Eternacept for the treatment of patients with rheumatoid arthritis and concurrent interstitial lung disease.


WHAT IS KNOWN AND OBJECTIVE:Tumour necrosis factor-α (TNF-α)-blocking agents are increasingly used in the management of refractory rheumatoid arthritis (RA). Although effective, they are associated with rare but potentially fatal adverse effects, including interstitial lung disease (ILD). In patients with pre-existing ILD, eternacept (ETN) monotherapy is often regarded as a suitable choice. Other anti-TNF-α blockers such as infliximab and adalimumab, are used in combination therapy with methotrexate (MTX) in most of the cases. We report on a case of fatal exacerbation of ILD in a patient given ETN monotherapy and review the literature on ETN-associated ILD. METHODS:We report on a case of a 75-year-old male with RA who developed severe ILD after the introduction of ETN, and we undertook a literature search to identify other reports of similar cases. We then critically assessed those reports. RESULTS AND DISCUSSION:In addition to our case, 11 other patients have been reported to have developed ILD in association with the use of ETN. Six patients had pre-existing ILD. Although four patients received MTX, eight patients developed severe ILD without MTX. Ten patients recovered after termination of ETN, although two patients died. WHAT IS NEW AND CONCLUSION:Although ETN is often regarded as safe for patients with ILD, our case and the literature reports suggest that caution is still required.


J Clin Pharm Ther


Horai Y,Miyamura T,Shimada K,Takahama S,Minami R,Yamamoto M,Suematsu E




Has Abstract


2012-02-01 00:00:00












  • Valproate population pharmacokinetics in children.

    abstract:OBJECTIVE:A population analysis of the kinetics of valproic acid (VPA) in children with epilepsy was performed in order to characterize the covariates which influence VPA clearance (CL). METHODS:A total of 770 steady-state serum concentration samples was analysed. These were collected during VPA therapy from 255 child...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Serrano BB,García Sánchez MJ,Otero MJ,Buelga DS,Serrano J,Domínguez-Gil A

    更新日期:1999-02-01 00:00:00

  • Semi-mechanistic autoinduction model of midazolam in critically ill patients: population pharmacokinetic analysis.

    abstract:WHAT IS KNOWN AND OBJECTIVE:Midazolam (MDZ) is commonly used for sedating critically ill patients. The daily dose required for adequate sedation increases in increments over 100 h after administration. The objectives of this study were to characterize the MDZ pharmacokinetics in critically ill patients and to describe ...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Aoyama T,Hirata K,Yamamoto Y,Yokota H,Hayashi H,Aoyama Y,Matsumoto Y

    更新日期:2016-08-01 00:00:00

  • A phase I trial assessing the safety, tolerability, pharmacokinetic and pharmacodynamic characteristics of single-dose Auron Misheil therapy in healthy male subjects.

    abstract:BACKGROUND AND OBJECTIVE:Auron Misheil therapy (AMT) is a combination of widely used pharmaceuticals and herbal components that has been used since the 1980s as a supportive therapy, mainly in end-stage cancer patients on a compassionate basis. This phase I study was conducted to assess the safety, tolerability, and ph...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Scheele J,Diergarten K,Drevs J,Niazi FR

    更新日期:2013-02-01 00:00:00

  • Omission of aspirin in patients following coronary artery bypass graft surgery.

    abstract::Graft patency is a major factor contributing to the long-term results of coronary artery bypass graft (CABG) surgery. The systematic overview of the Antiplatelet Trialists' Collaboration provides unequivocal evidence that antiplatelet therapy reduces by nearly one-half the odds of coronary graft occlusion following CA...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Galea J,Manché A,Goiti JJ,Locke TJ,Wilkinson GA,Smith GH

    更新日期:1994-12-01 00:00:00

  • Isradipine.

    abstract::Isradipine is a potent dihydropyridine calcium channel blocker. It is highly selective for vascular smooth muscle, with very few negative inotropic or chronotropic effects. It may have minor depressant effects on the sinoatrial node, hence reducing the incidence of reflex tachycardia. The drug is extensively metaboliz...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 临床试验,杂志文章,评审


    authors: Schachter M

    更新日期:1991-04-01 00:00:00

  • Potential novel targets for Alzheimer pharmacotherapy: I. Secretases.

    abstract::The prevailing major theory of Alzheimer's disease (AD) is that insoluble amyloid beta-peptide (Abeta) found in the cerebral plaques characteristic of the disease is causative or is at least a contributing factor. According to this theory, inhibition of aberrant Abeta production should prevent or at least limit the ex...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章,评审


    authors: Maiorini AF,Gaunt MJ,Jacobsen TM,McKay AE,Waldman LD,Raffa RB

    更新日期:2002-06-01 00:00:00

  • Pharmacokinetics of midazolam tablet in different Chinese ethnic groups.

