Abstract:
:In an open study 31 patients undergoing bone marrow transplantation for various haematological diseases received fluconazole as prophylaxis or treatment of fungal infections. In 26 of these patients an antecedent oral prophylaxis with polyene antimycotics had failed to prevent infections with Candida species. Five of the 31 patients received fluconazole as primary prophylaxis because of non-compliance for polyene antimycotics. Fluconazole was administered orally at a daily dose of 100 mg and 200 mg, respectively (n = 29), or intravenously at a dose of 100 mg and 400 mg (n = 2). Cure or efficient prophylaxis was achieved in 22/31 patients (71%) after a median of 52 (9 to 546+) treatment days. In three patients (10%) Candida was eradicated but the infection reappeared 14-28 days after cessation of the drug; in 6 patients (20%) the infection was persistent or progressive. Four patients developed lethal Aspergillus infection while on fluconazole medication. A moderate and reversible elevation of liver function tests under therapy was observed in 9 patients and was possibly attributable to fluconazole in 3 of them (10%). One patient developed tremor which resolved after cessation of fluconazole. No other adverse drug reactions could be noted. We conclude that fluconazole is a relatively safe and effective drug for the prevention and treatment of superficial and, possibly, deep Candida infections in severely immunocompromised patients. It is presumably without preventive value in Aspergillus infections.
journal_name
Mycosesjournal_title
Mycosesauthors
Quabeck K,Müller KD,Beelen DW,Dermoumi H,Kölbel M,Kraft J,Schaefer UWsubject
Has Abstractpub_date
1990-01-01 00:00:00pages
19-26eissn
0933-7407issn
1439-0507journal_volume
33 Suppl 1pub_type
杂志文章相关文献
MYCOSES文献大全abstract::This short communication presents a review on the work of the mycological laboratory of the Institute of Microbiology and Epidemics, Hannover, Germany, concerning the mycological investigation on feeding stuff. Out of the routine diagnostic work, examining more than 4000 probes in the last 10 years, some selected inve...
journal_title:Mycoses
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract::Invasive aspergillosis has increasingly been recognised to cause significant morbidity and mortality in immunocompromised patients. Fever unresponsive to broad-spectrum antibiotics is the earliest and most common sign of an invasive fungal infection. As invasive Aspergillus infections are usually acquired by inhalatio...
journal_title:Mycoses
pub_type: 杂志文章,评审
doi:10.1111/j.1439-0507.1997.tb00559.x
更新日期:1997-01-01 00:00:00
abstract::The authors report a case of subcutaneous mucormycosis in a diabetic patient with verrucous lesions in the fourth finger of the right hand. Initially diagnosed as a fixed cutaneous sporotrichosis case, success was obtained with the use of potassium iodide with healing of the lesion in a period of nearly 5 months. At p...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/myc.1990.33.5.241
更新日期:1990-05-01 00:00:00
abstract::An atypical strain of Microsporum canis was isolated in our laboratory, which was characterized by a variety of polymorphous macroconidia. These are demonstrated by illustrations. Based on our observation and literature, the relationship between Microsporum canis and Microsporum distortum is discussed. Epidemiologic a...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.1989.tb02167.x
更新日期:1989-01-01 00:00:00
abstract::Sepsis is a leading cause of death in the intensive care unit (ICU), with Candida spp. in the forefront among the important pathogens. As recent studies have shown, survival outcome is strongly influenced by adequate antifungal therapy at an early stage that is often delayed by the time lag associated with microbiolog...
journal_title:Mycoses
pub_type: 杂志文章,评审
doi:10.1111/j.1439-0507.2010.01885.x
更新日期:2011-09-01 00:00:00
abstract::Posaconazole is indicated for prophylaxis and treatment of invasive aspergillosis. Therapeutic drug monitoring (TDM) of posaconazole is used to optimise drug exposure. The aim of this study was to analyse and describe the TDM practices and exposure of posaconazole tablets. Patients who received posaconazole for treatm...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/myc.12948
更新日期:2019-08-01 00:00:00
abstract::A 1-year study was conducted on 151 patients with finger- or toenail disease attending a dermatology clinic in Al Ain, United Arab Emirates. Nail scrapings and or clippings were collected and investigated with a KOH preparation for direct microscopy and cultured for fungi. Eighty-nine (59%) patients were females. Most...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.1995.tb00075.x
更新日期:1995-09-01 00:00:00
abstract::The article reviews 37 cases of phaeohyphomycosis from the world literature up to 1992 accepted as being caused by Wangiella dermatitidis. The various clinical aspects of these infections are characterized, and the nomenclatural implications in the history of this emerging pathogen are discussed. ...
