Abstract:
:Concussion or mild traumatic brain injury (mTBI) is a condition that affects hundreds of thousands of patients worldwide. Understanding the pathophysiology of this disorder can help manage its acute and chronic repercussions. Immediately following mTBI, there are several metabolic, hemodynamic, structural, and electric changes that alter normal cerebral function. These alterations can increase the brain's vulnerability to repeat injury and long-term disability. This review evaluates current studies from the bench to the bedside of mTBI. Acute and chronic effects of concussion are measured in both animal and clinical studies. Also, the effect of repeat concussions is analyzed. Concussion-induced pathophysiology with regards to glucose metabolism changes, mitochondrial dysfunction, axonal injury, and structural damage are evaluated. Translational studies such as functional magnetic resonance imaging, magnetic resonance spectroscopy and diffusion tensor imaging prove to be effective clinical tools for both prognostic and treatment parameters. Understanding the neurobiology of concussion will lead to development and validation of physiological biomarkers of this common injury. These biomarkers (eg, laboratory tests, imaging, electrophysiology) will then allow for improved detection, better functional assessment and evidence-based return to play recommendations.
journal_name
Clin Sports Medjournal_title
Clinics in sports medicineauthors
Barkhoudarian G,Hovda DA,Giza CCdoi
10.1016/j.csm.2010.09.001subject
Has Abstractpub_date
2011-01-01 00:00:00pages
33-48, vii-iiiissue
1eissn
0278-5919issn
1556-228Xpii
S0278-5919(10)00075-Xjournal_volume
30pub_type
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journal_title:Clinics in sports medicine
pub_type: 杂志文章
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abstract::Although the immediate neurocognitive effects of sports-related concussion are well known, less is known about the intermediate or long-term effects of sports-related concussions. A sample of selected studies of high-school and collegiate athletes is reviewed and the intermediate effects of concussive injuries are dis...
journal_title:Clinics in sports medicine
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journal_title:Clinics in sports medicine
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journal_title:Clinics in sports medicine
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journal_title:Clinics in sports medicine
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journal_title:Clinics in sports medicine
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journal_title:Clinics in sports medicine
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journal_title:Clinics in sports medicine
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journal_title:Clinics in sports medicine
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journal_title:Clinics in sports medicine
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journal_title:Clinics in sports medicine
pub_type: 杂志文章
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journal_title:Clinics in sports medicine
pub_type: 杂志文章
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journal_title:Clinics in sports medicine
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journal_title:Clinics in sports medicine
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journal_title:Clinics in sports medicine
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journal_title:Clinics in sports medicine
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journal_title:Clinics in sports medicine
pub_type: 杂志文章
doi:
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journal_title:Clinics in sports medicine
pub_type: 杂志文章,评审
doi:
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journal_title:Clinics in sports medicine
pub_type: 杂志文章,评审
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journal_title:Clinics in sports medicine
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journal_title:Clinics in sports medicine
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journal_title:Clinics in sports medicine
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journal_title:Clinics in sports medicine
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journal_title:Clinics in sports medicine
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journal_title:Clinics in sports medicine
pub_type: 杂志文章
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journal_title:Clinics in sports medicine
pub_type: 杂志文章,评审
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journal_title:Clinics in sports medicine
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journal_title:Clinics in sports medicine
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journal_title:Clinics in sports medicine
pub_type: 杂志文章,评审
doi:
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