当前位置： SCI文献检索 > JOURNAL OF CRITICAL CARE期刊下所有文献 > Persistent sepsis-induced hypotension without hyperlactatemia: is it really septic shock?

Persistent sepsis-induced hypotension without hyperlactatemia: is it really septic shock?

Abstract：

PURPOSE:The prognostic value of hyperlactatemia in septic shock is unquestionable. However, as current definitions do not include hyperlactatemia as a mandatory criterion, some hypotensive patients may be diagnosed as having septic shock despite exhibiting normolactatemia. The significance of persistent sepsis-induced hypotension without hyperlactatemia is unclear. Is it really septic shock? Our aim was to determine differences in outcome between patients diagnosed as having septic shock but exhibiting normal vs elevated lactate levels during evolution. We also explored the potential implications of including hyperlactatemia as an obligatory diagnostic criterion. METHODS:We performed retrospective analyses on a cohort of 302 septic shock patients. RESULTS:When we divided patients according to the presence of hyperlactatemia, 34% evolved without hyperlactatemia and exhibited a very low mortality risk (7.7% compared with 42.9% of those with hyperlactatemia). These patients also presented less severe organ dysfunctions and higher central venous O(2) saturation values, and required lower norepinephrine doses. The potential inclusion of hyperlactatemia in septic shock definition would reduce incidence in 34% but increase absolute mortality risk in 11%. CONCLUSIONS:Persistent sepsis-induced hypotension without hyperlactatemia may not constitute a real septic shock. Our results support the need to review the current definition of septic shock. Hyperlactatemia could represent an objective parameter worth to be explored as a potential diagnostic criterion for septic shock.

journal_name

J Crit Care

journal_title

Journal of critical care

authors

Hernandez G,Castro R,Romero C,de la Hoz C,Angulo D,Aranguiz I,Larrondo J,Bujes A,Bruhn A

doi

10.1016/j.jcrc.2010.09.007

subject

Has Abstract

pub_date

2011-08-01 00:00:00

pages

435.e9-14

issue

4

eissn

0883-9441

issn

1557-8615

pii

S0883-9441(10)00280-7

journal_volume

26

pub_type

杂志文章

相关文献

JOURNAL OF CRITICAL CARE文献大全
  • Clinical results of early stabilization of spine fractures in polytrauma patients.

    abstract：PURPOSE:The purpose of study was to evaluate the clinical results of early stabilization of spine fractures in polytrauma patients. MATERIALS AND METHODS:Between August 2003, and May 2012, 166 polytrauma patients with thoracolumbar spine fractures were included. Patients were divided into 2 groups according to injury-...

    journal_title：Journal of critical care

    pub_type： 杂志文章

    doi：10.1016/j.jcrc.2014.03.003

    authors： Park KC,Park YS,Seo WS,Moon JK,Kim BH

    更新日期：2014-08-01 00:00:00

  • Bedside implantation of a new temporary vena cava inferior filter - Safety and efficacy results of the European ANGEL-Registry.

    abstract：PURPOSE:Pulmonary embolism (PE) is a frequently occurring complication in critically ill patients. Simultaneous occurrence of PE and life-threatening bleeding, may render medical anticoagulation impossible. For these patients, inferior vena cava filters (IVCF) present a valuable therapeutic alternative. The Angel® cath...

    journal_title：Journal of critical care

    pub_type： 杂志文章

    doi：10.1016/j.jcrc.2017.10.009

    authors： Baumann S,Becher T,Giannakopoulos K,Jabbour C,Rutsch M,Fastner C,El-Battrawy I,Ansari U,Lossnitzer D,Behnes M,Alonso A,Kirschning T,Michels G,Stern D,Dissmann R,Kueck O,Taccone FS,Waldmann C,Bunker N,Postiglione M,

    更新日期：2018-04-01 00:00:00

  • Predicting success of high-flow nasal cannula in pneumonia patients with hypoxemic respiratory failure: The utility of the ROX index.

