CSF 5-HIAA and exposure to and expression of interpersonal violence in suicide attempters.


BACKGROUND:Serotonin is implicated in impaired impulse control, aggression and suicidal behaviour. Low cerebrospinal fluid (CSF) concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) have been found in violent suicide attempters, suicide victims and in violent offenders. CSF 5-HIAA concentrations have both genetic and environmental determinants. Childhood trauma may have an effect on central monoamine function as an adult. AIM:The aim of this study was to assess the relationship of CSF 5-HIAA and the exposure to and the expression of violence in childhood and during adult life measured with the Karolinska Interpersonal Violence Scale (KIVS). METHOD:42 medication free suicide attempters underwent lumbar puncture and were assessed with the Karolinska Interpersonal Violence Scale (KIVS) to assess history of childhood exposure to violence and lifetime expressed violent behaviour. RESULTS:In women, but not in men, CSF 5-HIAA showed a significant negative correlation to exposure to violence during childhood. Furthermore, suicide attempters with low CSF 5-HIAA were more prone to commit violent acts as an adult if exposed to violence as a child compared to suicide attempters with high CSF 5-HIAA. In the non-traumatized group, CSF 5-HIAA showed a significant negative correlation to expressed violent behaviour in childhood. CONCLUSIONS:Although central serotonergic function has important genetic determinants, exposure to childhood trauma may also affect serotonergic function. Low serotonergic function may facilitate impaired aggression control in traumatized suicide attempters.


J Affect Disord


Moberg T,Nordström P,Forslund K,Kristiansson M,Asberg M,Jokinen J




Has Abstract


2011-07-01 00:00:00














  • Life events in bipolar patients: a comparative study with siblings and healthy controls.

    abstract:BACKGROUND:While many studies have focused on life events in depressive disorders, data regarding them in bipolar disorder are scant. The aim of this work was to explore the characteristics of life events in bipolar patients. METHODS:Sixty bipolar patients have been included in our study. The evaluation focused on the...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: El Kissi Y,Krir MW,Ben Nasr S,Hamadou R,El Hedda R,Bannour S,Ben Hadj Ali B

    更新日期:2013-10-01 00:00:00

  • Breastfeeding and the use of psychotropic medication: a review.

    abstract::The advisability of continuing breastfeeding is an important issue for women with postpartum depression or psychosis. A review of the literature on psychotropic drugs in breast milk is presented. All of the major classes of psychotropic drugs (antidepressants, antipsychotics, antianxiety agents, lithium, hypnotics) ha...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,评审


    authors: Buist A,Norman TR,Dennerstein L

    更新日期:1990-07-01 00:00:00

  • VEGF plasma level variations in duloxetine-treated patients with major depression.

    abstract:BACKGROUND:The vascular endothelial growth factor (VEGF) signaling, which modulates angiogenesis and neurogenesis within the neurovascular unit, might play an important role in the neuro-endocrine-immune (NEI) stress-adaptation system. Recent evidence suggests that VEGF is involved in the pathophysiology of a number of...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Fornaro M,Rocchi G,Escelsior A,Contini P,Ghio M,Colicchio S,De Berardis D,Amore M,Fornaro P,Martino M

    更新日期:2013-11-01 00:00:00

  • Alcohol abuse in social phobic patients: is there a bipolar connection?

    abstract:BACKGROUND:Epidemiological and clinical studies have reported the frequent co-occurrence of social phobia (SP) and alcohol use disorders. Patients with SP often use alcohol to cope with the social situations they fear, and to lessen anticipatory anxiety, behavioral inhibition, and phobic avoidance. We investigated whet...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Perugi G,Frare F,Madaro D,Maremmani I,Akiskal HS

    更新日期:2002-02-01 00:00:00

  • A multi-level analysis of the relationship between spatial clusters of outpatient-treated depression, risk factors and mental health service planning in Catalonia (Spain).

    abstract:BACKGROUND:Previous research identified high/low clusters of prevalence of outpatient-treated depression at municipal level in Catalonia (Spain). This study aims to analyse potential risk factors, both socioeconomic and related to the mental health service planning, which could influence the occurrence of hot/cold spot...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Rodero-Cosano ML,Salinas-Pérez JA,González-Caballero JL,García-Alonso CR,Lagares-Franco C,Salvador-Carulla L

    更新日期:2016-09-01 00:00:00

  • Electrodermal hyporeactivity and antisocial behavior: does anxiety mediate the relationship?