    abstract:WHAT IS KNOWN AND OBJECTIVES:Subjects of different ethnic groups may respond differently to drugs. The present study was conducted to compare the oral pharmacokinetics of midazolam among healthy volunteers from five different ethnic groups in China: Han, Mongolian, Uygur, Hui and Korean. METHODS:Healthy volunteers (10...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 临床试验,杂志文章


    authors: Guo T,Mao GF,Xia DY,Su XY,Zhao LS

    更新日期:2011-06-01 00:00:00

  • Lithium reduces maternal child abuse behaviour: a preliminary report.

    abstract:OBJECTIVE:To find out in child abusing mothers whether aggressiveness in general, but which is directed towards their children in particular, could be reduced by giving lithium. METHOD:An open trial of lithium in eight child-abusing mothers. Assessment of aggression using Yudofsky's Overt Aggression Scale. RESULTS:Th...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 临床试验,杂志文章


    authors: do Prado-Lima P,Knijnik L,Juruena M,Padilla A

    更新日期:2001-08-01 00:00:00

  • Minimizing antipsychotic medication obviated the need for enema against severe constipation leading to paralytic ileus: a case report.

    abstract:OBJECTIVE:To report the usefulness of antipsychotic dose-reduction for avoiding paralytic ileus in a patient with chronic schizophrenia and comorbid dementia. CASE SUMMARY:A 65-year-old in-patient developed severe paralytic ileus warranting a transfer to the general hospital. Constipation was very troublesome and he o...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Suzuki T,Uchida H,Watanabe K,Kashima H

    更新日期:2007-10-01 00:00:00

  • Pharmacokinetics and safety of bromotetrandrine (BrTet, W198) after single-dose intravenous administration in healthy Chinese volunteers.

    abstract:OBJECTIVE:To investigate the safety and pharmacokinetics of bromotetrandrine (BrTet, W198), a novel inhibitor of P-glycoprotein (P-gp), after single-dose i.v. infusion in healthy Chinese volunteers. METHODS:We conducted a randomized, dose-escalating, phase I clinical study for that purpose. Thirty healthy subjects rec...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章,随机对照试验


    authors: Zheng L,Qing YP,Xu N,Yu Q,Wang Y,Wang FP,Li ZY

    更新日期:2010-02-01 00:00:00

  • Baking soda misuse as a home remedy: case experience of the California Poison Control System.

    abstract:WHAT IS KNOWN AND OBJECTIVE:Baking soda is a common household product promoted by the manufacturer as an antacid. It contains sodium bicarbonate and has the potential for significant toxicity when ingested in excessive amounts. Characterizing the patterns and outcomes from the misuse of baking soda as a home remedy can...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Al-Abri SA,Kearney T

    更新日期:2014-02-01 00:00:00

  • Paracetamol (acetaminophen) pack size restrictions and poisoning severity: time trends in enquiries to a UK poisons centre.

    abstract:BACKGROUND AND OBJECTIVE:In September 1998, legislation was introduced in the United Kingdom to limit paracetamol pack sizes to 16 tablets of 500 mg at general sales outlets and 32 tablets of 500 mg at pharmacies. The effect of the regulations on severity of paracetamol poisoning is unclear. The aim of this study was t...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Morgan O,Hawkins L,Edwards N,Dargan P

    更新日期:2007-10-01 00:00:00

  • Long-acting formulation leading to severe long-term adverse effects: a case report of fluphenazine and persistent extrapyramidal symptoms.

    abstract:WHAT IS KNOWN AND OBJECTIVE:Long-acting formulations are an important therapeutic option for non-adherent patients with schizophrenia. There is a commonly held view that management of long-acting formulation-induced side effects is difficult. CASE DESCRIPTION:We present a patient with schizophrenia who developed acute...

    journal_title:Journal of clinical pharmacy and therapeutics



    authors: Omi T,Mitsui Y,Matsunaga H

    更新日期:2018-02-01 00:00:00

  • Heparin-induced acute adverse reaction--case report of a patient with acute trauma and a genetic predisposition to thrombotic events: a concurrence of events.

    abstract:WHAT IS KNOWN AND OBJECTIVE:The most common complication of heparin therapy is bleeding. Allergic reactions to heparin are rare, and the mechanisms are poorly understood. We report on a case of acute systemic reaction after subcutaneous injections of a low-molecular-weight heparin (LMWH) in a patient with a genetic pre...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章,评审


    authors: Leone S,Zuccoli ML,Fucile C,Storace S,Martelli A,Mattioli F

    更新日期:2012-12-01 00:00:00

  • Aminoglycoside pharmacokinetics in African-Americans with normal renal function.

