsia (RLD), where predominant epigastric pain is associated with heartburn and/or regurgitation, is a common clinical syndrome in both primary and specialty care. Because symptom frequency and severity vary, overlap among gastroesophageal reflux disease (GERD), non-erosive reflux disease (NE...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Roorda AK,Marcus SN,Triadafilopoulos G

    更新日期:2011-10-01 00:00:00

  • Pathophysiology, Aetiology and Treatment of Gastroparesis.

    abstract::Gastroparesis is characterized by delayed gastric emptying, with symptoms such as nausea, vomiting and abdominal pain, in the absence of mechanical obstruction. In most cases, it is idiopathic although diabetes mellitus is another leading cause. The physiology of gastric emptying is a complex process which is influenc...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审


    authors: Sullivan A,Temperley L,Ruban A

    更新日期:2020-06-01 00:00:00

  • Transgenic Expression of Vitamin D Receptor in Gut Epithelial Cells Ameliorates Spontaneous Colitis Caused by Interleukin-10 Deficiency.

    abstract:BACKGROUND:Vitamin D deficiency is common in patients with inflammatory bowel diseases. The vitamin D receptor (VDR) is a nuclear hormone receptor mediating the activity of vitamin D hormone. Our previous studies showed that intestinal epithelial VDR signaling inhibits colitis by protecting the mucosal epithelial barri...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Golan MA,Liu W,Shi Y,Chen L,Wang J,Liu T,Li YC

    更新日期:2015-07-01 00:00:00

  • Drug and treatment efficacy of chenodeoxycholic acid in 97 patients with cholelithiasis and increased surgical risk.

    abstract::Patients with symptomatic cholelithiasis who represent higher than normal surgical risks may be the most suitable candidates for medical dissolution of gallstones. Chenodeoxycholic acid was given to 97 patients in a dosage of 15 mg/kg of body weight per day for a period of two years. Complete gallstone dissolution occ...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章


    authors: Tangedahl T,Carey WD,Ferguson DR,Forsythe S,Williams M,Paradis K,Hightower NC

    更新日期:1983-06-01 00:00:00

  • Serial sectioning of a portion of a rectal biopsy detects more focal abnormalities: a prospective study of patients with inflammatory bowel disease.

    abstract::The diagnostic accuracy of two different methods of sectioning rectal biopsies was evaluated prospectively. The frequency of focal and diffuse findings in more than 80 serial sections from a limited portion of the well-oriented areas of 74 biopsies was compared with that found in three or more step sections distribute...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Surawicz CM

    更新日期:1982-05-01 00:00:00

  • Impaired alveolar gas exchange in acute pancreatitis.

    abstract::We evaluated the alveolar-arterial oxygen difference (deltaA-a) and the ratio between PaO2 and the fractional concentration of inspired oxygen (P/F) in acute pancreatitis. Eleven patients had mild uncomplicated disease, six showed acute abdominal fluid collections, six had acute abdominal collections and asymptomatic ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Salomone T,Tosi P,Di Battista N,Binetti N,Raiti C,Tomassetti P,Migliori M,Gullo L

    更新日期:2002-09-01 00:00:00

  • Factors affecting the success of endoscopic bougia dilatation of radiation-induced esophageal stricture.

    abstract:AIMS:The purpose of this retrospective study was to assess clinical outcomes of endoscopic bougie dilation of esophageal strictures after radiation therapy for head and neck cancer, and to assess the risk factors which affect the treatment success. METHODS:Thirty-one patients with esophageal stricture due to radiation...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Tuna Y,Koçak E,Dinçer D,Köklü S

    更新日期:2012-02-01 00:00:00

  • A pancreatic extract-enriched diet corrects ileal mucosa atrophy in endotoxemic aged rats.

    abstract::An altered adaptive response of the pancreas and small intestine to nutritional stress has an adverse impact upon nutritional status in elderly humans or senescent rats. We evaluated the effects of a pancreatic extract nutritional supplement on intestinal mucosa adaptation in LPS-treated aged rats. Endotoxemic rats we...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Farges MC,Raul F,Cezard JP,Davot P,Meunier MT,Cynober L,Vasson MP

