Abstract:
:Salen-manganese complexes, such as EUK-8 and EUK-134 are known as catalase mimetics with superoxide dismutase (SOD) and peroxidase mimetic activity. Here we show that the concentration-dependent use of salen-manganese complexes within the appropriate time window and with parallel control of signaling parameters allows complex interactions during intercellular induction of apoptosis to be studied. At very low concentrations, salen-manganese complexes can abrogate consumption reactions between HOCl and hydrogen peroxide, as well as NO and hydrogen peroxide, and thus the major signaling pathways are enhanced. At higher concentrations of the compounds, all major signaling pathways are inhibited, thereby the catalase mimetic activity of the compounds affects both hydrogen peroxide and peroxynitrite. The ratio between available hydrogen peroxide and salen-manganese complexes defines whether reactive oxygen species (ROS) effects are inhibited or apoptosis is induced by the compounds. The SOD mimetic activity of salen-manganese complexes seems to be insufficient to interfere with intercellular ROS signaling.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Ophoven SJ,Bauer Gsubject
Has Abstractpub_date
2010-10-01 00:00:00pages
3967-79issue
10eissn
0250-7005issn
1791-7530pii
30/10/3967journal_volume
30pub_type
杂志文章abstract::Experimental biochemical modulation of 1-hexylcarbamoyl-5-fluorouracil (HCFU) with l-leucovorin (LV) was carried out using human gastric (H-111) and colon (Co-4) carcinoma xenografts serially transplanted into nude mice. Thirty-five or 70 mg/kg HCFU dissolved in 0.2 ml of 1% hydroxymethyl cellulose was administered po...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1992-09-01 00:00:00
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journal_title:Anticancer research
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1995-03-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2007-09-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2007-03-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2009-11-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1998-07-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2010-02-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:10.21873/anticanres.11256
更新日期:2016-12-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2007-07-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2000-05-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章,评审
doi:10.21873/anticanres.14105
更新日期:2020-03-01 00:00:00
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journal_title:Anticancer research
pub_type: 临床试验,杂志文章
doi:
更新日期:1995-11-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2005-05-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1991-11-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章,多中心研究
doi:
更新日期:2006-03-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:10.21873/anticanres.13693
更新日期:2019-09-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1989-07-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2004-07-01 00:00:00
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journal_title:Anticancer research
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
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journal_title:Anticancer research
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doi:
更新日期:2003-03-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2004-09-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
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更新日期:1997-01-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章,评审
doi:
更新日期:1987-05-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2002-11-01 00:00:00
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journal_title:Anticancer research
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doi:
更新日期:2013-10-01 00:00:00
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journal_title:Anticancer research
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更新日期:2017-05-01 00:00:00
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