    abstract::Electrodermal hyporeactivity in the anticipation of aversive stimuli is a highly reliable correlate of diagnosed psychopathy and undersocialized aggressive conduct disorder (UACD), and it has been interpreted as reflecting a weak behavioral inhibition system (BIS) as conceptualized in Gray's work (e.g., in: Royce, J.R...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,评审


    authors: Fowles DC

    更新日期:2000-12-01 00:00:00

  • Development of the Macquarie Anxiety Behavioural Scale (MABS): A parent measure to assess anxiety in children and adolescents including young people with autism spectrum disorder.

    abstract:OBJECTIVE:This study examined measurement variance for Autism Spectrum Disorder (ASD) in the Spence Children's Anxiety Scale - Parent Form (SCAS-P; Spence, 1999). In addition, we developed and evaluated a new parent report measure for anxiety (Macquarie Anxiety Behavioural Scale; MABS). METHOD:The sample consisted of ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Toscano R,Hudson JL,Baillie AJ,Lyneham HJ,McLellan LF

    更新日期:2020-11-01 00:00:00

  • Nonverbal attunement between depressed patients and an interviewer predicts subsequent improvement.

    abstract::Depressed patients' support-seeking behaviour and the responses to this behaviour by others (support-giving) are presumed to play a causal role in depression. In interactions between normals, attuning nonverbal behaviour (i.e., equalizing levels of specific behavioural activities) is important for satisfaction of the ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Geerts E,Bouhuys N,Van den Hoofdakker RH

    更新日期:1996-09-09 00:00:00

  • Costs of the principal mood disorders: a study of comparative direct and indirect costs incurred by those with bipolar I, bipolar II and unipolar disorders.

    abstract:BACKGROUND:While there have been many studies comparing direct and indirect costs engendered individually and nationally by those with unipolar (UP) and bipolar (BP) disorders, there has been no previous study comparing costs across the bipolar I (BP I) and bipolar II (BP II) disorders. METHODS:We examine direct and i...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Parker G,McCraw S,Hadzi-Pavlovic D,Fletcher K

    更新日期:2013-07-01 00:00:00

  • Access to means of lethal overdose among psychiatric patients with co-morbid physical health problems: Analysis of national suicide case series data from the United Kingdom.

    abstract:BACKGROUND:Many physical health problems are associated with elevated suicide risk whilst also providing access to means of overdose. We aimed to investigate whether psychiatric patients with physical co-morbidities who die by suicide were more likely than those without co-morbidities to self-poison with non-psychotrop...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Pitman A,Tham SG,Hunt IM,Webb RT,Appleby L,Kapur N

    更新日期:2019-10-01 00:00:00

  • Validation of the self-reporting questionnaire (SRQ 20) in British Pakistani and White European population in the United Kingdom.

    abstract:BACKGROUND:The incidence of depression is difficult to determine because of low clinical depression detection rates in the primary care setting. This low level of detection is a significantly greater problem in people from ethnic minority communities. The availability of culturally validated screening questionnaires mi...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Husain N,Chaudhry N,Rhouma A,Sumra A,Tomenson B,Waheed W

    更新日期:2016-01-01 00:00:00

  • Family functioning, trauma exposure and PTSD: A cross sectional study.

    abstract:OBJECTIVE:Only a minority of trauma-exposed individuals go on to develop post traumatic stress disorder (PTSD). Previous studies in high income countries suggest that maladaptive family functioning adversities (MFFA) in childhood may partially explain individual variation in vulnerability to PTSD following trauma. We t...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Dorrington S,Zavos H,Ball H,McGuffin P,Sumathipala A,Siribaddana S,Rijsdijk F,Hatch SL,Hotopf M

    更新日期:2019-02-15 00:00:00

  • Does Attention Deficit Hyperactivity Disorder increase the risk of suicide attempts?

    abstract:OBJECTIVE:To determine if Attention Deficit Hyperactivity Disorder (ADHD) is a risk factor for suicide attempts. METHODS:Data were drawn from the National Comorbidity Replication Survey (NCS-R), a nationally representative sample of adults (N=8098). RESULTS:Of the 365 adults with current ADHD, 16% attempted suicide. ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Agosti V,Chen Y,Levin FR

    更新日期:2011-10-01 00:00:00

  • A double-blind double-dummy study of citalopram comparing infusion versus oral administration.

    abstract:BACKGROUND:This study compares antidepressant efficacy and tolerability of citalopram given either orally or as a slow drop infusion. METHODS:Citalopram (40 mg/day) was administered double-blindly as tablets or slow-drop infusion during the first 10 days and then open, orally, up to treatment Day 42. RESULTS:In 60 mo...

