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Increased expression of Toll-like receptor-9 has close relation with tumour cell proliferation in oral squamous cell carcinoma.

Abstract：

OBJECTIVE:Toll-like receptor-9 (TLR-9), a new member of the interleukin-1 receptor superfamily, was recently found to have a high level of expression in many carcinoma specimens. The objective of this study was to examine the TLR-9 expression and its role in tumour cell proliferation in oral squamous cell carcinoma. MATERIALS AND METHODS:Western blot and immunohistochemistry were used to detect TLR-9 protein in oral squamous cell carcinoma (OSCC) Tca-8113 cell lines and clinical specimens (n=60). The relationship between TLR-9 expression and clinicopathologic features was analysed. Cell proliferation and inflammatory chemokines secretion were tested by MTT and ELISA methods respectively. RESULTS:Results showed that TLR-9 expression level was higher in OSCC tissues than in paired adjacent normal tissues (P<0.01), and the expression level of TLR-9 was significantly associated with tumour size (P=0.001), tumour clinical stage (P=0.003) and Ki-67 expression (P<0.01). In vitro results also suggested that stimulation of Tca-8113 cells with TLR-9 agonist CpG-ODN could significantly increase tumour cell proliferation as well as subsequent IL-1α and IL-6 secretions (P<0.01), which could be partially inhibited by usage of anti-TLR-9 protein. CONCLUSIONS:It was therefore hypothesized that increased expression of TLR-9 may be of great value in assessing the development of OSCC, and could be used as a new target for OSCC prevention and therapy in future.

journal_name

Arch Oral Biol

journal_title

Archives of oral biology

authors

Min R,Zun Z,Siyi L,Wenjun Y,Lizheng W,Chenping Z

doi

10.1016/j.archoralbio.2011.01.010

subject

Has Abstract

pub_date

2011-09-01 00:00:00

pages

877-84

issue

9

eissn

0003-9969

issn

1879-1506

pii

S0003-9969(11)00030-6

journal_volume

56

pub_type

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