CSF 5-HIAA and exposure to and expression of interpersonal violence in suicide attempters.


BACKGROUND:Serotonin is implicated in impaired impulse control, aggression and suicidal behaviour. Low cerebrospinal fluid (CSF) concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) have been found in violent suicide attempters, suicide victims and in violent offenders. CSF 5-HIAA concentrations have both genetic and environmental determinants. Childhood trauma may have an effect on central monoamine function as an adult. AIM:The aim of this study was to assess the relationship of CSF 5-HIAA and the exposure to and the expression of violence in childhood and during adult life measured with the Karolinska Interpersonal Violence Scale (KIVS). METHOD:42 medication free suicide attempters underwent lumbar puncture and were assessed with the Karolinska Interpersonal Violence Scale (KIVS) to assess history of childhood exposure to violence and lifetime expressed violent behaviour. RESULTS:In women, but not in men, CSF 5-HIAA showed a significant negative correlation to exposure to violence during childhood. Furthermore, suicide attempters with low CSF 5-HIAA were more prone to commit violent acts as an adult if exposed to violence as a child compared to suicide attempters with high CSF 5-HIAA. In the non-traumatized group, CSF 5-HIAA showed a significant negative correlation to expressed violent behaviour in childhood. CONCLUSIONS:Although central serotonergic function has important genetic determinants, exposure to childhood trauma may also affect serotonergic function. Low serotonergic function may facilitate impaired aggression control in traumatized suicide attempters.


J Affect Disord


Moberg T,Nordström P,Forslund K,Kristiansson M,Asberg M,Jokinen J




Has Abstract


2011-07-01 00:00:00














  • Sex-specific time patterns of suicidal acts on the German railway system. An analysis of 4003 cases.

    abstract:OBJECTIVE:To examine sex-specific time patterns of suicidal behaviour on railway tracks as basis of suicide preventive strategies. METHOD:Cases were derived from the National Central Registry of all person accidents on the German railway net (STABAG) between 1997 and 2002 satisfying the operational definition of suici...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Erazo N,Baumert J,Ladwig KH

    更新日期:2004-11-15 00:00:00

  • Women's reproductive related disorders (RRDs).

    abstract:BACKGROUND:In some but not all women, periods of hormonal change may be associated with diversified physical, mental and cognitive symptoms that may be severe enough to warrant treatment. These reproductive-life periods include pregnancy, post-partum, the premenstrual and perimenopausal periods. CONCLUSIONS:Disorders ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,评审


    authors: Halbreich U

    更新日期:2010-04-01 00:00:00

  • Two-year stability and change of neuroticism and extraversion in treated and untreated persons with depression: findings from the Netherlands Study of Depression and Anxiety (NESDA).

    abstract:BACKGROUND:The personality dimensions neuroticism and extraversion likely represent part of the vulnerability to depression. The stability over longer time periods of these personality dimensions in depressed patients treated with psychological treatment or medication and in untreated persons with depression in the gen...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Renner F,Penninx BW,Peeters F,Cuijpers P,Huibers MJ

    更新日期:2013-09-05 00:00:00

  • Duration of subsequent episodes and periods of recovery in recurrent major depression.

    abstract:BACKGROUND:Little is known about the duration of subsequent depressive episodes and periods of recovery, and much is based on potentially biased retrospective data. We therefore prospectively assessed whether duration of depressive episodes and recoveries is correlated within subjects and across episodes, and whether d...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: de Jonge P,Conradi HJ,Kaptein KI,Bockting CL,Korf J,Ormel J

    更新日期:2010-09-01 00:00:00

  • Bupropion and paroxetine differentially influence cardiovascular and neuroendocrine responses to stress in depressed patients.

    abstract:BACKGROUND:There exists a need to identify safe and effective treatments for depression in patients with coronary heart disease (CHD). METHODS:Using a cross-sectional design, 17 depressed patients being treated with bupropion (200-450 mg/day) were compared with 17 depressed patients being treated with paroxetine (10-5...

    journal_title:Journal of affective disorders

    pub_type: 临床试验,杂志文章


    authors: Straneva-Meuse PA,Light KC,Allen MT,Golding M,Girdler SS

    更新日期:2004-04-01 00:00:00

  • Breastfeeding and the use of psychotropic medication: a review.

