Abstract:
:A 14-year-old female from Yemen presented with intense abdominal pain and headache. She was born at term to distant cousins, developmentally delayed and significantly dysmorphic. Four years ago, she was diagnosed with diabetes mellitus and undiagnosed hepatic, cardiac, genetic, neurologic, endocrine, musculoskeletal, and gastrointestinal disorders. No therapy was prescribed. Admission laboratory data showed blood glucose = 391 mg/dl, hemoglobin A1c= 12.2%, C-peptide = 3.5 ng/ml, insulin = 6.8 uIU/ml, triglyceride =385 mg/dl, and serum leptin <0.5 ng/ml, (1.1-27.5). Chromosome analysis (46, XX) was normal and serology for Glutamic acid Decarboxylase (GAD), hepatitis and HIV were negative. Clinical examination and laboratory data suggested congenital generalized lipodystrophy (CGL, type BSCL-2). This case illustrates that CGL should be in the differential diagnosis for non-obese patients with diabetes and insulin resistance.
journal_name
J Clin Res Pediatr Endocrinoljournal_title
Journal of clinical research in pediatric endocrinologyauthors
Roth T,Nair S,Kumar Adoi
10.4274/jcrpe.v2i4.176subject
Has Abstractpub_date
2010-01-01 00:00:00pages
176-9issue
4eissn
1308-5727issn
1308-5735journal_volume
2pub_type
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journal_title:Journal of clinical research in pediatric endocrinology
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journal_title:Journal of clinical research in pediatric endocrinology
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更新日期:2016-09-01 00:00:00
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journal_title:Journal of clinical research in pediatric endocrinology
pub_type: 杂志文章,多中心研究
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更新日期:2019-05-28 00:00:00
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journal_title:Journal of clinical research in pediatric endocrinology
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更新日期:2017-12-15 00:00:00
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journal_title:Journal of clinical research in pediatric endocrinology
pub_type: 杂志文章
doi:10.4274/Jcrpe.958
更新日期:2013-09-10 00:00:00
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journal_title:Journal of clinical research in pediatric endocrinology
pub_type: 杂志文章
doi:10.4008/jcrpe.v1i3.46
更新日期:2009-01-01 00:00:00
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journal_title:Journal of clinical research in pediatric endocrinology
pub_type: 杂志文章,评审
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更新日期:2017-12-30 00:00:00
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journal_title:Journal of clinical research in pediatric endocrinology
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journal_title:Journal of clinical research in pediatric endocrinology
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更新日期:2011-01-01 00:00:00
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journal_title:Journal of clinical research in pediatric endocrinology
pub_type: 杂志文章
doi:10.4008/jcrpe.v1i2.31
更新日期:2008-01-01 00:00:00
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journal_title:Journal of clinical research in pediatric endocrinology
pub_type: 杂志文章,评审
doi:10.4274/jcrpe.3209
更新日期:2016-12-01 00:00:00
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journal_title:Journal of clinical research in pediatric endocrinology
pub_type: 杂志文章
doi:10.4274/jcrpe.680
更新日期:2012-09-01 00:00:00
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journal_title:Journal of clinical research in pediatric endocrinology
pub_type: 杂志文章,随机对照试验
doi:10.4274/jcrpe.2136
更新日期:2016-03-05 00:00:00
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journal_title:Journal of clinical research in pediatric endocrinology
pub_type: 杂志文章
doi:10.4274/jcrpe.3873
更新日期:2017-09-01 00:00:00
abstract::Peutz-Jeghers syndrome (PJS) is inherited as an autosomal dominant trait characterized by multiple gastrointestinal hamartomatous polyps, mucocutaneous pigmentation, and an increased risk of neoplasm. Large-cell calcifying Sertoli cell tumor (LCCSCT) is a kind of sex cord-stromal tumor which may co-exist with PJS and ...
journal_title:Journal of clinical research in pediatric endocrinology
pub_type: 杂志文章
doi:10.4274/jcrpe.3625
更新日期:2017-06-01 00:00:00
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journal_title:Journal of clinical research in pediatric endocrinology
pub_type: 杂志文章
doi:10.4274/jcrpe.v3i2.20
更新日期:2011-01-01 00:00:00
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journal_title:Journal of clinical research in pediatric endocrinology
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2016-12-01 00:00:00
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journal_title:Journal of clinical research in pediatric endocrinology
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更新日期:2019-11-22 00:00:00
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journal_title:Journal of clinical research in pediatric endocrinology
pub_type: 杂志文章
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更新日期:2017-12-15 00:00:00
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journal_title:Journal of clinical research in pediatric endocrinology
pub_type: 杂志文章
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更新日期:2020-03-19 00:00:00
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journal_title:Journal of clinical research in pediatric endocrinology
pub_type: 杂志文章,多中心研究
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更新日期:2016-09-01 00:00:00
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journal_title:Journal of clinical research in pediatric endocrinology
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更新日期:2013-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2011-01-01 00:00:00
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更新日期:2020-10-13 00:00:00
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更新日期:2015-12-01 00:00:00
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journal_title:Journal of clinical research in pediatric endocrinology
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更新日期:2020-06-03 00:00:00