Computational design of peptide ligands.


:Peptides possess several attractive features when compared to small molecule and protein therapeutics, such as high structural compatibility with target proteins, the ability to disrupt protein-protein interfaces, and small size. Efficient design of high-affinity peptide ligands via rational methods has been a major obstacle to the development of this potential drug class. However, structural insights into the architecture of protein-peptide interfaces have recently culminated in several computational approaches for the rational design of peptides that target proteins. These methods provide a valuable alternative to experimental high-resolution structures of target protein-peptide complexes, bringing closer the dream of in silico designed peptides for therapeutic applications.


Trends Biotechnol


Trends in biotechnology


Vanhee P,van der Sloot AM,Verschueren E,Serrano L,Rousseau F,Schymkowitz J




Has Abstract


2011-05-01 00:00:00














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