    abstract：PURPOSE:The purpose of the study is to describe early predictors and to develop a prediction tool that accurately identifies the need for mechanical ventilation (MV) in pneumonia patients with hypoxemic acute respiratory failure (ARF) treated with high-flow nasal cannula (HFNC). MATERIALS AND METHODS:This is a 4-year ...

    journal_title：Journal of critical care

    pub_type： 杂志文章

    doi：10.1016/j.jcrc.2016.05.022

    authors： Roca O,Messika J,Caralt B,García-de-Acilu M,Sztrymf B,Ricard JD,Masclans JR

    更新日期：2016-10-01 00:00:00

  • Detection of invasive pulmonary aspergillosis in critically ill patients by combined use of conventional culture, galactomannan, 1-3-beta-D-glucan and Aspergillus specific nested polymerase chain reaction in a prospective pilot study.

    abstract：:Invasive pulmonary aspergillosis (IPA) is an emerging and life-threatening infectious disease in patients admitted to the intensive care unit (ICU). Most diagnostic studies are conducted in hematological patients and results cannot readily be transferred to ICU patients lacking classical host factors. In a multicenter...

    journal_title：Journal of critical care

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jcrc.2018.07.001

    authors： Boch T,Reinwald M,Spiess B,Liebregts T,Schellongowski P,Meybohm P,Rath PM,Steinmann J,Trinkmann F,Britsch S,Michels JD,Jabbour C,Hofmann WK,Buchheidt D

    更新日期：2018-10-01 00:00:00

  • A noninvasive method for monitoring cerebral perfusion during cardiopulmonary resuscitation.

    abstract：PURPOSE:This study evaluates the use of transcranial Doppler (TCD) ultrasound in assessing the changes experienced by the cerebral circulation during cardiopulmonary resuscitation (CPR) and compares it with measurements of internal carotid artery (ICA) flow rates (ultrasonic flow-meter measurements) and cerebral blood ...

    journal_title：Journal of critical care

    pub_type： 杂志文章

    doi：10.1016/0883-9441(94)90013-2

    authors： Lewis LM,Stothert JC Jr,Gomez CR,Ruoff BE,Hall IS,Chandel B,Standeven J

    更新日期：1994-09-01 00:00:00

  • Liberation of neurosurgical patients from mechanical ventilation and tracheostomy in neurocritical care.

    abstract：:Neurosurgical patients commonly require mechanical ventilation and monitoring in a neurocritical care unit. There are only few studies that specifically address the process of liberation from mechanical ventilation in this population. Patients who remain ventilator or artificial airway dependent receive a tracheostomy...

    journal_title：Journal of critical care

    pub_type： 杂志文章,评审

    doi：10.1016/j.jcrc.2011.08.018

    authors： Lazaridis C,DeSantis SM,McLawhorn M,Krishna V

    更新日期：2012-08-01 00:00:00

  • Integration of urinary neutrophil gelatinase-associated lipocalin with serum creatinine delineates acute kidney injury phenotypes in critically ill children.

    abstract：PURPOSE:Acute kidney injury (AKI) is prevalent in critically ill patients and associated with poor outcomes. Current AKI diagnostics- changes to serum creatinine (SCr) and urine output- are imprecise. Integration of injury biomarkers with SCr may improve diagnostic precision. METHODS:We performed a secondary analysis ...

    journal_title：Journal of critical care

    pub_type： 杂志文章

    doi：10.1016/j.jcrc.2019.05.017

    authors： Stanski N,Menon S,Goldstein SL,Basu RK

    更新日期：2019-10-01 00:00:00

  • Risk factors for postoperative delirium in patients after coronary artery bypass grafting: A prospective cohort study.

    abstract：PURPOSE:This study was designed to identify the incidence and independent perioperative risk factors associated with postoperative delirium of patients who underwent coronary artery bypass grafting (CABG) in a large intensive care unit setting in China. METHODS:Delirium was diagnosed by the confusion assessment method...