journal_title:Mycoses
pub_type: 杂志文章,评审
doi:10.1111/j.1439-0507.1993.tb00743.x
更新日期:1993-05-01 00:00:00
abstract::The first case of a cutaneous cryptococcosis associated with systemic erythematous lupus (SLE) diagnosed in our Mycology Reference Centre is presented: a 24-year-old female patient diagnosed with SLE, nephrotic syndrome, arterial hypertension, renal insufficiency due to glomerulonephritis type IV and cellulitis in the...
journal_title:Mycoses
pub_type: 信件
doi:10.1046/j.1439-0507.2001.00661.x
更新日期:2001-11-01 00:00:00
abstract::Terbinafine was remarkably effective in tinea barbae due to Trichophyton rubrum on the cheek in front of the right ear in a 75-year-old man. This patient also showed tinea pedis and unguium, but these were due to Trichophyton mentagrophytes and were unrelated to the tinea in the cheek. This patient showed an atypical ...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.1998.tb00382.x
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Sporotrichosis is a subcutaneous mycosis caused by Sporothrix species that affects humans and animals. Little information on the genetic diversity and population structure of the pathogen is available for Brazil, which is needed to design effective strategies to tackle the advance of sporotrichosis in endemi...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/myc.13230
更新日期:2020-12-18 00:00:00
abstract::Eight cases of imported mycetomata in The Netherlands are reviewed. Seven of these were cultured; only one isolate, Actinomadura madurae, belonged to a species commonly known as an agent of mycetoma. The remaining strains either belonged to very rare species, such as Phialophora cyanescens, or could not be identified ...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.1993.tb00693.x
更新日期:1993-03-01 00:00:00
abstract::Cutaneous infections by Zygomycetes may have underestimated clinical consequences. Apophysomyces elegans is a Zygomycete that rarely causes disease in humans. However, it has been reported with increasing frequency in warm climate zones as a result of infection in healthy patients after injury to the cutaneous barrier...
journal_title:Mycoses
pub_type: 信件
doi:10.1111/j.1439-0507.2009.01698.x
更新日期:2010-05-01 00:00:00
abstract::Prophylactic treatment with human granulocyte colony-stimulating factor (hG-CSF) affords significant protection against systemic aspergillosis or pulmonary aspergillosis in neutropenic (cyclophosphamide-treated) mice but not in cortisone-treated animals. Cryptococcosis does not respond to hG-CSF therapy. Our data show...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.1991.tb00645.x
更新日期:1991-05-01 00:00:00
abstract::To evaluate caspofungin in high-risk invasive aspergillosis (IA) patient, a retrospective review of patient characteristics, antifungal therapies and clinical outcomes on hospitalised patients at sites in Russia, Canada, Germany, and Thailand was performed. Fifty-five patients were included, six with proven and 49 wit...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.2010.01861.x
更新日期:2011-07-01 00:00:00
abstract::The minimum inhibitory concentrations (MIC, microg ml-1) of itraconazole and terbinafine against overall 34 Aspergillus isolates from the external ear canals with otomycosis have been determined with M38-P microdilution method suggested by National Committee for Clinical Laboratory Standards (NCCLS). MIC intervals in ...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.2004.00988.x
更新日期:2004-08-01 00:00:00
abstract:BACKGROUND:Candidaemia in the elderly has not been extensively investigated. OBJECTIVES:We compared the management of candidaemia in the elderly patients (age ≥65 years) and the very elderly subgroup of patients (age ≥75 years) with those belonging to the younger group (age <65 years) using the European Confederation ...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/myc.13134
更新日期:2020-09-01 00:00:00
abstract::The amount of protein released into liquid culture medium and weight loss were taken as measures of wool degradation by Trichophyton simii and Aspergillus niger. Protein released into the culture medium was observed to be greater after T. simii treatment than after A. niger treatment. Sulphitolysis was shown by T. sim...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.1996.tb00103.x
更新日期:1996-11-01 00:00:00
abstract::Cryptococcal meningitis (CM) is one of the most common opportunistic infections of acquired immunodeficiency syndrome (AIDS), as well as an important cause of hospitalisation and death. In recent years, the mortality of CM has remained high in HIV/AIDS population, with up to 30%, including within developed countries. ...
