Abstract：
:Mammalian Na+/H+ exchangers (NHEs) play a fundamental role in cellular ion homeostasis. NHEs exhibit an appreciable variation in expression, regulation, and physiological function, dictated by their dynamics in subcellular localization and/or interaction with regulatory proteins. In recent years, a subgroup of NHEs consisting of four isoforms has been identified, and its members predominantly localize to the membranes of the Golgi apparatus and endosomes. These organellar NHEs constitute a family of transporters with an emerging function in the regulation of luminal pH and in intracellular membrane trafficking as expressed, for example, in cell polarity development. Moreover, specific roles of a variety of cofactors, regulating the intracellular dynamics of these transporters, are also becoming apparent, thereby providing further insight into their mechanism of action and overall functioning. Interestingly, organellar NHEs have been related to mental disorders, implying a potential role in the brain, thus expanding the physiological significance of these transporters.
journal_name
Biochemistryjournal_title
Biochemistryauthors
Ohgaki R,van IJzendoorn SC,Matsushita M,Hoekstra D,Kanazawa Hdoi
10.1021/bi101082esubject
Has Abstractpub_date
2011-02-01 00:00:00pages
443-50issue
4eissn
0006-2960issn
1520-4995journal_volume
50pub_type
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