Platelet aggregation in erythropoietin treated dialysis patients.

abstract：:The aim of these studies was to investigate the extent of platelet P2Y(12) receptor inhibition by the thienopyridine active metabolite of prasugrel, R-138727. Blood was taken from healthy volunteers and pre-incubated with R-138727 or cangrelor (AR-C66931MX). Platelet aggregation was assessed in platelet rich plasma (P...

journal_title：Platelets

authors： Judge HM,Buckland RJ,Sugidachi A,Jakubowski JA,Storey RF

更新日期：2008-03-01 00:00:00

abstract：:Prominence has been given recently to the use of platelet-rich plasma (PRP) in combination with bone graft materials for predictably obtaining periodontal regeneration through bioengineering. The purpose of this report was to present clinical, radiographic and re-entry results of a generalized aggressive periodontitis...

journal_title：Platelets

authors： Yilmaz S,Cakar G,Kuru BE,Yildirim B

更新日期：2007-11-01 00:00:00

abstract：:This manuscript reviews pathogenic variants in RASGRP2, which are the cause of a relatively new autosomal recessive and nonsyndromic inherited platelet function disorder, referred to as platelet-type bleeding disorder-18 (BDPLT18)(OMIM:615888). To date, 18 unrelated BDPLT18 pedigrees have been reported, harboring 19 d...

journal_title：Platelets

authors： Palma-Barqueros V,Ruiz-Pividal J,Bohdan N,Vicente V,Bastida JM,Lozano M,Rivera J

更新日期：2019-01-01 00:00:00

abstract：:Selective activation of the platelet TXA2 receptor is sufficient to mediate concurrent aggregation, deaggregation and shape change (SC) responses without activation of known Gi-coupled receptors (Platelets 2003; 14: 89). However, Gi-coupled receptor activation strongly influences the hemostasis response in vivo. This ...

journal_title：Platelets

authors： Maayani S,Schwarz TE,Patel ND,Craddock-Royal BD,Tagliente TM

更新日期：2003-09-01 00:00:00

abstract：:Standardized Ginkgo biloba extract, EGb761, has been shown to possess polyvalent properties, such as anti-oxidation, anti-apoptosis and anti-inflammation. Recently, it has also been proposed to have direct protective effects on mitochondria. The effects of EGb761 make it a potential anti-aging drug. Despite that, the ...

journal_title：Platelets

authors： Shi C,Xiao S,Liu J,Guo K,Wu F,Yew DT,Xu J

更新日期：2010-01-01 00:00:00

abstract：:Recently, our laboratory has reported the presence of one acidifying Cl-/HC exchange mechanism in human platelets. This paper demonstrates that this exchanger decreases its activity after inhibition of carbonic anhydrase. BCECF-loaded platelets, previously equilibrated in a bicarbonate/CO2 buffered solution, were resu...

journal_title：Platelets

authors： Gende OA

更新日期：2005-11-01 00:00:00

abstract：:The potential roles of serum butyrylcholinesterase (BChE) activity and platelet indices in type 1 diabetes (T1D) remain uncertain. We aimed to investigate the correlation among the platelet indices, serum BChE activity, and diabetic ketoacidosis (DKA). Sixty-one T1D patients, 29 patients with DKA, and 30 age- and sex-...

journal_title：Platelets

authors： Ma SG,Yang LX,Qiu XQ

更新日期：2013-01-01 00:00:00

abstract：:Hemorrhage is a significant pathological feature of some fever or hyperthermia-related diseases, such as dengue fever and heatstroke. Although the mechanisms of hemorrhage in these diseases are thought to be complex, whether there is an association between hemorrhage and hyperthermia or fever remains unclear. Platelet...

journal_title：Platelets

authors： Wang Z,Shi Q,Li S,Du J,Liu J,Dai K

更新日期：2010-01-01 00:00:00

abstract：:Several lines of evidence are consistent with the hypothesis that activated platelets contribute to colorectal tumorigenesis and metastatization through direct cell-cell interactions and the release of different lipid and protein mediators, and microvesicles. This review examines the clinical pharmacology of low-dose ...

journal_title：Platelets

authors： Patrignani P,Patrono C

更新日期：2018-12-01 00:00:00

abstract：:Platelet aggregation and microaggregate formation were measured in samples of stirred whole blood by flow cytometry. Blood samples were stirred in a multi-sample agitator with ADP, fixed and labelled with a platelet-specific CD42a-FITC fluorescent antibody. The blood was then diluted and applied directly to a flow cyt...

