Abstract:
BACKGROUND:Several international clinical studies have found diamorphine treatment for opioid-dependent patients to show significantly better effects compared with methadone maintenance treatment. AIMS:This analysis of the German trial of heroin-assisted treatment investigates the effects on patients' health and drug use after switching from 12-month methadone to 12-month diamorphine treatment under similar study conditions. METHODS:For a period of 24 months, the state of health was explored using the Opiate Treatment Index (OTI) health scale and the Symptom Checklist-90-R (SCL-90-R), while drug use and social situation by an extended version of the European Addiction Severity Index (EuropASI) every 6 months. Changes in these criteria were tested for significance by repeated measures analyses. Of the 434 patients, who started the 2nd year of study treatment, 90 were methadone-diamorphine switchers, and 344 received diamorphine for 2 years. RESULTS:In the 2nd year, the methadone-diamorphine switchers succeed in catching up with the diamorphine patients. After switching to diamorphine, significant improvements in health and use of street heroin and cocaine were achieved during 1 year of diamorphine treatment. CONCLUSIONS:The results of the course of methadone-diamorphine switchers are a methodologically independent contribution toward confirming the positive effects of diamorphine treatment for difficult-to-treat opioid-dependent patients. This study supports the hypothesis that changing from optimized methadone treatment under the conditions of the clinical trial to diamorphine treatment is associated with improvements in health and drug use behavior. The study's limitations are noted.
journal_name
Subst Use Misusejournal_title
Substance use & misuseauthors
Verthein U,Haasen C,Reimer Jdoi
10.3109/10826084.2010.540624subject
Has Abstractpub_date
2011-01-01 00:00:00pages
980-91issue
8eissn
1082-6084issn
1532-2491journal_volume
46pub_type
杂志文章,随机对照试验abstract:BACKGROUND:Discrimination is detrimental to physical and mental health, particularly insofar as health-risk behaviors are concerned. Particular attention has been paid to excess alcohol consumption and smoking in view of the ready availability of these substances in Western societies. OBJECTIVES:To determine whether a...
journal_title:Substance use & misuse
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journal_title:Substance use & misuse
pub_type: 杂志文章
doi:10.3109/10826080009147700
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abstract::Introduction: As marijuana legalization progresses in the U.S., this study investigated the perceptions of marijuana use among non-college-educated young adult smokers. Methods: Twelve focus groups were conducted to explore themes related to marijuana and marijuana use among a racially and ethnically diverse sample of...
journal_title:Substance use & misuse
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journal_title:Substance use & misuse
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doi:10.1080/10826084.2019.1660677
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abstract::In recent decades, methamphetamine developed a peculiar geographic distribution in the United States, with limited diffusion in the Northeast. While use within gay clubs received attention, methamphetamine in club subcultures more broadly remains less clear. Using quantitative and qualitative data, we provide a descri...
journal_title:Substance use & misuse
pub_type: 杂志文章
doi:10.3109/10826084.2013.808217
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abstract:BACKGROUND:While there is evidence for socioeconomic inequalities in some adolescent substance use behaviors, there is limited information on how socioeconomic inequalities compare across European countries and over time. OBJECTIVES:To compare socioeconomic inequalities in problematic adolescent substance use (regular...
journal_title:Substance use & misuse
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abstract::The upsurge of consumption of party drugs among adolescents in recent years in Hong Kong has been part of the global trend of adolescent recreational use of drugs at rave parties, discos and similar party settings. Scholars in Western societies have recently proposed the thesis of "normalization of adolescent drug use...
journal_title:Substance use & misuse
pub_type: 杂志文章
doi:10.1080/10826080601026019
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journal_title:Substance use & misuse
pub_type: 杂志文章
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abstract::Background: Research has demonstrated consistent associations between anxiety and illicit drug use. However, few studies to date have examined the shared risk factors that may contribute to this common comorbidity. Therefore, the current investigation tested the indirect effect of trait anxiety on drug use disorder sy...
journal_title:Substance use & misuse
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abstract::Given the feminization of the HIV epidemic in India and Bangladesh, understanding substance-use-related concerns among women is important for effective HIV prevention. This review is based on published research, reports (2000-2005), and primary data from treatment centers for drug-using women. We identify four main th...
