Abstract:
AIM:The aim of this manuscript is to review the current state of knowledge regarding C-reactive protein (CRP) kinetics after standard neurosurgical procedures, and to determine the value of CRP as a screening test for early post-operative infectious complications as opposed to other more commonly used tests, and as a marker of peri-operative surgical insult. METHODS:Over 18 months period, CRP levels, alongside with ESR and WCC were assessed pre-operatively (at day 0) and post-operatively (at days 1,2,3,4 and 5) in 50 consecutive female patients and 50 consecutive male patients undergoing seven neurosurgical procedures. Each of the seven procedures involved a different level of intra-operative trauma. Factors of possible influences on CRP, including volume of blood transfused intra-operatively, type of anaesthetic administered, use of anti-inflammatory drugs and antibiotics levels were recorded. RESULTS:The median age of our study population was 29.1 (mean ± SD: 28.4 ± 10.2; range: 20.4-53.8). Of the 100 patients recruited for our study, 13 developed post-operative infectious complications. In these patients, a secondary CRP rise or failure to decrease as expected had sensitivity, specificity, negative and positive predictive value of 100%, 93.1%, 100% and 68.4%, respectively, for detecting infectious complications. The mean post-operative CRP levels were highest in the most surgically traumatic procedure--lobotomy for epilepsy intervention, and lowest in the least surgically traumatic procedure--stereotactic brain biopsy (p < 0.001). Volume of blood transfused intra-operatively, type of anaesthetic administered, use of anti-inflammatory drugs and antibiotics levels did not affect CRP kinetics. CONCLUSION:The results of this study suggest that CRP is a more reliable screening test for post-operative infectious complications in the practice of neurosurgery than other more commonly used tests (WCC and ESR). Furthermore, the results suggest that peak post-operative CRP levels mirrors the level of incurred intra-operative surgical insult.
journal_name
Br J Neurosurgjournal_title
British journal of neurosurgeryauthors
Al-Jabi Y,El-Shawarby Adoi
10.3109/02688697.2010.500408subject
Has Abstractpub_date
2010-12-01 00:00:00pages
653-9issue
6eissn
0268-8697issn
1360-046Xjournal_volume
24pub_type
杂志文章abstract::Hemangiopericytoma is a rare mesenchymal tumor originating from capillary pericytes, known as Zimmermann pericytes. The adult form is not uncommon and generally malignant but tumor is found rarely in children. Here we describe an intracranial hemangiopericytoma in a preterm newborn whose had the tumor resected success...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2017.1366420
更新日期:2019-08-01 00:00:00
abstract::Among 344 patients with posterior fossa tumours treated from 1979 to 1986 a ventriculoperitoneal, or, less commonly, a ventriculatrial shunt was inserted in 164 cases pre-operatively. Haematoma following the insertion of a shunt was found to be an important cause of deterioration. While the occurrence of cerebrospinal...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688699008992760
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abstract::A case of spinal extradural cavernous angioma is described. The symptomatology and prognosis of such lesions is discussed and the relevant literature reviewed. ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章,评审
doi:10.3109/02688699308995060
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abstract::Tonsillar herniation is a rare and seldom reported complication after lumboperitoneal (LP) shunting. There have been only few reports that have presented possible options for treatment with varying degrees of success. In this report, we describe a rare case of tonsillar herniation after LP shunting and review related ...
journal_title:British journal of neurosurgery
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doi:10.1080/02688697.2018.1538481
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journal_title:British journal of neurosurgery
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doi:10.3109/02688699409027975
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journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2012.717983
更新日期:2013-04-01 00:00:00
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journal_title:British journal of neurosurgery
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doi:10.3109/02688699108998477
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journal_title:British journal of neurosurgery
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pub_type: 杂志文章
doi:10.1080/02688697.2020.1862053
更新日期:2020-12-22 00:00:00
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journal_title:British journal of neurosurgery
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doi:10.3109/02688699008992713
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journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688699308995051
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journal_title:British journal of neurosurgery
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doi:
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journal_title:British journal of neurosurgery
pub_type: 杂志文章,评审
doi:10.1080/02688697.2017.1297364
更新日期:2017-06-01 00:00:00
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