journal_title：Platelets

authors： Fox SC,Sasae R,Janson S,May JA,Heptinstall S

更新日期：2004-03-01 00:00:00

abstract：:The inhibitory effects of a cyclooxygenase inhibitor, indomethacin, and a thromboxane (TX) A(2) receptor antagonist, S-145, on thrombin-stimulated rabbit platelet responses were examined for their contribution to the TXA-mediated amplification mechanism. Although thrombin (0.01-0.3 U/ml) induced the dosedependent aggr...

journal_title：Platelets

authors： Kawamura M,Huang A,Harada Y,Katori M

更新日期：1994-01-01 00:00:00

abstract：:Platelet activation has long been known to be accompanied by secretion from at least three types of compartments. These include dense granules, the major source of small molecules; α-granules, the major protein storage organelle; and lysosomes, the site of acid hydrolase storage. Despite ~60 years of research, there a...

journal_title：Platelets

authors： Yadav S,Storrie B

更新日期：2017-03-01 00:00:00

abstract：:A goal of platelet storage is to maintain the quality of platelets from the point of donation to the point of transfusion - to suspend the aging process. This effort is judged by clinical and laboratory measures with varying degrees of success. Recent work gives encouragement that platelets can be maintained ex vivo b...

journal_title：Platelets

authors： Smethurst PA

更新日期：2016-09-01 00:00:00

abstract：:A 38-year-old female patient was diagnosed with anemia for 3 years. Medical examination showed slight splenomegaly (250 × 62 mm), thrombocytopenia (platelets 51 × 109/L), anemia (Hb levels 107 g/L), and β-glucocerebrosidase activity (GBA) in leukocytes was lower than normal. Microscopic findings of bone marrow smear d...

journal_title：Platelets

authors： Wan L,Wu H,Xie F,Nie Y

更新日期：2017-12-01 00:00:00

abstract：:Recent experimental evidence demonstrates that the platelet-specific collagen receptor, glycoprotein (GP)VI is essentially all uncleaved on normal circulating platelets, but is shed from the platelet surface in a metalloproteinase-dependent manner in response to GPVI ligands (including collagen), anti-GPVI antibodies ...

journal_title：Platelets

authors： Al-Tamimi M,Mu FT,Moroi M,Gardiner EE,Berndt MC,Andrews RK

更新日期：2009-05-01 00:00:00

abstract：:Vascular diseases such as myocardial infarction and ischemic stroke are associated with increased platelet function whilst the risk of recurrence is reduced by antiplatelet agents such as aspirin, clopidogrel, and prasugrel. However, some patients exhibit high platelet reactivity, especially with clopidogrel. Existing...

journal_title：Platelets

authors： Bath PM,May J,Heptinstall S

更新日期：2018-07-01 00:00:00

abstract：:The SDF-1-CXCR4 axis plays an essential role in the regulation of platelet production, by directing megakaryocyte (MK) migration toward the vascular niche, thus allowing terminal maturation and proplatelet formation, and also regulates platelet function in an autocrine manner. Inherited thrombocytopenias (IT) comprise...

journal_title：Platelets

authors： Salim JP,Glembotsky AC,Lev PR,Marin Oyarzún CP,Goette NP,Molinas FC,Marta RF,Heller PG

更新日期：2017-09-01 00:00:00

abstract：:Platelets in flowing blood at high-shear stress are recruited to exposed subendothelial collagen of injured vessels by GPIb-von Willebrand factor (vWf) and integrin alpha(2)beta(1) (alpha(2)beta(1))-collagen interactions. Platelet adhesion to type I collagen depends mainly on the alpha(2)beta(1)-collagen interaction a...

journal_title：Platelets

authors： Jung SM,Sonoda M,Tsuji K,Jimi A,Nomura S,Kanaji T,Moroi M

更新日期：2010-01-01 00:00:00

abstract：:It has recently been demonstrated that both initiators and inhibitors (viz iloprost) of aggregation stimulate the uptake of [(45)Ca(2+)] by human platelets. Since it was postulated that this calcium uptake reflects changes associated with signal transduction, we investigated the role of cAMP-dependent protein kinases ...

journal_title：Platelets

authors： Gill J,Jeremy JY,Mikhailidis DP

更新日期：1993-01-01 00:00:00

abstract：:Glycoprotein (GP) IIb-IIIa (αIIbβ3-integrin) is the central receptor of platelet aggregation. Activated GP IIb-IIIa binds fibrinogen or von Willebrand factor, which forms molecular bridges between aggregating platelets. This review summarizes data on the relationship between GP IIb-IIIa expression on the platelet surf...