    abstract::The advisability of continuing breastfeeding is an important issue for women with postpartum depression or psychosis. A review of the literature on psychotropic drugs in breast milk is presented. All of the major classes of psychotropic drugs (antidepressants, antipsychotics, antianxiety agents, lithium, hypnotics) ha...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,评审


    authors: Buist A,Norman TR,Dennerstein L

    更新日期:1990-07-01 00:00:00

  • Comparative efficacy of racemic ketamine and esketamine for depression: A systematic review and meta-analysis.

    abstract:BACKGROUND:Ketamine appears to have a therapeutic role in certain mental disorders, most notably depression. However, the comparative performance of different formulations of ketamine is less clear. OBJECTIVES:This study aimed to assess the comparative efficacy and tolerability of racemic and esketamine for the treatm...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,评审


    authors: Bahji A,Vazquez GH,Zarate CA Jr

    更新日期:2021-01-01 00:00:00

  • Disrupted white matter integrity in first-episode, drug-naive, late-onset depression.

    abstract:BACKGROUND:Abnormalities of white matter integrity in frontal and limbic regions have been postulated to play a key role in the pathophysiology of geriatric depression. However, there is no diffusion tensor imaging (DTI) study in patients with first-episode, drug-naive, late-onset depression (LOD). The aim of this stud...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Guo W,Liu F,Xun G,Hu M,Guo X,Xiao C,Chen H,Chen J,Zhao J

    更新日期:2014-07-01 00:00:00

  • Antidepressant drug use in Lombardy, Italy: a population-based study.

    abstract:BACKGROUND:The patterns of antidepressant drug prescribing have rarely been studied in large and geographically defined catchment areas. In the present study, we examined the prevalence and distribution of antidepressant prescribing in Lombardy, a northern Italy region of nine million inhabitants. METHODS:This study u...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Percudani M,Barbui C,Fortino I,Petrovich L

    更新日期:2004-12-01 00:00:00

  • Switching methods of self-harm at repeat episodes: Findings from a multicentre cohort study.

    abstract:BACKGROUND:Self-poisoning and self-injury have widely differing incidences in hospitals and in the community, which has led to confusion about the concept of self-harm. Categorising self-harm simply by a method may be clinically misleading because many hospital-attending patients switch from one method of harm to anoth...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,多中心研究


    authors: Owens D,Kelley R,Munyombwe T,Bergen H,Hawton K,Cooper J,Ness J,Waters K,West R,Kapur N

    更新日期:2015-07-15 00:00:00

  • Model-based comparing efficacy of fluoxetine between elderly and non-elderly participants with major depressive disorder.

    abstract:BACKGROUND:The high heterogeneity was existed among the studies of the elderly participants with major depressive disorder (MDD), which may lead to incorrect conclusions in the previous meta-analysis. This study used model based meta-analysis to compare the efficacy of fluoxetine between the elderly and non-elderly par...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,meta分析


    authors: Dong L,Xu L,Li Y,Lv Y,Liu H,Li Y,Xu F,Wu J,Zheng Q,Li L

    更新日期:2018-03-15 00:00:00

  • Family religion and psychopathology in children of depressed mothers: ten-year follow-up.

    abstract:BACKGROUND:Previously we found that transmission of religion from mother to adult offspring as measured by correlations on ratings of personal importance of religion and frequency of attendance at religious services was hindered by maternal depression. Concordance of denomination, a measure indicating successful transm...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Jacobs M,Miller L,Wickramaratne P,Gameroff M,Weissman MM

    更新日期:2012-02-01 00:00:00

  • Treatment credibility, expectancy, and preference: Prediction of treatment engagement and outcome in a randomized clinical trial of hatha yoga vs. health education as adjunct treatments for depression.

    abstract:BACKGROUND:Hatha yoga may be helpful for alleviating depression symptoms. The purpose of this analysis is to determine whether treatment program preference, credibility, or expectancy predict engagement in depression interventions (yoga or a control class) or depression symptom severity over time. METHODS:This is a se...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,随机对照试验


    authors: Uebelacker LA,Weinstock LM,Battle CL,Abrantes AM,Miller IW

    更新日期:2018-10-01 00:00:00

  • Short communication: Self-reported sleep-wake disturbances preceding onset of full-threshold mood and/or psychotic syndromes in community residing adolescents and young adults.

