Kaposi's sarcoma in two primary liver allograft recipients occurring under FK506 immunosuppression.

Abstract:

:Of 1463 liver allograft recipients receiving the combination of FK506 and steroids as their primary immunosuppressive regimen, 2 patients developed Kaposi's sarcoma. Although previously described as a complication of organ transplantation, this is the first case report of Kaposi's sarcoma occurring in association with the macrolide immunosuppressive agent FK506. A discussion of the clinical presentation and course of Kaposi's sarcoma in these 2 patients, as well as a review of the past literature on Kaposi's sarcoma in organ transplant recipients, emphasizes the therapeutic difficulties encountered. Kaposi's sarcoma is also compared to lymphoproliferative disorders, another well-recognized complication of immunosuppression, highlighting the differences between these two entities.

journal_name

Clin Transplant

journal_title

Clinical transplantation

authors

Kadry Z,Bronsther O,Van Thiel DH,Randhawa P,Fung JJ,Starzl TE

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

188-194

eissn

0902-0063

issn

1399-0012

journal_volume

7

pub_type

杂志文章
  • Histological features of renal allograft biopsies in ABO minor-mismatched kidney transplantation.

    abstract::We examined histological features of allograft biopsies in ABO minor-mismatched kidney transplantation. Forty-five patients who underwent ABO minor-mismatched kidney transplantation between September 1999 and December 2001 at our institute. The mean age was 32.6 years, with 28 males and 17 females. We divided them int...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.17.s10.1.x

    authors: Shimizu T,Tanabe K,Tokumoto T,Shimmura H,Ishikawa N,Ishida H,Toma H,Kawaguchi H,Tokiwa M,Yamaguchi Y

    更新日期:2003-01-01 00:00:00

  • Depletion of natural antibodies in non-human primates--a step towards successful discordant xenografting in humans.

    abstract::There is evidence to suggest that long-term survival of discordant xenografts may be possible if the organ is transplanted at a time when the host natural anti-species (xenoreactive) antibodies are temporarily absent or otherwise inhibited from reacting with the donor antigens. There is also evidence that the target ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:

    authors: Cooper DK

    更新日期:1992-06-01 00:00:00

  • Outcomes, complications, and economic impact of ABO-incompatible living kidney transplantation: A single-center Japanese cohort study.

    abstract::ABO-incompatible kidney transplantation (ABO-ILKT) has been reported to have a higher rate of early complications and higher medical costs than ABO-compatible kidney transplantation (ABO-CLKT). We aimed to compare the clinical outcomes, complications, and medical costs between ABO-ILKTs and ABO-CLKTs at 2 years post-t...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/ctr.13591

    authors: Kakuta Y,Okumi M,Unagami K,Iizuka J,Takagi T,Ishida H,Tanabe K

    更新日期:2019-06-01 00:00:00

  • Use of enteric-coated mycophenolate sodium in liver transplant patients with intestinal intolerance caused by mycophenolate mofetil.

    abstract:BACKGROUND:Post-transplant gastrointestinal (GI) side effects can impair a patient's quality of life (QoL). This study investigates the improvement in GI side effects and related QoL changes in recipients of liver transplantation (OLT) after converting patients from mycophenolate mofetil (MMF) to enteric-coated mycophe...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1399-0012.2009.01019.x

    authors: Doria C,Ramirez CB,Frank AM,Vaccino S,Fraser N,Marino IR

    更新日期:2009-11-01 00:00:00

  • Influence of immunosuppressive regimens on short-term morbidity and mortality in heart transplantation.

    abstract:BACKGROUND:The goal of immunosuppressive therapy in heart transplantation is to maximize safety and efficacy while minimizing morbidity and mortality. We now have numerous drug combinations, but few have been compared with each other. AIM:To compare various immunosuppressive regimens assessing morbidity and mortality ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2007.00751.x

    authors: Aguero J,Almenar L,Martínez-Dolz L,Moro JA,Rueda J,Raso R,Chamorro C,Sanchez JM,Salvador A

    更新日期:2008-01-01 00:00:00

  • Renal allograft outcomes following early corticosteroid withdrawal in Hispanic transplant recipients.

    abstract:BACKGROUND:Renal transplant outcomes in Hispanics have been conflicting regarding acute rejection (AR) and allograft survival. Additionally, the feasibility of early corticosteroid withdrawal (ECW) regimens among Hispanics has not been adequately addressed. The purpose of this study is to report outcomes following ECW ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12218

    authors: Afaneh C,Cheng E,Aull MJ,Watkins AC,Kim J,Leeser DB,Kapur S

    更新日期:2013-11-01 00:00:00

  • Short- and midterm results for internal jugular vein extension for short right renal vein kidney transplant.