    journal_title：Journal of critical care

    pub_type： 杂志文章

    doi：10.1016/j.jcrc.2015.02.003

    authors： Zhang WY,Wu WL,Gu JJ,Sun Y,Ye XF,Qiu WJ,Su CQ,Zhang SQ,Ye WQ

    更新日期：2015-06-01 00:00:00

  • Contradictions in end-of-life decisions for self and other, expressed by relatives of chronically ventilated patients.

    abstract：OBJECTIVES:In certain populations, social, legal, and religious factors may influence end-of-life decisions in ventilator-dependent patients. This study aims to evaluate attitudes of first-degree relatives of chronically ventilated patients in Israel, toward end-of-life decisions regarding their loved ones, themselves,...

    journal_title：Journal of critical care

    pub_type： 杂志文章

    doi：10.1016/j.jcrc.2009.01.011

    authors： Sviri S,Garb Y,Stav I,Rubinow A,Linton DM,Caine YG,Marcus EL

    更新日期：2009-06-01 00:00:00

  • Major publications in the critical care pharmacotherapy literature: 2019.

    abstract：PURPOSE:To summarize selected meta-analyses and trials related to critical care pharmacotherapy published in 2019. MATERIALS AND METHODS:The Critical Care Pharmacotherapy Literature Update (CCPLU) Group screened 36 journals monthly for impactful articles and reviewed 113 articles during 2019 according to Grading of Re...

    journal_title：Journal of critical care

    pub_type： 杂志文章,评审

    doi：10.1016/j.jcrc.2020.12.018

    authors： Condeni MS,Basting AT,Costello PG,DePriest A,Eriksson EA,Evans H,Hertel K,Holder AL,Kester AN,Kowalski KR,Bell CM,McLean B,Reichert M,Santibañez M,Wieruszewski PM,Newsome AS

    更新日期：2020-12-27 00:00:00

  • Changing trends in the use of seizure prophylaxis after traumatic brain injury: a shift from phenytoin to levetiracetam.

    abstract：PURPOSE:Current guidelines for traumatic brain injury (TBI) recommend antiepileptic drugs (AEDs) for 7 days after injury to decrease posttraumatic seizure risk. Phenytoin decreases seizure risk 73% vs placebo during this time. Levetiracetam (LEV) is an alternative; however, no published data validate comparable efficac...

    journal_title：Journal of critical care

    pub_type： 杂志文章

    doi：10.1016/j.jcrc.2012.11.020

    authors： Kruer RM,Harris LH,Goodwin H,Kornbluth J,Thomas KP,Slater LA,Haut ER

    更新日期：2013-10-01 00:00:00

  • Acinetobacter baumannii infection was decreased by the structural renovation of a medical intensive care unit.

    abstract：PURPOSE:The study aimed to determine whether improvements in intensive care unit (ICU) structural environment affect the incidence of ICU-acquired infections (IAIs), particularly those caused by multidrug-resistant pathogens. METHODS:The incidence of IAI and the number of infections caused by organisms during the 6 mo...

    journal_title：Journal of critical care

    pub_type： 杂志文章

    doi：10.1016/j.jcrc.2012.12.013

    authors： Nah SS,Park YH,Chung JW,Yoo S,Hong SB,Lim CM,Koh Y

    更新日期：2013-08-01 00:00:00

  • Medication issues experienced by patients and carers after discharge from the intensive care unit.

    abstract：PURPOSE:Medication-related problems (MRPs) frequently occur at the interfaces of care settings. We examined this further because little has been published about MRPs experienced by patients/carers after discharge from the intensive care unit (ICU). METHODS AND MATERIALS:Medication history data were collected before, d...

    journal_title：Journal of critical care

    pub_type： 杂志文章

    doi：10.1016/j.jcrc.2012.06.002

    authors： Eijsbroek H,Howell DC,Smith F,Shulman R

    更新日期：2013-02-01 00:00:00

  • Patient-ventilator dyssynchronies: Are they all the same? A clinical classification to guide actions.

    abstract：:Patient ventilatory dyssynchrony (PVD) is a mismatch between the respiratory drive of the patient and ventilatory assistance. It is a complex event seen in almost all ventilated patients and at any ventilator mode, with uncertain significance and prognosis. Due to its different pathophysiological mechanisms, there is ...