    abstract:OBJECTIVE:To compare aminoglycoside pharmacokinetics in African-Americans with normal renal function with published adult population values. DESIGN:An Institutional Review Board approved concurrent study. SETTING:The study was conducted at Howard University Hospital, Washington DC. SUBJECTS:All subjects had serum cr...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 临床试验,杂志文章


    authors: Oparaoji EC,Siram S,Elemihe U,Mezghebe HM,Cho T,Bashiri M,Piedrahita K,Pipalla RS

    更新日期:1998-06-01 00:00:00

  • Comparison of two databases to detect potential drug-drug interactions between prescriptions of HIV/AIDS patients in critical care.

    abstract:WHAT IS KNOWN AND OBJECTIVE:Adverse drug events (ADE), common and underestimated in ICU patients, have direct consequences on length of stay, mortality and hospital costs. Critically ill patients with HIV/AIDS are at a high risk of ADE because of their need for multiple drug therapies. ADE can be prevented, especially ...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Ramos GV,Guaraldo L,Japiassú AM,Bozza FA

    更新日期:2015-02-01 00:00:00

  • Computerized pharmaceutical intervention to reduce reconciliation errors at hospital discharge in Spain: an interrupted time-series study.

    abstract:WHAT IS KNOWN AND OBJECTIVE:It is well known that medication reconciliation at discharge is a key strategy to ensure proper drug prescription and the effectiveness and safety of any treatment. Different types of interventions to reduce reconciliation errors at discharge have been tested, many of which are based on the ...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: García-Molina Sáez C,Urbieta Sanz E,Madrigal de Torres M,Vicente Vera T,Pérez Cárceles MD

    更新日期:2016-04-01 00:00:00

  • Therapeutic drug monitoring-based dose optimization for imatinib-associated serious cutaneous reactions in a patient with gastrointestinal stromal tumours: A case report.

    abstract:WHAT IS KNOWN AND OBJECTIVE:Imatinib mesylate (IM) is the first-line therapy for unresectable or metastatic gastrointestinal stromal tumours (GISTs). Here, we report a case of successful progressive dose optimization by therapeutic drug monitoring (TDM) for a patient with GISTs who developed IM-associated serious cutan...

    journal_title:Journal of clinical pharmacy and therapeutics



    authors: Huang W,Li J,Qiu F,Wu X,Zhang J,Li X,Yao G,Zhu S

    更新日期:2020-08-01 00:00:00

  • CYP2D6 phenotypes among Malays in Malaysia.

    abstract:BACKGROUND:Although they originated from China, Malays have undergone a lot of intermarriages. A study suggested that CYP2D6 poor metabolism (PM) phenotype was more common in Malays compared to Chinese. CYP2D6 is highly polymorphic and is involved in the metabolism of many drugs and has been implicated in some environm...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Ismail R,Hussein A,Teh LK,Nizam Isa M

    更新日期:2000-10-01 00:00:00

  • What do the suffixes--XR, ER, Chrono, Chronosphere--really mean as it pertains to modified-release antiepileptic drugs?

    abstract:BACKGROUND:Epilepsy is a disease requiring chronic therapy with antiepileptic drugs (AEDs). Many conventional AEDs currently available have either too rapid an absorption or elimination, requiring the patient to take multiple doses per day, which may adversely impact adherence or cause peak-related side-effects. Conseq...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Reed RC,Meinhold J,Dutta S,Liu W,Qiu Y

    更新日期:2010-08-01 00:00:00

  • Blood ribavirin concentration in high-dose ribavirin for adenovirus-induced haemorrhagic cystitis - a case report.

    abstract::Blood ribavirin concentration was monitored after the administration of high-dose oral ribavirin in a case of adenovirus-induced haemorrhagic cystitis post-stem-cell transplantation. Combination use of intravenous gamma immunoglobulin (15 g/3 days) and high-dose ribavirin (RBV; 9000 mg/4 days) provided plasma ribaviri...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Homma M,Inoue Y,Hasegawa Y,Kojima H,Kohda Y

    更新日期:2008-02-01 00:00:00

  • A retrospective study to determine the impact of medical- and lifestyle-based contraindications to a prescribed HAART regimen on clinical outcomes and adherence.

    abstract:OBJECTIVE:To determine whether patients who are prescribed a highly active antiretroviral therapy regimen, that minimizes medical and lifestyle contraindications, will be better able to adhere to their drug regimens and will have better clinical outcomes, than patients who do not have such a regimen. METHODS:A retrosp...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Lal LS,Grimes RM,Swint JM,Risser J

    更新日期:2006-10-01 00:00:00

  • Imatinib-induced apoptosis: a possible link to topoisomerase enzyme inhibition.