journal_title:Mycoses
pub_type: 杂志文章,评审
doi:10.1111/myc.12977
更新日期:2019-10-01 00:00:00
abstract::Invasive candidiasis is a common nosocomial infection among critically ill patients, constitutes an important cause of sepsis, and is associated with significant morbidity and mortality. The Infectious Diseases Society of America (IDSA) has created evidence-based guidelines for the management of invasive candidiasis. ...
journal_title:Mycoses
pub_type: 杂志文章,评审
doi:10.1111/j.1439-0507.2008.01571.x
更新日期:2008-09-01 00:00:00
abstract::The in vitro antifungal activity of D0870 against eight isolates of fluconazole-resistant Candida albicans was compared with that of itraconazole, ketoconazole and miconazole. The colorimetric MTT [3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H tetrazolium bromide] assay was used to assess the antifungal activities. The...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.1998.tb00709.x
更新日期:1998-12-01 00:00:00
abstract::Among fungi, Curvularia inaequalis is a rare pathogen. We report the first case of non-invasive fungal rhinosinusitis caused by this species. Endoscopic sinus surgery revealed massive polyposis and the presence of viscous eosinophilic mucus that allowed the growth of the fungus. We diagnosed eosinophilic fungal rhinos...
journal_title:Mycoses
pub_type: 信件
doi:10.1111/j.1439-0507.2008.01671.x
更新日期:2010-01-01 00:00:00
abstract::Airborne invasive fungal infections in various risk groups of people suffering from immunodeficiencies are an increasing problem for modern medicine. Because of the acute and rapid course of invasive infections, prevention is of principal significance. Such prevention mainly concerns the control of fungal spores in in...
journal_title:Mycoses
pub_type: 杂志文章,评审
doi:10.1111/j.1439-0507.1992.tb00877.x
更新日期:1992-11-01 00:00:00
abstract:BACKGROUND:Loop-mediated isothermal amplification (LAMP) assays, which operate at a single temperature and require no postreaction processing, have been described for rapid species-specific detection of numerous fungi. The technology has much less commonly been applied to identification of other key genetic traits such...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/myc.12959
更新日期:2019-09-01 00:00:00
abstract::The aim was to evaluate efficacy and tolerance of a short-schedule treatment regimen using a small dose of itraconazole in pulse intermittently. The open study evaluated the pulse therapy consisting of monthly 1-week cycles of oral itraconazole 200 mg daily for 2-3 consecutive months in 42 patients with onychomycosis....
journal_title:Mycoses
pub_type: 临床试验,杂志文章
doi:10.1111/j.1439-0507.1997.tb00258.x
更新日期:1997-12-01 00:00:00
abstract::New antifungal agents are needed to match the currently increasing rate of systemic fungal infections and the development of resistant fungal strains. This appears possible by the introduction of second generation azole antifungals which potently inhibit ergosterol synthesis, but also by a partial synthetic echinocand...
journal_title:Mycoses
pub_type: 杂志文章,评审
doi:
更新日期:2003-01-01 00:00:00
abstract::Tinea faciei is an uncommon dermatophytosis affecting the glabrous skin of the face. Between 1988 and 2007 at the Dermatology Department of Cagliari University, 107 cases of tinea faciei have been diagnosed, involving 72 females and 35 males, aged 2-72 years. Incidence peaks were observed between 6 and 15 years (48.59...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.2009.01748.x
更新日期:2010-11-01 00:00:00
abstract::A 45-year-old woman was found to have cerebral phaeohyphomycosis caused by an Exophiala species. The portal of entry of the fungus remained unknown. Despite surgery and antimycotic therapy the patient died from circulation failure. The fungus is compared to several related Exophiala species. ...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.1991.tb00651.x
更新日期:1991-05-01 00:00:00
abstract::A new semi-solid culture medium was developed by substituting the agar in Sabouraud glucose medium by Lutrol FC 127 (BASF, Ludwigshafen, Germany). This culture medium can be liquefied by cooling it down from the incubation temperature to 5-10 degrees C, thus allowing the full harvest of fungal mycelium without any con...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.1992.tb00893.x
更新日期:1992-11-01 00:00:00
abstract::We have investigated the course of infection of Balb/c mice with Candida albicans. After intravenous infection of mice, the yeasts were evenly distributed in the liver sections. There was a 90% reduction in the yeasts found within 7 days after infection. This reduction was accompanied by an increase in the number of p...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.1997.tb00169.x
更新日期:1997-01-01 00:00:00