Abstract:
BACKGROUND:Insulin glargine provides effective glycemic control when administered at bedtime in adults. OBJECTIVE:This study aims to investigate whether insulin glargine is equally effective if administered in the morning or at bedtime in combination with preprandial anologue insulin. METHODS:Twenty-eight patients that have been treated with an intensified insulin regimen for at least one year were randomized to insulin glargine injection at breakfast (06:00-09:00) (12 patients) or bedtime (21:00-24:00) (16 patients), plus meal-time anologue insulin in the two groups. Glucose data from each day were analyzed at four different times: between 9:00 and 21:00 (t1), between 21:00 and 24:00 (t2), between 24:00 and 04:00 (t3),04:00 and 09:00 (t4) by the Minimed continuous glucose monitoring system. RESULTS:Baseline characteristics were similar in the two groups. The sensor values were lower before breakfast in the bedtime group (180.5 ± 49.0 vs 223.8 ± 47.3 mg/dl, p=0.03). There were 13.7 events.patient (-1).day(-1) in the bedtime group and 6.9 events.patient (-1).day(-1) in the breakfast group in which glucose levels fell below 60 mg/dl (p=0.3). There were 121.6 events.patient (-1).day(-1) in the bedtime group and 162.4 events.patient (-1).day(-1) in the breakfast group in which glucose levels exceeded 180 mg/dl (p=0.05). Nighttime hypoglycemia only reached to a statistical significance between the two groups between 24:00 and 04:00. There were no significant correlations between the duration of nocturnal hypoglycemia, age, duration of diabetes, gender and HbA1c levels. CONCLUSION:Breakfast group is hyperglycemic during the day and hyperglycemia starts in the morning at 04:00. There is no significant difference in the frequency or duration of hypo/hyper glycemia during the day and night irrespective of the timing of glargine injection except pre-breakfast levels are significantly better in the bedtime group and hypoglycemia occurs between midnight and 04:00 in the bedtime group.
journal_name
J Clin Res Pediatr Endocrinoljournal_title
Journal of clinical research in pediatric endocrinologyauthors
Şimşek DG,Yıldız B,Asar G,Darcan Sdoi
10.4008/jcrpe.v1i1.10subject
Has Abstractpub_date
2008-01-01 00:00:00pages
15-20issue
1eissn
1308-5727issn
1308-5735journal_volume
1pub_type
杂志文章,随机对照试验abstract:OBJECTIVE:Papillary thyroid cancer (PTC) may behave differently in prepubertal children as compared to pubertal children and adults. BRAF gene activating mutations may associate with PTC by creating aberrant activation. We aimed to evaluate the clinicopathological characteristics of PTC patients with emphasis on the pu...
journal_title:Journal of clinical research in pediatric endocrinology
pub_type: 杂志文章
doi:10.4274/jcrpe.3873
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVE:In this study, we aimed to investigate the association of W64R polymorphism of the β3-adrenergic receptor gene (β-3AR) with childhood obesity and related pathologies. METHODS:β-3AR gene W64R genotyping was carried out in 251 children aged 6-18 years. Of these subjects, 130 were obese (62 boys) and 121 were n...
journal_title:Journal of clinical research in pediatric endocrinology
pub_type: 杂志文章
doi:10.4274/jcrpe.1629
更新日期:2015-03-01 00:00:00
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journal_title:Journal of clinical research in pediatric endocrinology
pub_type: 杂志文章,meta分析
doi:10.4274/jcrpe.2583
更新日期:2016-09-01 00:00:00
abstract::Mutations in the insulin receptor (INSR) gene are associated with insulin resistance and hyperglycaemia. Various autosomal dominant heterozygous INSR mutations leading to hyperinsulinemic hypoglycaemia (HH) have been described in adults and children (more than 3 years of age) but not in the neonatal period. Family 1: ...
journal_title:Journal of clinical research in pediatric endocrinology
pub_type: 杂志文章
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abstract::The enzyme 17-β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) catalyzes the biosynthesis of testosterone from Δ4-androstenedione, and plays an important role in the final steps of androgen synthesis. 17β-HSD3 deficiency originates from mutations in the HSD17B gene, causing an autosomal recessive 46, XY sex developmen...
journal_title:Journal of clinical research in pediatric endocrinology
pub_type: 杂志文章
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更新日期:2021-01-04 00:00:00
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journal_title:Journal of clinical research in pediatric endocrinology
pub_type: 杂志文章
doi:10.4274/jcrpe.4510
更新日期:2017-12-15 00:00:00
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journal_title:Journal of clinical research in pediatric endocrinology
pub_type: 杂志文章
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更新日期:2015-12-01 00:00:00
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journal_title:Journal of clinical research in pediatric endocrinology
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更新日期:2014-12-01 00:00:00
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journal_title:Journal of clinical research in pediatric endocrinology
pub_type: 临床试验,杂志文章
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更新日期:2017-03-01 00:00:00
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journal_title:Journal of clinical research in pediatric endocrinology
pub_type: 杂志文章
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更新日期:2020-03-19 00:00:00
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journal_title:Journal of clinical research in pediatric endocrinology
pub_type: 杂志文章
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journal_title:Journal of clinical research in pediatric endocrinology
pub_type: 杂志文章
doi:10.4274/jcrpe.galenos.2018.2019.0241
更新日期:2019-09-03 00:00:00
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journal_title:Journal of clinical research in pediatric endocrinology
pub_type: 杂志文章
doi:10.4274/jcrpe.galenos.2019.2019.0101
更新日期:2020-09-02 00:00:00
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journal_title:Journal of clinical research in pediatric endocrinology
pub_type: 杂志文章
doi:10.4274/Jcrpe.1139
更新日期:2013-01-01 00:00:00
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journal_title:Journal of clinical research in pediatric endocrinology
pub_type: 杂志文章
doi:10.4274/Jcrpe.1454
更新日期:2014-09-01 00:00:00
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journal_title:Journal of clinical research in pediatric endocrinology
pub_type: 杂志文章
doi:10.4274/jcrpe.galenos.2019.2019.0080
更新日期:2020-03-19 00:00:00
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pub_type: 杂志文章
doi:10.4274/jcrpe.v1i5.233
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journal_title:Journal of clinical research in pediatric endocrinology
pub_type: 杂志文章
doi:10.4274/jcrpe.5374
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journal_title:Journal of clinical research in pediatric endocrinology
pub_type: 杂志文章
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journal_title:Journal of clinical research in pediatric endocrinology
pub_type: 杂志文章
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更新日期:2012-03-01 00:00:00
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journal_title:Journal of clinical research in pediatric endocrinology
pub_type: 杂志文章
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更新日期:2020-06-02 00:00:00
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journal_title:Journal of clinical research in pediatric endocrinology
pub_type: 杂志文章
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更新日期:2020-10-13 00:00:00
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journal_title:Journal of clinical research in pediatric endocrinology
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doi:10.4274/jcrpe.galenos.2019.2019.0108
更新日期:2020-06-03 00:00:00
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journal_title:Journal of clinical research in pediatric endocrinology
pub_type: 杂志文章
doi:10.4274/jcrpe.v3i1.05
更新日期:2011-01-01 00:00:00
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journal_title:Journal of clinical research in pediatric endocrinology
pub_type: 杂志文章
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更新日期:2020-03-19 00:00:00
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journal_title:Journal of clinical research in pediatric endocrinology
pub_type: 杂志文章
doi:10.4274/jcrpe.galenos.2019.2019.0045
更新日期:2020-06-03 00:00:00
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journal_title:Journal of clinical research in pediatric endocrinology
pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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更新日期:2015-09-01 00:00:00