    journal_title：Journal of critical care

    pub_type： 杂志文章,评审

    doi：10.1016/j.jcrc.2020.07.016

    authors： Damiani LF,Bruhn A,Retamal J,Bugedo G

    更新日期：2020-12-01 00:00:00

  • Identifying essential elements to include in Intensive Care Unit to hospital ward transfer summaries: A consensus methodology.

    abstract：PURPOSE:Transitions of care from the intensive care unit (ICU) to a hospital ward are high risk and contingent on effective communication. We sought to identify essential information elements to be included in an ICU to hospital ward transfer summary tool, and describe tool functionality and composition perceived to be...

    journal_title：Journal of critical care

    pub_type： 杂志文章

    doi：10.1016/j.jcrc.2018.10.001

    authors： ICU Transfer Summary Consensus Panel,.,de Grood C,Job McIntosh C,Boyd JM,Zjadewicz K,Parsons Leigh J,Stelfox HT

    更新日期：2019-02-01 00:00:00

  • Prognostic factors for heart recovery in adult patients with acute fulminant myocarditis and cardiogenic shock supported with extracorporeal membrane oxygenation.

    abstract：BACKGROUND:Extracorporeal membrane oxygenation (ECMO) is an effective support method for acute fulminant myocarditis (AFM) with cardiogenic shock. However, deciding whether to bridge to a left ventricular assist device (LVAD) or to maintain ECMO support until heart recovery is still controversial. MATERIAL AND METHODS...

    journal_title：Journal of critical care

    pub_type： 杂志文章

    doi：10.1016/j.jcrc.2020.03.007

    authors： Chou HW,Wang CH,Lin LY,Chi NH,Chou NK,Yu HY,Chen YS

    更新日期：2020-06-01 00:00:00

  • ICU-acquired pneumonia in immunosuppressed patients with acute hypoxemic respiratory failure: A post-hoc analysis of a prospective international cohort study.

    abstract：OBJECTIVE:Intensive Care Units (ICU) acquired Pneumonia (ICU-AP) is one of the most frequent nosocomial infections in critically ill patients. Our aim was to determine the effects of having an ICU-AP in immunosuppressed patients with acute hypoxemic respiratory failure. DESIGN:Post-hoc analysis of a multinational, pro...

    journal_title：Journal of critical care

    pub_type： 杂志文章

    doi：10.1016/j.jcrc.2020.09.027

    authors： Martin-Loeches I,Darmon M,Demoule A,Antonelli M,Schellongowski P,Pickkers P,Soares M,Rello J,Bauer P,van de Louw A,Lemiale V,Grimaldi D,Balik M,Mehta S,Kouatchet A,Barratt-Due A,Valkonen M,Reignier J,Metaxa V,Moreau

    更新日期：2020-09-29 00:00:00

  • Implementation of a structured communication tool improves family satisfaction and expectations in the intensive care unit.

    abstract：BACKGROUND:Intensive care unit (ICU) physicians should provide relatives of critically ill patients with appropriate and clear information, regarding prognosis, treatment options and expectations. OBJECTIVES:To assess whether a structured communication tool improves satisfaction with care and engenders realistic expec...

    journal_title：Journal of critical care

    pub_type： 杂志文章

    doi：10.1016/j.jcrc.2019.01.011

    authors： Sviri S,Geva D,vanHeerden PV,Romain M,Rawhi H,Abutbul A,Orenbuch-Harroch E,Bentur N

    更新日期：2019-06-01 00:00:00

  • Development and validation of a clinical prediction rule for candidemia in hospitalized patients with severe sepsis and septic shock.

    abstract：OBJECTIVE:To develop and internally validate a prediction rule for the presence of candidemia in patients with severe sepsis and septic shock (candidemia rule) that will fill the gap left by previous rules. To compare the accuracy of the available Candida prediction models. DESIGN:Retrospective cohort study. SETTING:...

