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Circulating 25-hydroxyvitamin D levels and frailty in older men: the osteoporotic fractures in men study.

Abstract：

OBJECTIVES:To determine the cross-sectional and longitudinal associations between 25-hydroxyvitamin D (25(OH)D) levels and frailty status in older men. DESIGN:Prospective cohort study. SETTING:Six U.S. community-based centers. PARTICIPANTS:One thousand six hundred six men aged 65 and older. MEASUREMENTS:25(OH)D (liquid chromatography tandem mass spectroscopy) and frailty status (criteria similar to those used in the Cardiovascular Health Study) measured at baseline; frailty status assessment repeated an average of 4.6 years later. Frailty status was classified as robust, intermediate, or frail at baseline and robust, intermediate, frail, or dead at follow-up. RESULTS:After adjusting for multiple potential confounders, men with 25(OH)D levels less than 20.0 ng/mL had 1.5 times higher odds (multivariate odds ratio (MOR)=1.47, 95% confidence interval (CI)=1.07-2.02) of greater frailty status at baseline than men with 25(OH)D levels of 30.0 ng/mL or greater (referent group), whereas frailty status was similar in men with 25(OH)D levels from 20.0 to 29.9 ng/mL and those with levels of 30.0 ng/mL or greater (MOR=1.02, 95% CI=0.78-1.32). However, in 1,267 men not classified as frail at baseline, there was no association between lower baseline 25(OH)D level and odds of greater frailty status at the 4.6-year follow-up. Findings were the same when 25(OH)D was expressed in quartiles or as a continuous variable. CONCLUSION:Lower levels of 25(OH)D (<20.0 ng/mL) in community-dwelling older men were independently associated with greater evidence of frailty at baseline but did not predict greater risk of greater frailty status at 4.6 years.

journal_name

J Am Geriatr Soc

journal_title

Journal of the American Geriatrics Society

authors

Ensrud KE,Blackwell TL,Cauley JA,Cummings SR,Barrett-Connor E,Dam TT,Hoffman AR,Shikany JM,Lane NE,Stefanick ML,Orwoll ES,Cawthon PM,Osteoporotic Fractures in Men Study Group.

doi

10.1111/j.1532-5415.2010.03201.x

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

101-6

issue

eissn

0002-8614

issn

1532-5415

journal_volume

pub_type

杂志文章,多中心研究

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Circulating 25-hydroxyvitamin D levels and frailty in older men: the osteoporotic fractures in men study.