    更新日期:1998-10-01 00:00:00

  • Endoscopic management of Barrett's esophagus: advances in endoscopic techniques.

    abstract::Barrett's esophagus (BE) is a well-known premalignant condition that can be associated with the development of dysplasia and adenocarcinoma. In the past, esophagectomy was the standard treatment for patients with BE with high grade dysplasia (HGD) and early cancer (EC). However, esophagectomy is not necessarily the on...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审


    authors: Azarm A,Lukolic I,Shukla M,Concha-Parra R,Gress F

    更新日期:2012-12-01 00:00:00

  • Cumulative Inflammation Could Be a Risk Factor for Intestinal Failure in Crohn's Disease.

    abstract:BACKGROUND:Intestinal failure is the most critical complication of Crohn's disease. Intestinal failure requires home parenteral nutrition, which worsens the quality of life of the patients and sometimes causes life-threatening complications. AIMS:The purpose of this study was to investigate the incidence and risk fact...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Watanabe Y,Miyoshi N,Fujino S,Takahashi H,Haraguchi N,Hata T,Matsuda C,Yamamoto H,Doki Y,Mori M,Mizushima T

    更新日期:2019-08-01 00:00:00

  • Lipoprotein pattern and plasma lipoprotein lipase activities in patients with primary biliary cirrhosis. Relationship with increase of HDL2 fraction in Lp-X-positive and Lp-X-negative subjects.

    abstract::Plasma lipids, apoprotein A-I and B in serum and in lipoprotein fractions (VLDL + LDL, HDL2, and HDL3) obtained by preparative ultracentrifugation, as well as postheparin lipoprotein lipase activity (H-TGL and LPL) were evaluated in 17 subjects with primary biliary cirrhosis (stage II and III) subdivided into two grou...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Baldo-Enzi G,Baiocchi MR,Grotto M,Floreani AR,Zagolin M,Chiaramonte M,Cera F,Fellin R

    更新日期:1988-10-01 00:00:00

  • Impact of immunosuppressive treatment on liver fibrosis in autoimmune hepatitis.

    abstract::The impact of treatment on progression of fibrosis in autoimmune hepatitis (AIH) is unknown. We assessed the changes in liver fibrosis before and after treatment among these patients. Nineteen AIH patients who had paired liver biopsies were studied. Of these, seven had been treated with 6 months of cyclosporine A and ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Mohamadnejad M,Malekzadeh R,Nasseri-Moghaddam S,Hagh-Azali S,Rakhshani N,Tavangar SM,Sedaghat M,Alimohamadi SM

    更新日期:2005-03-01 00:00:00

  • Characterization of early developmental pattern of expression of neurotensin/neuromedin N gene in foregut and midgut.

    abstract::The gut endocrine gene, neurotensin (NT/N), is expressed in a strict temporally and spatially specific pattern. Utilizing a sensitive reverse transcription-polymerase chain reaction procedure, we analyzed foregut and midgut organs for NT/N expression, determined the earliest apparent time point that NT/N is expressed ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Wang XM,Evers BM

    更新日期:1999-01-01 00:00:00

  • Colon PillCam: why not just take a pill?

    abstract::This review article deals with the clinical value of capsule endoscopy for visualization of the colon. Since its introduction in 2006, the colon capsule endoscopy underwent major technological improvements. The improved performance of colon capsule endoscopy is reviewed based on three multicenter prospective studies. ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审


    authors: Eliakim R,Adler SN

    更新日期:2015-03-01 00:00:00

  • Women's health training in gastroenterology fellowship: a national survey of fellows and program directors.

    abstract:BACKGROUND AND AIMS:The Gastroenterology Core Curriculum requires training in women's digestive disorders; however, requirements do not necessarily produce knowledge and competence. Our study goals were: (1) to compare perceptions of education, fellow-reported levels of competence, and attitudes towards training in wom...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Saha S,Roberson E,Richie K,Lindstrom MJ,Esposti SD,Wald A

    更新日期:2011-03-01 00:00:00

  • Growth hormone-releasing hormone (GRH)-producing pancreatic tumor with no evidence of multiple endocrine neoplasia type 1.

