Abstract：
:Peptides possess several attractive features when compared to small molecule and protein therapeutics, such as high structural compatibility with target proteins, the ability to disrupt protein-protein interfaces, and small size. Efficient design of high-affinity peptide ligands via rational methods has been a major obstacle to the development of this potential drug class. However, structural insights into the architecture of protein-peptide interfaces have recently culminated in several computational approaches for the rational design of peptides that target proteins. These methods provide a valuable alternative to experimental high-resolution structures of target protein-peptide complexes, bringing closer the dream of in silico designed peptides for therapeutic applications.
journal_name
Trends Biotechnoljournal_title
Trends in biotechnologyauthors
Vanhee P,van der Sloot AM,Verschueren E,Serrano L,Rousseau F,Schymkowitz Jdoi
10.1016/j.tibtech.2011.01.004subject
Has Abstractpub_date
2011-05-01 00:00:00pages
231-9issue
5eissn
0167-7799issn
1879-3096pii
S0167-7799(11)00014-Xjournal_volume
29pub_type
杂志文章,评审abstract：:In 2006, the group of Dr C.M. Lieber pioneered the field of nanowire sensors by fabricating devices for the ultra-sensitive label-free detection of biological macromolecules. Since then, nanowire sensors have demonstrated their ability to detect cancer-associated analytes in peripheral blood, tumor tissue, and the exh...
journal_title：Trends in biotechnology
pub_type： 杂志文章,评审
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更新日期：2019-01-01 00:00:00
abstract：:Bacterial genomics has provided a plethora of potential targets for antibacterial drug discovery, however, success in the hunt for new antibiotics will hinge on selecting targets with the highest potential. A recent paper by Liu and coworkers describes a new approach to target selection that uncovers strategies used b...
journal_title：Trends in biotechnology
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journal_title：Trends in biotechnology
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更新日期：2007-04-01 00:00:00
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journal_title：Trends in biotechnology
pub_type： 杂志文章,评审
doi：10.1016/j.tibtech.2018.08.002
更新日期：2019-01-01 00:00:00
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journal_title：Trends in biotechnology
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journal_title：Trends in biotechnology
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journal_title：Trends in biotechnology
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journal_title：Trends in biotechnology
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journal_title：Trends in biotechnology
pub_type： 杂志文章,评审
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journal_title：Trends in biotechnology
pub_type： 杂志文章
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更新日期：2014-01-01 00:00:00
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journal_title：Trends in biotechnology
pub_type： 杂志文章,评审
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journal_title：Trends in biotechnology
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更新日期：2019-02-01 00:00:00
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journal_title：Trends in biotechnology
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doi：10.1016/s0167-7799(99)01342-6
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journal_title：Trends in biotechnology
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journal_title：Trends in biotechnology
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journal_title：Trends in biotechnology
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journal_title：Trends in biotechnology
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journal_title：Trends in biotechnology
pub_type： 杂志文章,评审
doi：10.1016/j.tibtech.2007.07.014
更新日期：2007-11-01 00:00:00
abstract：:The mapping of the human genome was completed earlier this year and efforts are underway to understand the role of gene products (i.e. proteins) in biological pathways and human disease and to exploit their functional roles to derive protein therapeutics and protein-based drugs. A key component to the next revolution ...
journal_title：Trends in biotechnology
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journal_title：Trends in biotechnology
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abstract：:Traditionally, biotechnology design has focused on the manufacture of chemicals and biologics. Still, a majority of biotechnology products that appear on the market today is the result of mechanical-electric (mechatronic) construction. For these, the biological components play decisive roles in the design solution; th...
journal_title：Trends in biotechnology
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更新日期：2010-05-01 00:00:00
abstract：:Type 1 Diabetes (T1D) is an autoimmune disease resulting from the destruction of pancreatic insulin-producing beta cells that most frequently occurs in genetically predisposed children. Recent observations illustrating the regenerative capability of the endocrine pancreas in addition to advances in stem cell and gene ...
journal_title：Trends in biotechnology
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doi：10.1016/j.tibtech.2006.08.007
更新日期：2006-11-01 00:00:00