    abstract:WHAT IS KNOWN AND OBJECTIVE:Imatinib is a specific BCR/ABL inhibitor, commonly used for the treatment of chronic myeloid leukaemia (CML), a hematological malignancy resulting from a chromosomal translocation that generates the BCR/ABL fusion protein. Recent studies showed that the imatinib has cytotoxic and apoptotic e...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Baran Y,Zencir S,Cakir Z,Ozturk E,Topcu Z

    更新日期:2011-12-01 00:00:00

  • Exacerbation of psoriatic skin lesions in a patient with psoriatic arthritis receiving adalimumab.

    abstract:OBJECTIVE:To report a case of a patient with psoriatic arthritis (PsA) receiving adalimumab, who developed an exacerbation of palmoplantaris pustulosa psoriasis. CASE SUMMARY:A 38-year-old woman diagnosed with PsA had received treatment with non-steroidal antiinflammatory drugs. Two months prior to admission, the pati...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Borrás-Blasco J,Gracia-Perez A,Nuñez-Cornejo C,Rosique-Robles JD,Mateu-Puchades A,Casterá MD,Rubio-Fabra M

    更新日期:2008-06-01 00:00:00

  • The effect of a residential care pharmacist on medication administration practices in aged care: A controlled trial.

    abstract:WHAT IS KNOWN AND OBJECTIVE:With the ageing of the population also comes increasing comorbidities and the use of multiple medications and administration methods, along with greater susceptibility to adverse drug reactions. Dosage form modification to facilitate drug administration in older adults can be potentially pro...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: McDerby N,Kosari S,Bail K,Shield A,Peterson G,Naunton M

    更新日期:2019-08-01 00:00:00

  • Genetic predisposition to atorvastatin-induced myopathy: a case report.

    abstract:WHAT IS KNOWN AND OBJECTIVE:The major clinical complication of statins is a variety of muscle complaints ranging from myalgia to rhabdomyolysis. There is growing evidence that carriers of genetic polymorphisms in the enzymes and transporters implicated in statin disposition, particularly the SLCO1B1 gene, are at increa...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Francesca Notarangelo M,Marziliano N,Antonietta Demola M,Pigazzani F,Guidorossi A,Angelica Merlini P,Ardissino D

    更新日期:2012-10-01 00:00:00

  • Could a common biochemical mechanism underlie addictions?

    abstract::The subject of 'drug addiction' is multifaceted and many aspects of it (even some of the definitions) are controversial. Collateral medical problems include the spread of HIV and hepatitis C virus secondary to i.v. drug abuse and effects on prenatal brain development (1). Progress in the understanding of the causes of...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章,评审


    authors: Betz C,Mihalic D,Pinto ME,Raffa RB

    更新日期:2000-02-01 00:00:00

  • Transition from intravenous or subcutaneous prostacyclin therapy to inhaled treprostinil in patients with pulmonary arterial hypertension: a retrospective case series.

    abstract:WHAT IS KNOWN AND OBJECTIVE:Inhaled treprostinil represents an attractive alternative to the other available prostacyclin formulations by obviating the use of continuous infusions and its associated risks. Published evidence describing the process of transition from infusion prostacyclin therapy to inhaled treprostinil...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Enderby CY,Soukup M,Al Omari M,Zeiger T,Burger C

    更新日期:2014-10-01 00:00:00

  • Incretin-based therapy and acute cholecystitis: a review of case reports and EudraVigilance spontaneous adverse drug reaction reporting database.

    abstract:WHAT IS KNOWN AND OBJECTIVE:Glucagon-like peptide-1 (GLP-1) receptor agonists delay gastric and bowel emptying. A similar inhibitory effect of GLP-1 on gallbladder motility has been suggested, possibly leading to an increased risk of cholecystitis related to incretin-based medications, which include GLP-1 antagonists. ...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章,评审


    authors: Pizzimenti V,Giandalia A,Cucinotta D,Russo GT,Smits M,Cutroneo PM,Trifirò G

    更新日期:2016-04-01 00:00:00

  • High-performance liquid chromatographic analysis of ranitidine in plasma and urine.

    abstract::A high-performance liquid chromatographic method for the analysis of ranitidine in plasma and urine is described. Plasma samples were extracted with dichloromethane while urine samples were injected directly after dilution. The mobile phase consisted of: 0.05 M ammonium acetate buffer containing 0.01 M octane sulphona...

    journal_title:Journal of clinical pharmacy and therapeutics

    pub_type: 杂志文章


    authors: Shiekh Salem M,Gharaibeh AM,Alkaysi HN,Badwan A

    更新日期:1988-10-01 00:00:00