    abstract:BACKGROUND:Insomnia may predict onset of mental disorders in adults. However, it is unclear whether the same directional relationship exists during the peak age range for the onset of major mental disorders and/or whether other types of sleep-wake disturbance, such as hypersomnia, show similar associations. METHODS:Lo...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Scott J,Byrne E,Medland S,Hickie I

    更新日期:2020-12-01 00:00:00

  • Impact of temperament on depression and anxiety symptoms and depressive disorder in a population-based birth cohort.

    abstract:BACKGROUND:The aim of this study was to characterize at the population level how innate features of temperament relate to experience of depressive mood and anxiety, and whether these symptoms have separable temperamental backgrounds. METHODS:The study subjects were 4773 members of the population-based Northern Finland...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Nyman E,Miettunen J,Freimer N,Joukamaa M,Mäki P,Ekelund J,Peltonen L,Järvelin MR,Veijola J,Paunio T

    更新日期:2011-06-01 00:00:00

  • Measuring treatment response in psychotic depression: the Psychotic Depression Assessment Scale (PDAS) takes both depressive and psychotic symptoms into account.

    abstract:BACKGROUND:There is no established psychometric instrument dedicated to the measurement of severity in psychotic depression (PD). The aim of this study was to investigate whether a new composite rating scale, the Psychotic Depression Assessment Scale (PDAS), covering both the psychotic and the depressive domains of PD,...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,随机对照试验


    authors: Østergaard SD,Meyers BS,Flint AJ,Mulsant BH,Whyte EM,Ulbricht CM,Bech P,Rothschild AJ,STOP-PD Study Group.

    更新日期:2014-05-01 00:00:00

  • A meta-analysis of depression severity and cognitive function.

    abstract:BACKGROUND:Studies examining the way in which cognitive impairment is associated with depression have produced inconsistent findings. Different severity of depressed mood across studies may account for such conflicting reports. However, inconsistent results have also been reported in relation to the specific associatio...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,meta分析


    authors: McDermott LM,Ebmeier KP

    更新日期:2009-12-01 00:00:00

  • Successful group psychotherapy of depression in adolescents alters fronto-limbic resting-state connectivity.

    abstract:BACKGROUND:Current resting state imaging findings support suggestions that the neural signature of depression and therefore also its therapy should be conceptualized as a network disorder rather than a dysfunction of specific brain regions. In this study, we compared neural connectivity of adolescent patients with depr...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Straub J,Metzger CD,Plener PL,Koelch MG,Groen G,Abler B

    更新日期:2017-02-01 00:00:00

  • Serum levels of TDP-43 in late-life patients with depressive episode.

    abstract:BACKGROUND:Recent reports have suggested a relationship between affective disorder including depression and bipolar disorder (BP) and frontotemporal dementia (FTD). TAR DNA binding protein (TDP) -43 is a protein found in the brain and peripheral fluid of patients with FTD. To examine a possible association between affe...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Ichikawa T,Baba H,Maeshima H,Shimano T,Inoue M,Ishiguro M,Yasuda S,Shukuzawa H,Suzuki T,Arai H

    更新日期:2019-05-01 00:00:00

  • A double-blind, placebo-controlled study of edivoxetine as an adjunctive treatment for patients with major depressive disorder who are partial responders to selective serotonin reuptake inhibitor treatment.

    abstract:BACKGROUND:This phase 2 study examined the efficacy and tolerability of edivoxetine, a highly selective norepinephrine reuptake inhibitor, as an adjunctive treatment for patients with major depressive disorder (MDD) who have a partial response to selective serotonin reuptake inhibitor (SSRI) treatment. METHODS:Study d...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,随机对照试验


    authors: Ball S,Dellva MA,D'Souza DN,Marangell LB,Russell JM,Goldberger C

    更新日期:2014-01-01 00:00:00

  • Natural disasters and suicidal behaviours: a systematic literature review.

    abstract:BACKGROUND:Various consequences including suicidal behaviours can arise in the aftermath of natural disasters. The aim of the present review was to systematically analyse the existing literature on the potential impact of natural disasters on suicidal behaviours. METHODS:A systematic search of English-language article...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,评审


    authors: Kõlves K,Kõlves KE,De Leo D

    更新日期:2013-03-20 00:00:00

  • Mind and body exercises (MBE), prescribed antidepressant medication, physical exercise and depressive symptoms - a longitudinal study.

