Natural agents: cellular and molecular mechanisms of photoprotection.

Abstract:

:The skin is the largest organ of the body that produces a flexible and self-repairing barrier and protects the body from most common potentially harmful physical, environmental, and biological insults. Solar ultraviolet (UV) radiation is one of the major environmental insults to the skin and causes multi-tiered cellular and molecular events eventually leading to skin cancer. The past decade has seen a surge in the incidence of skin cancer due to changes in life style patterns that have led to a significant increase in the amount of UV radiation that people receive. Reducing excessive exposure to UV radiation is desirable; nevertheless this approach is not easy to implement. Therefore, there is an urgent need to develop novel strategies to reduce the adverse biological effects of UV radiation on the skin. A wide variety of natural agents have been reported to possess substantial skin photoprotective effects. Numerous preclinical and clinical studies have elucidated that natural agents act by several cellular and molecular mechanisms to delay or prevent skin cancer. In this review article, we have summarized and discussed some of the selected natural agents for skin photoprotection.

journal_name

Arch Biochem Biophys

authors

Afaq F

doi

10.1016/j.abb.2010.12.007

subject

Has Abstract

pub_date

2011-04-15 00:00:00

pages

144-51

issue

2

eissn

0003-9861

issn

1096-0384

pii

S0003-9861(10)00503-5

journal_volume

508

pub_type

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