    abstract::Renal transplantation remains the definitive treatment for end-stage renal disease (ESRD). The shorter renal vein in right donor nephrectomies is associated with higher incidence of technical failure. We present here our experience with autologous internal jugular vein (IJV) conduits to facilitate living-donor transpl...

    journal_title:Clinical transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/ctr.13312

    authors: Lu T,Yi SG,Bismuth J,Knight RJ,Gaber AO,Bechara CF

    更新日期:2018-08-01 00:00:00

  • The impact of intraoperative fluid management during laparoscopic donor nephrectomy on donor and recipient outcomes.

    abstract:BACKGROUND:Intraoperative fluid management during laparoscopic donor nephrectomy (LDN) may have a significant effect on donor and recipient outcomes. We sought to quantify variability in fluid management and investigate its impact on donor and recipient outcomes. METHODS:A retrospective review of patients who underwen...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13542

    authors: Williams AM,Kumar SS,Bhatti UF,Biesterveld BE,Kathawate RG,Sung RS,Woodside KJ,Englesbe MJ,Alameddine MB,Waits SA

    更新日期:2019-06-01 00:00:00

  • The profile of inflammatory and metabolic response in children undergoing heart transplantation.

    abstract::Inflammatory and metabolic response is an important factor to determine clinical outcomes. However, it remains unknown in children undergoing heart transplantation (HTx). We examined the perioperative changes in the inflammatory and metabolic response markers C-reactive protein (CRP) and prealbumin (PA) in 38 heart-tr...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2011.01566.x

    authors: Yu X,Larsen B,Urschel S,Cheung PY,Ross DB,Rebeyka I,West L,Li J

    更新日期:2012-03-01 00:00:00

  • Chronic allograft nephropathy--a clinical syndrome: early detection and the potential role of proliferation signal inhibitors.

    abstract::Chronic allograft nephropathy (CAN) leads to the majority of late graft loss following renal transplantation. Detection of CAN is often too late to permit early intervention and successful management. Most current strategies for managing CAN rely on minimizing or eliminating calcineurin inhibitors (CNIs) once CAN has ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-0012.2009.01057.x

    authors: Campistol JM,Boletis IN,Dantal J,de Fijter JW,Hertig A,Neumayer HH,Oyen O,Pascual J,Pohanka E,Ruiz JC,Scolari MP,Stefoni S,Serón D,Sparacino V,Arns W,Chapman JR

    更新日期:2009-11-01 00:00:00

  • Sirolimus-based rescue therapy after rejection in liver transplantation.

    abstract::Steroid-resistant acute rejection (SR-AR) and ductopenic rejection (DR) after liver transplantation are infrequent, but difficult to manage. We performed a retrospective review of patients with SR-AR or DR treated with sirolimus-based therapy. Since 2002, we have treated five patients with SR-AR and eight patients wit...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2008.00906.x

    authors: Lladó L,Fabregat J,Castellote J,Ramos E,Torras J,Serrano T,Figueras J,Rafecas A

    更新日期:2009-01-01 00:00:00

  • Thrombotic microangiopathy after liver-small bowel transplant.

    abstract::We herein report the first case of immunosuppression-associated thrombotic microangiopathy (TMA) in which an extrarenal graft was primarily affected by the characteristic microvascular lesions. Although TMA is a well-known complication of cyclosporine (CSA) or tacrolimus therapy in renal and extrarenal (liver, heart, ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Humar A,Jessurun J,Sharp HL,Gruessner RW

    更新日期:1998-12-01 00:00:00

  • Microemulsion technology in the reformulation of cyclosporine: the reason behind the pharmacokinetic properties of Neoral.

    abstract::Management of transplant patients receiving cyclosporine therapy is complicated by interpatient and intrapatient variability in pharmacokinetic parameters caused by the drug's unpredictable bioavailability. Cyclosporine, a highly lipophilic cyclic polypeptide, has recently been reformulated using a microemulsion deliv...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,评审

    doi:

    authors: Ritschel WA

    更新日期:1996-08-01 00:00:00

  • Clinical analysis of living donor liver transplantation in patients with portal vein thrombosis.

    abstract::The aim of this study was to improve outcomes in living donor liver transplantation (LDLT) patients with portal vein thrombosis (PVT). Of 246 adult patients who underwent LDLT with a right lobe graft between January 2000 and May 2007, PVT was diagnosed in 50 patients (20.3%), who were further subdivided into partial (...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2010.01217.x

    authors: Kim SJ,Kim DG,Park JH,Moon IS,Lee MD,Kim JI,Yoon YC,Yoo YK

    更新日期:2011-01-01 00:00:00

  • Bosentan in heart transplantation candidates with severe pulmonary hypertension: efficacy, safety and outcome after transplantation.