journal_title:Substance use & misuse
pub_type: 杂志文章,评审
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abstract::A study was conducted in June 2004 to find out the epidemiology of HIV infection among injecting drug users (IDUs) of Darjeeling District of West Bengal, eastern India. The district headquarter, Darjeeling town, also known as "Queen of Hills," is a beautiful spot situated in Himalayan West Bengal that attracts a large...
journal_title:Substance use & misuse
pub_type: 杂志文章
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abstract::Three large U.S. epidemiological surveys researching the prevalence of comorbid psychiatric illness and "substance abuse disorders" are reviewed: the Epidemiological Catchment Area Study, (N=20,219); the National Comorbidity Survey (N=8098), and the National Longitudinal Alcohol Epidemiological Survey (N=42,862). Find...
journal_title:Substance use & misuse
pub_type: 杂志文章
doi:10.1081/ja-120004178
更新日期:2002-06-01 00:00:00
abstract::Background: Cannabis use is widely perceived to produce an "amotivational syndrome" characterized by reduced desire to work or compete, passivity, and lower achievement orientation. The notion that cannabis diminishes motivation has been perpetuated in popular culture, despite the equivocal results of past research. M...
journal_title:Substance use & misuse
pub_type: 杂志文章
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abstract::Employment enhances the outcomes of substance dependency treatment. Unfortunately, although unemployed methadone treatment patients frequently state they are interested in a job, many fail to participate in vocational services when available. Unless patients become engaged, vocational services do not have an opportuni...
journal_title:Substance use & misuse
pub_type: 杂志文章
doi:10.1080/10826080500411551
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abstract::This study assessed the relationship between community characteristics and alcohol use among 6,636 youth, aged from 14 to 20, in 2004. After adjusting for individual-level characteristics, youth from communities with a greater proportion of grandparents as caregivers, larger numbers of married couple families, and hig...
journal_title:Substance use & misuse
pub_type: 杂志文章
doi:10.1080/10826080802347594
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abstract::This paper reports on the effects of Hurricanes Katrina and Rita on drug and alcohol treatment in Texas in 2005-2006. Findings are based on a secondary analysis of administrative data on 567 hurricane-related admissions and on interview data from a sample of 20 staff in 11 treatment programs. Katrina evacuees differed...
journal_title:Substance use & misuse
pub_type: 杂志文章
doi:10.3109/10826080902962011
更新日期:2009-01-01 00:00:00
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journal_title:Substance use & misuse
pub_type: 杂志文章
doi:10.3109/10826089709027316
更新日期:1997-04-01 00:00:00
abstract::The present study examined the role of distress tolerance (DT) and race in relation to cigarette smoking. For this study, between 2008 and 2010, 153 women (62.1% White, 37.9% African American) from the Washington, DC metropolitan area completed a computerized behavioral DT task and self-reported smoking history. Resul...
journal_title:Substance use & misuse
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journal_title:Substance use & misuse
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journal_title:Substance use & misuse
pub_type: 杂志文章
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journal_title:Substance use & misuse
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journal_title:Substance use & misuse
pub_type: 杂志文章
doi:10.1080/10826084.2017.1318148
更新日期:2017-12-06 00:00:00
abstract::This paper presents a qualitative investigation of peer mentoring among HIV seropositive injection drug users in a randomized controlled trial, the INSPIRE study. Qualitative analyses of 68 in-depth open-ended interviews conducted in 2005 in Baltimore, New York, Miami, and San Francisco revealed that these individuals...
journal_title:Substance use & misuse
pub_type: 杂志文章
doi:10.3109/10826084.2012.644122
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to assess differences in the prevalence of HIV and HCV infection and associated risk factors between new (injecting for ≤5 years) and long-term injectors and to estimate HIV/HCV incidence among new injectors. METHODS:Cross-sectional study among people who inject drugs (PWID) who at...
journal_title:Substance use & misuse
pub_type: 杂志文章
doi:10.3109/10826084.2015.1092991
更新日期:2016-01-28 00:00:00
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journal_title:Substance use & misuse
pub_type: 杂志文章
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