Toxicity of chemotherapy and radiation on female reproduction.

Abstract:

:One of the most devastating consequences of cancer treatment in the young female population is ovarian damage, resulting in diminished fertility potential. The extent of damage is related to age, chemotherapeutic regimen, and dose of pelvic radiation received. It is crucial that physicians know the impact each of these factors has on future fertility to advice patients on fertility preservation options. Anticancer drugs injure the female reproductive system through ovarian follicular and stromal damage. Although the exact mechanisms of damage remain unclear, it is essential to better understand these mechanisms to develop methods to diminish ovarian injury.

journal_name

Clin Obstet Gynecol

authors

Meirow D,Biederman H,Anderson RA,Wallace WH

doi

10.1097/GRF.0b013e3181f96b54

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

727-39

issue

4

eissn

0009-9201

issn

1532-5520

pii

00003081-201012000-00004

journal_volume

53

pub_type

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