    abstract::The characteristic features of a 48-year-old male presenting with isolated acromegaly caused by a GRH-producing pancreatic endocrine tumor bearing no relation to MEN1 was reported. The clinical features, laboratory findings, and sellar enlargement were improved after removal of the pancreatic tumor. The resected pancr...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Kawa S,Ueno T,Iijima A,Midorikawa T,Fujimori Y,Tokoo M,Oguchi H,Kiyosawa K,Imai Y,Kaneko G,Kuroda T,Hashizume K,Osamura RY,Katakami H

    更新日期:1997-07-01 00:00:00

  • Effects of ischemia and reperfusion on P2X2 receptor expressing neurons of the rat ileum enteric nervous system.

    abstract:PURPOSE:We investigated the effects of ischemia/reperfusion in the intestine (I/R-i) on purine receptor P2X2-immunoreactive (IR) neurons of the rat ileum. METHODS:The superior mesenteric artery was occluded for 45 min with an atraumatic vascular clamp and animals were sacrificed 4 h later. Neurons of the myenteric and...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Paulino AS,Palombit K,Cavriani G,Tavares-de-Lima W,Mizuno MS,Marosti AR,da Silva MV,Girotti PA,Liberti EA,Castelucci P

    更新日期:2011-08-01 00:00:00

  • There Is a Great Future in Plastics: Personalized Approach to the Management of Hilar Cholangiocarcinoma Using a 3-D-Printed Liver Model.

    abstract::In recent years, three-dimensional (3-D) printing technology has become a standard tool that is used in several medical applications such as education, surgical training simulation and planning, and doctor-patient communication. Although liver surgery is ideally complemented by the use of preoperative 3-D-printed mode...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Larghi Laureiro Z,Novelli S,Lai Q,Mennini G,D'andrea V,Gaudenzi P,Marinozzi F,Engelmann C,Mookarje R,Raptis D,Rossi M,Jalan R

    更新日期:2020-08-01 00:00:00

  • Lack of correlation between serum lipoproteins and biliary cholesterol saturation in patients with gallstones.

    abstract::It has been suggested that elevated serum lipoprotein cholesterol levels may be a determinant of biliary cholesterol saturation and cholesterol gallstone disease. The aim of this study was to correlate serum lipoprotein cholesterol and apolipoprotein levels with biliary cholesterol saturation in patients with gallston...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Marks JW,Cleary PA,Albers JJ

    更新日期:1984-12-01 00:00:00

  • Ultra-short Celiac Disease Is a Distinct and Milder Phenotype of the Disease in Children.

    abstract:BACKGROUND AND AIMS:Approximately 10% of children with celiac disease (CD) have ultra-short celiac disease (USCD), where histological abnormalities are limited to the duodenal bulb. The aim of our retrospective study was to identify clinical and serological characteristics at baseline and at follow-up of children with ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Doyev R,Cohen S,Ben-Tov A,Weintraub Y,Amir A,Galai T,Moran-Lev H,Yerushalmy-Feler A

    更新日期:2019-01-01 00:00:00

  • Metoclopramide therapy in patients with delayed gastric emptying: a randomized, double-blind study.

    abstract::Twenty-eight patients with delayed gastric emptying as measured by an abnormal barium "burger" were treated with metoclopramide in a randomized, double-blind fashion. Five had diabetic gastroparesis, four had undergone vagotomy and pyloroplasty, and 19 were idiopathic. Patients received either metoclopramide or placeb...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Perkel MS,Moore C,Hersh T,Davidson ED

    更新日期:1979-09-01 00:00:00

  • Examination of tissue distribution of Helicobacter pylori within columnar-lined esophagus.

    abstract::H. pylori may colonize columnar-lined esophagus, although an etiologic role in esophageal adenocarcinoma is unproven. H. pylori can adhere to intestinal metaplasia in the stomach. This study was designed to examine if H. pylori adheres to specialized intestinal metaplasia in columnar-lined esophagus. Esophageal biopsi...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Sharma VK,Demian SE,Taillon D,Vasudeva R,Howden CW

    更新日期:1999-06-01 00:00:00