Computational design of peptide ligands.


:Peptides possess several attractive features when compared to small molecule and protein therapeutics, such as high structural compatibility with target proteins, the ability to disrupt protein-protein interfaces, and small size. Efficient design of high-affinity peptide ligands via rational methods has been a major obstacle to the development of this potential drug class. However, structural insights into the architecture of protein-peptide interfaces have recently culminated in several computational approaches for the rational design of peptides that target proteins. These methods provide a valuable alternative to experimental high-resolution structures of target protein-peptide complexes, bringing closer the dream of in silico designed peptides for therapeutic applications.


Trends Biotechnol


Trends in biotechnology


Vanhee P,van der Sloot AM,Verschueren E,Serrano L,Rousseau F,Schymkowitz J




Has Abstract


2011-05-01 00:00:00














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    journal_title:Trends in biotechnology

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    authors: Weissman KJ

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  • Enzyme reactions in the presence of cyclodextrins: biosensors and enzyme assays.

    abstract::Cyclodextrins, macrocyclic carbohydrates with apolar internal cavities, can form complexes with, and solubilize many normally water-insoluble compounds. Ferrocene and its derivatives, tetrathiafulvalene and tetramethylbenzidine, can function as redox mediators, but are insoluble in water; when they are complexed with ...

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    authors: Luong JH,Brown RS,Male KB,Cattaneo MV,Zhao S

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    authors: Frenz J,Hancock WS

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    authors: O'Donovan C,Apweiler R,Bairoch A

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    authors: Velasco-Garcia MN,Mottram T

    更新日期:2001-11-01 00:00:00

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    authors: Rugh CL

    更新日期:2004-10-01 00:00:00

  • Imaging techniques in the analysis of brain function and behaviour.

    abstract::Techniques such as positron-emission tomography, single-photon-emission computed tomography, functional magnetic-resonance imaging and magnetoencephalography permit the observation of biological processes in the brain in a noninvasive manner. They have yielded new insights into the biological interrelations of sensory...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Müller-Gärtner HW

    更新日期:1998-03-01 00:00:00

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    authors: Fan C,Plaxco KW,Heeger AJ

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  • Sustainability considerations for integrated biorefineries.

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    authors: Rajkumar M,Ae N,Prasad MN,Freitas H

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    pub_type: 杂志文章,评审


    authors: McCarty NS,Ledesma-Amaro R

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    authors: Chung SY,Wong L

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    pub_type: 杂志文章,评审


    authors: van der Werf MJ,van den Tweel WJ,Kamphuis J,Hartmans S,de Bont JA

    更新日期:1994-03-01 00:00:00

  • Serum-free hybridoma culture: ethical, scientific and safety considerations.

    abstract::Despite considerable progress in the development of cell culture techniques, including the development of the serum- and protein-free media that now routinely support hybridoma and mammalian cell growth, fetal bovine serum (FBS) supplemented media are still commonly used: a practice that raises ethical, scientific and...

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    authors: Even MS,Sandusky CB,Barnard ND

    更新日期:2006-03-01 00:00:00

  • Rethinking production of Taxol® (paclitaxel) using endophyte biotechnology.

    abstract::Taxol® (generic name paclitaxel) represents one of the most clinically valuable natural products known to mankind in the recent past. More than two decades have elapsed since the notable discovery of the first Taxol®-producing endophytic fungus, which was followed by a plethora of reports on other endophytes possessin...

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  • Phase and antigenic variation--the impact on strategies for bacterial vaccine design.

    abstract::Many pathogens have the ability to vary the antigenic composition of surface-associated antigens. Often, this variation is mediated by the regulation of gene expression. By varying its antigenicity, the pathogen is able to avoid host immune responses more efficiently; however, this makes the design of vaccines against...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Maskell D,Frankel G,Dougan G

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  • Four-dimensional imaging: the exploration of space and time.

    abstract::The process of studying dynamic three-dimensional samples has a long history in biological research. Recent advances in hardware and software have made it easier to visualise and record interior detail from multiple focal planes of three-dimensional samples as they change over time (four-dimensional imaging). Once cap...

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    authors: Thomas CF,White JG

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  • Metabolic engineering of carotenoid biosynthesis in plants.

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    journal_title:Trends in biotechnology

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    authors: Giuliano G,Tavazza R,Diretto G,Beyer P,Taylor MA

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    abstract::Study of mutations that improve enzyme properties reveals that in many, but not all, cases closer mutations are more effective than distant ones. For enantioselectivity, substrate selectivity and new catalytic activity (catalytic promiscuity) closer mutations improved enzymes more effectively than distant ones. Howeve...

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  • Decellularized Extracellular Matrix for Bioengineering Physiomimetic 3D in Vitro Tumor Models.

    abstract::Recent advances in the extraction and purification of decellularized extracellular matrix (dECM) obtained from healthy or malignant tissues open new avenues for engineering physiomimetic 3D in vitro tumor models, which closely recapitulate key biomolecular hallmarks and the dynamic cancer cell-ECM interactions in the ...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Ferreira LP,Gaspar VM,Mano JF

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    abstract::The hand-held gene gun provides a rapid and efficient method of incorporating fluorescent dyes into cells, a technique that is becoming known as diolistics. Transporting fluorescent dyes into cells has, in the past, used predominantly injection or chemical methods. The use of the gene gun, combined with the new genera...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: O'Brien JA,Lummis SC

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    abstract::The mapping of the human genome was completed earlier this year and efforts are underway to understand the role of gene products (i.e. proteins) in biological pathways and human disease and to exploit their functional roles to derive protein therapeutics and protein-based drugs. A key component to the next revolution ...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Maggio ET,Ramnarayan K

    更新日期:2001-07-01 00:00:00

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    abstract::Predicting the future use of biocatalysts for the transformation of organic compounds--both natural substrates and other compounds--needs to take many factors into account. To date, relatively few biotransformations have been developed to the industrial scale, primarily because there has been little economic incentive...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Faber K,Franssen MC

    更新日期:1993-11-01 00:00:00

  • Mechatronics design principles for biotechnology product development.

    abstract::Traditionally, biotechnology design has focused on the manufacture of chemicals and biologics. Still, a majority of biotechnology products that appear on the market today is the result of mechanical-electric (mechatronic) construction. For these, the biological components play decisive roles in the design solution; th...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章


    authors: Mandenius CF,Björkman M

    更新日期:2010-05-01 00:00:00

  • Rehabilitation of adaptive immunity and regeneration of beta cells.

    abstract::Type 1 Diabetes (T1D) is an autoimmune disease resulting from the destruction of pancreatic insulin-producing beta cells that most frequently occurs in genetically predisposed children. Recent observations illustrating the regenerative capability of the endocrine pancreas in addition to advances in stem cell and gene ...

    journal_title:Trends in biotechnology

    pub_type: 杂志文章,评审


    authors: Pasquali L,Fan Y,Trucco M,Ringquist S

    更新日期:2006-11-01 00:00:00