    abstract:BACKGROUND:Increased pulmonary vascular resistance (PVR) is associated with increased right ventricular failure and mortality after heart transplantation. METHODS:In this prospective study, 22 patients considered high-risk candidates for heart transplantation because of severe pulmonary hypertension (PVR = 6 ± 2 Wood ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2012.01689.x

    authors: Perez-Villa F,Farrero M,Cardona M,Castel MA,Tatjer I,Penela D,Vallejos I

    更新日期:2013-01-01 00:00:00

  • Diagnosis of kidney transplant obstruction using Mag3 diuretic renography.

    abstract::Kidney transplant obstruction (KTO) following renal transplantation remains an important reversible cause of allograft dysfunction, requiring prompt diagnosis to prevent long-term graft damage. Although ultrasound can accurately diagnose renal transplant hydronephrosis, it cannot be used to assess its functional signi...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2001.150103.x

    authors: Nankivell BJ,Cohn DA,Spicer ST,Evans SG,Chapman JR,Gruenewald SM

    更新日期:2001-02-01 00:00:00

  • Impact of dose reductions on efficacy outcome in heart transplant patients receiving enteric-coated mycophenolate sodium or mycophenolate mofetil at 12 months post-transplantation.

    abstract::Mycophenolic acid (MPA) dose reduction is associated with increased risk of rejection and graft loss in renal transplantation. This analysis investigated the impact of MPA dose changes with enteric-coated mycophenolate sodium (EC-MPS) or mycophenolate mofetil (MMF) in de novo heart transplant recipients. In a 12-month...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1399-0012.2008.00887.x

    authors: Segovia J,Gerosa G,Almenar L,Livi U,Viganò M,Arizón JM,Yonan N,Di Salvo TG,Renlund DG,Kobashigawa JA,ERL 2401 Study Group.

    更新日期:2008-11-01 00:00:00

  • Mast cell phenotypes in the allograft after lung transplantation.

    abstract:BACKGROUND:The burden of mast cell (MC) infiltration and their phenotypes, MC-tryptase (MCT ) and MC-tryptase/chymase (MCTC ), after lung transplantation (LT) has not been evaluated in human studies. METHODS:We reviewed 20 transbronchial lung biopsy (TBLB) specimen from patients with early normal allograft (<6 months ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12758

    authors: Banga A,Han Y,Wang X,Hsieh FH

    更新日期:2016-07-01 00:00:00

  • Limitations of pediatric donor kidneys for transplantation.

    abstract:BACKGROUND:The shortage of grafts for kidney transplantation (Tx) has resulted in an expansion of criteria for pediatric donors. However, the limitations of pediatric donors for kidney Tx are not yet clearly established. We investigated the outcomes of recipients with pediatric kidney grafts from Colorado to elucidate ...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:

    authors: Yagisawa T,Kam I,Chan L,Springer JW,Dunn S

    更新日期:1998-12-01 00:00:00

  • Epidemiology, risk factors, and impact of bacterial infections on outcomes for pancreatic grafts.

    abstract::We aimed to determine the epidemiology, risk factors, and impact of bacterial infection on pancreatic function after pancreas transplantation. Data for pancreas transplant recipients were retrospectively reviewed between 2000 and 2014 for at least 1 year. We collected and analyzed post-transplant data for bacterial in...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13333

    authors: Bodro M,Ferrer J,Ricart MJ,Sanclemente G,Linares L,Cervera C,Cofan F,Ventura-Aguiar P,Lopez-Boado MÁ,Marco F,Fuster J,García-Valdecasas JC,Moreno A

    更新日期:2018-08-01 00:00:00

  • Psychosocial outcome of living donors after living donor liver transplantation: a pilot study.

    abstract::In view of the scarcity of organ resources available for transplantation, living donor liver transplantation (LDLT) is gaining growing importance in the treatment of chronically terminal liver diseases. In the period between December 1999 and October 2000, 47 potential living liver donors were evaluated and 24 right h...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2002.02002.x

    authors: Walter M,Bronner E,Pascher A,Steinmüller T,Neuhaus P,Klapp BF,Danzer G

    更新日期:2002-10-01 00:00:00

  • Low-dose basiliximab induction therapy in heart transplantation.

    abstract::We prospectively studied efficacy and safety outcomes of two 10-mg doses of intravenous basiliximab on day 0 and day 4 for induction therapy in 17 consecutive de novo heart transplant recipients. By the 2-week assessment post-transplant, there were no deaths, graft failures, or acute cellular rejections (ACRs) ISHLT g...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.13132

    authors: Kittipibul V,Tantrachoti P,Ongcharit P,Ariyachaipanich A,Siwamogsatham S,Sritangsirikul S,Thammanatsakul K,Puwanant S

    更新日期:2017-12-01 00:00:00

  • Serum globulin levels in predicting the extent of hepatic fibrosis in patients with recurrent post-transplant hepatitis C infection.