    journal_title:Journal of affective disorders

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Baumann P,Nil R,Bertschy G,Jecker A,Brändli H,Morand J,Kasas A,Vuagniaux O,Ramseier F

    更新日期:1998-06-01 00:00:00

  • Parenting stress and family resilience affect the association of adverse childhood experiences with children's mental health and attention-deficit/hyperactivity disorder.

    abstract:INTRODUCTION:Exposure to adverse childhood experience (ACE) has harmful consequences for children's health and well-being. However, it is less clear how different social processes may amplify or mitigate the effects of ACE on children's mental health. We examined how parenting stress mediates and family resilience mode...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Uddin J,Alharbi N,Uddin H,Hossain MB,Hatipoğlu SS,Long DL,Carson AP

    更新日期:2020-07-01 00:00:00

  • Postnatal depression and mother and infant outcomes after infant massage.

    abstract:BACKGROUND:Postnatal depression can be a long lasting condition which affects both the mother and her baby. A pilot study indicated that attending baby massage improved maternal depression and mother-infant interactions. The current study further investigates any benefits of baby massage for mothers with postnatal depr...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: O'Higgins M,St James Roberts I,Glover V

    更新日期:2008-07-01 00:00:00

  • Shame, pride, and suicidal ideation in a military clinical sample.

    abstract:BACKGROUND:Suicide risk among U.S. military personnel has been increasing over the past decade. Fluid vulnerability theory (FVT; Rudd, 2006) posits that acute suicidal episodes increase in severity when trait-based (e.g., shame) and state-based (e.g., hopelessness) risk factors interact, especially among individuals wh...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Bryan CJ,Ray-Sannerud B,Morrow CE,Etienne N

    更新日期:2013-05-01 00:00:00

  • Cognitive functioning of bipolar I patients and relatives from families with or without schizophrenia or schizoaffective disorder.

    abstract:BACKGROUND:Bipolar I disorder patients show cognitive impairments, and genetic vulnerability to other psychotic disorders may modify these impairments. We set out to assess cognitive functions and estimate their heritability in bipolar I disorder patients (bipolar families) and unaffected relatives in a group of famili...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Antila M,Partonen T,Kieseppä T,Suvisaari J,Eerola M,Lönnqvist J,Tuulio-Henriksson A

    更新日期:2009-07-01 00:00:00

  • Prognosis of depressive disorders in the general population- results from the longitudinal Finnish Health 2011 Study.

    abstract:BACKGROUND:Depressive disorders are among the most pressing public health challenges worldwide. Yet, not enough is known about their long-term outcomes. This study examines the course and predictors of different outcomes of depressive disorders in an eleven-year follow-up of a general population sample. METHODS:In a n...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Markkula N,Härkänen T,Nieminen T,Peña S,Mattila AK,Koskinen S,Saarni SI,Suvisaari J

    更新日期:2016-01-15 00:00:00

  • Complex polypharmacy in bipolar disorder: Side effect burden, adherence, and response predictors.

    abstract:BACKGROUND:Complex polypharmacy (CP) is common in bipolar disorder (BD). We assessed the associations between CP, adherence, and side effect burden, and patient traits associated with clinical improvement in relationship to CP. METHODS:We conducted a secondary analysis of 482 adult BD participants in the Bipolar CHOIC...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Fung VC,Overhage LN,Sylvia LG,Reilly-Harrington NA,Kamali M,Gao K,Shelton RC,Ketter TA,Bobo WV,Thase ME,Calabrese JR,Tohen M,Deckersbach T,Nierenberg AA

    更新日期:2019-10-01 00:00:00

  • Disrupted white matter integrity in first-episode, drug-naive, late-onset depression.

    abstract:BACKGROUND:Abnormalities of white matter integrity in frontal and limbic regions have been postulated to play a key role in the pathophysiology of geriatric depression. However, there is no diffusion tensor imaging (DTI) study in patients with first-episode, drug-naive, late-onset depression (LOD). The aim of this stud...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Guo W,Liu F,Xun G,Hu M,Guo X,Xiao C,Chen H,Chen J,Zhao J

    更新日期:2014-07-01 00:00:00

  • Ergopsychometry in depressive patients.

    abstract::Thirteen patients with major depressive disorder, 25 patients with dysthymia and 12 healthy controls underwent ergopsychometric testing. The effect of self-paced and set-paced load on mood, vigilance and perseveration tendency was recorded. Within the clinical groups, various types of load seemed to result mainly in v...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Günther V,Kryspin-Exner I

    更新日期:1991-10-01 00:00:00

  • Model-based comparing efficacy of fluoxetine between elderly and non-elderly participants with major depressive disorder.

