Abstract:
:Peptides possess several attractive features when compared to small molecule and protein therapeutics, such as high structural compatibility with target proteins, the ability to disrupt protein-protein interfaces, and small size. Efficient design of high-affinity peptide ligands via rational methods has been a major obstacle to the development of this potential drug class. However, structural insights into the architecture of protein-peptide interfaces have recently culminated in several computational approaches for the rational design of peptides that target proteins. These methods provide a valuable alternative to experimental high-resolution structures of target protein-peptide complexes, bringing closer the dream of in silico designed peptides for therapeutic applications.
journal_name
Trends Biotechnoljournal_title
Trends in biotechnologyauthors
Vanhee P,van der Sloot AM,Verschueren E,Serrano L,Rousseau F,Schymkowitz Jdoi
10.1016/j.tibtech.2011.01.004subject
Has Abstractpub_date
2011-05-01 00:00:00pages
231-9issue
5eissn
0167-7799issn
1879-3096pii
S0167-7799(11)00014-Xjournal_volume
29pub_type
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