journal_title：Platelets

authors： Yakushkin VV,Zyuryaev IT,Khaspekova SG,Sirotkina OV,Ruda MY,Mazurov AV

更新日期：2011-01-01 00:00:00

abstract：:The purpose of the study was to evaluate safety, effects on platelet aggregation and pharmacokinetics of F(ab')(2) fragments of anti-glycoprotein (GP) IIb-IIIa murine monoclonal antibody FRaMon (F(ab')(2) FRaMon) upon its intravenous administration in patients undergoing high-risk coronary angioplasty. Patients were t...

journal_title：Platelets

authors： Mazurov AV,Pevzner DV,Antonova OA,Byzova TV,Khaspekova SG,Semenov AV,Vlasik TN,Samko AN,Staroverov II,Ruda MY

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND:Low-grade inflammatory status was thought to be a major underlying mechanism in MetS. White blood cell (WBC) count was one of the inflammatory markers identified to be associated with MetS. Moreover, not only WBC but also hemoglobin (Hb) and platelet (PLT) were all associated with MetS. OBJECTIVE:In this st...

journal_title：Platelets

authors： Liu H,Hsu CH,Lin JD,Hsieh CH,Lian WC,Wu CZ,Pei D,Chen YL

更新日期：2014-01-01 00:00:00

abstract：:Recent findings have identified critical roles for the actin filament-crosslinking protein filamin A (FlnA) in platelets and megakaryocytes. This short review focuses on the structure of FlnA and its interaction with the Von Willebrand Factor receptor GPIb-IX-V complex and the fibrinogen receptor, the integrin αIIbβ3 ...

journal_title：Platelets

authors： Falet H

更新日期：2013-01-01 00:00:00

abstract：:Studies have reported the polymorphism of human platelet antigen (HPA)-17w, -18w, -19w, -20w, and -21w. However, the distribution of these five antigens in Chinese Cantonese is still unknown. In this study, we designed new sequence-specific primers for HPA-19w to -21w and used published primers for HPA-17w and -18w to...

journal_title：Platelets

authors： Zhou H,Ding H,Chen Y,Li X,Ye X,Nie Y

更新日期：2015-01-01 00:00:00

abstract：:The ADP receptor P2Y12, the thromboxane A2 receptor (TXA2R) and the C-type lectin-like receptor 2 (CLEC-2) mediate platelet activation by different mechanisms. Only little is known about the expression of the receptors in human megakaryopoiesis. Our study aimed to establish a flow cytometry (FC) method for the measure...

journal_title：Platelets

authors： Gerhards C,Uhlig S,Etemad M,Christodoulou F,Bieback K,Klüter H,Bugert P

更新日期：2020-07-03 00:00:00

abstract：:SUMMARY. Blood platelets exposed to hypotonic medium are known to undergo a regulatory volume decrease (RVD), mediated by increased conductive permeability of K(+) and Cl(-). It is presently shown that RVD in platelets is controlled by a lipoxygenase product, apparently by a selective regulation of K(+) permeability. ...

journal_title：Platelets

authors： Margalit A,Livne AA

更新日期：1991-01-01 00:00:00

abstract：:Combined inhibition of platelet aggregation is essential to prevent recurrent ischemic episodes in patients with acute coronary syndromes and after percutaneous coronary interventions (PCIs). In combination with aspirin, the ADP receptor antagonist clopidogrel is used widespread for this purpose; however, platelet rea...

journal_title：Platelets

authors： Aradi D,Komócsi A

更新日期：2012-01-01 00:00:00

abstract：:Statins reduce coronary heart disease risk by altering blood lipids and other mechanisms. One of the possible other mechanisms is through an effect on thrombosis. We assessed the effect of simvastatin 80 mg daily versus placebo given in a single blind crossover fashion on platelet size in response to standard ex vivo ...

journal_title：Platelets

authors： Isley WL,Park Y,Harris WS

更新日期：2006-08-01 00:00:00

abstract：:The distribution of some proteoglycan anionic sites and carbohydrate moieties on the diabetic platelet surface has been investigated by cytochemical methods. Human blood platelets obtained from either diabetic patients (serum glycaemia 9.6-19.2 mmol/L) or normal donors were labeled with specific stains (Ruthenium Red,...

journal_title：Platelets

authors： Lupu C,Rizescu M,Calb M

更新日期：1994-01-01 00:00:00

abstract：:Tissue factor (TF) is the most important initiator of intravascular coagulation. This article will review published evidence on the contribution of platelets to TF exposure to the circulating blood. The following mechanisms will be discussed: decryption of monocyte TF by platelets, contribution of platelets to TF expr...

journal_title：Platelets

authors： Lösche W

更新日期：2005-09-01 00:00:00