Abstract：
:The major phospholipids, phosphatidylcholine and spingomyelin, of low density lipoprotein (LDL) are accessible to small amounts of Pr3+, suggesting that the head groups of all mobile phospholipids are on the surface of the particle in contact with the aqueous medium. The major source of the nuclear Overhauser effect enhancement of 31P resonances is the N-methyl proton of the choline moiety, indicating close N-methyl phosphate group interactions, probably similar to those found previously in phospholipid vesicles. This behavior of the phospholipid head groups in LDL is similar to that in small vesicles without cholesterol, suggesting that in LDL most of the cholesterol is not associated with mobile, surface phospholipids. In contrast to LDL, where the presence of a large protein immobilizes some phospholipid head groups, immobilization does not occur in high density lipoprotein, consistent with occurrence of smaller peptides in the latter.
journal_name
Biochemistryjournal_title
Biochemistryauthors
Yeagle PL,Martin RB,Pottenger L,Langdon RGdoi
10.1021/bi00607a002subject
Has Abstractpub_date
1978-07-11 00:00:00pages
2707-10issue
14eissn
0006-2960issn
1520-4995journal_volume
17pub_type
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