    abstract:AIMS:Earlier studies show that participation in mind and body exercises (MBE) is cross-sectionally associated with high levels of depressive symptoms and antidepressants. This study investigates the longitudinal interrelationship between depressive symptoms, MBE and antidepressants. METHODS:3269 men and 4318 women age...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Rådmark L,Hanson LM,Montgomery S,Bojner Horwitz E,Osika W

    更新日期:2020-03-15 00:00:00

  • Couples' relationship affects mothers' and fathers' anxiety and depression trajectories over the transition to parenthood.

    abstract:BACKGROUND:The association between the couple relationship and the mothers' and fathers' psychological adjustment to the transition to parenthood has been examined in the literature. However, the direction of effects between these variables has not been extensively explored. This study aimed to assess the direction of ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Figueiredo B,Canário C,Tendais I,Pinto TM,Kenny DA,Field T

    更新日期:2018-10-01 00:00:00

  • Late-life depression symptom dimensions and cognitive functioning in the Longitudinal Aging Study Amsterdam (LASA).

    abstract:BACKGROUND:Depression often co-occurs in late-life in the context of declining cognitive functions, but it is not clear whether specific depression symptom dimensions are differentially associated with cognitive abilities. METHODS:The study sample comprised 3107 community-dwelling older adults from the Longitudinal Ag...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Brailean A,Comijs HC,Aartsen MJ,Prince M,Prina AM,Beekman A,Huisman M

    更新日期:2016-09-01 00:00:00

  • Social support and depressive symptom disparity between urban and rural older adults in China.

    abstract:BACKGROUND:Depressive symptom disparity between urban and rural older adults is an important public health issue in China. Social support is considered as an effective way to alleviate depression of older adults. This study aimed to investigate the extent to which social support could explain the depressive symptom dis...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Hu H,Cao Q,Shi Z,Lin W,Jiang H,Hou Y

    更新日期:2018-09-01 00:00:00

  • One year clinical and psychosocial outcomes of early-onset chronic depression.

    abstract:BACKGROUND:Results from short-term treatment studies have demonstrated the efficacy of antidepressant medications for outpatients with early-onset chronic depression. However, scant data exists regarding the long-term outcome of these patients treated for this disorder. METHODS:The author conducted a one-year naturali...

    journal_title:Journal of affective disorders

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Agosti V

    更新日期:1999-07-01 00:00:00

  • Darwinian depression.

    abstract:BACKGROUND:The standard evolutionary explanation for depression is that being in an emotionally depressed state is adaptive. METHOD:The article first undertakes a critical review of the extant literature. It then provides an alternative evolutionary explanation for event-based depression and elation. It argues that be...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,评审


    authors: Wittman D

    更新日期:2014-10-01 00:00:00

  • Emerging issues and questions on peripartum depression prevention, diagnosis and treatment: a consensus report from the cost action riseup-PPD.

    abstract:BACKGROUND:Peripartum depression [PPD] is a public health problem which has been widely studied. Nonetheless, study findings and clinical guidelines for PPD treatment differ among countries and the condition is still underdiagnosed and undertreated, suggesting the importance of a global understanding of PPD. The Riseup...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,评审


    authors: Fonseca A,Ganho-Ávila A,Lambregtse-van den Berg M,Lupattelli A,Rodriguez-Muñoz MF,Ferreira P,Radoš SN,Bina R

    更新日期:2020-09-01 00:00:00

  • The Observer-Rated Scale for Mania (ORSM): development, psychometric properties and utility.

    abstract:BACKGROUND:The diagnosis of mania largely depends on the quality of information the physician is provided with. Often, the patient cannot give an accurate account of the symptom development and thus information from relatives and friends is required. No systematic rating instrument is available, however, to facilitate ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Krüger S,Quilty L,Bagby M,Lippold T,Bermpohl F,Bräunig P

    更新日期:2010-04-01 00:00:00

  • Pathological jealousy: romantic relationship characteristics, emotional and personality aspects, and social adjustment.

    abstract:BACKGROUND:The aim of this study was to identify romantic relationship characteristics, emotional and personality aspects and social adjustment in subjects with pathological jealousy (PJ) and to compare them to control group. METHODS:The participants, 32 individuals with PJ and 31 healthy volunteers completed measures...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Costa AL,Sophia EC,Sanches C,Tavares H,Zilberman ML

    更新日期:2015-03-15 00:00:00