    journal_title：Journal of critical care

    pub_type： 杂志文章

    doi：10.1016/j.jcrc.2015.03.010

    authors： Guillamet CV,Vazquez R,Micek ST,Ursu O,Kollef M

    更新日期：2015-08-01 00:00:00

  • Quality of care and safety measures of acute renal replacement therapy: Workgroup statements from the 22nd acute disease quality initiative (ADQI) consensus conference.

    abstract：PURPOSE:There is wide variation in the practice of acute renal replacement therapy (RRT). Quality of care is suboptimal, and substantial knowledge-to-care gaps need to be addressed. The quality of care for patients receiving acute RRT has been recognized as a clinical and research priority. Quality indicators (QIs) can...

    journal_title：Journal of critical care

    pub_type： 共识发展会议,杂志文章

    doi：10.1016/j.jcrc.2019.07.003

    authors： Rewa OG,Tolwani A,Mottes T,Juncos LA,Ronco C,Kashani K,Rosner M,Haase M,Kellum J,Bagshaw SM,ADQI Consensus Meeting Members on behalf of ADQI XXII.

    更新日期：2019-12-01 00:00:00

  • Intensive care admission criteria for traumatic brain injury patients across Europe.

    abstract：:Within a prospective, observational, multi-center cohort study 68 hospitals (of which 66 responded), mostly academic (n = 60, 91%) level I trauma centers (n = 44, 67%) in 20 countries were asked to complete questionnaires regarding the "standard of care" for severe neurotrauma patients in their hospitals. From the que...

    journal_title：Journal of critical care

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jcrc.2018.11.002

    authors： Volovici V,Ercole A,Citerio G,Stocchetti N,Haitsma IK,Huijben JA,Dirven CMF,van der Jagt M,Steyerberg EW,Nelson D,Cnossen MC,Maas AIR,Polinder S,Menon DK,Lingsma HF

    更新日期：2019-02-01 00:00:00

  • The diagnosis of myocardial infarction in critically ill patients: an agreement study.

    abstract：PURPOSE:The aim of the study was to assess agreement among 4 intensivists in diagnosing myocardial infarction (MI) in critically ill patients based on screening electrocardiograms (ECGs) and cardiac troponin (cTn) levels. METHODS:Consecutive patients admitted to a medical-surgical intensive care unit (ICU) underwent s...

    journal_title：Journal of critical care

    pub_type： 杂志文章

    doi：10.1016/j.jcrc.2008.08.012

    authors： Lim W,Tkaczyk A,Holinski P,Qushmaq I,Jacka M,Khera V,Devereaux PJ,Terrenato I,Schunemann H,Heels-Ansdell D,Crowther M,Cook D

    更新日期：2009-09-01 00:00:00

  • Evaluation of a dosing regimen for continuous vancomycin infusion in critically ill patients: an observational study in intensive care unit patients.

    abstract：PURPOSE:We aimed to evaluate a dosing algorithm for continuous vancomycin administration in intensive care unit patients. MATERIALS AND METHODS:This observational study was conducted in a medical intensive care unit (German university hospital; June 2012-February 2013). Following a loading dose of 20 mg per kg actual ...

    journal_title：Journal of critical care

    pub_type： 杂志文章

    doi：10.1016/j.jcrc.2013.12.007

    authors： Saugel B,Gramm C,Wagner JY,Messer M,Lahmer T,Meidert AS,Schmid RM,Huber W

    更新日期：2014-06-01 00:00:00

  • Risk factors and treatment outcome in scuba divers with spinal cord decompression sickness.

    abstract：PURPOSE:This study was designed to determine the recompression strategy and the potential risk factors associated with the development of severe diving-related spinal cord decompression sickness (DCS). MATERIAL AND METHODS:Sixty-three injured recreational divers (52 men and 11 women; 46 +/- 12 years) presenting with s...

    journal_title：Journal of critical care

    pub_type： 杂志文章

    doi：10.1016/j.jcrc.2009.05.011

    authors： Gempp E,Blatteau JE

    更新日期：2010-06-01 00:00:00

  • Admission hyperlactatemia: causes, incidence, and impact on outcome of patients admitted in a general medical intensive care unit.