    abstract:BACKGROUND:The high heterogeneity was existed among the studies of the elderly participants with major depressive disorder (MDD), which may lead to incorrect conclusions in the previous meta-analysis. This study used model based meta-analysis to compare the efficacy of fluoxetine between the elderly and non-elderly par...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,meta分析


    authors: Dong L,Xu L,Li Y,Lv Y,Liu H,Li Y,Xu F,Wu J,Zheng Q,Li L

    更新日期:2018-03-15 00:00:00

  • The association of myelin oligodendrocyte glycoprotein gene and white matter volume in obsessive-compulsive disorder.

    abstract:BACKGROUND:Morphological changes of white matter have been described in patients with obsessive-compulsive disorder (OCD). The aim of our study was to determine whether a functional polymorphism of the myelin oligodendrocyte glycoprotein (MOG) G511C (Val142Leu) is associated with white matter volumes in patients with O...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Atmaca M,Onalan E,Yildirim H,Yuce H,Koc M,Korkmaz S

    更新日期:2010-08-01 00:00:00

  • Is subclinical anxiety an endophenotype for bipolar I patients? A study from a Costa Rican sample.

    abstract:BACKGROUND:Although genetic influences on bipolar I disorder are well established, localization of genes that predispose to the illness has been difficult. Some genes predisposing to bipolar I disorder may be transmitted without expression of the categorical clinical phenotype. One strategy to overcome this obstacle is...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Contreras J,Hare E,Pacheco A,Escamilla M,Raventos H

    更新日期:2010-05-01 00:00:00

  • Trajectories of maternal stress and anxiety from pregnancy to three years and child development at 3 years of age: Findings from the All Our Families (AOF) pregnancy cohort.

    abstract:BACKGROUND:Existing literature on maternal distress has focused on stress and anxiety during the pregnancy or postnatally and their relationship with child development. However, few studies have investigated the association between maternal stress and anxiety symptoms over time and child development in preschool childr...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Mughal MK,Giallo R,Arnold P,Benzies K,Kehler H,Bright K,Kingston D

    更新日期:2018-07-01 00:00:00

  • GWAS and systems biology analysis of depressive symptoms among smokers from the COPDGene cohort.

    abstract:BACKGROUND:Large sample GWAS is needed to identify genetic factors associated with depression. This study used genome-wide genotypic and phenotypic data from the COPDGene study to identify genetic risk factors for depression. METHODS:Data were from 9716 COPDGene subjects with ≥10 pack-year history. Depression was defi...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Heinzman JT,Hoth KF,Cho MH,Sakornsakolpat P,Regan EA,Make BJ,Kinney GL,Wamboldt FS,Holm KE,Bormann N,Robles J,Kim V,Iyer AS,Silverman EK,Crapo JD,Han S,Potash JB,Shinozaki G,COPDGene Investigators.

    更新日期:2019-01-15 00:00:00

  • The utility of a classificatory decision tree approach to assist clinical differentiation of melancholic and non-melancholic depression.

    abstract:BACKGROUND:Studies suggest that differentiating melancholic from non-melancholic depressive disorders is advanced by use of illness course as well as symptom variables but, in practice, potentially differentiating variables are generally positioned as having equal value. Judging that differentiating features are more l...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Parker G,McCraw S,Hadzi-Pavlovic D

    更新日期:2015-07-15 00:00:00

  • Early effect on general interest, and short-term antidepressant efficacy and safety of agomelatine (25-50mg/day) and escitalopram (10-20mg/day) in outpatients with Major Depressive Disorder. A 12-week randomised double-blind comparative study.

    abstract:BACKGROUND:A double-blind, randomized, study was conducted in 29 centers in Romania to evaluate the effect of agomelatine 25-50mg/day (n=144 patients) on general interest, overall clinical efficacy, and functionality in comparison with escitalopram 10-20mg/day (n=143 patients) in out-patients diagnosed with moderate to...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,随机对照试验


    authors: Udristoiu T,Dehelean P,Nuss P,Raba V,Picarel-Blanchot F,de Bodinat C

    更新日期:2016-07-15 00:00:00

  • Incident mental disorders in the aftermath of traumatic events: A prospective-longitudinal community study.

    abstract:BACKGROUND:Few strictly prospective-longitudinal community studies examined the role of traumatic events for risk of developing a broad range of incident mental disorders over several years. METHOD:A representative community sample of adolescents and young adults (n = 2797, baseline age 14-24) was prospectively examin...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Asselmann E,Wittchen HU,Lieb R,Perkonigg A,Beesdo-Baum K

    更新日期:2018-02-01 00:00:00