Computational design of peptide ligands.

Abstract:

:Peptides possess several attractive features when compared to small molecule and protein therapeutics, such as high structural compatibility with target proteins, the ability to disrupt protein-protein interfaces, and small size. Efficient design of high-affinity peptide ligands via rational methods has been a major obstacle to the development of this potential drug class. However, structural insights into the architecture of protein-peptide interfaces have recently culminated in several computational approaches for the rational design of peptides that target proteins. These methods provide a valuable alternative to experimental high-resolution structures of target protein-peptide complexes, bringing closer the dream of in silico designed peptides for therapeutic applications.

journal_name

Trends Biotechnol

journal_title

Trends in biotechnology

authors

Vanhee P,van der Sloot AM,Verschueren E,Serrano L,Rousseau F,Schymkowitz J

doi

10.1016/j.tibtech.2011.01.004

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

231-9

issue

5

eissn

0167-7799

issn

1879-3096

pii

S0167-7799(11)00014-X

journal_volume

29

pub_type

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