    abstract：PURPOSE:The aim of this study was to evaluate the causes, incidence, and impact on outcome of admission hyperlactatemia in patients admitted to a general medical intensive care unit (ICU). METHODS:A retrospective cohort study was done in an 8-bed general ICU of tertiary care hospital over 15 months. Data regarding pat...

    journal_title：Journal of critical care

    pub_type： 杂志文章

    doi：10.1016/j.jcrc.2010.11.009

    authors： Juneja D,Singh O,Dang R

    更新日期：2011-06-01 00:00:00

  • Determinants of outcome in patients with a clinical suspicion of ventilator-associated pneumonia.

    abstract：INTRODUCTION:In the absence of a reference standard, a probabilistic approach to the diagnosis of ventilator-associated pneumonia (VAP) has been proposed; and clinician judgment augmented by microbiological tests is used to guide therapy for patients having a clinical suspicion of VAP (CSVAP). However, the correlation ...

    journal_title：Journal of critical care

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.jcrc.2007.12.007

    authors： Muscedere JG,McColl C,Shorr A,Jiang X,Marshall J,Heyland DK,Canadian Critical Care Trials Group.

    更新日期：2008-03-01 00:00:00

  • Evidence summary resources may influence clinical decision making: A case-based scenario evaluation of an evidence summary tool.

    abstract：PURPOSE:Evidence summary resources are popular with clinicians but it is unknown whether they can influence clinical decision making. We evaluated whether an extremely condensed and explicit evidence summary tool could influence clinical decision making. MATERIALS AND METHODS:An evidence summary tool was developed usi...

    journal_title：Journal of critical care

    pub_type： 杂志文章

    doi：10.1016/j.jcrc.2019.10.001

    authors： Heighes PT,Doig GS

    更新日期：2020-02-01 00:00:00

  • Entrustable professional activities (EPAs) for postgraduate competency based intensive care medicine training in the Netherlands: The next step towards excellence in intensive care medicine training.

    abstract：INTRODUCTION:The Competency Based Training in Intensive Care Education (CoBaTrICE) programme developed common standards of ICM training by describing competencies of an intensivist. Entrustable Professional Activities (EPAs) of Intensive Care Medicine (ICM) (EPAsICM) are presented as a new workplace-based assessment to...

    journal_title：Journal of critical care

    pub_type： 杂志文章

    doi：10.1016/j.jcrc.2019.09.012

    authors： van Bockel EAP,Walstock PA,van Mook WNKA,Arbous MS,Tepaske R,van Hemel TJD,Müller MCA,Delwig H,Tulleken JE

    更新日期：2019-12-01 00:00:00

  • Risk factors for noninvasive ventilation failure in patients with acute cardiogenic pulmonary edema: A prospective, observational cohort study.

    abstract：PURPOSE:We identified risk factors for noninvasive ventilation (NIV) failure in patients with acute cardiogenic pulmonary edema (ACPE). MATERIALS AND METHODS:We conducted an observational cohort study over a 3-year period in a 28-bed emergency intensive care unit (EICU) and prospectively included all consecutive patie...

    journal_title：Journal of critical care

    pub_type： 杂志文章

    doi：10.1016/j.jcrc.2017.01.001

    authors： Luo Z,Han F,Li Y,He H,Yang G,Mi Y,Ma Y,Cao Z

    更新日期：2017-06-01 00:00:00

  • The effect of a checklist on the quality of patient handover from the operating room to the intensive care unit: A randomized controlled trial.

    abstract：PURPOSE:Handover of patient care is a potential safety risk for the patient due to loss of information which may result in adverse outcome. We hypothesized that a checklist for handover from the operating room (OR) to the intensive care unit (ICU) will lead to an increase of quality regarding information transfer compa...

    journal_title：Journal of critical care

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jcrc.2015.12.016

    authors： Salzwedel C,Mai V,Punke MA,Kluge S,Reuter DA

    更新日期：2016-04-01 00:00:00