    abstract::The progression of HCV-related disease is particularly aggressive in the post-transplantation setting. Recipients with recurrent HCV infection undergo repeated liver biopsies in order to estimate disease progression. A strong association was found between serum immunoglobulins levels and hepatic fibrosis in non-transp...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2007.00657.x

    authors: Schmilovitz-Weiss H,Cohen M,Pappo O,Sulkes J,Braun M,Tur-Kaspa R,Ben-Ari Z

    更新日期:2007-05-01 00:00:00

  • Living-donor liver transplantation for congenital biliary atresia with porto-pulmonary hypertension and moderate or severe pulmonary arterial hypertension: Kyoto University experience.

    abstract::Porto-pulmonary hypertension with moderate or severe pulmonary arterial hypertension (PAH) is viewed as a contraindication to liver transplantation (LT) because of associated poor outcomes; however, patients with biliary atresia (BA) are generally good candidates for LT. Ten patients with moderate/severe PAH underwent...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12415

    authors: Ogawa E,Hori T,Doi H,Segawa H,Uemoto S

    更新日期:2014-09-01 00:00:00

  • A randomized trial of thymoglobulin vs. alemtuzumab (with lower dose maintenance immunosuppression) vs. daclizumab in renal transplantation at 24 months of follow-up.

    abstract:INTRODUCTION:A long-term prospective randomized trial evaluating alemtuzumab, a humanized anti-CD52 monoclonal antibody, in a predominantly non-Caucasian population has yet to be reported. METHODS:Ninety deceased donor (DD) first renal transplant recipients were randomized into three different antibody induction group...

    journal_title:Clinical transplantation

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1399-0012.2007.00774.x

    authors: Ciancio G,Burke GW,Gaynor JJ,Roth D,Kupin W,Rosen A,Cordovilla T,Tueros L,Herrada E,Miller J

    更新日期:2008-03-01 00:00:00

  • The use of flow cytometry for the detection of CMV-specific antigen (pp65) in leukocytes of kidney recipients.

    abstract::Flow cytometric assay (FCA) was used to detect a cytomegalovirus (CMV) specific antigen (pp65) in CMV-infected fibroblast cells and in leukocytes of kidney recipients. FCA distinguished clearly between the infected and non-infected fibroblast cells. Regarding transplant patients, the FCA was positive when the number o...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2000.140208.x

    authors: Essa S,Pacsa AS,Al-Attiyah R,El-Shazly A,Raghupathy R,Said T

    更新日期:2000-04-01 00:00:00

  • Hyperhomocysteinemia and transplant coronary artery disease in cardiac transplant recipients.

    abstract:BACKGROUND:In cardiac transplant recipients, long-term survival may be limited by transplant coronary artery disease (TxCAD). Hyperhomocysteinemia (Hhcy) has been associated with vascular disease and is common in transplant recipients. The objective of this study was to determine the relationship between fasting homocy...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-0012.2001.150407.x

    authors: Miner SE,Cole DE,Evrovski J,Verma A,Daly PA,Ross HJ

    更新日期:2001-08-01 00:00:00

  • Long-term outcomes of dual kidney transplantation-a single center experience.

    abstract::The shortage of kidney donors has led to broadening of the acceptance criteria for deceased donor organs beyond the traditional use of young donors. We determined long-term post-transplant outcomes in recipients of dual expanded criteria donor kidneys (dECD, n = 44) and compared them to recipients of standard criteria...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-0012.2009.00956.x

    authors: Salifu MO,Norin AJ,O'Mahony C,Sumrani N,Apel A,Ikram M,Alam A,Hayat A,Jindal RM,Friedman EA,Distant DA

    更新日期:2009-06-01 00:00:00

  • Autoimmunity after liver transplantation: a frequent event but a rare clinical problem.

    abstract::Autoantibodies are frequently detected after liver transplantation (LT), but their role is unclear. This study was designed to address three points: autoantibody prevalence pre-LT and over time up to five yr after LT, identification of possible predictors of autoantibody formation, and correlation between autoantibodi...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1111/ctr.12498

    authors: Foschi A,Zavaglia CA,Fanti D,Mazzarelli C,Perricone G,Vangeli M,Viganò R,Belli LS

    更新日期:2015-02-01 00:00:00

  • Immunization by blood-type antigen in human immunoglobulin products before ABO-incompatible kidney transplantation.

    abstract::A 29-year-old man wanted to receive an ABO-incompatible kidney transplant. His blood type was O, and the donor, his father, was A1. After endoscopic splenectomy performed before kidney transplantation, the recipient developed a high fever and leukocytosis, and he was treated with antibiotics and 5 g of human immunoglo...

    journal_title:Clinical transplantation

    pub_type: 杂志文章

    doi:10.1046/j.1399-0012.2003.00144.x

    authors: Sawada T,Ando T,Sato S,Kubota K,Fuchinoue S,Teraoka S

    更新日期:2004-04-01 00:00:00